George Sen

George Sen is a Professor at the University of California, San Diego (UCSD) within the Department of Cellular and Molecular Medicine. His research focuses on the molecular mechanisms of epidermal stem cell self-renewal and differentiation, aiming to understand how disruptions in this balance contribute to skin disorders like psoriasis and carcinomas.

• Research areas: Developmental Biology, Genetics and Genomics, Epigenetics, Stem Cell Biology
• Current NIH grants: R01CA225463 (2018-2023), R01AR072590 (2018-2023), R01AR066530 (2015-2026)

His work emphasizes epigenetic factors such as HDACs, DNMT1, and RNA-binding proteins in maintaining stem cell identity and driving differentiation. Recent publications highlight collaborations with researchers like Ye Liu, Uyanga Batzorig, and Richard Gallo on topics including UVB-induced skin inflammation, transcriptional elongation, and immune tolerance.

Articles show strong representation in Cell Biology, Dermatology, and Allergy/Immunology, with subfields spanning RNA processing, chromatin dynamics, skin tumorigenesis, and cytoplasmic body function. The Sen Lab at UCSD continues to explore novel regulators of epidermal homeostasis through NIH-funded projects.