جست‌وجوی استاد و پژوهشگر

Yuki Aoiمشاهده پروفایل

استادیار

• Biochemistry
• Molecular Genetics
• Gene Regulation
• +۳ مورد دیگر

Yuki Aoi, PhD, serves as Assistant Professor in the Department of Biochemistry and Molecular Genetics at Northwestern University's Feinberg School of Medicine, where her research integrates molecular mechanisms of gene regulation with disease pathology in adrenal tumors and nephrology. Education: PhD in Chemical Biology from University of Tokyo, Japan (2013) Project Researcher at JST-ERATO, Japan (2017) Postdoctoral Fellow in Biochemistry at Northwestern University (2024) Her research program centers on transcriptional regulation, epigenetic modifications, and chromatin dynamics using biochemical, genomic, and bioinformatic approaches. Current investigations focus on RNA polymerase II stability mechanisms, locus-specific genomic labeling techniques, and molecular pathways linking chromatin modifiers to cancer progression in adrenal and renal systems. Recent publications reveal a cohesive trajectory exploring protein degradation systems in transcription (2025), innovative genome-editing tools for protein interactome mapping (2024), and disease mechanisms of chromatin complex mutations (2023), demonstrating translational relevance across cancer biology and nephrology. Dr. Aoi operates within Dr. Ali Shilatifard's research laboratory, contributing to collaborative projects on gene expression regulation while developing novel methodologies like TurboCas for genomic analysis.

Davide Seruggiaمشاهده پروفایل

استاد مدعو

• Chromatin Biology
• Genome Editing
• Pediatric Cancer Research
• +۳ مورد دیگر

Davide Seruggia is an Adjunct Professor at CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences and Principal Investigator at St. Anna Children’s Cancer Research Institute (CCRI), Vienna, Austria. His career spans institutions including Boston Children’s Hospital, Harvard Medical School, and the National Center for Biotechnology (CNB-CSIC), Madrid. Dr. Seruggia obtained his PhD in Molecular Biology from CNB-CSIC (2014) and specialized in chromatin biology, genome editing, and pediatric leukemia during postdoctoral work at Boston Children’s Hospital (2015–2021). He was promoted to Instructor in Pediatrics at Harvard Medical School (2019) and secured an ERC Starting Grant (2020) to launch his independent group. Research Focus His laboratory investigates: Non-coding regulatory sequences (enhancers, insulators) in pediatric leukemia 3D genome architecture and drug resistance mechanisms TFIID/SAGA chromatin complex roles in MYC-driven cancers CRISPR-based functional genomics and computational biology approaches Translational implications for targeted therapies in hematologic malignancies Recent Publications Dr. Seruggia’s work on enhancer dependence in gene regulation (2020), SAGA complex vulnerabilities in leukemia (2025), and HDAC1 roles in immune-oncology (2025) highlights his expertise in cross-disciplinary cancer research. His CRISPR-CLEAR methodology (2024) enables high-resolution mapping of regulatory elements. Awards & Funding ERC Starting Grant (2020) WES Foundation grant Pedals for Pediatrics funding Students & Collaborators His team includes postdoctoral fellows (Paul Batty, Ana Patricia Kutschat), predoctoral students (Hannah Beneder, Leonie Lehmayer, Sandra Wittibschlager), a diploma student (Carlos Roche), and technical staff (Gerlinde Karbon, Sophie Müller).

Kavitha Sarmaمشاهده پروفایل

دانشیار

• Epigenetic Gene Regulation
• RNA Biology
• Chromatin Architecture
• +۶ مورد دیگر

Dr. Kavitha Sarma is an Associate Professor at The Wistar Institute, where she leads research in the Genome Regulation and Cell Signaling Program within the Ellen and Ronald Caplan Cancer Center. Her work focuses on epigenetic gene regulation mechanisms, particularly examining how RNA-mediated processes impact cellular function and disease development. Dr. Sarma earned her Ph.D. in biochemistry from Rutgers University Postdoctoral training at Massachusetts General Hospital-Harvard Medical School Her research centers on the mechanisms of RNA-mediated epigenetic gene regulation, with special emphasis on R-loops - triplex nucleic acid structures comprising DNA:RNA hybrids and displaced single-stranded DNA. She investigates how these structures form during transcription, particularly in G-rich repetitive regions where they can adopt G-quadruplex (G4) structures. Her lab explores the roles of R-loops in neuronal cancers and neurodegenerative diseases, developing innovative techniques like MapR for genome-wide identification of native R-loops without antibody dependence. Analysis of Dr. Sarma's publications reveals consistent focus on R-loop biology across nearly two decades, with recent work (2020-2025) increasingly examining the relationship between R-loops, G-quadruplex structures, and genome organization. Her research has evolved from foundational studies on chromatin modifiers to sophisticated investigations of how these nucleic acid structures influence CTCF binding, genome folding, and ultimately gene expression patterns in disease states. Dr. Sarma mentors graduate students and postdoctoral fellows in her laboratory, guiding research that bridges biochemistry, cell biology, and functional genomics. Her team employs approaches including biochemical assays, cell and molecular biology techniques, and genome-wide analyses using embryonic stem cell, neural stem cell, and cancer cell models. The Sarma Laboratory includes Postdoctoral Fellows: Michelle Lynskey, Shachin Dissanayaka Mudiyanselage, Phillip Wulfridge Graduate Students: Emanuel Forciniti, Kelvin Okpokpo Research Assistants: Kuo-Chen Fang Lab Technicians: Afrora Muca Her lab investigates how epigenetic alterations impact neuronal cancers and neurodegenerative diseases, with the goal of identifying new pathways that can be targeted to correct epigenetic perturbations.

