معرفی
Xiaolu Yang is a Professor of Cancer Biology at the University of Pennsylvania Perelman School of Medicine, with affiliations at the Abramson Cancer Center, Abramson Family Cancer Research Institute, and Center for Molecular Studies in Digestive and Liver Diseases. Their research bridges cancer biology and neurodegeneration through studies of cellular stress responses and metabolic regulation.
- Member, Abramson Cancer Center
- Member, Abramson Family Cancer Research Institute
- Member, Center for Molecular Studies in Digestive and Liver Diseases
- Member, Institute for Immunology
Research Focus: Dr. Yang's lab investigates two major areas: (1) the tumor suppressor p53's role in metabolism and autophagy, revealing its critical function in regulating metabolic pathways for biosynthesis and redox balance; and (2) novel protein quality control systems (TRIM and polyD/E proteins) that combat neurodegenerative diseases like Alzheimer's and Parkinson's through ATP-independent mechanisms.
Publication Trends: Their work spans cancer biology, neurodegeneration, metabolic regulation, protein homeostasis, and autophagy, with recent studies focusing on TRIM proteins in neuroprotection and metabolic reprogramming in oncogenic transformation.
Lab Personnel: The Yang laboratory includes postdoctoral researchers (Jiale Wu, Zi-Yang Zhang, Yujin Xiang, Jiajia Wang, Ruifang Wang, Sixiang Yu, Kai Huang) and undergraduate researchers (Rachel Ou, Steven Su, Megan Zhang, Hong Yu Liu).
