جست‌وجوی استاد و پژوهشگر

Dirk Hockemeyerمشاهده پروفایل

استاد

• Telomere Biology
• Cancer Biology
• Stem Cell Research
• +۳ مورد دیگر

Dirk Hockemeyer is the C.H. and Annie Li Chair in Molecular Biology of Diseases and a Professor in the Department of Cell Biology, Development and Physiology. His research focuses on telomeres, telomerase, and their roles in cancer, aging, and stem cell biology. He has developed innovative methods for genetic modification of human pluripotent stem cells (hPSCs), enabling studies of telomerase regulation during differentiation and tumor formation. Research Interests: Understanding telomere dynamics and their implications in genomic integrity Investigating telomerase reactivation in cancer and stem cells Developing gene-editing technologies for disease modeling Studying cellular senescence and aging mechanisms Key Contributions: Pioneered robust protocols for deriving and modifying hPSCs Explored telomere biology in cancer and neurodevelopmental disorders using brain organoids Advanced CRISPR-based functional genomics approaches Labs/Teams: Leads a lab focused on telomere biology and stem cell research, collaborating on projects like gene editing and disease modeling. His work bridges molecular biology, genetics, and translational medicine.

Gary Karpenمشاهده پروفایل

استاد

• Chromatin Structure
• Epigenetics
• Cell Biology
• +۵ مورد دیگر

Gary Karpen is a Professor of Cell Biology, Development, and Physiology at the University of California, Berkeley, within the College of Letters & Science and Department of Molecular and Cell Biology. His research focuses on chromatin structure, centromere function, and chromosome organization in metazoans, primarily using Drosophila melanogaster as a model system. Key projects include analyzing centromere identity, nuclear organization proteins, and heterochromatin sequence analysis. His work bridges molecular, genetic, and biochemical approaches to understand epigenetic regulation of centromeres and their role in mitosis, aneuploidy prevention, and cancer. Research highlights include studies on CENP-A histone variants as centromere epigenetic markers, the structural dynamics of kinetochores, and the role of heterochromatin in DNA repair and genome stability. His lab has revealed conserved mechanisms across species, such as the cylindrical centromere structure observed in flies and humans. Collaborative projects include studies on space radiation effects and centromere-based cancer diagnostics. Publications span topics like HP1-driven phase separation in heterochromatin, DNA repair mechanisms in chromatin domains, and genomic mapping of centromeres. His work emphasizes interdisciplinary approaches to unravel fundamental biological processes with implications for human health.

Alex Bishopمشاهده پروفایل

دانشیار

• Ewing Sarcoma
• DNA Repair
• R-loops
• +۳ مورد دیگر

Dr. Alex Bishop is an Associate Professor in the Department of Cell Systems and Anatomy at The University of Texas Health San Antonio, within the Joe R. and Teresa Lozano Long School of Medicine. His research focuses on unraveling the molecular mechanisms underlying pediatric cancers, particularly Ewing sarcoma, with emphasis on R-loop regulation, DNA repair pathways, and oncogenic transcriptional dysregulation. Dr. Bishop holds a DPhil from Oxford University and completed further training at Harvard Medical School. He has led groundbreaking studies including identifying R-loop accumulation as a therapeutic target in Ewing sarcoma and discovering links between BRCA1 dysfunction and cancer progression. His work has been published in high-impact journals like Nature and supported by grants from Stand Up To Cancer and Cancer Research UK. Key research areas include understanding how the EWSR1-FLI1 fusion protein drives genomic instability, developing mouse models for sarcoma research, and advancing computational tools like RLSuite for R-loop analysis. Collaborations with institutions such as the Greehey Children’s Cancer Research Institute and Mays Cancer Center enable translational research bridging basic science and clinical applications. Dr. Bishop’s contributions have advanced targeted therapies for pediatric cancers, with recent efforts exploring combination treatments and novel biomarkers. His lab employs cutting-edge technologies including mass cytometry and single-cell transcriptomics to dissect tumor biology and resistance mechanisms.

