Chinmay Trivedi

Dr. Chinmay Trivedi is a Professor of Medicine at UMass Chan Medical School, with additional affiliations in Molecular, Cell and Cancer Biology, and Translational Science programs. His research focuses on elucidating chromatin-modifying mechanisms in congenital cardiovascular and lymphatic diseases.

• Director, Division of Cardiovascular Medicine Research
• Research Director, Translational Science Program (Morningside Graduate School)
• Principal Investigator in Trivedi Lab

Research Highlights: His laboratory established causal links between:

• Hdac3 mutations and Emberger syndrome (lymphedema) through non-coding DNA element analysis
• KRAS/BRAF mutations and hepatic vascular cavernomas with RAS-MAPK1 pathway inhibition as treatment
• Hdac1/Hdac2 roles in cryptic transcription suppression during cardiogenesis
• Tbx5-Hdac3 interactions in Holt-Oram syndrome pathogenesis
• YAP1 activation in vascular tumor epithelioid hemangioendothelioma

Publication Trends show consistent work across Journal of Clinical Investigation, Science Advances, and Circulation Research, with recent emphasis on:

• Epigenetic regulation of cardiovascular development
• Signaling pathway modulation in lymphatic diseases
• Translational models for congenital defects
• Metabolic basis of cardiac pathologies

Training Opportunities: The lab offers rotation projects for graduate students and postdoctoral positions requiring expertise in:

• Murine models
• ChIP-seq and epigenetic analysis
• Biochemical signaling assays
• Translational biology techniques

Key Concepts: Histone deacetylases, non-coding DNA, RAS-MAPK1 pathway, oscillatory shear stress, cryptic transcription, enhanceosome complexes