جستجوی استاد راهنمای دانشگاهی

Ramsay Mcfarlaneمشاهده پروفایل

مدرس ارشد

• Cancer Genetics
• Genome Stability
• Stem Cell Biology
• +۵ مورد دیگر

Dr. Ramsay Mcfarlane serves as Senior Lecturer in Biomedical Sciences (Medical & Molecular Genetics) at Bangor University's North Wales Medical School, where he concurrently holds positions as Research Group Leader and Deputy Head of School for Research. His work focuses on elucidating how cancer cells exploit germline and stem cell genes to manipulate cell proliferation and genome dynamics, with the ultimate goal of developing novel diagnostic tools and therapeutic interventions for cancer patients through the identification of druggable targets and biomarkers. Education: Ph.D. in Medical Genetics, Liverpool University, UK (Supervised by Prof. John Saunders) Dr. McFarlane's research program centers on cancer genetics and genome stability mechanisms, specifically investigating germ line genes, cancer testis antigens, meiosis, and telomere biology in human cancer cells, model organisms, and pluripotent stem cells. His group has demonstrated non-uniform DNA replication failure across the genome and identified conserved protein complexes governing telomere maintenance in cancer progression. This work has yielded significant discoveries in cancer-specific biomarker genes with direct applications for patient stratification, early diagnosis, and development of both conventional and immunotherapeutic drug targets. Analysis of his recent publications (2017-2022) reveals a cohesive research trajectory focused on molecular mechanisms of genome instability, with particular emphasis on Translin/Trax complexes, Brachyury signaling, and germ cell-specific gene networks like TEX19. These studies consistently bridge fundamental molecular biology with translational oncology, highlighting novel vulnerabilities in cancer cell regulation that inform therapeutic development. Scientific Awards: NIH Postdoctoral Fellowship at Fred Hutchinson Cancer Research Center, Seattle, USA Dr. McFarlane has supervised 30 research students and projects while securing major funding from the MRC, Wellcome Trust, Royal Society, BBSRC, North West Cancer Research, Cancer Research Wales, NHS, and the Saudi Arabian Government. Current initiatives include the Wales Cancer Research Centre (2020-2025) and the application of cancer-testis genes to address unmet clinical needs in oncology (2023-2027), demonstrating sustained impact in translational cancer research. He established the North West Cancer Research Institute at Bangor University in partnership with the regional cancer charity, creating a dedicated research ecosystem focused on genome dynamics in cancer. His laboratory features state-of-the-art facilities including human cancer/embryonic stem cell culture suites, confocal microscopy, fluorescence-activated cell sorting, and advanced molecular biology technologies, enabling comprehensive investigation of cancer stem cell mechanisms and therapeutic targeting.

Donald Mark Coenمشاهده پروفایل

استاد

• Herpesvirus Replication
• Viral Latency
• MicroRNA Biology
• +۵ مورد دیگر

Donald Mark Coen, Ph.D. is a Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School . His research focuses on molecular mechanisms of herpesvirus replication and latency , with a particular emphasis on herpes simplex virus (HSV) and human cytomegalovirus (HCMV). Investigates viral microRNAs and their role in latency maintenance Studies structural biology of herpesvirus DNA replication proteins Develops antiviral therapies targeting nuclear egress mechanisms The lab has recently transitioned to a closed status while continuing manuscript preparation and reagent support. Collaborations with the Hogle, Abraham, and Arthanari labs have been instrumental in structural studies and drug mechanism analyses. Recent publications highlight advancements in: Small molecule targeting of HCMV nuclear egress MiR-9 mediated HSV-1 latency mechanisms DNA polymerase structural insights for drug resistance Nuclear egress complex phosphorylation studies Chemical genetic approaches to drug development Research foci include post-transcriptional regulation , replication protein functional dissection , and novel antiviral targets through chemical genetics and biophysical approaches. Despite no current positions available, the lab maintains its legacy through ongoing manuscript work and resource sharing.

