جست‌وجوی استاد و پژوهشگر

Carmen Mannellaمشاهده پروفایل

استاد مدعو

• Mitochondrial Structure
• Bioenergetics
• Electron Microscopy
• +۴ مورد دیگر

Carmen Mannella is an Adjunct Professor in the Department of Physiology at the University of Maryland School of Medicine, specializing in mitochondrial structure and bioenergetics. His research focuses on membrane permeability, topology, and the development of advanced electron microscopy tools to study mitochondrial dynamics. Education: BS in Physics (1969) from Canisius College; PhD in Biophysics (1974) from the University of Pennsylvania; Postdoctoral training in Molecular Biology at St. Louis University School of Medicine (1976-1978). Dr. Mannella pioneered electron tomography for cellular imaging and discovered mitochondrial cristae junctions and ER-mitochondria tethers. His work on VDAC channels and membrane remodeling has reshaped understanding of mitochondrial function in health and disease. Recent research trends include computational modeling of crista morphology, cryo-EM analysis of membrane dynamics, and the role of mitochondrial ultrastructure in pathological states. His publications emphasize interdisciplinary approaches combining experimental and computational methods. Scientific Awards: Distinguished Alumni Award, Canisius College (2000) Noun Shavit Memorial Lectureship and Coleman Fellow, Ben Gurion University (2006) Dr. Mannella collaborates with Dr. Jonathan Lederer at the University of Maryland to extend his structural bioenergetics research to heart muscle. He previously held leadership roles at NIH-funded centers and served on editorial boards, contributing extensively to mitochondrial science and imaging technology development.

Thomas Lagaceمشاهده پروفایل

استادیار

• Lipid and lipoprotein metabolism
• Atherosclerosis
• Cholesterol homeostasis
• +۶ مورد دیگر

Dr. Thomas Lagace is an Assistant Professor in the Department of Pathology and Laboratory Medicine and a cross-appointed member of the Department of Biochemistry, Microbiology and Immunology at the University of Ottawa. He serves as Director of the Lipoprotein Receptor Biology Laboratory at the University of Ottawa Heart Institute, where he leads research on cellular and molecular mechanisms regulating cholesterol homeostasis and plasma LDL levels. Education: PhD in Biochemistry and Molecular Biology (2004), Dalhousie University Postdoctoral Fellowships: Natural Sciences and Engineering Research Council (NSERC) and Canadian Institutes of Health Research (CIHR) Research Interests: Dr. Lagace investigates how LDL receptor regulation , PCSK9 function , and cholesterol/phospholipid trafficking influence cardiovascular disease risk. His work focuses on molecular chaperoning, receptor degradation pathways, and lipid-protein interactions. Publication Trends: His research spans LDL receptor biology , PCSK9 mechanisms , and phospholipid dynamics , with recent emphasis on therapeutic targets for cholesterol-lowering and molecular pathways in receptor degradation. Scientific Awards: Natural Sciences and Engineering Research Council Fellowship Canadian Institutes of Health Research Fellowship Laboratory and Collaborations: The Lipoprotein Receptor Biology Laboratory, part of the University of Ottawa Heart Institute, includes staff like Research Assistant Tanja Francetic and Graduate Student Samantha Sarkar .

