جست‌وجوی استاد و پژوهشگر

Aydan Bulut-Karslıoğluمشاهده پروفایل

استادیار

• Embryonic diapause
• Stem cell state transitions
• Fate commitment
• +۷ مورد دیگر

Dr. Aydan Bulut-Karslıoğlu is a Research Group Leader at the Max Planck Institute for Molecular Genetics in Berlin, where she leads the Bulut-Karslıoğlu Lab focused on gene-environment interactions in stem cells and development. Her work has significantly advanced our understanding of embryonic diapause and stem cell state transitions. Dr. Bulut-Karslıoğlu's educational background includes: B.Sc. in Chemical Engineering (major) and Biology (minor) from Middle East Technical University, Ankara, Turkey (2006) M.Sc. in Molecular Biology and Genetics from Bilkent University, Ankara, Turkey (2008) Ph.D. from Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany (2013) Her research focuses on mechanisms regulating stem cell state transitions and fate commitment, particularly how cells communicate signals from their surroundings to the gene expression machinery. She has pioneered work on mammalian embryonic diapause - a reversible dormant state that gives embryos extra time to develop. Her lab uses a combination of functional perturbation methods in stem cells and early mouse embryos with omics, imaging, and biochemistry to reveal how genetic networks adjust to the status of the embryo. Analysis of her recent publications reveals a strong focus on the epigenetic and metabolic regulation of embryonic diapause, with particular emphasis on mTOR signaling, lipid metabolism, and DNA methylation dynamics. Her work bridges developmental biology, stem cell research, and metabolism, demonstrating how environmental cues like oxygen levels and nutrient availability influence developmental timing and cell fate decisions. Her notable scientific achievements include: Sofja Kovalevskaja Award (2018) ERC Starting Grant (2023) ERC Proof of Concept Grant (2025) GSCN Young Investigator Award (2025) Dr. Bulut-Karslıoğlu actively mentors the next generation of scientists, currently supervising multiple PhD students including Persia Akbari-Omgba, Anastasios Balaskas, Heleen Mallie, and Gunwant Patil. Her lab has received substantial funding through prestigious grants, including the Sofja Kovalevskaja Award, ERC Starting Grant, and ERC Proof of Concept Grant, enabling her team to pursue innovative research at the intersection of developmental biology and metabolism. The Bulut-Karslıoğlu Lab maintains a vibrant research environment with both computational and experimental scientists working together to unravel the mysteries of embryonic diapause and stem cell regulation. The lab actively participates in the International Max Planck Research School for Biology And Computation (IMPRS-BAC), contributing to the training of doctoral candidates at the interface of molecular life sciences and computational sciences.

• Bayesian statistics
• robust estimation
• information-assisted hypothesis testing
• +۳ مورد دیگر

Jordan Bryan is an Assistant Professor of Data Science at the University of Virginia's School of Data Science, specializing in multivariate statistical methods with applications spanning environmental monitoring, high-energy physics, and cancer genomics. He earned his Ph.D. in Statistics from Duke University in 2023 and a B.S. in Mathematics from Stanford University, and currently serves as Secretary of the junior section of the International Society for Bayesian Analysis. Education: Ph.D. in Statistics, Duke University B.S. in Mathematics, Stanford University Research Interests: Dr. Bryan develops advanced methodologies in Bayesian statistics , robust estimation , and information-assisted hypothesis testing , with particular emphasis on integrating auxiliary data sources to enhance statistical power. His work bridges theoretical rigor with real-world applications in genomics, environmental systems, and physics, recently expanding to incorporate large language model-derived information for genomic analysis. Publication Trends: Analysis of his 15 most recent publications (2020-2025) reveals a dual trajectory: foundational contributions to statistical methodology (e.g., multirank likelihood frameworks, subscedastic estimation) and high-impact applications in cancer genomics (functional screens, drug repurposing) and environmental science (source apportionment). A notable 2025 publication pioneers LLM integration for genomic hypothesis testing, signaling a strategic expansion into AI-augmented statistics. Scientific Awards: No specific awards, prizes, or fellowships were documented in the source materials. Advising and Grants: Supported by National Institute of Environmental Health Sciences (NIEHS) and National Heart Lung and Blood Institute (NHLBI) training grants during his UNC Chapel Hill postdoctoral fellowship, Dr. Bryan now leads independent research at UVA. While formal student advising isn't detailed in current records, his extensive publication record suggests active mentorship in collaborative projects.

