Miguel Rivera

Miguel Rivera, MD is an Associate Professor of Pathology at Harvard Medical School and Assistant Molecular Pathologist at Massachusetts General Hospital (MGH), with additional affiliation as Associate Member of the Broad Institute and Thomas F. Ryan MGH Research Scholar. His clinical expertise centers on molecular pathology for adult patients, supported by board certifications in Molecular Genetic Pathology and Anatomic Pathology.

His educational foundation includes an MD from Harvard Medical School and residency training at Brigham and Women's Hospital. Rivera's research laboratory, embedded within MGH's Molecular Pathology Unit and Krantz Family Center for Cancer Research, pioneers genomic approaches to dissect gene regulation abnormalities in pediatric cancers.

Research focuses on chromatin remodeling mechanisms in Wilms tumor, Ewing sarcoma, and medulloblastoma, with seminal work on the WTX tumor suppressor gene and prion-like domains in oncogenesis. His group integrates genome-wide chromatin profiling, functional genomics, and in vivo modeling to uncover therapeutic targets in pediatric solid tumors.

Publication trends reveal consistent innovation in cancer epigenomics since 2004, with recent emphasis on intrinsically disordered protein domains and 3D chromatin architecture. Key contributions include elucidating EWS-FLI1's divergent chromatin remodeling mechanisms and developing DisP-seq for mapping disordered protein functions.

Major recognitions include:

• MGH Research Scholar designation
• 2024 Krantz Breakthrough Award for targeting disordered protein domains in cancer

Rivera directs a multidisciplinary team advancing $19 million in pathology research at MGH, with current projects exploring microsatellite repeat perturbation and WTX family functions in stem cell regulation. His work bridges genomic discovery with clinical translation in molecular diagnostics.