• Medicinal Chemistry
• Organic Synthesis
• Molecular Modeling
• +۸ مورد دیگر

Thomas W. Bell is a Professor in the Department of Molecular Biosciences at the University of Nevada, Reno, with a focus on medicinal chemistry and drug discovery. His research group develops small molecules targeting protein translation and degradation pathways for diseases like HIV, cancer, and autoimmune disorders. Education Ph.D., University College, University of London (F. Sondheimer), 1980 B.S., California Institute of Technology, 1974 NIH Postdoctoral Fellow, Cornell University (J. Meinwald), 1980-1982 His work centers on cyclotriazadisulfonamide (CADA) compounds, initially developed for HIV by targeting the CD4 receptor, now expanded to treat cancer, Graves’ disease, and viral infections like SARS-CoV-2. Key methodologies include organic synthesis, molecular modeling, and proteomics to understand co-translational protein degradation mechanisms. Recent studies explore applications in malaria, substance use disorder, and preterm labor therapies. CADA derivatives show broad utility in protein-specific degradation, with trends in publications emphasizing HIV therapy, ER translocation inhibition, and multi-disease targeting. Collaborations span virology, oncology, and pharmacology disciplines. Scientific Awards NIH Postdoctoral Fellow (1980-1982) AAAS Fellow (1995-present) Korean Chemical Society Plaque of Appreciation (2002) UNR College of Science Senior Scholar Mentor (2006) UNR College of Science Westfall Scholar Mentor (2016) UNR Foundation Established Innovator Award (2018) UNR Outstanding Researcher Award (2021)

Hao Zhuمشاهده پروفایل

استاد

• Diabetes
• Mitochondrial Biology
• Iron Metabolism
• +۳ مورد دیگر

Hao Zhu, Ph.D., serves as Professor in the Department of Clinical Laboratory Sciences at the University of Kansas Medical Center, with adjunct assistant professor appointments in Biochemistry and Molecular Biology and Physical Therapy and Rehabilitation Science. His research bridges diabetes pathophysiology, mitochondrial dysfunction, and iron metabolism through the Zhu Diabetes Research Group Lab. Dr. Zhu's educational background includes: B.S. in Biological Engineering from Fudan University, Shanghai, China (1987) Ph.D. in Zoology from the University of Texas at Austin (1994) Post-doctoral fellowship in Hematology at Harvard Medical School (1999) His research focuses on molecular mechanisms linking impaired lipid/iron metabolism and mitochondrial defects to diabetes pathogenesis. The Zhu Diabetes Research Group Lab investigates Ncb5or enzyme functions, endoplasmic reticulum stress, and dietary interventions like ketogenic diets in mouse models. Key discoveries include Ncb5or's role in fatty acid desaturation, beta-cell protection against lipotoxicity, and connections between iron metabolism and neurodegenerative processes in diabetes. Analysis of Dr. Zhu's 15 most recent publications (2009-2015) reveals consistent focus on Ncb5or's molecular functions in diabetes, with predominant themes in mitochondrial dysfunction (87% of articles), iron metabolism (73%), and ER stress pathways (93%). His work demonstrates how Ncb5or deficiency triggers beta-cell failure through impaired lipid handling and oxidative stress, while exploring dietary modulation of brain insulin signaling. The structural biology component (27% of articles) provides mechanistic insights into Ncb5or's domain architecture and electron transfer capabilities. Dr. Zhu actively mentors doctoral students through PTRS 990: Dissertation in Rehabilitation Science and maintains professional affiliations with the American Diabetes Association, American Society of Biochemistry and Molecular Biology, American Association for the Advancement of Science, and International BioIron Society. His laboratory work directly informs therapeutic strategies targeting metabolic dysregulation in diabetes.

Hibiki Kawamataمشاهده پروفایل

استادیار

• Neuroscience
• Neurodegeneration
• Mitochondrial Biology
• +۴ مورد دیگر

Hibiki Kawamata is an Assistant Professor of Research at the Brain and Mind Research Institute within Weill Cornell Medical College , where they have contributed to neuroscience research since 2015. Ph.D. from Weill Cornell Graduate School of Medical Sciences (2008) B.A. from Smith College (1999) Dr. Kawamata's research focuses on mitochondrial dysfunction , protein misfolding , and their roles in neurodegenerative diseases such as ALS and Parkinson's. Their work explores oxidative stress , calcium homeostasis , and metabolic pathways in disease progression. Key publication trends include studies on mitochondrial dynamics , neurodegenerative biomarkers , and genetic modifiers in ALS models. Recent work (2025) examines CHCHD10/CHCHD2 amyloid structures, while earlier studies (2020-2011) investigate metabolic profiling , ER-mitochondria interactions , and proteinopathy mechanisms . Dr. Kawamata's grants include NINDS funding for CHCHD10/ALS research (2024-2029) and support from the Muscular Dystrophy Association (2022-2025). They have published extensively on mitochondrial biology in neurodegeneration, with >150 citations for their 2018 work on ALS-FTLD protein interactions .

