جستجوی استاد راهنمای دانشگاهی

• Precision Medicine
• Cancer Biology
• Drug Discovery
• +۵ مورد دیگر

Brinton Seashore-Ludlow is an Associate Professor at the Department of Oncology-Pathology, Karolinska Institute (KI), where he serves as team leader in Olli Kallioniemi's research group and group leader of the biology team at Chemical Biology Consortium Sweden (CBCS), SciLifeLab's national infrastructure. PhD in Biochemistry, KTH Royal Institute of Technology (2012) MSc in Chemical Biology, California Institute of Technology (2007) BA in Biochemistry, Macalester College (2001) His research bridges precision medicine and cancer biology through: Developing ex vivo patient-derived models for drug response prediction Molecular determinants of therapeutic efficacy Integration of high-content imaging with translational studies Focus on ovarian, breast, and pediatric cancers AI-driven analysis of drug sensitivity data Recent articles demonstrate: 3D tumor spheroid platforms for drug testing Epigenetic regulators in neuroblastoma Microfluidics for high-throughput assays Cancer-stroma interactions in treatment resistance Clinical validation of precision diagnostics He co-organizes the Overview Course in Cancer Drug Discovery at KI and leads projects funded by the Swedish Childhood Cancer Foundation.

• Environmental Chemistry
• Ecotoxicology
• Exposure Assessment
• +۵ مورد دیگر

M.T.O. (Chiel) Jonker is an Assistant Professor at the Faculty of Veterinary Medicine , Utrecht University , affiliated with the Institute for Risk Assessment Sciences (IRAS) and its Toxicology division . He specializes in exposure assessment of hydrophobic organic chemicals (e.g., PFAS , PAHs , PCBs ), focusing on sorption processes , bioaccumulation dynamics , and passive sampling techniques in both in vivo and in vitro settings. His research emphasizes methodological innovation for high-quality chemical analysis (GC-MS, LC-MS) and environmental risk assessment . Recent work includes PFAS degradation , sediment toxicity testing , and temperature/salinity effects on contaminant partitioning. His 2018-2024 publications highlight passive sampling calibration , mechanistic toxicity models , and bioavailability prediction using polyoxymethylene and silicone rubber samplers .

Charlotte Kuperwasserمشاهده پروفایل

استاد

• Breast Cancer Research
• Mammary Gland Biology
• Cancer Prevention
• +۴ مورد دیگر

Dr. Charlotte Kuperwasser is a distinguished Professor in the Department of Developmental, Molecular, and Chemical Biology at Tufts University School of Medicine . She directs the Tufts Convergence Laboratory and focuses on molecular mechanisms governing breast tissue development, cancer prevention, and organoid technologies. Her work integrates stem cell biology, epigenetics, and environmental influences such as endocrine disruptors. Education: Bachelor of Science (1997), University of Massachusetts Amherst PhD (2000), University of Massachusetts Amherst Jane Coffin Childs Postdoctoral Fellow (MIT/Whitehead Institute) Research Interests: Her lab develops 3D breast organoid models to study cancer initiation, microenvironmental interactions, and BRCA1-related mechanisms. Recent efforts include analyzing HPV-driven cancers via circulating tumor DNA and studying fibroblast signaling (e.g., DDR1) in tumor progression. Grants & Awards: Howard Hughes Fellowship, Merck Fellowship COG/Aventis Young Investigator Award Natalie V. Zucker Award NIH grants on V-ATPases and obesity-cancer links Professional Contributions: She chairs Tufts’ Sackler Convergence Laboratory and serves on AACR committees. Teaching includes courses on Molecular Cell Biology of Development and Cancer Genetics . Labs/Teams: Leads the Kuperwasser Lab, focusing on translational cancer research with cross-disciplinary collaborations in organoid engineering and clinical diagnostics.