• Micro and Nano Systems
• Biophysics
• Bacterial Dynamics
• +۳ مورد دیگر

A. Japaridze is a researcher at Delft University of Technology's Department of Mechanical Engineering, specializing in the Dynamics of Micro and Nano Systems . Their work bridges nanotechnology with microbiology, focusing on bacterial behavior and chromosome mechanics. Research Outputs: 19 publications including patents and peer-reviewed articles Key Collaborations: Working with C. Dekker, F. Alijani, and P.G. Steeneken Research interests include: Micro/nano-scale bacterial dynamics Chromosome structural analysis Graphene-based biosensing systems Microfluidic device applications Recent publications examine: Graphene drum sensors for bacterial detection Chromosome morphology in expanded Bacillus cells Microwell-enhanced optical detection systems Datasets contributed include: Single-bacteria nanomotion tracking Replisome movement patterns Microwell optical detection frameworks

Frederic D. Bushmanمشاهده پروفایل

استاد

• Microbiology
• Human Microbiome
• Human Virome
• +۷ مورد دیگر

Frederic D. Bushman is the William Maul Measey Professor in Microbiology at the University of Pennsylvania's Perelman School of Medicine, where he serves as Chair of the Department of Microbiology and Co-Director of the PennCHOP Microbiome Program. His research focuses on the complex interactions between humans and their microbial communities, with particular emphasis on developing new technologies for research and biotechnology applications. Dr. Bushman's educational background includes: B.A. in Biology and English from Amherst College (1980) Ph.D. in Cellular and Developmental Biology from Harvard University (1988) His primary research interests span the human microbiome , the human virome , SARS-CoV-2 , human gene therapy , and HIV . Dr. Bushman's laboratory investigates the gigantic community of microbes that live in association with humans, specific viruses like SARS-CoV-2 and HIV, and methods for understanding and improving human gene therapy approaches, particularly focusing on integration by viral vectors. Analysis of Dr. Bushman's recent publications reveals a strong focus on the human microbiome and virome, with significant contributions to understanding how microbial communities influence human health and disease. His work spans multiple disciplines including microbiology, virology, genomics, and computational biology, often employing cutting-edge sequencing technologies to explore host-microbe interactions at unprecedented resolution. Dr. Bushman has received numerous prestigious honors and awards: Fellow of the American Association for the Advancement of Science (2014) Pioneer Award from the Journal of Human Gene Therapy (2014) Fellow of the American Academy of Microbiology (2009) Master of Arts, Honoris Causa from the University of Pennsylvania (2004) Stohlman Scholar from the Leukemia and Lymphoma Society of America (2001) Multiple fellowships and scholarships from the Leukemia Society of America (1989-2001) Dr. Bushman serves as a mentor for graduate students through the Genomics and Computational Biology and Cell and Molecular Biology graduate groups. His laboratory supports the Viral/Molecular High Density Sequencing Core, which provides genomic analysis for human gene therapy research with particular focus on the consequences of gene modification for the human genome. He has secured significant grant funding from organizations including the Leukemia and Lymphoma Society and the National Institutes of Health. The Bushman Lab operates as a dynamic research environment dedicated to understanding human-microbe interactions. The lab maintains strong collaborations with researchers across the University of Pennsylvania and Children's Hospital of Philadelphia (CHOP), particularly through the PennCHOP Microbiome Program which Dr. Bushman co-directs. The lab's work combines experimental and computational approaches to address fundamental questions in microbiome and virome research.