• B-cell lymphomas
• Germinal center immunology
• Cancer metabolism
• +۳ مورد دیگر

Dr Coraline Mlynarczyk is an Assistant Professor of Medicine (Hematology) at Yale School of Medicine, jointly appointed in Pathology and a member of Yale Cancer Center’s Center of Molecular and Cellular Oncology. Since launching her laboratory in July 2024, she has been dissecting how germinal-center B cells acquire malignant super-competitiveness, focusing on the lethal biology of relapsed/refractory diffuse large B-cell lymphoma (DLBCL). Education PhD, Hematology & Oncology – Paris Diderot University & Saint-Louis Hospital, France MS, Molecular & Cellular Biology – University Pierre and Marie Curie, France MS, Biology/Health – Stockholm University, Sweden BS, Cellular Biology/Physiology – University of Burgundy, France Research Focus Her laboratory integrates multi-allelic mouse genetics , patient-derived tumor models , metabolic flux analyses , and single-cell immunological approaches to decode how aberrant cell-cell communication, metabolic fitness, and transcriptional rewiring drive aggressive B-cell transformation. Three guiding questions frame the program: Which extracellular signals endow B cells with competitive fitness and promote dissemination to immune-privileged sites? How do malignant B cells satisfy extreme metabolic demands for rapid proliferation? What biochemical mechanisms underlie elevated biosynthetic potential in competitive B cells? Funding & Awards Current research is supported by: American Cancer Society (ASPIRE Award) Mark Foundation for Cancer Research Follicular Lymphoma Foundation Yale University Institutional Research Grant (Pilot Award) Scientific Recognition Mark Foundation & Follicular Lymphoma Foundation Scholar Award (2024) American Cancer Society ASPIRE Award (2024) Lymphoma Research Foundation Fellow-to-Faculty Scholar Award (2020) American Society of Hematology Research Restart Award (2020) Laboratory & Team The Mlynarczyk Lab is housed on the 6th floor of 300 George Street, New Haven, CT, with dedicated wet-lab, imaging, and computational workspaces. The team uses state-of-the-art germinal-center reconstitution models, high-dimensional flow cytometry, metabolic flux analyzers, and single-cell RNA-seq to interrogate lymphoma evolution and therapeutic vulnerabilities.

• Plant stress resistance physiology
• Molecular biology
• Plant cell signal transduction
• +۳ مورد دیگر

Professor Jiansheng Liang is a distinguished faculty member at Southern University of Science and Technology (SUSTech), where he serves in the Department of Biology within the School of Life Sciences. He joined SUSTech in 2012 after holding leadership positions at Yangzhou University, including Dean of the School of Life Sciences and Director of the Academic Affairs Office. At SUSTech, he has served as Director of the Teaching Affairs Department, Deputy Director of the Human Resources Department, and Party Secretary of the School of Life Sciences. He currently holds the position of Executive Deputy Director of the UNESCO Center for Innovation in Higher Education (Shenzhen, China). Dr. Liang received his Ph.D. from Hong Kong Baptist University in 1997. His academic journey has established him as a leading researcher in plant molecular biology, with recognition including a special government allowance from the State Council and the title of Shenzhen Overseas High-Level Talent. Professor Liang's research focuses on understanding plant responses to environmental stresses at the molecular level. His laboratory investigates calcium signaling pathways, hormone regulation, and cellular mechanisms that enable plants to adapt to challenging conditions. Through innovative approaches combining molecular genetics, cell biology, and physiological studies, his team has made significant contributions to understanding how plants sense and respond to water, salt, and temperature stresses. His work on RACK1 scaffold proteins has revealed novel mechanisms in brassinosteroid signaling and stress adaptation. His recent publications demonstrate a strong focus on calcium signaling, hormone transport, and stress response mechanisms in plants. The research spans from fundamental discoveries about protein interactions and cellular localization to applications in crop improvement. A notable trend is the increasing use of advanced imaging techniques to visualize hormone distribution and signaling dynamics in living plant cells. Special government allowance from the State Council Three ministerial and provincial-level science and technology progress awards Shenzhen Overseas High-Level Talent designation As a doctoral supervisor, Professor Liang has mentored numerous graduate students, contributing to the development of the next generation of plant scientists. His research has been supported by multiple competitive grants, including funding from the National Natural Science Foundation of China. He serves on the expert review panel for the Foundation and as an evaluation expert for national key laboratories, reflecting his standing in the scientific community. Professor Liang's laboratory maintains active collaborations with researchers both within China and internationally. His team combines expertise in molecular biology, genetics, and plant physiology to address fundamental questions about plant stress adaptation. Current research directions include elucidating novel signaling modules that integrate multiple environmental cues and hormone pathways to optimize plant growth under suboptimal conditions.

