جست‌وجوی استاد و پژوهشگر

Michael Lampsonمشاهده پروفایل

استاد

• Cell and Developmental Biology
• Evolution
• Cell biology of meiotic drive
• +۷ مورد دیگر

Michael Lampson is Professor of Biology at the University of Pennsylvania's School of Arts and Sciences, with secondary appointments in the Department of Cell and Developmental Biology. He serves as faculty in the Cell and Molecular Biology (CAMB) and Biochemistry and Molecular Biophysics (BMB) Graduate Groups, and is affiliated with the American Society for Cell Biology (ASCB). Ph.D., Cornell University, Weill Medical College, 2002 AB, Harvard College, 1994 Dr. Lampson's research program focuses on fundamental mechanisms of chromosome biology, with particular emphasis on cell division, centromere inheritance, and meiotic drive. His lab investigates how selfish genetic elements can violate Mendel's First Law through meiotic drive, the stability of centromere chromatin through the germline, and the role of repetitive satellite DNA in chromosome segregation. Using innovative approaches including mouse model systems, optogenetic tools, and biochemical techniques, his work bridges cell biology, genetics, and evolutionary biology to address questions with implications for reproductive biology, cancer, and genetic inheritance. Analysis of Dr. Lampson's recent publications reveals a strong focus on the intersection of centromere biology, meiotic drive, and chromosome segregation mechanisms. His work increasingly incorporates computational approaches alongside experimental systems to study evolutionary aspects of centromere function. The research demonstrates consistent innovation in methodology, particularly in developing optogenetic tools for precise manipulation of cellular processes. Key themes include the role of satellite DNA variation, mechanisms of non-Mendelian inheritance, and the stability of chromatin structures through cell division and development. Searle Scholar Award American Association for the Advancement of Science (AAAS) fellow Dr. Lampson's research is supported by multiple NIH grants including from NIGMS, NHGRI, NICHD, and NCI, as well as University of Pennsylvania funding sources including the University Research Foundation, Abramson Cancer Center, and several specialized research centers. He collaborates extensively with researchers across disciplines, including Ben Black (Biochemistry), Dennis Discher (Chemical Engineering), Dave Chenoweth (Chemistry), and Roger Greenberg (Cancer Biology), reflecting the interdisciplinary nature of his work. His lab has trained numerous graduate students and postdocs who have gone on to successful careers in academia and industry. The Lampson Lab maintains state-of-the-art facilities for cell biological, genetic, and biochemical research, with specialized equipment for live-cell imaging, optogenetic manipulation, and mouse genetics. The lab fosters a collaborative environment that bridges molecular, cellular, and evolutionary perspectives on chromosome biology.

Peter A. Jonesمشاهده پروفایل

استاد

• Epigenetics
• DNA methylation
• Cancer epigenetics
• +۷ مورد دیگر

Peter A. Jones is President and Chief Scientific Officer at the Van Andel Institute (VAI) in Grand Rapids, Michigan, where he leads the Department of Epigenetics. He previously served as Director of the USC Norris Comprehensive Cancer Center from 1993 to 2011 and has been a central figure in advancing epigenetics research, particularly in cancer. His laboratory investigates DNA methylation, chromatin dynamics, and epigenetic therapies. Research Interests: Dr. Jones's work centers on epigenetic mechanisms in cancer, including DNA methylation, histone modifications, nucleosome positioning, and the therapeutic potential of epigenetic drugs. His research has pioneered the use of DNA methylation inhibitors like 5-azacytidine and explored viral mimicry as a mechanism for immune activation in cancer. He also studies transposable elements and their role in gene regulation and immune response. Publication Trends: His recent publications (2021–2024) reveal a strong focus on the interplay between epigenetics and immunotherapy, particularly how DNA methyltransferase inhibitors (DNMTi) induce viral mimicry, enhance immune recognition, and improve responses to checkpoint blockade. Studies span hematological malignancies, solid tumors, and T cell biology, with frequent collaboration with Stephen Baylin and others. Scientific Awards: Member, National Academy of Sciences Member, National Academy of Medicine Fellow, AACR Academy Fellow, AAAS Fellow, American Academy of Arts and Sciences Kirk A. Landon Award for Basic Cancer Research (2009) Medal of Honor, American Cancer Society (2011) Outstanding Investigator Grant, NCI Harvey Prize (2024) Advising and Grants: Dr. Jones mentors multiple postdoctoral fellows, graduate students, and research scientists. His lab is supported by major grants, including the VAI-SU2C Epigenetics Dream Team, which has launched 15 clinical trials. He has received sustained funding from the National Cancer Institute and collaborates with institutions worldwide to advance epigenetic therapies. Labs and Teams: He leads the Peter Jones Laboratory at VAI, a multidisciplinary team investigating epigenetic regulation in cancer. The lab includes computational biologists, clinical researchers, and molecular biologists, working on both basic mechanisms and translational applications. The team is part of larger collaborative initiatives such as the VAI-SU2C Epigenetics Dream Team and the International Linked Clinical Trials Program.