Martin Jastrochمشاهده پروفایل

استاد

• Energy Metabolism
• Obesity Research
• Adipose Tissue Biology
• +۴ مورد دیگر

Martin Jastroch is a Professor at Stockholm University's Department of Molecular Biosciences, The Wenner-Gren Institute. His research focuses on the physiology and molecular mechanisms of energy metabolism from organism to molecule level. His primary research interests include: Energy metabolism physiology and molecular mechanisms Obesity and metabolic aspects Adipose tissue biology Mitochondrial mechanisms Thermogenesis and brown fat function Metabolic regulation in health and disease Professor Jastroch's research spans multiple disciplines, connecting molecular mechanisms with whole-organism physiology. His work on mitochondrial bioenergetics and thermogenesis has contributed significantly to understanding how energy metabolism is regulated across different biological scales. Recent publications show a growing interest in the evolutionary aspects of thermogenesis and the role of brown adipose tissue in metabolic diseases, with particular focus on UCP1 function, mitochondrial adaptations, and metabolic reprogramming in disease states. His scientific contributions include important findings on: UCP1 (Uncoupling Protein 1) function and regulation Mitochondrial bioenergetics in different tissue types Evolutionary aspects of mammalian thermogenesis Metabolic regulation in obesity and related disorders Links between mitochondrial dysfunction and neurodegenerative diseases Professor Jastroch leads 'Group Jastroch' at Stockholm University, where his team investigates the complex interplay between cellular energy metabolism and whole-body physiology, with implications for understanding and treating metabolic disorders.

Antti Posoمشاهده پروفایل

استاد

• Drug Design
• Molecular Modeling
• Anti-Cancer Drugs
• +۳ مورد دیگر

Antti Poso is a Professor of Drug Design at the University of Eastern Finland (Kuopio), affiliated with the School of Pharmacy under the Faculty of Health Sciences. His research focuses on computer-aided molecular design, particularly targeting anti-cancer drugs and anti-microbials. Key projects include the EDCMET project (2019–2024) and the GeneCellNano Flagship (2020–2028). He leads the Molecular Modeling and Drug Design Research Group, specializing in QSAR analysis, kinase inhibition profiling, and systems-level drug response modeling. Recent work includes studies on SARS-CoV-2 inhibitors, endocrine disruptors, and bacterial pathogenesis. His findings bridge chemical structure with biological outcomes, leveraging computational tools like CCA and molecular dynamics simulations. Collaborations span medicinal chemistry, pharmacology, and systems biology, contributing to both academic and applied drug discovery efforts. Education: Not explicitly stated in texts; assumed to hold advanced degrees in pharmacy or chemistry. Research Themes: Drug design, molecular modeling, QSAR, computational biology, and anti-infective agents. Key Contributions: Over 150+ publications, including influential works on chemoinformatics-driven drug response analysis and structure-based inhibitor design. Publications highlight advancements in kinase inhibitors, anti-microbial strategies, and viral hijacking mechanisms. His work emphasizes translating computational insights into therapeutic solutions for cancer, infectious diseases, and metabolic disorders.

• Environmental Toxicology
• Reproductive Health
• Metabolic Disorders
• +۳ مورد دیگر

Dr. Alison Holloway is a Professor at McMaster University's Faculty of Health Sciences, specializing in environmental toxicology and reproductive health. Her research focuses on the effects of environmental contaminants (e.g., oil sands pollutants, pesticides, endocrine disruptors) on maternal and child health, metabolic disorders, and developmental outcomes. She has conducted studies on naphthenic acids, synthetic food additives, and maternal exposure to pharmaceuticals like fluoxetine. Key research areas include: Environmental contaminants' impact on reproductive systems and placental function Metabolic disturbances caused by chemical exposures during critical developmental windows Neurobehavioral and gastrointestinal effects of prenatal drug exposure Assessment of urban air pollution on in vitro fertilization (IVF) success rates Her recent work highlights the role of the tryptophan-kynurenine pathway as a biomarker of environmental stress and the obesogenic effects of bisphenol analogs and food additives. Collaborations involve interdisciplinary teams addressing environmental health, with studies published in high-impact toxicology and public health journals. Dr. Holloway's research has informed policies on chemical safety and maternal health, emphasizing cross-species markers for organismal health and risk assessment of emerging contaminants like cannabis derivatives.

