معرفی
Dr. Charlotte Kuperwasser is a distinguished Professor in the Department of Developmental, Molecular, and Chemical Biology at Tufts University School of Medicine. She directs the Tufts Convergence Laboratory and focuses on molecular mechanisms governing breast tissue development, cancer prevention, and organoid technologies. Her work integrates stem cell biology, epigenetics, and environmental influences such as endocrine disruptors.
Education:
- Bachelor of Science (1997), University of Massachusetts Amherst
- PhD (2000), University of Massachusetts Amherst
- Jane Coffin Childs Postdoctoral Fellow (MIT/Whitehead Institute)
Research Interests: Her lab develops 3D breast organoid models to study cancer initiation, microenvironmental interactions, and BRCA1-related mechanisms. Recent efforts include analyzing HPV-driven cancers via circulating tumor DNA and studying fibroblast signaling (e.g., DDR1) in tumor progression.
Grants & Awards:
- Howard Hughes Fellowship, Merck Fellowship
- COG/Aventis Young Investigator Award
- Natalie V. Zucker Award
- NIH grants on V-ATPases and obesity-cancer links
Professional Contributions: She chairs Tufts’ Sackler Convergence Laboratory and serves on AACR committees. Teaching includes courses on Molecular Cell Biology of Development and Cancer Genetics.
Labs/Teams: Leads the Kuperwasser Lab, focusing on translational cancer research with cross-disciplinary collaborations in organoid engineering and clinical diagnostics.
