جستجوی استاد راهنمای دانشگاهی

Xin Zhouمشاهده پروفایل

پژوهشگر ارشد

• Computational Biology
• Health Informatics
• Cardiovascular Disease Modeling
• +۳ مورد دیگر

Dr. Xin Zhou is an Oxford-Bristol Myers Squibb Fellow at the Department of Computer Science, University of Oxford. Her research integrates computational modeling, clinical data, and experimental findings to investigate cardiac disease mechanisms and develop human-based simulations for drug evaluation. BSc and MSc in Life Sciences, Beijing Normal University DPhil in Computational Biology, University of Oxford Her work focuses on multi-scale cardiac modeling , particularly in ischemic heart disease and heart failure, exploring ionic currents, tissue conduction, and organ-level dynamics. She develops electromechanical simulations to study cardiac alternans and arrhythmic risks, translating these into clinical applications for patient stratification and pharmaceutical testing. Recent publications emphasize in silico clinical trials , sex-specific cardiometabolic analysis, and Purkinje network modeling. Collaborative efforts with clinicians and pharmaceutical partners highlight her translational approach to regulatory science. Model of the Year 2024, BioModels EPSRC Impact Acceleration Account Microsoft Research Project Award Recognition Award, University of Oxford She supervises PhD and MSc students in computational cardiology, while serving on the editorial board of Frontiers in Physiology . Her current projects involve digital twinning and predictive cardiac safety models to reduce animal testing reliance.

• Heart Failure
• Cardiovascular Immunology
• Cardiac Inflammation
• +۳ مورد دیگر

Xiaochen He serves as an Instructor in the Department of Physiology & Biophysics at the University of Mississippi Medical Center's School of Medicine, where he focuses on cardiovascular research and teaching within this foundational medical science department. His research program centers on the intersection of cardiac pathophysiology and immunometabolism, with core interests including: Mechanisms of immune-mediated cardiac inflammation in heart failure Role of T cell subsets (Th17, γδ T, CD8+) in pressure overload models Molecular regulation by IL-12 family cytokines and metabolic enzymes (TIGAR, SIRT3) Endothelial dysfunction in cardiac hypertrophy and failure progression Therapeutic interventions targeting inflammatory pathways Analysis of Dr. He's recent publications (2022-2025) reveals a concentrated research trajectory investigating how specific immune pathways drive heart failure progression. His work consistently employs genetic mouse models to demonstrate that IL-12β inhibition, TIGAR deficiency, and selenium supplementation attenuate cardiac inflammation and dysfunction, while CD8+ T cell metabolic reprogramming exacerbates disease. Key discoveries include GPR174's role in Th17 differentiation and NK1.1 signaling's contribution to cardiopulmonary inflammation, establishing critical immune-metabolic axes in heart failure pathogenesis. No scientific awards were documented in the available profile information. Current departmental records indicate no graduate students are formally listed under Dr. He's mentorship, and no research grants are specified in the public profile. Details regarding laboratory infrastructure, research teams, or collaborative networks were not provided in the available institutional documentation.

• Cardiology
• Nuclear Medicine
• Cardiovascular Imaging
• +۲ مورد دیگر

James Corbett serves as Professor of Radiology and Professor of Internal Medicine at the University of Michigan Medical School, with dual appointments reflecting his interdisciplinary expertise. He is an active Center Member of the Samuel and Jean Frankel Cardiovascular Center, contributing to one of the nation's leading cardiovascular research and clinical care institutions. Professor Corbett's research program centers on nuclear cardiology innovation, particularly PET-based myocardial blood flow quantification. His work bridges technical imaging optimization (e.g., Rb-82 dosing protocols, temporal sampling methods) with clinical applications in arrhythmia risk assessment, diastolic dysfunction, and pulmonary hypertension management. He has significantly influenced global standards through leadership in the IAEA Nuclear Cardiology Protocols Study (INCAPS) and SNMMI/ASNC clinical guidelines. His publication record from 2016-2019 reveals a strategic focus on advancing quantitative cardiac imaging while addressing real-world clinical challenges. The research demonstrates consistent methodology development paired with outcome studies, often through large multi-center collaborations that enhance generalizability of findings. As an active mentor (explicitly noted in his profile), Professor Corbett guides trainees through the University of Michigan's robust medical education system. His involvement in major international studies indicates substantial grant funding history, though current specific awards aren't detailed in the provided materials. The Samuel and Jean Frankel Cardiovascular Center affiliation provides Professor Corbett's team with state-of-the-art imaging facilities and access to diverse cardiovascular patient populations, enabling translational research from technical innovation to clinical implementation.