Kaat Alaertsمشاهده پروفایل

استاد

• Neurorehabilitation
• Oxytocin Research
• Autism Spectrum Disorder
• +۶ مورد دیگر

Professor Kaat Alaerts is a leading researcher at KU Leuven's Faculty of Movement and Rehabilitation Sciences, where she serves as Head of the Neurorehabilitation Research Group and Professor in the Department of Rehabilitation Sciences. Her work bridges neuroscience, psychology, and rehabilitation science to develop innovative interventions for stress regulation and social-cognitive functioning, with a particular focus on autism spectrum disorder and related conditions. Her primary research interests span neurorehabilitation , oxytocin research , autism spectrum disorder , stress regulation , mindfulness and meditation , neurostimulation , and social cognition . Dr. Alaerts employs a multidisciplinary approach that combines neuroscientific, physiological, and behavioral methods to study both clinical effectiveness and underlying brain mechanisms of neuromodulatory interventions. The research output demonstrates a strong focus on exploring the therapeutic potential of oxytocin, particularly for autism spectrum disorder. Her work examines both the standalone effects of oxytocin and its synergistic effects when combined with mindfulness training or other interventions. A growing body of research also investigates the gut-brain axis in autism and the role of microbiome composition in social and stress-related difficulties. Dr. Alaerts has received notable recognition including the KAGB Clinical Medicine Award in September 2024 for her work on oxytocin administration in children with autism. Her research group has also been honored with multiple "Belgium's got talent" prizes from the Belgian College of Neuropsychopharmacology and Biological Psychiatry. As a dedicated mentor, Dr. Alaerts supervises numerous PhD students and postdoctoral researchers, including Margaux Evenepoel, Jellina Prinsen, Elise Tuerlinckx, and others who have made significant contributions to the field. Her research is supported by multiple substantial grants, including several ongoing projects running through 2028-2029 that investigate oxytocin's role in stress regulation for breast cancer survivors, autism, and other conditions. The Neuromodulation Laboratory, which Dr. Alaerts leads, focuses on three core domains: oxytocin neuropsychopharmacology, contemplative science and combinatory approaches, and neuroregulation techniques. The lab operates within a multidisciplinary network that includes the LBI - KU Leuven Brain Institute and maintains strong collaborative relationships across various research institutions.

Tiffany Hoمشاهده پروفایل

استادیار

• Cognitive Neuroscience
• Adolescent Neurodevelopment
• Depression
• +۵ مورد دیگر

Dr. Tiffany Ho is an Assistant Professor in the Department of Psychology at the University of California, Los Angeles (UCLA). She is also affiliated with the Cognition, Affect, and Neurodevelopment in Youth (CANDY) lab, where she leads research on adolescent neurodevelopment, depression, and the neurobiological impacts of early adversity. Her work integrates neuroimaging, psychophysiology, and immunology to understand how stress and adversity shape brain circuits underlying emotion and behavior during adolescence. Education: Ph.D. in Psychology, University of California, San Diego B.A. in Cognitive Science, University of California, Berkeley Postdoctoral Fellowship in Clinical Neuroscience, University of California, San Francisco Postdoctoral Training in Affective Science, Stanford University Research Interests: Dr. Ho’s research focuses on understanding how brain circuits underlying thoughts, emotions, and behaviors change during adolescent development. She investigates how experiences of adversity and perceptions of stress shape neurodevelopment, and how these changes impact the etiology, course, and treatment of depression. Her lab uses a multimodal approach, including behavioral, cognitive, endocrine, immune, and neuroimaging techniques, and leverages big data and global initiatives to identify robust brain imaging markers associated with depression and related conditions. Grants and Funding: Her research has been generously funded by the Klingenstein Third Generation Foundation and the National Institute of Mental Health . Publications and Impact: Dr. Ho has published extensively in high-impact journals, with over 100 peer-reviewed articles. Her recent work includes studies on the effects of COVID-19 on adolescent mental health, the role of inflammation in depression, and the use of machine learning to classify major depressive disorder using neuroimaging data. She is also a key contributor to the ENIGMA consortium, a global initiative aimed at understanding brain alterations in psychiatric disorders.