Nicole C. Riddleمشاهده پروفایل

استاد

• Epigenetics
• Chromatin Structure
• Drosophila melanogaster
• +۳ مورد دیگر

Nicole C. Riddle is a Professor and Associate Chair for Research and Facilities in the Department of Biology at the University of Alabama at Birmingham (UAB). She holds a B.S. in Biology from the University of Missouri Columbia and a Ph.D. in Evolutionary and Population Biology from Washington University in St. Louis. Her research focuses on epigenetics and chromatin dynamics, particularly in the context of aging and sex differences using Drosophila melanogaster as a model system. Dr. Riddle's work explores how epigenetic mechanisms influence lifespan, genome stability, and phenotypic variation. She has pioneered the use of Drosophila to study exercise-induced physiological changes and their genetic underpinnings. Her lab investigates the roles of HP1 proteins in transcriptional regulation and chromatin organization, with recent studies emphasizing cross-species comparisons of aging mechanisms. Her research has been supported by grants including the BII: IISAGE project on sex-specific aging mechanisms. Notable contributions include developing novel tools like the Rotating Exercise Quantification System (REQS) to measure Drosophila activity levels. Dr. Riddle actively mentors students and postdoctoral researchers, inviting inquiries via riddlenc@uab.edu to join her lab.

John Diffleyمشاهده پروفایل

استاد

• DNA Replication
• Cell Cycle Control
• Chromosome Biology
• +۵ مورد دیگر

John Diffley is a Principal Group Leader and Associate Research Director at The Francis Crick Institute in London, UK, where he leads research on DNA replication mechanisms. His work focuses on understanding how cells precisely duplicate their DNA during cell division and how errors in this process contribute to cancer development. Diffley obtained his PhD from New York University in 1985 and completed postdoctoral training with Bruce Stillman at Cold Spring Harbor Laboratory until 1990. He established his research group at the Clare Hall Laboratories (originally Imperial Cancer Research Fund, then Cancer Research UK) before moving to The Francis Crick Institute in 2015. His research spans DNA replication initiation, cell cycle control, replication fork checkpoints, and epigenetic inheritance. Diffley's lab has pioneered methods to reconstitute chromatin replication using purified proteins, providing unprecedented insights into chromosome biology. His team combines genetics, cell biology, and biochemistry to study the molecular 'machines' that copy DNA in yeast and human cells. Analysis of Diffley's recent publications reveals a strong focus on structural mechanisms of DNA replication, particularly using cryo-EM to visualize replication machinery. His work examines helicase loading and activation, replication fork stability under stress, and the connection between replication errors and cancer development. The research spans model organisms to human cells, with increasing emphasis on structural approaches in recent years. FRS (Fellow of the Royal Society) FMedSci (Fellow of the Academy of Medical Sciences) Diffley actively mentors a diverse team of postdoctoral researchers and PhD students, investigating various aspects of DNA replication. His lab has received substantial funding to support their work on replication mechanisms, with projects spanning basic biochemical reconstitution to studies of replication errors in cancer contexts. The lab maintains multiple technical platforms including structural biology, biochemistry, and cell biology approaches. His research group operates within The Francis Crick Institute's collaborative environment, utilizing shared facilities for structural biology, microscopy, and genomics to advance understanding of DNA replication mechanisms and their implications for genome stability and disease.