• Genome Evolution
• Genome Rearrangement
• Molecular Evolution
• +۳ مورد دیگر

Laura Landweber is a Professor at Columbia University, affiliated with the Departments of Biochemistry and Molecular Biophysics, Biological Sciences, and Systems Biology in the Colleges of Physicians & Surgeons and Arts & Sciences. She previously served as faculty at Princeton University (1994-2016) and was a Junior Fellow at Harvard University (1993). Her research focuses on microbial eukaryotes with complex genome architectures, particularly the ciliate Oxytricha, investigating RNA-mediated epigenetic inheritance, genome rearrangement, and the co-evolution of transposons with genomic systems. Her work has been recognized through prestigious awards such as the Guggenheim Fellowship (2012), Blavatnik Award (2008), and fellowship in the American Association for the Advancement of Science (AAAS, 2005). She served as President of the Society for Molecular Biology and Evolution (2017) and contributed to advisory panels for the NSF, NIH, and NASA. Recent publications emphasize genome evolution, RNA-guided DNA reorganization, and computational tools for analyzing complex genomes. Her lab employs functional and comparative genomic experiments to study RNA’s role in programming genome architecture across generations, leveraging Oxytricha’s dual-nucleus system to dissect mechanisms of DNA rearrangement and epigenetic memory. Guggenheim Fellowship (2012) Blavatnik Award for Young Scientists (2008) AAAS Fellow (2005) President, Society for Molecular Biology and Evolution (2017) Her educational background includes an AB in Molecular Biology from Princeton University (1989) and a PhD from Harvard University (1993). She has edited three books and authored over 150 publications spanning genetics, evolution, and biological computation.

• Lung Transplantation
• Immunology
• Pulmonary Medicine
• +۳ مورد دیگر

John Greenland, MD, PhD is a Professor of Medicine at the University of California, San Francisco (UCSF) School of Medicine and a Staff Physician at the San Francisco VA Health Care System. His clinical work focuses on pulmonary medicine and critical care, with specialization in lung transplantation. As an Associate Editor for the American Journal of Transplantation and former member of the programming committee for the International Society for Heart and Lung Transplantation, Dr. Greenland has established himself as a leading expert in transplant medicine. Dr. Greenland earned his BS in Chemistry with minors in Computer Science and History from Stanford University in 2000, followed by a PhD in Virology and MD from Harvard Medical School, completing his MD through the Harvard-MIT Division of Health Science and Technology program in 2008. His research program centers on improving outcomes following lung transplantation, with groundbreaking work demonstrating that airway brush gene expression patterns can identify patients at risk for graft failure. His laboratory investigates novel rejection patterns including epithelial cell reprogramming, dysbiosis, and activation of immune cells in transplant recipients. This work leverages comprehensive bio-repositories for cellular immunology, genomic, epigenetic, and single-cell transcriptomic analyses, complemented by mouse models to understand airway infections and rejection mechanisms. Analysis of his recent publications reveals a clear trajectory toward molecular diagnostics for chronic lung allograft dysfunction (CLAD), with increasing emphasis on single-cell technologies and immune profiling to identify early markers of graft failure. His work demonstrates how understanding immune mechanisms can lead to personalized therapies that preserve transplanted lungs. NIH U01P0555037 Principal Investigator (2022-2027) CFF Airway Brush in CLAD Study Principal Investigator (2022-2027) NIH R01HL161048 Principal Investigator (2021-2026) NIH I01CX002011 Principal Investigator (2020-2024) NIH R01HL151552 Principal Investigator (2020-2025) As a clinician-scientist, Dr. Greenland maintains an active clinical practice serving as an attending physician in the intensive care unit, pulmonary consult service, and outpatient clinic at the SF VAHCS. His research program includes a multidisciplinary team working across immunology, genomics, and pulmonary medicine, with strong translational focus bridging laboratory discoveries to clinical applications in lung transplantation.

Jonathan Chouمشاهده پروفایل

پزشک-پژوهشگر

• Translational Oncology
• Prostate Cancer Biology
• Bladder Cancer Research
• +۶ مورد دیگر