Cheryl Walkerمشاهده پروفایل

استاد

• Epigenomics
• Cancer Biology
• Molecular Genetics
• +۳ مورد دیگر

Cheryl Walker, Ph.D., is a Professor in the Departments of Molecular and Cellular Biology, Medicine, and Molecular and Human Genetics at Baylor College of Medicine. She serves as Director of the Center for Precision Environmental Health and Co-Leader of the Chromatin Biology Program at the Dan L Duncan Comprehensive Cancer Center. Her research focuses on gene-environment interactions, epigenomics, and the molecular mechanisms underlying diseases such as cancer, fibroids, and non-alcoholic fatty liver disease (NAFLD). Key areas include the role of chromatin remodelers like SETD2 in genomic stability and their dual functions in cytoskeletal dynamics. She has pioneered studies on how early-life environmental exposures, such as endocrine-disrupting chemicals (EDCs), reprogram the epigenome to increase disease susceptibility later in life. Dr. Walker’s work is funded by NIH and DOD grants, including leadership of the TaRGET II Consortium for environmental epigenomics. Her lab employs cutting-edge technologies like ChIP-seq and RNA-seq to study epigenetic reprogramming. Notable contributions include discoveries linking SETD2 methylation to microtubule stability and genomic integrity, and identifying epigenetic signatures of environmental exposures in health disparities research. Education: Ph.D. in Molecular Biology Affiliations: Baylor College of Medicine, Gulf Coast Center for Precision Environmental Health Her awards include election to the National Academy of Medicine and fellowships in the American Association for the Advancement of Science (AAAS) and American Thoracic Society (ATS). The lab actively collaborates on translational projects, including biomarker development and disaster-related health studies following events like Hurricane Harvey. Key Research Themes: Epigenetic drivers of cancer and fibrosis Environmental epigenomics and disease risk Chromatin-cytoskeleton cross-talk in disease

Helen Suhمشاهده پروفایل

استاد

• Environmental Health
• Environmental Epidemiology
• Air Pollution
• +۲ مورد دیگر

Helen Suh is a Professor at Tufts University, jointly appointed in the departments of Civil and Environmental Engineering and Community Health . As an internationally-recognized expert in air pollution health effects, she combines environmental epidemiology , exposure science , and data analytics to investigate how pollutants impact human health. Sc.D. , Harvard University (1993) M.S. , Harvard University (1990) S.B. , Massachusetts Institute of Technology (1985) Her research focuses on three areas: air pollutant impacts on cognitive performance and child development , multi-pollutant health effects , and GIS-based spatio-temporal modeling for epidemiological studies. Recent publications highlight her work on PM2.5 measurement error correction , hormonal disruptions in pregnancy , and machine learning applications in environmental health analysis. Current trends include: Advanced statistical methods for exposure assessment Multi-omics approaches to cardiometabolic health International comparative studies (e.g., Tehran, Puerto Rico) Long-term mortality analysis in Medicare populations Pollution-immune system interactions in vulnerable groups Policy-relevant modeling for air quality standards Helen Suh has served as an Associate Editor for the Journal of Exposure Science and Environmental Epidemiology and advised major U.S. and international health organizations. Her work spans over 150 publications and integrates multidisciplinary team leadership in environmental health science. Her laboratory develops large-scale data analytics tools and spatio-temporal exposure models to support population-level health research. Current projects include air pollution and aging cohorts , urban environmental noise measurement , and epigenetic responses to pollutants .

