Ageliki Tsagaratouمشاهده پروفایل
استادیار
Dr. Ageliki Tsagaratou is an Assistant Professor in the Department of Genetics at the University of North Carolina at Chapel Hill School of Medicine, where she leads the Tsagaratou Lab focused on epigenetic mechanisms in immune cell development. Her research program investigates how TET family proteins regulate DNA demethylation and transcriptional networks during T cell differentiation in the thymus and periphery. Her primary research interests include: Epigenetic regulation of T cell lineage specification DNA demethylation mechanisms mediated by TET proteins (TET1, TET2, TET3) Role of 5-hydroxymethylcytosine in immune cell development Mechanisms linking epigenetic dysregulation to autoimmunity and hematological malignancies Transcriptional control of invariant natural killer T cell development Dr. Tsagaratou's laboratory employs genetically modified mouse models, primary cell culture, multiparameter flow cytometry, molecular biology assays, and next-generation sequencing technologies to elucidate epigenetic regulatory mechanisms. Recent publications demonstrate her team's focus on TET protein functions in T cell receptor repertoire formation, T follicular helper cell biology, and malignant transformation pathways. As a mentor, she emphasizes individualized development plans, daily communication, and collaborative problem-solving. Her lab participates in interdisciplinary seminars at UNC's Comprehensive Lineberger Cancer Center and Carolina Chromatin Consortium. The laboratory is located in the Burnett-Womack Building on UNC's Chapel Hill campus.