• Reproductive Biology
• Embryonic Diapause
• Wildlife Conservation
• +۳ مورد دیگر

Dr. Sandra Milena Bernal Ulloa is a Lecturer at the Department of Environmental Systems Science at ETH Zürich , Switzerland. Her research focuses on reproductive biology and embryonic diapause in wildlife species, particularly the European roe deer (Capreolus capreolus). Position: Lecturer Department: Environmental Systems Science Institution: ETH Zürich, Switzerland Her work explores the molecular mechanisms of embryonic dormancy, fetal development anomalies, and assisted reproductive technologies. She has developed novel cryopreservation protocols for pig embryos and pioneered stem cell research in roe deer. Publications span topics including: Embryonic Diapause: Follicular dynamics, cell proliferation rates, and endocrine interactions Genomics: Pangenome analysis of bovine depigmentation traits Wildlife Conservation: Reproductive anomalies and their implications for captive breeding programs Recent publications (2019-2025) demonstrate her expertise in wildlife reproductive physiology and embryology. Key collaborations include Dr. Susanne E. Ulbrich and international researchers in veterinary and computational biology. Contact: sandra.bernal@usys.ethz.ch

• Cancer Biology
• Epithelial-Mesenchymal Transition (EMT)
• Cancer Stem Cells
• +۴ مورد دیگر

Sendurai Mani is the Dean's Professor of Translational Oncology and Professor of Medicine at Brown University’s Warren Alpert Medical School. His research focuses on the epithelial-mesenchymal transition (EMT), cancer stem cells, and tumor metastasis. He has made groundbreaking contributions, including demonstrating that EMT generates cells with stem cell properties (Mani et al., Cell 2008), linking EMT to metastasis, and developing tools for targeting mesenchymal cancers. PhD, Indian Institute of Science (2000) MS, Madurai Kamaraj University (1993) BS, Madurai Kamaraj University (1991) Mani’s research interests center on molecular mechanisms of cancer progression, particularly how EMT enables metastasis, therapeutic resistance, and tumor cell plasticity. His lab investigates: EMT-driven cancer stem cell generation Immune-tumor cell interactions in metastasis Therapeutic strategies for hybrid EMT phenotypes Single-cell profiling of tumor heterogeneity Development of EMT/CSC biomarkers Novel approaches to target mesenchymal cancers His publications (115+ articles) reflect cutting-edge work in EMT, cancer stem cells, and tumor immunology. Recent studies include functional single-cell analysis of extracellular vesicles in breast cancer and pan-cancer EMT gene profiling (EMTome resource). Scientific awards and honors include: V-Scholar (2008-2011) MD Anderson Research Trust Fellow (2008-2014) American Cancer Society Research Scholar (2012-2015) AAAS Fellow (2020-present) Sigma Xi Full Member (2021-present) Mani serves as: Director, Translational Research Disease Groups at Brown Director, Stem Cell Center at Brown Co-leader of the Mani Lab at Brown University