• Hypertension
• Nephrology
• Global Health
• +۳ مورد دیگر

Marcelo Orias, MD, PhD, is an Adjunct Associate Professor affiliated with the Yale Institute for Global Health and the Department of Internal Medicine at the Yale School of Medicine. His research focuses on hypertension, nephrology, and global health initiatives, particularly in Latin America. He holds a MD from the National University of Córdoba (1987) and a PhD from the University of Córdoba (2003). Key projects include leading the HEARTS Initiative in Argentina to standardize hypertension control in primary care and contributing to international guidelines on antihypertensive medication timing and sodium intake policies. He has received the Teacher of the Year Award (2021) and serves as a representative for the Latin American Society of Nephrology. His recent publications emphasize global health policy, clinical trials for anemia treatments, and evidence-based hypertension management. Collaborations include work with the World Hypertension League and Resolve to Save Lives.

Shengyu Muمشاهده پروفایل

دانشیار

• Hypertension
• Heart Failure Mechanisms
• Immune-Mediated Pathways in Cardiovascular Disease
• +۴ مورد دیگر

Shengyu Mu is an Associate Professor in the Department of Pharmacology and Toxicology at the University of Arkansas for Medical Sciences (UAMS) College of Medicine. His research focuses on the pathogenesis of hypertension and its progression to heart failure, with a particular emphasis on immune mechanisms in renal salt retention. Mu holds an M.D. from TianJin Medical University (2004) and a Ph.D. from the University of Tokyo (2011). His research portfolio includes NIH-funded projects investigating T cell homing to the kidney and immune memory in hypertension. Current grants span NIH-NHLBI (2R01 HL146713), American Heart Association (AHA23TPA1076467), and USDA-NIFA collaborations. Completed projects include studies on renal lymph-angiogenesis and macrophage metabolism in diabetes/tuberculosis comorbidity. Research areas integrate physiology, molecular genetics, and epigenetics to bridge basic science and clinical applications. The Mu Lab includes Assistant Professor Yunmeng Liu, Ph.D. candidates Christoph Mora and Kathrine Deck, and research team members recognized for awards like the AHA Predoctoral Fellowship and APS Research Recognition Awards. Key themes include CD8+ T cell activation, IFNγ signaling, and macrophage transition in hypertension pathogenesis.

Antonia Beitzen-Heinekeمشاهده پروفایل

مدرس پزشکی

• Oncology
• Hematology
• Hemostaseology
• +۴ مورد دیگر

Antonia Beitzen-Heineke is a Medical Specialist in Internal Medicine, Hematology, and Oncology at the University Medical Center Hamburg-Eppendorf (UKE). She holds dual affiliations in the II. Medical Clinic and Polyclinic (Center for Oncology) and the Institute of Tumor Biology within the Center for Experimental Medicine. Her expertise spans oncology, hematology, and hemostaseology , with a focus on cardio-oncology, chemotherapy-induced toxicity, and coagulation disorders in cancer patients. Her research emphasizes translational studies in tumor biology, including the molecular mechanisms of coagulation activation in acute myeloid leukemia and the role of AXL inhibition in myeloproliferative neoplasms. She also investigates long-term cardiovascular effects of cancer therapies, leveraging cardiac MRI for early detection of myocardial dysfunction. Publications highlight her work on thrombosis in paroxysmal nocturnal hemoglobinuria, checkpoint inhibitor immunotherapy’s impact on hemostasis, and athlete cardiac adaptations. She collaborates with multidisciplinary teams in radiology, immunology, and pharmacology. Her clinical roles involve managing patients with hematologic malignancies and complex coagulation pathologies. No scientific awards are explicitly noted, but her active research profile underscores contributions to cardio-oncology and thrombosis biology.