R. Ariel Gomezمشاهده پروفایل

استاد

• Renin-synthesizing cells
• Kidney vascular development
• Epigenetic mechanisms
• +۵ مورد دیگر

R. Ariel Gomez is a Professor of Pediatrics at the University of Virginia School of Medicine, with a courtesy appointment in the Department of Biology (School of Arts and Sciences). He holds the Harrison Distinguished Professorship and has served in leadership roles such as Vice President for Research and Graduate Studies. His research focuses on renin-synthesizing cells, kidney vascular development, and epigenetic regulation of cell identity. Key projects include studying renin lineage plasticity, microRNA roles in cell differentiation, and mechanisms governing renal arteriolar formation. Dr. Gomez received his MD from the University of Buenos Aires (1975) and completed pediatric residency and nephrology fellowships at institutions in Argentina and the US. He joined UVA in 1984, establishing a NIH-funded lab. His work integrates lineage tracing, epigenetics, and genomic approaches to unravel kidney development and hypertension mechanisms. Research interests span renin cell identity maintenance via chromatin conformation, microRNA (miR-330/miR-125b-5p) regulation of renal phenotypes, and Notch signaling in renal vascular progenitors. He investigates how renal cells contribute to regeneration and immune defense, with implications for therapies targeting vascular diseases. His lab has developed cre-lox mouse models and CRISPR tools for studying renin lineage dynamics. Awards include the Excellence Award for Hypertension Research (2017). Collaborative efforts address kidney regeneration, hypertension pathophysiology, and transcriptional networks in development. Dr. Gomez’s work bridges basic science and clinical applications, emphasizing renal health in hypertension management and kidney regeneration post-injury. His research has advanced understanding of cell-lineage plasticity and epigenetic drivers of renal pathologies.

Kotaro Nakanishiمشاهده پروفایل

استاد

• RNA Interference
• MicroRNAs
• Argonaute Proteins
• +۵ مورد دیگر

Kotaro Nakanishi is a Professor in the Department of Chemistry & Biochemistry at The Ohio State University, specializing in RNA interference mechanisms and Argonaute proteins. His research focuses on understanding the molecular basis of RNA-induced silencing complexes (RISCs), particularly the roles of human Argonaute proteins (AGO1-4) in gene regulation and disease. Education: B.S. (Tokyo University of Science, 2000), M.S. (University of Tokyo, 2003), D.Sc. (Tokyo Institute of Technology, 2007). Postdoctoral work at Memorial Sloan-Kettering Cancer Center (2008-2013). Research interests include: 1) Target specificity of human AGOs, 2) Unique functional roles of each AGO paralog, 3) Regulation of RISC activity, and 4) Engineering AGOs for therapeutic applications. His lab has pioneered the use of tiny RNAs (cityRNAs) for programmable RNA cleavage, with applications in treating neurological disorders and cancer. Key achievements: NIH R01 grants, PRESTO (Japan Science and Technology Agency), and industry collaborations. Notable awards include the RNA Society/Scaringe Award (2012) and the Young Scientists’ Prize (2013). Recent work includes cryo-EM studies of AGO structures, discovery of AGO3's slicer activity, and development of DNA-induced slicing complexes (DISCs). His team collaborates with City Therapeutics on RNAi-based therapies.

• Bioorganic Chemistry
• Nucleic Acids Chemistry
• Breast Cancer Imaging
• +۳ مورد دیگر

John-Stephen Taylor is a Professor of Chemistry at Washington University. His research focuses on bioorganic chemistry, nucleic acids, and the molecular mechanisms underlying skin cancer and chemotherapy. He holds a SB from MIT and a PhD from Columbia University. Education: PhD in Chemistry, Columbia University SB in Chemistry, Massachusetts Institute of Technology Research Interests: Taylor’s work explores how sunlight-induced DNA damage (e.g., cyclobutane pyrimidine dimers) contributes to skin cancer, particularly via novel pathways involving dioxetanes and chromatin structures. He also investigates natural products that modulate heat shock proteins. Methodologies include NMR spectroscopy, NextGen sequencing, and cell culture. Article Trends: His publications emphasize photoproduct formation mechanisms, nucleosome dynamics, and telomeric DNA behavior under UV exposure. Recent work highlights structural insights into DNA repair and mutagenesis pathways. Awards: Phi Beta Kappa (1975) NIH Merit Award (1993–2001) Special Recognition for Excellence in Mentoring (2005–2007) Grants & Advising: Taylor has received sustained NIH funding and is recognized for mentoring. His lab employs interdisciplinary approaches, combining synthetic chemistry with genomic and structural biology techniques.

