Alex Bishop

Dr. Alex Bishop is an Associate Professor in the Department of Cell Systems and Anatomy at The University of Texas Health San Antonio, within the Joe R. and Teresa Lozano Long School of Medicine. His research focuses on unraveling the molecular mechanisms underlying pediatric cancers, particularly Ewing sarcoma, with emphasis on R-loop regulation, DNA repair pathways, and oncogenic transcriptional dysregulation.

Dr. Bishop holds a DPhil from Oxford University and completed further training at Harvard Medical School. He has led groundbreaking studies including identifying R-loop accumulation as a therapeutic target in Ewing sarcoma and discovering links between BRCA1 dysfunction and cancer progression. His work has been published in high-impact journals like Nature and supported by grants from Stand Up To Cancer and Cancer Research UK.

Key research areas include understanding how the EWSR1-FLI1 fusion protein drives genomic instability, developing mouse models for sarcoma research, and advancing computational tools like RLSuite for R-loop analysis. Collaborations with institutions such as the Greehey Children’s Cancer Research Institute and Mays Cancer Center enable translational research bridging basic science and clinical applications.

Dr. Bishop’s contributions have advanced targeted therapies for pediatric cancers, with recent efforts exploring combination treatments and novel biomarkers. His lab employs cutting-edge technologies including mass cytometry and single-cell transcriptomics to dissect tumor biology and resistance mechanisms.