Miles De Blasioمشاهده پروفایل

پژوهشگر ارشد

• Diabetes
• Cardiomyopathies
• Diabetic Complications
• +۶ مورد دیگر

Miles De Blasio is a Research Fellow in Drug Discovery Biology at Monash Institute of Pharmaceutical Sciences (MIPS), Monash University. He also holds adjunct and honorary roles as an Adjunct Research Fellow in Pharmacology at MIPS, Honorary Research Collaborator at the Baker Heart and Diabetes Institute, and Honorary Research Fellow at Monash Clayton’s Department of Pharmacology. His research focuses on novel therapies for diabetic cardiomyopathy, leveraging pharmacological agents and cardiac-selective gene therapies targeting pathways like the hexosamine biosynthesis pathway and adiponectin signaling. De Blasio earned his PhD in 2004 from the University of Adelaide, studying diabetes and obesity origins in fetal growth-restricted sheep. He later worked at the University of Cambridge, exploring fetal leptin’s role in lung and heart development, before shifting to diabetic cardiomyopathy in 2015. Since 2020, he leads MIPS’ efforts to develop cardioprotective treatments. His research interests emphasize translational cardiology and metabolic disease, with a focus on sex-specific differences, preclinical models, and therapeutic interventions. Projects include developing mouse models for diabetic cardiomyopathy and investigating next-generation glucose-lowering therapies’ cardiac benefits. He has secured over $7 million in grants as a Chief Investigator and supervised 10 PhD and 15 Honours students. His work contributes to UN Sustainable Development Goals related to health and well-being. Key Awards: Novartis Junior Investigator Award (Finalist, 2001) Ross Wishart Award (Finalist, 2001) Second Place, IGF Down Under Symposia Oral Presentation (2006) Second Place, GH-IGF International Conference Oral Presentation (2004) New Investigator Award, PSANZ (2002) Advising & Grants: De Blasio has supervised numerous students and secured major funding through NHMRC grants and Diabetes Australia. His labs, including the Cardio-Metabolic Physiology Lab and co-headed Heart Failure Pharmacology Lab, drive interdisciplinary research in drug discovery and cardiac protection. Labs & Collaborations: He leads the Cardio-Metabolic Physiology Laboratory at MIPS, collaborating with institutions like the Baker Heart and Diabetes Institute. Research spans cellular/molecular cardiology, mitochondrial function, and gene therapy applications in diabetes-related heart failure.

• Cardiology
• Pulmonary Medicine
• Cardiovascular Disease
• +۷ مورد دیگر

Jafar Alzubi is a Researcher in the Department of Internal Medicine at Yale School of Medicine. His work focuses on cardiovascular and pulmonary conditions with particular emphasis on cancer-cardiovascular comorbidities, interventional cardiology, and diagnostic imaging innovations. His research explores the intersection of malignant diseases with cardiovascular systems, device-based therapies, and critical care management. Key research areas include pulmonary embolism treatment strategies in oncology patients, left atrial appendage closure techniques, and the diagnostic utility of advanced echocardiography. He has investigated outcomes of spontaneous coronary artery dissection, non-bacterial thrombotic endocarditis, and Takotsubo cardiomyopathy in transplant recipients. His recent publications highlight trends in cardiovascular device performance, predictive modeling for disease progression (e.g., aortic stenosis), and epidemiological insights into sepsis mortality demographics. Notably, he has contributed to understanding how modern imaging modalities like 3D echocardiography improve diagnostic accuracy for conditions like infective endocarditis. No scientific awards have been listed. His advisory and grant activities remain unspecified in available records. He is affiliated with Yale University's clinical and research teams in cardiology and critical care medicine.