Ana Maria Velezمشاهده پروفایل

دانشیار

• Insect Toxicology
• Environmental Toxicology
• Resistance Management
• +۷ مورد دیگر

Ana Maria Velez is an Associate Professor at the Department of Entomology, University of Nebraska-Lincoln. Her research focuses on insect responses to chemical stressors, particularly RNA interference (RNAi) and Bt toxins for pest management. With a 80% research and 20% teaching appointment, she leads the Insect Toxicology Lab and teaches courses like 'Toxins in the Environment' and 'Insecticide Toxicology.' Education: Ph.D. in Entomology, University of Nebraska-Lincoln, 2013 M.S. in Entomology, Universidad Nacional de Colombia, 2009 B.S. in Biology, Pontificia Universidad Javeriana, Colombia, 2006 Her research spans molecular, organismal, and population levels to evaluate transgenic crops and RNAi technologies. Key areas include resistance mechanisms, non-target effects, and risk assessment frameworks. She has extensive publications on western corn rootworm and fall armyworm, emphasizing sustainable pest control. Her work also addresses sublethal impacts on non-target species like monarch butterflies and honeybees. Recent articles highlight RNAi delivery optimization, Bt resistance dynamics, and ecological impacts of insecticides. Her lab collaborates on patents for RNAi-based pest suppression methods targeting chromatin remodeling and developmental genes. Scientific Awards Distinguished Multicultural Alumni (2019) DuPont Young Professor Award (2016) International Congress of Entomology Travel Awards (2016) Widaman Trust Distinguished Graduate Assistant (2011) Milton E. Mohr Teaching Fellowship (2012) The Vélez Arango Lab investigates durability and safety of insect control technologies, with emphasis on RNAi and Bt crops. Their work informs integrated pest management (IPM) systems and regulatory frameworks.

Philip Booneمشاهده پروفایل

عضو هیئت علمی

• Medical Genetics
• Genomics
• Pediatric Genetics
• +۴ مورد دیگر

Philip Boone, MD, PhD, is an Attending Physician in the Division of Genetics and Genomics at Boston Children's Hospital and an Instructor of Pediatrics at Harvard Medical School. He specializes in medical genetics with particular expertise in rare disorders, medical mysteries, deletion and duplication syndromes, and Cornelia de Lange syndrome. Dr. Boone sees patients at Boston Children's Brookline location (2 Brookline Place, 7th Floor) and provides comprehensive genetic care including diagnostics, counseling, and individualized management. Stanford University (Undergraduate, 2006) Baylor College of Medicine (Graduate & Medical School, 2013-2014) Boston Combined Residency Program (Internship & Residency, 2016-2020) Harvard Medical School Genetics Training Program (Fellowship, 2020) Dr. Boone's research focuses on neurodevelopmental disorders, chromatin regulation, and genetic diagnostics. His work spans from fundamental genetic mechanisms to clinical applications, with particular emphasis on cohesinopathies including Cornelia de Lange syndrome. He has contributed significantly to understanding genetic variants associated with growth disorders, developmental features, and structural chromosomal abnormalities. His research combines advanced genomic technologies with clinical insights to improve diagnosis and management of rare genetic conditions. Analysis of Dr. Boone's publication record reveals a strong focus on medical genetics with emphasis on neurodevelopmental disorders, chromatin regulation, and genetic diagnostics. His work spans basic research on gene function and regulation to clinical applications in rare disease diagnosis. A notable trend is his investigation of cohesin complex disorders, particularly SMC3 variants and their relationship to Cornelia de Lange syndrome. His publications demonstrate expertise in both traditional genetic analysis and cutting-edge genomic technologies including long-read sequencing and telomere-to-telomere assembly. Dr. Boone actively contributes to medical education through publications on genetic diagnostics and distance learning resources for medical genetics. He has co-authored educational materials that help advance the field's knowledge base and training capabilities. As an attending physician in the Division of Genetics and Genomics at Boston Children's Hospital and a research fellow in the Center for Genomic Medicine at Massachusetts General Hospital, Dr. Boone works within one of the largest pediatric genetics practices in the country. The division includes over 30 board-certified clinical geneticists, genetic counselors, dieticians, and nursing staff who provide comprehensive care for patients with both common and extremely rare genetic conditions.