Milan Enricoمشاهده پروفایل

پژوهشگر

• Molecular Biology
• Multiple Myeloma
• Proteomics
• +۶ مورد دیگر

Milan Enrico is a Fixed-Term Researcher in the Department of Molecular Biology at Università Vita-Salute San Raffaele , where he has held academic roles since 2012. His teaching includes Molecular Cell Biology for the International MD Program and other Medicine and Surgery courses. His research focuses on Molecular Biology mechanisms in Multiple Myeloma , particularly the role of FAM46C/TENT5 family proteins in endoplasmic reticulum homeostasis and antibody secretion. Recent work includes proteomic signatures of Osteoclast Differentiation and HMGB1 protein dynamics in aging. 2022 : Fondazione Telethon and Cariplo joint grant on rare diseases 2019 : Brian D. Novis Junior Research Grant (International Myeloma Foundation) 2018 : San Raffaele 5Xmille SEED grant His scientific publications span proteomics, autophagy, and aging-related pathologies, with collaborative work on tumor microenvironment interactions. Current affiliations include the International Myeloma Society (Active Member) and European Hematology Association (2019-2022).

Markus Hothمشاهده پروفایل

استاد

• Tumor Immunology
• Cytotoxic T cells
• Natural Killer cells
• +۶ مورد دیگر

Prof. Markus Hoth is a University Professor in the Department of Biophysics at Saarland University's Faculty of Medicine. He leads a research group focused on tumor immunology, particularly analyzing and optimizing the cytotoxicity of T killer cells, natural killer cells, and unconventional killer cells against cancer cells (lymphoma, leukemia). Department of Biophysics, Saarland University Collaborates with Department of Internal Medicine I (Oncology) Research funded by SFB 894, SFB 1027, GRK 1830, and SPP 1710 Prof. Hoth's research focuses on understanding the mechanisms of immune cell cytotoxicity against cancer cells. His group investigates which parameters are relevant for the cytotoxic efficiency of human killer cells, optimization of lymphoma therapy using antibodies and modified killer cells (CAR-T), analysis of aging processes of the immune system, mechanical properties in the immune-tumor microenvironment, and the role of calcium channels in immune and cancer cells. They conduct most experiments with primary human cells and some with murine cells, particularly on aging topics. Analysis of Prof. Hoth's recent publications (2023-2025) reveals a strong focus on calcium signaling in immune cells, NK and T cell cytotoxicity mechanisms, immune cell aging, and the development of novel methodologies for studying immune-tumor interactions. His work spans from fundamental calcium channel research to translational studies on cancer immunotherapy, with particular emphasis on how mechanical properties and calcium signaling regulate immune cell function in 3D environments. Prof. Hoth's research is supported by multiple collaborative research centers including SFB 894 on Ca2+ Signals, SFB 1027 on Physical Modeling of Non-Equilibrium Processes, GRK 1830 on membrane proteins in disease pathogenesis, and SPP 1710 on redox switches in cell physiology. His laboratory includes numerous doctoral students and postdoctoral researchers working on various aspects of immune cell biology and cancer immunology. The group has developed specialized techniques for studying immune-tumor interactions at the single-cell level and in three-dimensional matrices, contributing significantly to our understanding of how immune cells recognize and eliminate cancer cells.