• Cardiology
• Cardiovascular Imaging
• Aortic Hemodynamics
• +۳ مورد دیگر

Zia Mehmood is a Research Fellow at Norwich Medical School, University of East Anglia, specializing in cardiovascular imaging and hemodynamics research. His work focuses on advanced cardiac imaging techniques with particular emphasis on aortic flow dynamics and their clinical applications in heart disease diagnosis and management. Dr. Mehmood's research interests center on the application of advanced imaging modalities in cardiovascular medicine. His work bridges the gap between technical imaging capabilities and clinical cardiac assessment, particularly focusing on aortic hemodynamics , cardiac MRI applications , and diagnostic innovations for conditions like aortic stenosis and heart failure with preserved ejection fraction (HFpEF). His research demonstrates how advanced flow analysis can provide incremental diagnostic value beyond traditional echocardiography. Analysis of Dr. Mehmood's publications reveals a strong focus on translational cardiovascular research with significant clinical implications. His work spans advanced cardiac imaging techniques , hemodynamic modeling , and diagnostic innovation in cardiovascular medicine. Several publications have garnered substantial attention, with one study picked up by 19 news outlets and multiple papers receiving significant social media engagement. Dr. Mehmood actively collaborates with leading cardiovascular researchers including Professor Pankaj Garg, Dr. Andrew Swift, and Professor Rob van der Geest, contributing to a robust research network focused on advancing cardiovascular diagnostics and understanding.

• Medical Education
• Geriatrics
• Chronic Illness Management
• +۲ مورد دیگر

John Day Gazewood, MD is an Associate Professor in the Department of Family Medicine at the University of Virginia . As the current Residency Program Director and Medical Director of the Primary Care Center , he focuses on enhancing medical education and improving patient care quality for the elderly and those with chronic illnesses. His academic journey includes a Chemistry degree from Grinnell College (Phi Beta Kappa) MD from Vanderbilt University School of Medicine (Alpha Omega Alpha) Residency in Family Medicine at University of Missouri-Columbia Geriatric Fellowship and Master of Science in Public Health at University of Missouri-Columbia Research interests center on medical education reform , geriatric care integration , and chronic disease management . His publications span topics like Bell's Palsy , Heart Failure , and Rosacea treatment , emphasizing evidence-based primary care. Awards include Best Doctors in America (2008, 2010, 2012) Harrison Teaching Associate Professor Master Educator Award Dean's Award for Excellence in Teaching Patient testimonials highlight exceptional care, clear communication, and responsiveness. He has served on the Geriatric Board Exam committee and maintains dual board certifications in Family Medicine and Geriatrics .

• Critical Care Medicine
• Cardiovascular Diseases
• Sepsis
• +۳ مورد دیگر

Clinical Professor Anthony McLean is affiliated with the Department of Intensive Care Medicine at the Nepean Clinical School, University of Sydney, within the Faculty of Medicine and Health. His research focuses on critical care echocardiography, sepsis, cardiovascular diseases, infection and immunity, and translational research. He has contributed to international guidelines for managing sepsis and septic shock, and has been involved in developing training standards for critical care ultrasound competency. Key research areas include biomarker identification for respiratory infections (e.g., IFI27), hemodynamic monitoring in critically ill patients, and the role of genetics and genomic signatures in sepsis and influenza pathogenesis. McLean has authored/co-authored major textbooks such as the 2020 Oxford Textbook of Advanced Critical Care Echocardiography and the 2012 Critical Care Ultrasound Manual , and has led studies on fluid therapy optimization, beta-blocker effects in sepsis, and post-partum catastrophic antiphospholipid syndrome. Hosted the ECHO-COVID multinational study analyzing echocardiography findings in ICU patients Co-developed the PRICES statement guiding critical care echocardiography research reporting Contributed to Surviving Sepsis Campaign international guidelines (2016) Explored molecular mechanisms linking metabolic pathways to critical illness outcomes His work emphasizes bridging clinical practice and research through translational approaches, with a focus on improving diagnostic accuracy and patient management in intensive care settings. He has collaborated extensively with organizations like the European Society of Intensive Care Medicine (ESICM) and the College of Intensive Care Medicine (CICM) to establish training frameworks and competency standards.