• Hematology
• Oncology
• Stem Cell Biology
• +۴ مورد دیگر

Andrew DeVilbiss, Ph.D., serves as an Instructor (academic rank equivalent to Lecturer) in the Department of Internal Medicine at UT Southwestern Medical Center, where he is a member of the Division of Hematology and Oncology. He joined the faculty in 2024 following a postdoctoral fellowship at UT Southwestern's Children's Research Institute. Education: Dual bachelor's degrees in Biochemistry and Cellular and Molecular Biology from the University of Wisconsin Ph.D. in Philosophy from the University of Wisconsin Postdoctoral fellowship at UT Southwestern Medical Center's Children's Research Institute Dr. DeVilbiss' research program centers on the molecular and metabolic regulation of hematopoiesis, with particular emphasis on hematopoietic stem cell biology, erythroid maturation, and leukemogenesis. His work integrates transcriptional regulation, epigenetics, and metabolism to dissect how genetic networks control blood cell development and disease. Key investigations include the role of GATA factors, chromatin modifiers, and metabolic pathways such as ascorbate metabolism and redox regulation in stem cell function and blood disorders. Analysis of his publication record (2013-2025) reveals an evolving research trajectory from foundational studies on transcriptional mechanisms in hematopoiesis toward contemporary investigations of metabolic regulation in stem cells. Recent work (2021-2025) demonstrates significant focus on ascorbate deficiency, redox sensors (KEAP1), and autophagy in stem cell quiescence, self-renewal, and aging, with implications for neutropenia, T cell dysfunction, and acute myeloid leukemia. His publications span high-impact journals including Blood, Science Immunology, and Cell Stem Cell. No scientific awards are listed in the provided information. No information regarding student advising or research grants is available in the provided text. There is no mention of specific laboratory groups or research teams led by Dr. DeVilbiss in the provided material.

• Genetics
• Molecular Biology
• Chromatin Modifications
• +۳ مورد دیگر

Daniel Ginsburg, Ph.D., is a Professor in the Department of Natural Sciences at Immaculata University. He holds a Ph.D. in Genetics and a B.S. in Chemistry, both from Stanford University. His postdoctoral research at the National Institutes of Health focused on the NuA4 lysine acetyltransferase complex and transcription elongation mechanisms in S. cerevisiae . His research explores chromatin dynamics, specifically investigating relationships between histone methylation and acetylation during transcription elongation. Key areas include: NuA4 complex recruitment mechanisms Histone modification crosstalk (H3K4/K36 methylation and acetylation) RNA polymerase II interactions with chromatin modifiers Phage integrase applications in genomic engineering He received the 2009 Fellows Award for Research Excellence from the NIH. As an active mentor, he has advised over 15 students in genetics and molecular biology research, resulting in award-winning presentations at regional and national conferences.

• Epigenetics
• Genome Biology
• Embryonic Development
• +۷ مورد دیگر

Zachary Smith is an Assistant Professor (Adjunct) in the Department of Genetics at Yale School of Medicine, with additional affiliations at the Yale Stem Cell Center, Center for RNA Science and Medicine, and the Genomics, Genetics, and Epigenetics program. His research focuses on epigenetic regulation during mammalian development. Dr. Smith received his B.S. in Biology from M.I.T. in 2008 and his Ph.D. in Biology from Harvard University in 2019. His doctoral work focused on applying cutting-edge genomic technologies to understand chromatin dynamics during mammalian development. He joined the Yale Stem Cell Center and Department of Genetics as an Assistant Professor in September 2020. Dr. Smith's research program investigates three critical developmental processes: fertilization, implantation, and gastrulation. His lab seeks to understand how the genome is reconstructed after fertilization, how distinct epigenetic states are established in embryonic versus extraembryonic lineages, and how chromatin regulators orchestrate the complex process of gastrulation. They employ advanced genomic techniques including single-cell sequencing, Cas9-mediated genome editing, and novel molecular recording technologies. His recent publications highlight significant contributions to understanding DNA methylation dynamics in development and disease, X-chromosome biology, and the development of innovative genomic technologies. Dr. Smith's work bridges fundamental developmental biology with potential applications to understanding developmental disorders and cancer. Epigenetic regulation of mammalian development Chromatin dynamics during embryogenesis DNA methylation reprogramming Single-cell genomic analysis Novel molecular recording technologies Dr. Smith's lab collaborates extensively with researchers at Yale and other institutions, including Michael Caplan, Berna Sozen, and Biff Forbush. His interdisciplinary approach combines expertise in genetics, developmental biology, and technology development to address fundamental questions about how epigenetic mechanisms shape development. Students and postdocs in Dr. Smith's lab have opportunities to work at the forefront of developmental epigenetics, gaining expertise in both experimental and computational approaches to studying genome regulation during development.