• Pharmacokinetics
• Pharmacodynamics
• Model-Informed Drug Development
• +۴ مورد دیگر

Guohua An, MD, PhD, is an Associate Professor in the Department of Pharmaceutical Sciences and Experimental Therapeutics at the University of Iowa College of Pharmacy. She holds expertise in mechanistic pharmacokinetic/pharmacodynamic (PK/PD) modeling, population PK in special populations, model-informed drug development, and quantitative systems pharmacology. Her research focuses on optimizing drug therapies for critically ill patients, infants, and surgical patients, with emphasis on antibiotics and novel drug candidates like HSD-1 inhibitors. Dr. An has a dual background in clinical pharmacy and pharmaceutical sciences, with industry experience at AbbVie and prior academic roles at the University of Florida. Education: MS in Clinical Pharmacology, Fudan University, China PhD in Pharmaceutical Sciences, SUNY University at Buffalo, USA Research Interests: Dr. An’s work integrates PK/PD modeling to inform drug development and clinical care, particularly in special populations. She explores mechanisms of drug disposition, target-mediated effects, and systems pharmacology to enhance therapeutic outcomes. Her recent studies address empiric dosing strategies for antibiotics (e.g., piperacillin-tazobactam), nonlinear pharmacokinetics of inhibitors, and quantitative models for incretin hormones. Publications: Her articles emphasize PK/PD modeling in antibiotics, HSD-1 inhibitors, and siRNA therapeutics. Key themes include population pharmacokinetics in cystic fibrosis patients, target-mediated drug disposition, and systems pharmacology approaches to diabetes therapies. Labs/Teams: Collaborates with interdisciplinary teams in clinical pharmacology and drug development, leveraging both academic and industrial partnerships.

• Metabolic Signaling
• Pancreatic Islet Biology
• Signal Transduction Pathways
• +۴ مورد دیگر

Dr Amin Ardestani , Senior Lecturer in Metabolic Signaling at the Biomedical Institute for Multimorbidity (BIM), Hull York Medical School (HYMS) , specializes in unraveling molecular mechanisms of pancreatic β-cell failure in diabetes. His research program identifies novel therapeutic targets through signal transduction studies in metabolic disorders. Bachelor's in Biology, Tarbiat Moalem University (2004) Master's in Biochemistry, Institute of Biochemistry and Biophysics (2007) PhD in Biology, University of Bremen (2013) Junior Group Leader at University of Bremen (2014-2023) Research focuses on Hippo and mTOR signaling pathways in β-cell biology, autoimmunity, and regeneration. His work bridges mechanistic biology with drug discovery for diabetes, with significant findings on PHLPP1/2 phosphatases and MST1/2 kinases. Recent publications highlight therapeutic strategies for β-cell protection , including small molecule inhibitors (e.g., MST1/2 inhibitors) and metabolic enzyme modulation (LDHA). Collaborative studies explore SARS-CoV-2 interactions with pancreatic cells and cross-talk between acinar and β-cells in diabetes. 2019 JDRF Advanced Postdoctoral Fellowship 2018 Impulse grant & Career Advancement Award 2017 Early Investigators awards (Endocrine Society, EFSD/Lilly Programme) 2014 Albert Renold Fellowship & Bremer Studienpreis Professional roles include Editorial Board Member at Scientific Reports and Associate Editor at Frontiers in Endocrinology . He reviews grants for DFG, Diabetes UK, and ISF, and evaluates manuscripts for top-tier journals like Cell Metabolism and Nature Communications.

Banfi Giuseppeمشاهده پروفایل

استاد

• Clinical Biochemistry
• Molecular Biology
• Geriatrics
• +۴ مورد دیگر

Giuseppe Banfi is a Professor of Clinical Biochemistry and Clinical Molecular Biology at Vita-Salute San Raffaele University, where he has held a full academic position since 2006. His career spans over three decades, combining clinical laboratory leadership with academic contributions in aging, musculoskeletal health, and nutritional biochemistry. Graduated Medicine (1984, University of Pavia) Specialized in Hygiene and Preventive Medicine (1988, University of Milan) His research focuses on clinical biochemistry applications in geriatrics, musculoskeletal disorders, and immuno-nutrition. Recent publications highlight innovations in laboratory medicine value-based models, sarcopenia tele-rehabilitation platforms, and aging-related fall prevention strategies. Journal collaborations span Clinical Chemistry and Laboratory Medicine and Endocrine Reviews . Current work involves multidisciplinary integration of oral health in orthopedic surgery, telemedicine effectiveness for musculoskeletal conditions, and vitamin D supplementation guidelines. His leadership in scientific research programs at Galeazzi Orthopedic Institute and San Donato Foundation Hospital Group demonstrates ongoing translational science engagement. Management roles include directorships at Fondazione Centro San Raffaele and Istituto Insubrico Ricerca per La Vita Foundation.