Alejandro R. Chadeمشاهده پروفایل

استاد

• Cardiovascular Physiology
• Renal Disease Mechanisms
• Microcirculatory Function
• +۳ مورد دیگر

Alejandro R. Chade, MD, is a Professor of Medical Pharmacology and Physiology at the University of Missouri School of Medicine and a NextGen Precision Health Investigator. His research focuses on cardiovascular and renal physiologic imaging, microcirculatory function, and mechanisms of renal and cardiac disease. Dr. Chade’s laboratory develops translational swine models of chronic kidney disease (CKD) and hypertension, leveraging advanced imaging techniques such as multi-detector CT and echocardiography to study renal and cardiac function. His work also explores novel therapeutic strategies targeting the renal and cardiac microcirculation to mitigate inflammation and improve organ function. Education: MD from Universidad Nacional de Cuyo (1996), Cardiology Residency and Fellowship at Hospital Lagomaggiore (2001), and postdoctoral training at the Mayo Clinic (2005). He has held roles at the University of Mississippi Medical Center before joining the University of Missouri. Research Interests include mechanisms linking CKD to cardiovascular disease, imaging-based diagnostics, and drug delivery systems for targeted therapies. His lab investigates macrophage polarization, NF-kB signaling pathways, and the role of mitochondrial DNA in renal injury. Key Awards: American Heart Association Established Investigator Award, Mid-Career Award, and numerous travel and recognition awards for hypertension and renal research. Publications focus on swine models, renal-cardiac crosstalk, and VEGF-based therapies, with high-impact contributions to American Journal of Physiology and Hypertension . Labs/Teams: Leads the NextGen Precision Health Initiative, collaborating on translational research to bridge basic science and clinical applications.

Horng H. Chenمشاهده پروفایل

استاد

• Cardiorenal dysfunction
• Heart failure
• Natriuretic peptide therapeutics
• +۶ مورد دیگر

Horng H. Chen, M.D., is a board-certified adult heart failure cardiologist and physician-scientist at Mayo Clinic in Rochester, Minnesota, holding the position of Professor of Medicine in the Department of Cardiovascular Medicine at Mayo Clinic College of Medicine. Dr. Chen serves as Chair of the Division of Circulatory Failure and is the Co-Director of Mayo Clinic's Cardiorenal Research Laboratory, where he has established an independent research program in human cardiorenal physiology in heart failure. Primary Appointment: Consultant, Division of Circulatory Failure, Department of Cardiovascular Medicine Administrative Appointment: Chair, Division of Circulatory Failure, Department of Cardiovascular Medicine Academic Rank: Professor of Medicine Location: Rochester, Minnesota Dr. Chen is a board-certified cardiologist with subspecialty certification in heart failure and transplantation and adult comprehensive echocardiography. With over 20 years of experience in translational research, he has advanced the field of cardiorenal therapeutics in heart failure, filing 10 patents for cardiorenal syndrome therapeutics. His pioneering work has changed thinking in congestive heart failure and cardiorenal biology by advancing the concept of cardiac natriuretic peptides as cardiorenal protective properties via cyclic guanosine monophosphate (cGMP) signaling. He is pursuing subcutaneous administration of native and novel designer natriuretic peptides, along with nanotechnologies like nanoparticles with embedded natriuretic peptides. Cardiorenal dysfunction: Established and developed independent research program in human cardiorenal physiology in heart failure Natriuretic peptide therapeutics: Advanced concepts of cardiac natriuretic peptides as cardiorenal protective properties Novel therapies: Bridging laboratory discoveries to patient care for cardiorenal dysfunction Dr. Chen's research has significant clinical impact, particularly through the Renal Optimization Strategies Evaluation in Acute Heart Failure (ROSE-AHF) study, which changed management approaches for acute heart failure patients. His work continues to discover and translate novel therapeutics for heart failure with a translational focus through Mayo's Center for Clinical and Translational Studies Activities (CTSA). Elected member, The American Society for Clinical Investigation (2012) Stanford University Names World's Top 2% Scientists (2021) Multiple Jay N. Cohn Young Investigator Awards from the Heart Failure Society of America Cardiovascular Diseases Outstanding Achievement Award Mayo Clinic (2001) Mayo Foundation Scholar Mayo Clinic (2001) Dr. Chen has been continuously NIH-funded since 2005, currently serving as principal investigator on three NHLBI research grants and co-investigator on the NHLBI Heart Failure Clinical Research Network. His mentoring extends through the NIH/NHLBI Cardiovasology T32 Training Grant, supporting the development of young cardiovascular researchers in the Department of Cardiovascular Diseases. As Co-Director of the Cardiorenal Research Laboratory, Dr. Chen leads a team actively developing novel therapeutics for heart failure and cardiorenal syndrome. The laboratory collaborates closely with Mayo's Center for Clinical and Translational Studies Activities to translate discoveries from bench to bedside, with particular focus on advancing nanotechnologies for therapeutic applications in cardiovascular medicine.