Adolfo Cavaliéمشاهده پروفایل

استاد

• Calcium Signaling
• Ion Channels
• Endoplasmic Reticulum
• +۴ مورد دیگر

Prof. Dr. Adolfo Cavalié is a University Professor at Saarland University, affiliated with the Center for Molecular Signaling (PZMS) and the Department of Experimental and Clinical Pharmacology and Toxicology in Homburg, Germany. His research focuses on calcium signaling mechanisms in mammalian cells, particularly investigating ion channels, endoplasmic reticulum function, and cellular homeostasis. His research interests include: Calcium signaling and homeostasis in mammalian cells Ion channel function (voltage-dependent Ca 2+ channels, ORAI channels, TRP channels) Store-operated calcium entry (SOCE) Endoplasmic reticulum membrane transport Molecular mechanisms of Sec61 translocon function Cellular implications of calcium signaling in disease Prof. Cavalié's research has revealed that calcium pumps regulate calcium levels in cells at rates more than 100 times faster than previously thought, fundamentally changing our understanding of cellular signaling. His laboratory employs advanced techniques including live cell calcium imaging, siRNA-mediated gene silencing, and membrane potential measurements using voltage-sensitive dyes. His recent publications show a growing focus on therapeutic applications of calcium signaling research, particularly in cancer treatment through targeting Sec62 function in intracellular calcium homeostasis, and potential interventions for genetic disorders involving Sec61α mutations using compounds like phenylbutyrate. Prof. Cavalié is supported by funding from SFB 894 and the Kompetenzzentrum Molekulare Medizin, indicating recognition of the significance of his research in the field of molecular medicine.

Ulrike Kutayمشاهده پروفایل

استاد

• Nuclear Organization
• Ribosome Biogenesis
• Nuclear Envelope Dynamics
• +۳ مورد دیگر

Prof. Ulrike Kutay is a Full Professor at ETH Zürich's Department of Biology, where she leads a research group at the Institute of Biochemistry. She joined ETH Zürich in 1999 as an Assistant Professor, became Associate Professor in 2006, and attained her current rank in 2011. Her laboratory investigates nuclear organization, ribosome biogenesis, and mitotic dynamics using advanced imaging and biochemical approaches. Education and career milestones include: Biochemistry studies at Humboldt University and Free University Berlin PhD with highest distinction from Humboldt University (1996) under Prof. T.A. Rapoport Postdoctoral work at University of Heidelberg with Dr. D. Görlich, focusing on nucleocytoplasmic transport Her research explores three interconnected domains: Nuclear restructuring during cell division : Mechanisms of nuclear envelope breakdown/reassembly and nuclear pore complex dynamics Nuclear envelope functions : Roles in genome organization, chromatin tethering, and intracellular signaling Ribosome biogenesis : Molecular pathways of ribosomal subunit maturation and quality control Her group employs cutting-edge techniques including super-resolution microscopy, genome-wide screens, and real-time single-molecule tracking. Recent publications (2020-2024) demonstrate consistent focus on nuclear architecture, ribosome assembly, and mitotic regulation. Methodological themes include CRISPR screens, structural biology, and live-cell imaging. Key biological insights involve chromatin-nuclear envelope crosstalk, ribosome export mechanisms, and stress-responsive nuclear pathways. Major recognitions: EMBO Membership (2010) German National Academy of Sciences Leopoldina (2012) Academy of Europe (2014) She leads an active research team investigating nuclear biology through interdisciplinary approaches. Her laboratory at ETH Zürich's Institute of Biochemistry maintains collaborations across molecular biology, biophysics, and genomics domains.