• Plant Developmental Biology
• Epigenetics
• Plant Genetics
• +۵ مورد دیگر

Ueli Grossniklaus is an Ordinary Professor at the University of Zurich within the Faculty of Mathematical and Natural Sciences , affiliated with the Department of Plant and Microbiology . His work focuses on plant developmental biology, particularly epigenetic and genetic mechanisms governing reproduction and adaptation. Key Courses: Epigenetics, Plant Biology Workshop, Group Seminars on Current Research Laboratory Techniques: Advanced methods in plant cell mechanics, transcriptomics, and genome editing Research Interests span plant epigenetics, reproductive biology, and the interplay between environmental stress and genetic regulation. He investigates: Mechanistic control of gametogenesis and fertilization Epigenetic contributions to plant adaptation Evolutionary implications of asexual reproduction Biophysical forces in plant cell growth Publication Trends (2025–2018) reveal expertise in: Arabidopsis and fern model systems Epigenetic regulation (DNA methylation, histone dynamics) Apomixis and hybrid seed failure mechanisms Biomechanics of pollen tubes and carnivorous plants Genome editing tools (CRISPR) and long-read sequencing Scientific Collaborations include interdisciplinary projects on: Microfluidic devices for plant cell analysis Gene drive ecology and ethics 3D imaging of plant reproductive structures Advising and Grants focus on mentoring through research internships in developmental biology, genetics, and systems biology. His lab engages in: Epigenetic response to environmental stress Cell wall mechanics in reproduction Computational modeling of plant growth Laboratory Teams integrate plant biologists, bioengineers, and computational scientists to study: Mechanistic gene regulation Evolutionary developmental biology Microrobotics for cellular force measurement

Miler T. Leeمشاهده پروفایل

دانشیار

• Gene Regulation
• Developmental Biology
• Computational Genomics
• +۹ مورد دیگر

Miler T. Lee is an Associate Professor at the University of Pittsburgh , focusing on gene regulation during early embryonic development through high-throughput experimental and computational genomics. He earned his Ph.D. in Genomics and Computational Biology in 2009 from the University of Pennsylvania under Dr. Junhyong Kim, followed by postdoctoral work with Dr. Antonio Giraldez at Yale University. Joining the university in 2016, his research spans maternal-to-zygotic transition (MZT), RNA stability, pluripotency networks, and evolutionary developmental biology, utilizing model organisms like zebrafish, Xenopus, and Hydractinia symbiolongicarpus. Key Research Themes: Maternally inherited RNA dynamics during embryogenesis Mechanisms of RNA degradation and transcriptome remodeling Evolution of pluripotency networks in hybrid species Role of zinc signaling in fertilization barriers Computational tools for RNA regulation and sensing Scientific Awards: Pan-American Society for Evolutionary Developmental Biology Junior Faculty Award (2024) Outstanding New Investigator – International Xenopus Board (2023) Basil O'Connor Scholar – March of Dimes (2017-2019) Recent publications highlight his work on enhancer classification, RNA degradation mechanisms, and cross-species MZT comparisons. His lab develops innovative methods like RESA for regulatory sequence analysis and studies evolutionary divergence in RNA localization patterns. While the articles span computational and experimental approaches, they consistently address RNA's role in cellular identity, developmental timing, and evolutionary adaptation. Applications include understanding pluripotency, designing RNA biosensors, and elucidating fertilization barriers. Prospective Ph.D. students are encouraged to contact him for opportunities in gene regulation, development, evo-devo, and computational genomics.

• Ocular Genetics
• Gene Therapy
• Children's Vision Screening
• +۷ مورد دیگر

Alex V. Levin, M.D., M.H.Sc., serves as Professor in the Department of Ophthalmology at the University of Rochester School of Medicine and Dentistry, holding the Adeline Lutz - Steven S.T. Ching, M.D. Distinguished Professorship. He concurrently holds joint appointments in the Center for Visual Science and the Department of Pediatrics, Genetics. As Chief of the Flaum Eye Institute's Pediatric Ophthalmology and Ocular Genetics team and Chief of Clinical Genetics at URMC, he leads cross-functional teams comprising ophthalmologists, optometrists, pediatric specialists, geneticists, nurses, and genetic counselors. Medical Degree: Jefferson Medical College Residency: Pediatrics at Children's Hospital of Philadelphia Residency: Ophthalmology at Wills Eye Hospital Fellowship: Pediatric Ophthalmology and Strabismus at Toronto's Hospital for Sick Children Masters of Health Science in Bioethics: University of Toronto (2001) Dr. Levin's research spans ocular genetics and gene therapy, children's vision screening, pediatric glaucoma/cataract/uveitis, ocular manifestations of child abuse, and bioethics. His work integrates clinical expertise in pediatric anterior segment eye conditions with scientific investigation into genetic eye diseases. He maintains the only simultaneous US Board Certifications in pediatrics, ophthalmology, and child abuse pediatrics worldwide. Analysis of his 15 most recent publications reveals predominant focus on genetic eye disorders (73%), with significant emphasis on retinal hemorrhage patterns in trauma (13%) and pediatric glaucoma (7%). His research demonstrates consistent translational application from basic science to clinical practice, particularly in ocular genetics and abusive head trauma diagnostics. Resident Guardian Award (2022) Edward A. Jaeger and John B. Jeffers Citizenship Award (2020) Albert Marquis Lifetime Achievement Award (2018) Al Biglan Medal in Pediatric Ophthalmology (2014) Ray E. Helfer Society Award for Child Abuse Research (2011) With over 35 years of experience and hundreds of peer-reviewed publications, Dr. Levin has secured funding from the National Institutes of Health, Canadian Institute of Health, and private foundations. His research portfolio demonstrates exceptional continuity in pediatric ophthalmology and ocular genetics, with recent emphasis on deep learning applications for retinal hemorrhage analysis and international registry development for childhood glaucoma. He has established comprehensive vision screening programs for underserved urban populations and pioneered ethical frameworks for genetic testing in pediatric ophthalmology. Dr. Levin directs the Ocular Genetics Program at URMC, which provides multidisciplinary care through the Pediatric Ophthalmology and Ocular Genetics team. His laboratory investigations focus on nascent chromatin structure in fibrosis and protein modeling for inherited retinal diseases, with active collaborations across the Montalcino Aortic Consortium and Sturge-Weber Foundation research networks.