David Ditorمشاهده پروفایل

استاد

• Spinal cord injury
• Exercise rehabilitation
• Chronic inflammation
• +۵ مورد دیگر

Dr. David Ditor is a Professor in the Department of Kinesiology at Brock University's Faculty of Applied Health Sciences. He serves as the director of the Brock Functional Inclusive Training (Bfit) Centre's POWER CORD, a wheelchair-accessible exercise program that functions as both a research center and a community-based exercise facility for individuals in Niagara. Dr. Ditor holds additional academic appointments as an Adjunct Professor in the Department of Kinesiology at McMaster University and in the Department of Kinesiology & Health Science at York University. He is also an Affiliate Member in the Centre for Disability Studies (CADS) at Brock University and serves on the Ontario Neurotrauma Foundation (ONF) Quality of Life for Persons with SCI Subcommittee and the Editorial board for Critical Reviews in Physical and Rehabilitation Medicine. His research program focuses on secondary health complications associated with spinal cord injury, with three primary emphases: chronic inflammation and its effects on physical and psychological outcomes, cardiovascular disease and dysfunction, and sexual function in both males and females. Dr. Ditor has published extensively on these topics in high-impact journals including Spinal Cord, Journal of Neuroinflammation, and Neurology. Spinal cord injury rehabilitation Exercise physiology for neurological populations Chronic inflammation and systemic effects Cardiovascular dysfunction in spinal cord injury Sexual health following neurological injury Body image and psychological outcomes Secondary complications of disability Dr. Ditor is the co-inventor of the anti-contracture elevating (ACE)-wheelchair leg rests, a patented device that attaches to any manual wheelchair to improve range of motion at the knee while reducing lower limb spasticity and edema in chronic wheelchair users. This innovation represents a practical application of his research to address common complications faced by individuals with mobility impairments. As director of the POWER CORD program, Dr. Ditor oversees evidence-based exercise interventions specifically designed for individuals with spinal cord injury, multiple sclerosis, Parkinson's disease, and amputees. This initiative bridges the gap between research and community application, providing accessible rehabilitation services while simultaneously advancing scientific understanding of exercise interventions for neurological conditions.

Frank Spinaleمشاهده پروفایل

استاد

• Cardiovascular Remodeling
• Heart Failure
• Extracellular Matrix
• +۴ مورد دیگر

Frank Spinale is a Professor and Director of Research at the University of South Carolina School of Medicine Columbia. With a dual MD/PhD background, his career spans over three decades of translational cardiovascular research, primarily focused on heart failure and cardiac remodeling mechanisms. Education: BS in Biology from Northeastern University (1977-1979), MS in Biometry from Medical University of South Carolina (1982-1984), MD from Medical University of South Carolina (1990-1993) Research Focus: Cardiovascular remodeling, extracellular matrix biology, matrix metalloproteinases in heart failure Current Role: Director of Research at USC School of Medicine Columbia Dr. Spinale's research has centered on the role of extracellular matrix (ECM) alterations in cardiovascular disease, particularly the dysregulation between matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in heart failure progression. His work has established causal relationships between MMP activity and adverse myocardial remodeling, especially following myocardial infarction. His research spans from basic molecular mechanisms to clinical applications, including the development of diagnostic biomarker panels for heart failure risk stratification. Analysis of his publication record shows consistent research productivity over three decades, with recent work focusing on myocardial stiffness estimation, mitral valve pathology, and novel therapeutic approaches for cardiac remodeling. His research bridges basic science with clinical applications, maintaining strong translational focus throughout his career. Dr. Spinale has received NIH funding for his research on MMP/TIMP dynamics in heart failure and has contributed significantly to understanding the structural underpinnings of cardiac remodeling. His work has influenced both basic cardiovascular science and clinical approaches to heart failure management.