Jonathan Chou is a physician-scientist at the University of California, San Francisco (UCSF) School of Medicine, actively contributing to both clinical practice and translational research in genitourinary oncology. As an attending physician in the Genitourinary Medical Oncology Clinic and member of the Division of Hematology/Oncology, he bridges patient care with innovative investigations into cancer biology. MD and PhD in Biomedical Sciences, UCSF A.P. Giannini Postdoctoral Fellow, 2018 Research focus on prostate and bladder cancer mechanisms Chou's research explores cancer biology with emphasis on transcription-replication conflicts and CDK12 regulation . His lab develops novel CAR T and radioimmunotherapies for genitourinary malignancies, utilizing transcriptomic and proteomic approaches to identify therapeutic targets. Current projects investigate resistance mechanisms to antibody-drug conjugates , synthetic lethality , and immunotherapeutic targets in aggressive cancer subtypes. His article analysis reveals expertise in prostate cancer (CDK12 biology, radioimmunotherapy), bladder cancer (TM4SF1, CA125+ cell states), and cross-cutting themes in genomic instability , translational imaging , and precision medicine . Research trends show integration of functional genomics (CRISPR screens), clinical trials (IMPACT trial), and health equity initiatives. Scientific recognition includes: Young Investigator Awards (BCAN 2023, Prostate Cancer Foundation 2020) DoD Physician Research Award (2019) Multiple UCSF fellowships (2017-2018) Goldwater Scholar (2003) Chou's clinical training under Eric Small, Terence Friedlander, and Chuck Ryan, combined with postdoctoral work with Felix Feng and Alan Ashworth, positions him at the intersection of clinical oncology and cutting-edge cancer research . His educational background from Stanford University and mentorship under Zena Werb further strengthens his foundation in tumor microenvironment and metastasis regulation studies.

Biju Bhargavanمشاهده پروفایل

مدرس

• Neurovirology
• Blood-Brain Barrier
• HIV-1 Pathogenesis
• +۵ مورد دیگر

Biju Bhargavan, PhD , is an Instructor in the Department of Anesthesiology at the University of Nebraska Medical Center (UNMC), affiliated with the College of Medicine. His research focuses on molecular mechanisms of HIV-1-induced blood-brain barrier (BBB) dysfunction, neuroinflammation, and epigenetic regulation in neuroAIDS pathogenesis. PhD in Pharmacology, Central Drug Research Institute, Lucknow, India (2009) Research Interests: Dr. Bhargavan investigates how HIV-1 subtypes differentially affect BBB integrity through viral proteins, adhesion molecules, cytokines, and chemokine receptors. His work explores TLR signaling, epigenetic modifications (e.g., DNA methylation, histone acetylation), and nanomedicine-based drug delivery systems for CNS targeting. Scientific Contributions: He holds multiple international patents for pharmaceutical compositions targeting bone disorders using Butea isoflavones. His publications reveal key insights into: HIV-1 Tat protein interactions with TLR4/6 in neuroinflammation Epigenetic regulation of LEDGF in aging and oxidative stress TLR3-mediated IL-6 expression via JNK/TAK1 pathways SARS-CoV-2 spike protein effects on endothelial injury and coagulation Methodologies: Utilizes in vitro BBB models, humanized mice, and molecular signaling analyses to study viral neuropathogenesis and develop antiretroviral nanotherapeutics.

Sven Rottenbergمشاهده پروفایل

استاد

• Oncology
• DNA Damage Response
• Comparative Oncology (Canine/Feline Models)
• +۵ مورد دیگر

Prof. Dr. Sven Rottenberg is a Group Leader at the Institute of Animal Pathology within the University of Bern , and a member of the Neglected Diseases Cluster at the Multidisciplinary Center for Infectious Diseases (MCID) . His research spans oncology and infectious diseases, focusing on DNA damage response mechanisms, PARP inhibitor resistance, and comparative oncology using canine/feline models. Specializes in spatial transcriptomics and CRISPR/Cas9 functional genomics Develops AI-driven tools for digital pathology and drug safety assessment Investigates tumor microenvironment dynamics and metabolic vulnerabilities Research Trends : His recent work emphasizes Spatial omics technologies for tumor heterogeneity mapping Host-pathogen interactions in malaria and hemoparasites Artificial intelligence applications in veterinary and human oncology Genetic dropout screens for chemotherapy optimization Replication fork stability in BRCA-deficient cancers Canine tumor organoid biobanking