• Epidermal Stem Cell Biology
• Epigenetics
• Developmental Biology
• +۴ مورد دیگر

George Sen is a Professor at the University of California, San Diego (UCSD) within the Department of Cellular and Molecular Medicine . His research focuses on the molecular mechanisms of epidermal stem cell self-renewal and differentiation , aiming to understand how disruptions in this balance contribute to skin disorders like psoriasis and carcinomas. Research areas: Developmental Biology, Genetics and Genomics, Epigenetics, Stem Cell Biology Current NIH grants: R01CA225463 (2018-2023), R01AR072590 (2018-2023), R01AR066530 (2015-2026) His work emphasizes epigenetic factors such as HDACs, DNMT1, and RNA-binding proteins in maintaining stem cell identity and driving differentiation. Recent publications highlight collaborations with researchers like Ye Liu , Uyanga Batzorig , and Richard Gallo on topics including UVB-induced skin inflammation, transcriptional elongation, and immune tolerance. Articles show strong representation in Cell Biology , Dermatology , and Allergy/Immunology , with subfields spanning RNA processing , chromatin dynamics , skin tumorigenesis , and cytoplasmic body function . The Sen Lab at UCSD continues to explore novel regulators of epidermal homeostasis through NIH-funded projects.

• Computational Genomics
• Maternal-Fetal Medicine
• Placental Biology
• +۳ مورد دیگر

Kathleen Fisch, PhD is an Assistant Professor at the University of California, San Diego School of Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences. She serves as Faculty Director of the Center for Computational Biology & Bioinformatics (CCBB) and Co-Director of the ACTRI Center for Excellence in Translational Immunogenomics (CETI), leading initiatives in computational genomics and bioinformatics infrastructure. University of California, Berkeley: B.A. in Integrative Biology University of California, Davis: Ph.D. in Ecology (Population Genetics) Her research focuses on genomic and computational approaches to maternal-fetal medicine, placental biology, and translational immunogenomics. This includes studies on preeclampsia, HPV-mediated cancers, and SARS-CoV-2 placental transmission using multi-omics and systems biology frameworks. Key publication trends include: Genomic analysis of placental lesions in preeclampsia Single-cell transcriptomics in reproductive tissues Computational modeling of pain signatures and opioid addiction HPV extrachromosomal DNA in oropharyngeal cancer Epigenetic regulation in viral infections and autoimmune conditions Dr. Fisch collaborates on NIH-funded projects including R21HD110893 (Placental Lesions in Preeclampsia), U54HD110347 (Pregnant Female Reproductive Tissue Mapping), and U54DA049115 (Acute to Chronic Pain Signatures Program).

Niall Barronمشاهده پروفایل

استاد

• Biomedical Engineering
• Biochemical Engineering
• Cellular and Molecular Biology
• +۵ مورد دیگر

Professor Niall Barron is a Professor of Biochemical Engineering at the School of Chemical and Bioprocess Engineering, University College Dublin (UCD), and a Principal Investigator at the National Institute for Bioprocessing Research and Training (NIBRT). He holds a BA (Mod) in Microbiology from Trinity College Dublin and a PhD in Applied Microbiology/Biochemistry from the University of Ulster (1997). His postdoctoral research at Baylor College of Medicine focused on nuclear steroid receptor function via genome engineering. He has held academic and research roles at Dublin City University (DCU), including Director of the National Institute for Cellular Biotechnology (NICB) from 2015–2017. His research focuses on genetic engineering strategies to improve recombinant protein production in CHO cells, AAV/LV vector manufacturing, and epigenetic regulation of bioprocess performance. He leads projects funded by industry and EU grants, including initiatives to enhance gene therapy vector production and mRNA methylation control. Education: BA (Mod) in Microbiology, Trinity College Dublin PhD in Applied Microbiology/Biochemistry, University of Ulster (1997) Research Interests: Targeted genome editing in CHO cells for improved biopharmaceutical production Optimization of AAV and LV vector systems for gene therapy miRNA and epitranscriptomic regulation of cellular processes Single-cell analysis to understand clonal variability and production instability Grants & Collaborations: Lead on grants from GSK, Enterprise Ireland, and Horizon 2020 (e.g., STACCATO, GeneClick) Focus on advancing bioprocess technologies and cell line engineering Teaching: Coordinates modules in biopharmaceutical manufacturing, biotechnology principles, and gene therapy processes Program Director for the MEngSc in Biopharmaceutical Manufacturing (Part-Time) Labs & Teams: Leads a multidisciplinary team at UCD and NIBRT focusing on biopharmaceutical engineering and cell line optimization