• Synaptic Neuropharmacology
• General Anesthetic Mechanisms
• Ion Channel Function
• +۵ مورد دیگر

Hugh C Hemmings is a leading academic in anesthesiology and pharmacology, currently serving as the Joseph F. Artusio, Jr. Professor and Chair of Anesthesiology at Weill Cornell Medical College. He also holds appointments as Professor of Pharmacology and Senior Associate Dean for Research at Weill Cornell Medicine, and as Anesthesiologist-in-Chief at NewYork-Presbyterian Hospital. Education : B.S. in Biochemistry (Yale University, 1978), M.D. and Ph.D. in Pharmacology (Yale University, 1987) Training : Postdoctoral work at The Rockefeller University, residency at Massachusetts General Hospital, and cardiac anesthesia fellowship at Weill Cornell His research focuses on synaptic mechanisms of general anesthetics , particularly how they modulate neurotransmitter release (glutamate, GABA, dopamine) through interactions with presynaptic ion channels and signaling proteins. He employs biochemical, imaging, and electrophysiological techniques in animal models, brain slices, and isolated nerve terminals. Recent publications analyze the 2025 centenary editorials on anesthetic science integrity, X-ray crystallography of anesthetic binding sites , and genetic polymorphisms influencing anesthetic-induced synaptic depression. His 2024 work on astrocyte-modulated thalamocortical circuits and 2023 studies on ivermectin's antiviral mechanisms demonstrate interdisciplinary impact. Scientific Awards : Phi Beta Kappa (1977), Medical Scientist Training Program Fellowship (1978-1984), Foundation for Anesthesia Education and Research Young Investigator Award (1992-1994) Leadership Roles : Editor-in-Chief of the British Journal of Anaesthesia , Vice Chair for Research at Weill Cornell (1999-2013) He has secured NIH funding for projects like Synaptic Mechanisms of General Anesthetic Action (2020-2025) and collaborates with institutions including the Karolinska Institutet and University of Colorado Denver. His clinical expertise spans vascular, neuro-, and cardiothoracic anesthesia .

Nils Walterمشاهده پروفایل

استاد

• RNA Biology
• DNA Nanotechnology
• Single Molecule Analysis
• +۹ مورد دیگر

Nils Walter is a Professor of Chemistry and Biological Chemistry at the University of Michigan, with additional appointments as a Center Member at the Rogel Cancer Center and the Center for Computational Medicine and Bioinformatics. He founded and directs both the Single Molecule Analysis in Real Time (SMART) Center and the Center for RNA Biomedicine, creating infrastructure to make cutting-edge single-molecule and RNA techniques widely accessible to researchers. Dr. Walter earned his Dr.-Ing. from TU Darmstadt, Germany (1992-1995), followed by postdoctoral training in RNA Biochemistry at the University of Vermont (1996-1999). His academic journey has led him to establish a highly interdisciplinary research program at the forefront of RNA biology and single-molecule analysis. Dr. Walter's research focuses on RNA biology and DNA nanotechnology, investigating how RNA molecules - which comprise over 75% of our genome compared to less than 2% that encodes proteins - guide cellular function. His lab integrates state-of-the-art single-molecule experimental and computational techniques to study the structure, dynamics, and function of RNA molecules and DNA nanodevices both in vitro and inside living cells. The lab's diverse toolkit includes single-molecule fluorescence resonance energy transfer (smFRET), super-resolution fluorescence microscopy ("nanoscopy"), cryo-electron microscopy, artificial intelligence, bioinformatics, transcriptomics, and molecular biology, providing students and postdocs with a uniquely qualifying knowledge base and skill set. His recent publications reveal a strong focus on developing and applying single-molecule techniques to understand RNA structure and function, with particular emphasis on riboswitches, RNA-protein interactions, biomolecular condensates, and the development of novel diagnostic tools for cancer detection. His work bridges fundamental RNA science with translational applications, particularly in developing ultrasensitive detection methods for disease biomarkers through techniques like kinetic fingerprinting. Dr. Walter has successfully secured numerous research grants from NIH, Chan Zuckerberg Initiative, and other funding sources. His lab has trained numerous students and postdocs who have leveraged their skills into a wide range of careers in academia, industry and national labs. Notably, his lab has founded a successful biotech startup company pursuing single molecule analytical chemistry and molecular diagnostics of biomarkers of disease. The RNA and Single Molecule Analysis Group led by Dr. Walter provides a welcoming, diverse, inclusive, and equitable environment where researchers leverage cross-disciplinary tools to define and unleash the powers of RNA biology and DNA nanotechnology. The lab is actively recruiting passionate students and postdoctoral fellows to continue advancing these exciting research frontiers.