Patrick Paddisonمشاهده پروفایل

استاد

• Cancer Stem Cells
• Functional Genomics
• Genome Editing
• +۵ مورد دیگر

Patrick Paddison is a Professor in the Human Biology Division at Fred Hutchinson Cancer Center, where he leads the Paddison Lab. His research employs cutting-edge genetic techniques, including CRISPR-Cas9 and RNAi, to investigate stem cell biology and cancer, with a particular focus on cancer stem cells in glioblastoma and the role of epigenetics and epitranscriptomics in development and disease. His educational background includes a PhD in Biological Sciences from Cold Spring Harbor Laboratory (2004) and dual bachelor's degrees in Psychology and Molecular Biology and Genetics from The Evergreen State College (1996). Dr. Paddison's research centers on functional genomics to dissect gene networks in stem and progenitor cells. His lab uses genome-wide screening to identify genes critical for stem cell self-renewal, differentiation, and survival, with applications in cancer therapy. Key areas include: Cancer stem cell biology, particularly quiescent states in glioblastoma Epigenetic and epitranscriptomic regulation (e.g., N6-adenosine methylation in erythropoiesis) Protein domain annotation via CRISPR tiling mutagenesis Developmental transitions in embryonic and somatic stem cells Analysis of his recent publications reveals a shift from RNAi-based methods to CRISPR-Cas9, with a sustained focus on cancer stem cells and the molecular mechanisms underlying developmental processes. His work increasingly integrates single-cell technologies and patient-derived models to address therapeutic resistance. Dr. Paddison mentors graduate students and postdoctoral fellows in his lab, fostering expertise in functional genomics and genome editing. While specific grant details are not provided, his extensive publication record indicates sustained funding for innovative research in cancer biology and stem cell science. The Paddison Lab is a dynamic research environment that combines high-throughput screening, molecular biology, and computational analysis to uncover fundamental biological mechanisms with translational potential in oncology.

Martin Vingronمشاهده پروفایل

استاد

• Computational Molecular Biology
• Functional Genomics
• Gene Regulation
• +۳ مورد دیگر

Prof. Martin Vingron is a Scientific Member and Director at the Max Planck Institute for Molecular Genetics. He holds an adjunct professorship at Freie Universität Berlin. His research focuses on computational molecular biology, integrating algorithmic and statistical methods to study gene regulation, epigenetics, and functional genomics. Education: Studied mathematics in Vienna, PhD (1991, Heidelberg University) under EMBL supervision. Postdocs at UCLA and Bonn University. Research: Current work emphasizes the interplay between epigenetic modifications and gene regulation. Develops methods for analyzing genomic sequences and functional genomics data. Leads the Vingron Lab, collaborating on transcriptional regulation and epigenetic studies. Awards: Max Planck Research Prize (2004), Leopoldina Membership, ISCB Fellowship. Labs/Teams: Heads the Transcriptional Regulation Group at MPIMG, focusing on computational methods for gene regulation analysis and data integration.

Aedin Culhaneمشاهده پروفایل

استاد

• Cancer Genomics
• Bioinformatics
• Single Cell Biology
• +۸ مورد دیگر

Aedin Culhane is a Professor of Biomedical Sciences (Cancer Genomics) at the University of Limerick School of Medicine. She leads the Limerick Digital Cancer Research Centre and co-leads the all-island eHealth-Hub for Cancer. Her expertise spans computational oncology, multi-omics data integration, and clinical bioinformatics, with over 20 years of experience in cancer genomics, including roles at the Dana-Farber Cancer Institute and Harvard T.H. Chan School of Public Health in Boston, USA. Education: PhD in Cloning and Characterisation of Interleukin-18 in rat brain, University of Manchester Research Interests: Cancer computational genomics, digital health, single-cell genomics, spatial biology, tumor microenvironment, immune-oncology, and open science initiatives like Bioconductor and OHDSI. She focuses on algorithm development for integrative multi-omics data analysis and translational oncology, including tumor drug resistance mechanisms and CAR-T cell therapies. Recent Article Trends: Her work emphasizes spatial profiling of cancer microenvironments, CAR-T cell engineering, and genomic minimal datasets for precision oncology. Key themes include immune response modulation, Myc activity regulation in treatment persistence, and CRISPR-based functional genomics. Awards: Young European Research Universities Network (YERUN) Open Science Award (2023) Bioconductor Community Award (2021) Grants & Collaborations: Leads the €730,000 Chan Zuckerberg Initiative-funded eHealth-Hub for Cancer. Active in the 1+ Million Genomes Program and Genomic Data Infrastructure (GDI) projects. Collaborates internationally in spatial profiling and multi-omics integration through hackathons and open-source initiatives. Labs & Teams: Directs the Limerick Digital Cancer Research Centre, a hub for AI-driven cancer research and translational genomics. Engages with global networks like the Human Cell Atlas and National Spatial Profiling Platform.