• Cancer Biology
• Cell Biology
• Molecular Biology
• +۲ مورد دیگر

Nirakar Rajbhandari is an Assistant Project Scientist in the Department of Surgery at the University of California, San Diego (UCSD). His research focuses on pancreatic cancer biology, tumor microenvironment dynamics, and cancer stem cell mechanisms. He actively contributes to translational medicine through collaborative publications in premier journals. Current Affiliation: Department of Surgery, UCSD Research Interests: Cancer Biology, Cell Biology, Molecular Oncology Dr. Rajbhandari's research explores pancreatic cancer metastasis, tumor dormancy mechanisms, and epigenetic regulation of cancer progression. His work often involves single-cell analysis, mouse models, and signaling pathway investigations. Recent publications (2023-2025) show increasing focus on epigenetic modulation , single-cell heterogeneity , and pancreatic cancer subtypes . Key methodologies include RNA sequencing and protein interaction analysis. Selected Collaborators: Andrew Lowy (UCSD) Marcie Kritzik (UCSD) Bharti Garg (UCSD) Roman Sasik (UCSD) Kwun Wah Wen (UCSF) His work appears in journals like Cancer Research , Nature Communications , and Cell , with citations in both basic and clinical research contexts.

Paula M. Vertinoمشاهده پروفایل

استاد

• Cancer Epigenetics
• Gene Silencing Mechanisms
• Cancer Genomics
• +۳ مورد دیگر

Dr. Paula M. Vertino is a distinguished academic holding multiple roles at the University of Rochester: Professor in the Department of Biomedical Genetics and Department of Pathology and Laboratory Medicine, Wilmot Distinguished Professorship in Cancer Genomics , and Senior Associate Dean for Basic Research in the School of Medicine and Dentistry. Her research focuses on cancer epigenetics , gene silencing mechanisms , and cancer genomics , with emphasis on DNA methylation, histone modifications, and their roles in tumorigenesis. Key contributions include studies on the interplay between epigenetic regulation and cellular invasion, the impact of exercise on cancer survivorship, and mechanisms of drug resistance in multiple myeloma. She has pioneered work on chromatin accessibility profiling and the role of transposon DNA in tumor progression. Dr. Vertino’s work bridges basic science and clinical translation, with recent studies addressing aging-related cancer biology and the application of mobile health interventions in oncology. She holds the Wilmot Distinguished Professorship, a testament to her impactful contributions to cancer research. Her interdisciplinary research involves collaborations across departments (Pathology, Genetics, Oncology) and institutions, addressing topics such as tumor microenvironment dynamics and epigenetic therapy development. She leads initiatives in basic research administration, shaping the strategic direction of translational science at the University of Rochester.

• Genomics
• Epigenetics
• Personalised Health
• +۴ مورد دیگر

Dr Anita Sathyanarayanan is a Postdoctoral Research Fellow at the Centre for Genomics and Personalised Health, University of New South Wales. Her work focuses on integrating multi-omics data to understand complex diseases such as psychiatric disorders, cancers, and infectious diseases. She specializes in epigenetic mechanisms, genetic risk prediction, and translational biomarker discovery. Key research areas include: Epigenetic effects of trauma and childhood adversity Genetic links between blood analytes and severe diseases Multi-omics approaches for PTSD and cancer subtyping Pharmacogenetic optimization of lithium therapy Her methodological contributions span bioinformatics tool development for omics integration, ChIP-Seq analysis, and exome sequencing interpretation. Current projects emphasize personalized medicine applications in oncology and mental health. Lab affiliations: Centre for Genomics and Personalised Health (UNSW)