Deborah Strokaمشاهده پروفایل

استاد

• Molecular Biology
• Hepatology
• Cancer Research
• +۳ مورد دیگر

Prof. Deborah Stroka is a Professor and Head of Research Group at the Department of Biomedical Research (DBMR), Faculty of Medicine, University of Bern, with dual affiliation to the Department of Visceral Surgery and Medicine at Bern University Hospital. Her research bridges molecular mechanisms of liver disease, cancer biology, and infectious disease pathogenesis through the Multidisciplinary Center for Infectious Diseases (MCID). Her primary research focuses on DNA replication stress in metabolic dysfunction-associated steatohepatitis (MASH), tight junction protein functions (particularly claudin-3) in hepatic barrier integrity, bacterial ATP-mediated inflammation in sepsis, and nanoplastic biodistribution. She investigates tumor budding mechanisms in colorectal cancer, MET receptor signaling in DNA damage response, and lymphatic regulation in gut-liver axis pathologies using advanced spatial transcriptomics and lipidomics approaches. Recent publications reveal strong emphasis on molecular intersections between infection, metabolism, and tissue repair, with innovative techniques in X-ray fluorescence imaging for nanotoxicology and Skyline-based lipid isomer analysis. Recurring themes include bacterial translocation impacts on liver regeneration, replication stress in aging, and therapeutic targeting of fibrosis pathways. As Head of Research Group within MCID, she leads interdisciplinary teams developing models for abdominal sepsis, radiation-induced liver disease, and orthotopic cancer systems while pioneering analytical methods for nanoplastics and lipid isomers in disease contexts.

Wolfram Bruneمشاهده پروفایل

استاد

• Virology
• Immunology
• Molecular Biology
• +۳ مورد دیگر

Prof. Dr. Wolfram Brune is Deputy Scientific Director and Head of the Research Department on Virus-Host Interaction at the Leibniz Institute of Virology (LIV) , University of Hamburg. His research focuses on cytomegalovirus-host interactions , including mechanisms of immune evasion, programmed cell death inhibition, and host species specificity. Key areas: Viral inhibition of apoptosis/necroptosis/pyroptosis , stress response modulation , and antiviral target discovery Current projects: Decoding host dependency factors , developing herpesvirus BAC systems , and analyzing glycoprotein variants in viral tropism Recent publications highlight his work on viral phase-separated compartments , BAC mutagenesis , and host restriction factors like Pkr. Collaborations with institutions like UKE Hamburg and Umeå University emphasize translational virology. Techniques employed include BAC genome engineering , CRISPR-Cas screening , and in vivo infection models . His team has contributed to antiviral drug development and cross-species transmission studies .

Alexandra Pikeمشاهده پروفایل

استادیار

• Molecular Biology
• Biochemistry
• DNA Replication
• +۵ مورد دیگر

Alexandra Pike serves as an Assistant Professor of Biology within the Department of Biology at Oberlin College's College of Arts and Sciences. Her research focuses on genome maintenance mechanisms, utilizing both biochemical and genetic approaches in yeast models to investigate DNA replication, repair, and telomere-length regulation. Education: BS in Biochemistry from Indiana University Bloomington (2011) PhD in Cellular and Molecular Medicine from Johns Hopkins University School of Medicine (2017) Postdoctoral Fellowship at Massachusetts Institute of Technology (2018-2022) Dr. Pike's research program examines how DNA-binding proteins coordinate molecular machinery involved in genome maintenance, with particular emphasis on telomere protection mechanisms and the consequences of replication failures. Her work bridges fundamental cellular processes with pathological conditions like short-telomere syndromes, employing mammalian cell culture and budding yeast systems to elucidate disease mechanisms. Scientific Recognition: No scientific awards were documented in the provided materials Since January 2023, Dr. Pike has established her independent research laboratory at Oberlin College while teaching cellular and molecular biology courses. Her lab investigates single-stranded DNA binding proteins and their roles in maintaining genomic stability through integrated biochemical and genetic methodologies. Outside academic pursuits, she maintains active interests in outdoor exploration, running, culinary arts, and restorative naps.