• Stem Cell Biology
• Cancer Stem Cells
• Hematopoiesis
• +۴ مورد دیگر

Mick Bhatia is a Professor in the Department of Biochemistry & Biomedical Sciences at McMaster University, affiliated with the Faculty of Health Sciences. He leads the Bhatia Program, focusing on cancer stem cell biology and regenerative medicine applications. His work targets leukemias and other cancers by identifying vulnerabilities in cancer stem cells while sparing normal stem cells. Research Interests: Bhatia's lab investigates cancer stem cell biology, hematopoiesis from pluripotent stem cells, and development of therapies targeting leukemia-initiating cells. Key areas include chemical genomics for drug discovery, epigenetic regulation in cancer, and stem cell reprogramming to model diseases like acute myeloid leukemia (AML). Key Contributions: Pioneered methods to detect cancer stem cells and developed drug screening platforms using patient-derived cells. Notable for discovering that dopamine receptor signaling can selectively target AML progenitors and identifying SUMOylation dependencies in cancer stem cells. His work bridges basic science with clinical translation through drug efficacy/toxicity studies and stem cell-derived models. Lab/Teams: The Bhatia Program integrates interdisciplinary teams across cancer biology, chemical biology, and regenerative medicine. Collaborations focus on translating stem cell discoveries into clinical tools for cancer treatment and diagnosis.

Marc Thierمشاهده پروفایل

پژوهشگر

• Stem Cell Research
• Neural Reprogramming
• Clinical Translation
• +۳ مورد دیگر

Dr. Marc Thier is a Researcher at the German Cancer Research Center (DKFZ) and Heidelberg University, leading the Neural Reprogramming and Clinical Translation group. His work bridges stem cell biology, direct cellular reprogramming, and clinical applications in cancer and endocrinology. Key Research Themes: Stem Cell Engineering Neural Reprogramming Cancer Metastasis Mechanisms Hyperparathyroidism Surgery Outcomes Notable Collaborations: Prof. Frank Edenhofer, Prof. Andreas Trumpp, Dr. Michael Milsom Dr. Thier's recent publications focus on glioblastoma neuron-tumor interactions (2025), miRNA-driven reprogramming (2012), and stem cell dormancy models (2016). He has contributed to over 15 peer-reviewed studies since 2009. His laboratory develops protocols for converting somatic cells into expandable neural progenitors and investigates cancer stem cell dynamics. Current projects include retrograde tracing in glioblastomas and longitudinal metabolic studies in post-surgical endocrinology.

Liang Songمشاهده پروفایل

استادیار

• Plant Hormone Signaling
• Seed Development
• Gene Expression Regulation
• +۴ مورد دیگر