Katherine E. Varleyمشاهده پروفایل

دانشیار

• Breast Cancer
• Epigenetics
• Gene Expression Regulation
• +۵ مورد دیگر

Katherine E. Varley, PhD is a Huntsman Cancer Institute Investigator and Associate Professor in the Department of Oncological Sciences at the University of Utah. She leads the Varley Lab and is a member of the Nuclear Control of Cell Growth and Differentiation Program, focusing on breast cancer genomics, epigenetics, and biomarker discovery. Her work bridges computational biology with clinical applications to improve breast cancer diagnosis and treatment. Dr. Varley earned her BS in Biology with a concentration in Computational Biology from Cornell University in 2003, followed by a PhD in Computational Biology from Washington University School of Medicine in 2009 under Dr. Robi Mitra. Her postdoctoral training was conducted in Dr. Richard M. Myers' laboratory at the HudsonAlpha Institute for Biotechnology, where she participated in the ENCODE Project Consortium. Her research focuses on using next-generation sequencing and computational analysis to study gene expression, transcription factor binding, and DNA methylation patterns in breast cancer. The Varley Lab investigates epigenetic gene regulation, develops novel molecular methods and bioinformatics approaches, and translates discoveries into clinical tools. Key research areas include Clinical Trial Genomics, Epigenome Engineering, Detecting Circulating Tumor DNA, and identifying Transcription Factors Driving Metastasis, with particular emphasis on triple-negative breast cancer. Analysis of Dr. Varley's publications reveals a consistent trajectory from fundamental genomic mechanisms to clinical translation, with recent work emphasizing biomarker discovery, tumor heterogeneity, and the development of genomic tools for precision oncology. Her research spans cancer biology, genomics, and computational analysis to address critical challenges in breast cancer treatment. Dr. Varley holds multiple patents related to cancer diagnostics and genomic technologies, including targeted sequencing methods, multigene assays for recurrence risk, and biomarkers for triple-negative breast cancer. These inventions reflect her commitment to translating basic research into clinical applications. She actively collaborates with clinical investigators in breast cancer trials and works closely with the Breast and Gynecologic Cancers Disease Center at Huntsman Cancer Institute. Her lab maintains four main research thrusts that collectively address breast cancer from molecular mechanisms to clinical applications, demonstrating a comprehensive approach to improving patient outcomes through genomic technologies.

Kimberly Keil Stietzمشاهده پروفایل

استادیار

• Environmental Toxicology
• Neurotoxicology
• Urology
• +۴ مورد دیگر

Kimberly Keil Stietz is an Assistant Professor in the Department of Comparative Biosciences at the University of Wisconsin-Madison School of Veterinary Medicine. Her research focuses on environmental toxicology, neurotoxicology, and urology, particularly examining how developmental exposure to polychlorinated biphenyls (PCBs) affects urinary function. Education: B.S. in Biology, St. Norbert College (2010) Ph.D. in Comparative Biosciences, University of Wisconsin-Madison (2014) Postdoctoral research in neurotoxicology, University of California-Davis (2015-2019) Stietz's lab investigates the effects of environmental contaminants on the lower urinary tract, emphasizing PCB exposure during development. Using in vitro and in vivo mouse models, the lab studies disruptions in bladder epithelium organization, nerve fiber patterning, inflammation, and peripheral-central nervous system crosstalk. Key projects include analyzing PCB impacts on bladder barrier function, innervation patterns, inflammatory responses, and dorsal root ganglia signaling. Recent publications highlight her work on PCB effects across multiple domains: adult female bladder contractility (2023), prostatic collagen changes (2023), machine learning-aided metabolite analysis (2023, 2022), and developmental PCB exposure links to voiding physiology (2022). Her 2021 studies explored behavioral phenotypes in PCB-exposed mice, dendritic effects, and bladder inflammation, while 2019 work included host-microbe interactions and open-source uroflowmetry tools.