Leon Aarons

Leon Aarons is a Professor in the Manchester Pharmacy School at the University of Manchester, UK. He joined the institution in 1976 after a postdoctoral fellowship at the School of Chemistry, University of Leeds. His research focuses on pharmacokinetics, with specialties in population pharmacokinetics and pharmacodynamics (PK/PD), data analysis, and drug development. He collaborates widely in academia and industry, particularly in Europe, and contributes to initiatives like CAPKR (Computer Aided Pharmacokinetic Research) and the COST B25 management committee. Aarons holds editorial roles for journals including the Journal of Pharmacokinetics and Pharmacodynamics (European Editor) and British Journal of Clinical Pharmacology (Executive Editor). His work addresses variability in drug response across populations, with applications in malaria, pediatric care, anti-inflammatories, and oncology. He leads the Statistical Modelling Research Group and oversees collaborations with researchers like Kayode Ogungbenro and Hitesh Mistry.

Education:

• PhD in Pharmacy (1973), University of Manchester
• MSc in Pharmacy (1971), University of Calgary
• BSc in Pharmacy (1968), University of Sydney

Research Interests:

• Population PK/PD modeling using Maximum Likelihood and Bayesian techniques
• Optimal design for clinical trials and PK/PD studies
• Computer-aided trial design (CATD) via stochastic simulation
• Drug-drug interaction analysis in diverse patient populations

Impact & Collaboration: Aarons' research contributes to UN Sustainable Development Goals, particularly in advancing drug development practices for precision dosing and addressing global health challenges. His work has influenced regulatory policies and industrial practices in pharmacokinetics.

Labs & Teams: Active in the Statistical Modelling Research Group, CAPKR collaboration, and affiliated with the Digital Futures Institute and Christabel Pankhurst Institute at the University of Manchester.