Amanda Stormمشاهده پروفایل

دانشیار

• Protein Biochemistry
• Molecular Biology
• Plant Genetics
• +۳ مورد دیگر

Dr. Amanda Storm is an Associate Professor of Biology at Western Carolina University (WCU), affiliated with the College of Arts and Sciences. Her research focuses on understanding protein sequence-structure-function relationships, particularly in plants, aiming to leverage this knowledge for agricultural innovation and medical applications. She teaches courses including General Biology, Biotechnology, Introductory Genetics, and Protein Bioinformatics. Education: Ph.D., Miami University, Ohio B.S., Central State University, Ohio Postdoctoral Research at James Madison University Research Interests: Dr. Storm’s lab investigates protein interactions and functional diversity through approaches like transgenic plant generation, enzyme kinetics, and molecular cloning. Key areas include optimizing crops for climate resilience and identifying antibiotic targets. Recent projects focus on cotton genome annotation and Arabidopsis β-amylase enzyme dynamics. Articles Overview: Her publications emphasize plant genetics, enzyme regulation, and protein structure-function relationships, with a focus on cotton and Arabidopsis systems. Themes include gene annotation, stress tolerance mechanisms, and metabolic pathway regulation. Lab & Students: Undergraduate and graduate students in her lab engage in projects spanning plant genetics, bioinformatics, and enzyme analysis. No specific grants or awards are listed, but her work contributes to foundational understanding of plant molecular biology.

Emiliano Maianiمشاهده پروفایل

دانشیار

• Molecular Biology
• Oncology
• Cell Signaling
• +۶ مورد دیگر

Emiliano Maiani is an Associate Professor of Molecular Biology at UniCamillus and serves as Vice Dean of the Departmental Faculty of Medicine. He holds concurrent roles as Research Delegate coordinating the University’s Integrated Research Center and Visiting Scientist at the Danish Cancer Institute. His expertise lies in cellular signaling mechanisms, particularly DNA damage response, autophagy regulation, and S-nitrosylation pathways. He earned his Ph.D. in Cellular and Molecular Biology from the University of Rome Tor Vergata (2013) and conducted postdoctoral research at the Danish Cancer Society Research Center until 2021. His research focuses on molecular mechanisms underlying cancer progression, genomic stability, and cell cycle control. Key areas include GSNOR-mediated regulation of tumor growth, AMBRA1’s role in cyclin D stability, and autophagy’s role in tissue homeostasis. He has published in high-impact journals like Nature and Nature Medicine , with recent work addressing S-nitrosylation in embryonal rhabdomyosarcoma and tendon biology. Maiani serves as a peer reviewer for major scientific journals and evaluates national and EU research projects (Horizon Europe, Marie Skłodowska-Curie Fellowships). His collaborative efforts span computational biology, structural bioinformatics, and protein disorder prediction through initiatives like DisProt database improvements. He also contributes to methodological standards in autophagy research via guideline publications.

• Molecular Genetics
• Epigenetics
• Cancer Biology
• +۵ مورد دیگر

Carol IMBRIANO is an Associate Professor at the University of Modena and Reggio Emilia, Department of Life Sciences ex-Biology. She specializes in molecular genetics, epigenetics, and their applications in cancer biology and medical biotechnology. Her research focuses on transcription factors like NF-Y, particularly their roles in tumor progression, metabolic reprogramming, and epigenetic regulation. She also develops biosensor technologies using organic electrochemical transistors for DNA detection. Her teaching responsibilities include courses on molecular genetics and epigenetics for biosciences, genetics laboratory work for biotechnology students, and personalized therapy modules in medical biotechnology. These courses integrate theoretical and practical components, such as bioinformatics analysis and lab safety protocols. She emphasizes critical thinking and data interpretation through written and oral exams, often using international scientific literature. Research interests revolve around the molecular mechanisms underlying cancer aggressiveness, including NF-Y splicing dynamics in metastasis, estrogen receptor interactions in prostate cancer, and sigma-2 receptor targeting for melanoma therapy. She explores how epigenetic modifications (e.g., DNA methylation, histone variants) contribute to disease development and leverages nanomedicine for therapeutic delivery and diagnostic innovation. Her work bridges basic science with clinical applications in precision medicine and cancer stratification. Publications consistently highlight advanced topics in transcription factor biology, cancer metabolism, and nanosensor development. She collaborates with multidisciplinary teams on projects like EGOT biosensors and drug discovery for CRPC. Despite her extensive contributions, no scientific awards or grants are explicitly listed in the provided texts. She maintains an open-door policy for students via prior arrangement and uses digital platforms like Teams for course materials.