Liang Song serves as an Assistant Professor in the Department of Botany within the Faculty of Science at the University of British Columbia (UBC). His research program investigates molecular mechanisms underlying plant stress responses and seed development through transcriptional regulation. Education: BSc, Fudan University PhD, Pennsylvania State University Postdoctoral Fellow, Salk Institute for Biological Studies Dr. Song's research focuses on two interconnected domains: (1) Abscisic acid (ABA)-regulated gene expression networks that orchestrate plant stress responses and developmental decisions, and (2) Environmental and genetic control of seed development stages including storage reserve deposition, desiccation tolerance, and dormancy. His work employs Arabidopsis thaliana as a model system to dissect transcriptional networks involving activators, repressors, and co-regulators that integrate hormonal and environmental signals. Current investigations examine how combinatorial transcription factor interactions govern seed maturation and stress adaptation. Analysis of Dr. Song's publication record (2016-2024) reveals consistent emphasis on transcriptional networks in seed development and stress responses, with particular focus on ABA and auxin signaling crosstalk. His research demonstrates how co-repressors like AtSDR4L and transcription factor hierarchies coordinate developmental transitions and environmental adaptation through precise gene expression control. The work bridges fundamental molecular mechanisms with potential applications in crop resilience. Scientific Awards: No major personal awards documented in available sources Dr. Song actively mentors five graduate students (Milad Alizadeh, Ryan Hoy, Renwei Zheng, Gloria Bailan Lu, Dongeun Go) and multiple undergraduates, with trainees securing competitive funding including UBC 4 Year Fellowships, BC Graduate Scholarships, and NSERC USRA awards. His lab maintains collaborative relationships with the UBC Botanical Garden and Beaty Biodiversity Centre, supported by student awards and institutional resources. The research group emphasizes teamwork, evidenced by regular group activities including hiking excursions and social events. The Song Lab operates from the Biological Sciences Building (rooms 2231/2234) utilizing UBC's Bioimaging Facility and Herbarium resources. Current projects investigate molecular dialogues between transcriptional activators and repressors during seed-to-seedling transitions, with implications for understanding crop adaptation mechanisms under climate change.

Christina Voelkel-Johnsonمشاهده پروفایل

دانشیار

• Sphingolipid metabolism and signaling
• Cancer cell death pathways
• Cancer therapeutics
• +۲ مورد دیگر

Christina Voelkel-Johnson, Ph.D., is an Associate Professor in the Department of Biochemistry & Molecular Biology at the Medical University of South Carolina (MUSC). Her research focuses on sphingolipid metabolism, cancer cell death pathways, and therapeutic strategies targeting solid tumors. Education: Ph.D., North Carolina State University (1995) Postdoctoral Training: MUSC (1995–2000) Her work explores the role of sphingolipids in tumor suppression, necroptosis, and immunotherapy. Recent studies highlight ceramide synthase 6, RIPK1, and antioxidant mechanisms in T-cell exhaustion and colitis models. Key grants include NIH/NCI P01 CA203628 (Project Leader) and VA CSR&D Merit Award CX001880 (Co-Investigator), both targeting sphingolipid signaling in cancer therapy. She is based in the Basic Science Building, Room 208G, and can be reached at johnsocv@musc.edu .

Michael Rendlمشاهده پروفایل

استاد

• Stem Cell Biology
• Developmental Biology
• Regeneration
• +۳ مورد دیگر

Michael Rendl is a Professor in Cell, Developmental & Regenerative Biology and Dermatology, studying stem cell niches in hair follicle development and regeneration. His work focuses on niche cells such as dermal papilla and sheath cells, uncovering mechanisms governing embryonic and adult hair growth. He leads the Rendl Lab, which combines genetic mouse models with advanced imaging to explore niche signaling pathways like BMP, TGF-β, and endothelin. Education: MD from Medical University of Vienna; Postdoctoral Fellow at Rockefeller University. Key Research Areas: Hair follicle stem cell niches, mechanotransduction, tissue regeneration Notable Techniques: 4D live imaging, genetic lineage tracing, mouse models Awards include the 2014 Irma T. Hirschl Trust Award and 2009 Dermatology Foundation Career Development Award. His lab's discoveries advance both basic biology and regenerative medicine therapies for hair loss and skin repair.

• Computational Biology
• Bioinformatics
• Genomics
• +۴ مورد دیگر

Martin Vingron is a Scientific Member and Director at the Max Planck Institute for Molecular Genetics (MPIMG) in Berlin since 2000. He also holds an adjunct professorship at Freie Universität Berlin . His research spans computational molecular biology , focusing on gene regulation , epigenetic modifications , and functional genomics . After postdoctoral work in Los Angeles and Bonn , Vingron led the Theoretical Bioinformatics Division at the German Cancer Research Center (DKFZ) before joining MPIMG. His work combines algorithmic development with statistical modeling to analyze biological sequences , gene expression data , and multiomic datasets . Recent publications highlight his contributions to transcription factor activity trade-offs, embryo dormancy mechanisms , and liver cell differentiation . These studies intersect with fields like epigenetics , developmental biology , and 3D genome modeling . Scientific Awards: Max Planck Research Prize (2004) Member of the German Academy of Sciences Leopoldina Elected Fellow of the International Society for Computational Biology Vingron's career demonstrates sustained leadership in bioinformatics and computational genomics , with significant impacts across developmental biology , cancer research , and neuroimmunology .