• DNA Replication
• Transcription
• Translation
• +۷ مورد دیگر

Kevin S Lang serves as an Assistant Professor in the Department of Veterinary and Biomedical Sciences at the University of Minnesota's College of Veterinary Medicine. His research program investigates fundamental biological processes during host-pathogen interactions with a particular focus on DNA replication, transcription, and translation mechanisms. The Lang Lab employs a comprehensive multi-disciplinary approach integrating genetics, biochemistry, cell biology, proteomics, and genomics to address critical questions in bacterial pathogenesis and antibiotic resistance. Their work has significant implications for understanding replication-transcription conflicts, R-loop formation, and the development of antimicrobial resistance. Lang's research portfolio demonstrates consistent productivity with publications spanning from 2007 to 2023, including high-impact papers in Nature, Nature Structural and Molecular Biology, and Cell Reports. His work shows particular strength in elucidating the molecular mechanisms underlying transcription-replication conflicts and their consequences for genome stability. Lang secured competitive funding through a USDA National Institute of Food and Agriculture grant (2013-2015) as Principal Investigator for the project "Reducing resistance: determining underlying mechanisms," focusing on plasmid-mediated multidrug resistance. His research has garnered significant attention, with publications highlighted by news outlets, referenced in policy sources and Wikipedia pages, and widely shared across academic platforms. The Lang Lab maintains active collaborations across multiple institutions and countries, as evidenced by the international collaboration network visualizations. His work contributes to UN Sustainable Development Goals related to health and well-being, particularly through research addressing antimicrobial resistance challenges.

John Schimentiمشاهده پروفایل

استاد

• Genetics
• Meiosis
• Genome Maintenance
• +۵ مورد دیگر

John Schimenti is a James Law Professor of Genetics at the Department of Biomedical Sciences , Cornell University College of Veterinary Medicine . His research focuses on the genetics of reproduction , meiosis , and genome maintenance , particularly checkpoint mechanisms that prevent chromosomal aberrations and birth defects. He has developed CRISPR-based models for studying human infertility alleles. Education: BA from Rutgers University, PhD from University of Cincinnati Children's Hospital, Postdoctoral training at Princeton University Professional Experience: Assistant Professor at Case Western Reserve University (1987-1992), Staff Scientist at The Jackson Laboratory (1992-2004), Director of Cornell Center for Vertebrate Genomics (2004-2019) Research Interests span reproductive genetics, DNA replication stress responses, and mechanisms ensuring germ cell quality. His recent work explores epigenetic regulators in primordial germ cell development and organoid mutagenesis for ovarian cancer drivers. Publications cover meiotic recombination, infertility genetics, ovarian cancer modeling, and genome stability during development. Key areas include CHK2/CHK1 signaling , CDK2 functions , and RABL2A variants . Scientific Awards : March of Dimes Basil O'Connor Award, Searle Scholars Award, NSF Presidential Young Investigator, AAAS Fellow, SUNY Chancellor's Award Teaching includes BioMG Genomics 4000/6000 for 19+ years. Affiliations: Primary in Biomedical Sciences (Cornell CVM), Joint in Molecular Biology and Genetics.

Patrick Meraldiمشاهده پروفایل

استاد

• Mitosis
• Centrosome
• Chromosome Segregation
• +۵ مورد دیگر

Patrick Meraldi is a Full Professor at the Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva. He serves as Head of Department since 2022 and previously led the Gender Equality Commission (2019-2022) and Translational Research Centre in Onco-Hematology (2016-2022). PhD in Molecular Biology (University of Geneva) Diploma in Biology (ETH Zurich) His research focuses on mitotic spindle dynamics , centrosome function , and chromosome segregation mechanisms in human cells. Key studies examine microtubule-kinetochore interactions , spindle symmetry regulation , and aneuploidy consequences in cancer and developmental disorders. Recent publications highlight asymmetric spindle organization and replication stress impacts on mitosis. He has secured multiple Swiss National Science Foundation grants for spindle regulation research and cryo-EM infrastructure. Ernst Th. Jucker Prize (2011) Walther Flemming Medal (2011) EMBO YIP Award (2009) Collaborations include MIT , Max Planck Institute , and ETH Zurich . His lab employs quantitative light microscopy , genetic perturbations , and biochemical analysis to unravel mitotic error mechanisms.