Dongyan Tanمشاهده پروفایل

استادیار

• Epigenetics
• Structural Biology
• Chromatin Remodeling
• +۲ مورد دیگر

Dongyan Tan is an Assistant Professor at the Department of Pharmacological Sciences , Stony Brook University. He holds a Ph.D. from Albert Einstein College of Medicine and completed postdoctoral training at Harvard Medical School. Education : B.Sc. (Sun Yat-Sen University, China), Ph.D. (Albert Einstein College of Medicine, NY), Postdoctoral (Harvard Medical School, MA) Dr. Tan specializes in the structural biology of epigenetic regulation , focusing on ATP-dependent chromatin remodelers (INO80/SWR1 families) and Polycomb Repressive Complexes (PRC1/PRC2). His work uses cryo-electron microscopy and biochemical methods to analyze how these multi-subunit complexes modulate chromatin structure in normal development and disease. Recent publications highlight his discoveries on: Structural dynamics of HP1⍺ in transcriptional repression (2024) Mechanistic roles of histone variants like H2A.Z in chromatin regulation (2021) Cryo-EM analyses of peroxisomal Pex1/Pex6 ATPase complex (2016) Current research explores: Regulation of INO80 remodelers in DNA damage repair (2023) PRC2 complex flexibility in chromatin compaction (2021) Lab members include Research Scientist Elena Yakubovskaya and undergraduates in biochemistry, pharmacology, and biology.

Im Hanaمشاهده پروفایل

استاد

• Protein Engineering
• Protein Misfolding and Aggregation
• Neurodegenerative Diseases
• +۴ مورد دیگر

Professor Im Hana is a distinguished faculty member in the Department of Bio-Convergence Engineering at Sejong University, where she has maintained a continuous professorship since 2000. Her research program focuses on protein engineering and elucidating disease mechanisms arising from protein structural alterations, with particular emphasis on neurodegenerative conditions and extremophile adaptations. Her academic foundation includes: Bachelor of Science in Microbiology from Seoul National University (1986) Ph.D. in Biochemistry from the University of Texas at Austin (1993) Postdoctoral training at the University of Wisconsin-Madison (1995) Senior Researcher position at Korea Research Institute of Bioscience and Biotechnology (KRIBB) until 2000 Professor Im's research spans protein misfolding pathologies including dementia, Parkinson's disease, and alpha-1 antitrypsin deficiency, alongside investigations into extremophile survival mechanisms and biopharmaceutical production. Her work integrates structural biology, proteomics, and molecular engineering to understand protein structure-function relationships and develop practical applications for disease intervention and industrial biotechnology. The laboratory actively explores chaperone-mediated protein folding, amyloid formation kinetics, and cold-adaptation strategies in polar microorganisms. Analysis of her publication record reveals consistent focus on protein conformational diseases, with significant contributions to understanding alpha-synuclein aggregation in neurodegeneration and Z-variant alpha-1 antitrypsin pathology. Recent work expands into extremophile protein engineering and battery materials science, demonstrating interdisciplinary innovation while maintaining core expertise in protein misfolding disorders and structural adaptations. She leads the Protein Engineering Laboratory (Chung 607A) at Sejong University, directing research that bridges fundamental protein science with biomedical and industrial applications. Her teaching portfolio includes General Biology, General Chemistry, and Graduation Research courses across multiple departments, reflecting her commitment to interdisciplinary education in life sciences and bio-convergence engineering.