معرفی
Guohua An, MD, PhD, is an Associate Professor in the Department of Pharmaceutical Sciences and Experimental Therapeutics at the University of Iowa College of Pharmacy. She holds expertise in mechanistic pharmacokinetic/pharmacodynamic (PK/PD) modeling, population PK in special populations, model-informed drug development, and quantitative systems pharmacology. Her research focuses on optimizing drug therapies for critically ill patients, infants, and surgical patients, with emphasis on antibiotics and novel drug candidates like HSD-1 inhibitors. Dr. An has a dual background in clinical pharmacy and pharmaceutical sciences, with industry experience at AbbVie and prior academic roles at the University of Florida.
Education:
- MS in Clinical Pharmacology, Fudan University, China
- PhD in Pharmaceutical Sciences, SUNY University at Buffalo, USA
Research Interests: Dr. An’s work integrates PK/PD modeling to inform drug development and clinical care, particularly in special populations. She explores mechanisms of drug disposition, target-mediated effects, and systems pharmacology to enhance therapeutic outcomes. Her recent studies address empiric dosing strategies for antibiotics (e.g., piperacillin-tazobactam), nonlinear pharmacokinetics of inhibitors, and quantitative models for incretin hormones.
Publications: Her articles emphasize PK/PD modeling in antibiotics, HSD-1 inhibitors, and siRNA therapeutics. Key themes include population pharmacokinetics in cystic fibrosis patients, target-mediated drug disposition, and systems pharmacology approaches to diabetes therapies.
Labs/Teams: Collaborates with interdisciplinary teams in clinical pharmacology and drug development, leveraging both academic and industrial partnerships.
