معرفی
Carman Man-chung Li is an Assistant Professor of Cancer Biology at the Perelman School of Medicine, University of Pennsylvania. He is also an Assistant Investigator at the Abramson Family Cancer Research Institute and a Core Investigator at The Basser Center for BRCA. His research focuses on hereditary cancer mechanisms, particularly how heterozygous loss-of-function mutations in tumor suppressor genes drive early tumorigenesis beyond the classical 'two-hit' hypothesis.
- Education: A.B. in Molecular Biology (High Honors), Princeton University (2009); Ph.D. in Biology, Massachusetts Institute of Technology (2015)
Using genetically engineered mouse models, organoid cultures, and multi-omics, his lab investigates gene haploinsufficiency effects, epigenetic alterations, and stromal-epithelial interactions. Recent work includes mapping early tumor drivers in BRCA1-mutant models and cross-ancestry cancer risk stratification.
Scientific Affiliations:
- Abramson Family Cancer Research Institute
- The Basser Center for BRCA
- Graduate Groups: Pharmacology, Cell and Molecular Biology
His lab collaborates with the Penn Medicine Biobank, VA Million Veterans Program, and EDISYN Consortium for translational studies in Li-Fraumeni Syndrome and BRCA-related cancers. Funding sources include the National Cancer Institute, Prostate Cancer Foundation, and Li Fraumeni Syndrome Association.