• Adult Stem Cell Biology
• Organ Size Regulation
• Hematopoiesis
• +۳ مورد دیگر

Dr. Fernando Camargo is a Principal Investigator at Boston Children's Hospital and Professor of Stem Cell and Regenerative Biology at Harvard University. His laboratory investigates adult stem cell biology, organ size regulation, and cancer mechanisms through Hippo/YAP pathway research. Harvard University Department of Stem Cell and Regenerative Biology Boston Children's Hospital Stem Cell Program Research Background: Dr. Camargo received his Ph.D. from Baylor College of Medicine under Dr. Margaret Goodell, followed by Whitehead Fellowship research on stem cell regulation. His work established the Hippo pathway's role in stem cell biology and tissue regeneration. Scientific Contributions: His lab developed groundbreaking tools for in vivo hematopoietic stem cell lineage tracing and CRISPR-Cas9 models for simultaneous gene expression analysis. Key discoveries connect organ size regulation to stem cell activity and tumor suppression. Awards & Honors: 2022 Regenerative Biology Endowed Chair Howard Hughes Medical Institute Scholar Vilcek Prize for Creative Promise in Biomedical Science ISSCR Susan Lim Award NIH New Innovator Award PEW Biomedical Scholar Current Projects: Ongoing research focuses on hematopoietic stem cell dynamics during aging, embryonic development, and cancer progression, while exploring Hippo pathway's role in tissue regeneration and metabolic regulation.

Joan Massagueمشاهده پروفایل

استاد

• Cancer Biology
• Metastasis
• TGF-β Signaling
• +۷ مورد دیگر

Joan Massagué is a Professor and the Chief Scientific Officer and Director of the Sloan Kettering Institute at Memorial Sloan Kettering Cancer Center (MSK). He is affiliated with the Cell Biology Program and holds the Marie-Josée and Henry R. Kravis Foundation Chair. He is also closely associated with the Weill Cornell Graduate School of Medical Sciences through tri-institutional collaborations. His research focuses on cancer metastasis , particularly the biology of metastatic stem cells, their stromal niches, and the role of TGF-β signaling in immune regulation, tissue homeostasis, and tumor progression. His lab investigates the phenotypic plasticity of cancer cells during dormancy and reactivation, aiming to identify drug targets and enable clinical trials for metastatic cancer. The recent publications reflect a strong emphasis on metastatic mechanisms , TGF-β pathway dynamics , organ-specific colonization , and immune evasion . These studies integrate molecular oncology, stem cell biology, and translational research to uncover fundamental principles of cancer spread. His scientific honors include: HHMI Investigator (1990–2013) and Scientific Advisor (2014–present) Member, National Academy of Sciences Member, National Academy of Medicine Member, American Academy of Arts and Sciences Member, European Molecular Biology Organization AACR Pezcoller Foundation International Award Prince of Asturias Prize Vilcek Prize BBVA Frontiers of Science Prize Dr. Massagué has mentored numerous scientists and leads a vibrant research team dedicated to understanding and combating metastasis. His lab is supported by major grants from the NIH, HHMI, and private foundations. He plays a key leadership role in shaping cancer research strategy at MSK and beyond. He leads the Massagué Lab , which utilizes advanced models including organoids and in vivo systems to study metastatic progression, dormancy, and therapeutic resistance. The lab fosters interdisciplinary collaboration and trains the next generation of cancer biologists.