• Computational Genomics
• Gene Regulation
• RNA Biology
• +۴ مورد دیگر

Susanne Bornelöv is a Professor in the Department of Biochemistry at the University of Cambridge. Her research focuses on computational genomics and gene regulation, particularly exploring posttranscriptional mechanisms such as codon optimality-mediated mRNA decay and transposon silencing. She uses computational methods, ribosome profiling, and Drosophila models to study how codon usage, tRNA availability, and RNA modifications influence gene regulation and genome evolution. Her work integrates artificial intelligence (AI) and comparative genomics to model gene regulatory processes and design novel regulatory elements. Key research areas include piRNA clusters' roles in suppressing retroviruses, codon usage bias in pluripotent stem cells, and the interplay between mRNA methylation and protein synthesis. The Bornelöv Group collaborates widely, including with institutions like Cold Spring Harbor Laboratory, to advance understanding of fundamental gene expression principles. Publications highlight contributions to topics like deep learning in genomics, evolutionary conserved piRNA mechanisms, and transcriptional regulation. She leads a group open to interns, students, and researchers, fostering interdisciplinary approaches to address complex biological questions.

Laura Ruscheمشاهده پروفایل

استاد

• Chromatin Biology
• Gene Expression Regulation
• Evolutionary Genomics
• +۳ مورد دیگر

Laura Rusche is a Professor in the Department of Biological Sciences at the University at Buffalo. Her research focuses on chromatin structure, gene expression regulation, and evolutionary mechanisms in yeast. She investigates how sirtuins and heterochromatin proteins like Sir3 contribute to epigenetic control and respond to metabolic stress. Her work spans multiple yeast species to understand evolutionary adaptations in protein functions and transcriptional circuits. Education: BS from Yale University (Molecular Biophysics & Biochemistry), PhD from Johns Hopkins University (Biochemistry), and postdoctoral training at UC Berkeley. Research Interests: Chromatin dynamics, sirtuin-mediated epigenetic regulation, gene duplication consequences, and fungal pathogen biology. Key projects include studying Sir2's role in NAD+ stress responses and the evolution of Sir3 from replication proteins. Lab: The Rusche Lab explores centromere stability, heterochromatin formation in Candida species, and evolutionary genomics. Recent work highlights unique centromere structures in Candida auris and the functional divergence of sirtuins across yeasts.

• Epigenetics
• Epigenomics
• Genetics
• +۴ مورد دیگر

Dr. Steven Jacobsen is a Professor in the Molecular, Cell, and Developmental Biology Department at the University of California, Los Angeles (UCLA), where he leads the Jacobsen Lab. His work focuses on epigenetic inheritance and gene regulation in Arabidopsis thaliana and mammalian stem cells, utilizing genetic screens, genomics, epigenomics, and biochemical approaches. The lab also pioneers CRISPR-mediated genome editing techniques. University: University of California, Los Angeles Department: Molecular, Cell, and Developmental Biology Research Interests: Jacobsen's research spans multiple interconnected domains in epigenetics, including DNA methylation patterning, histone modification interplay, and transposable element silencing. His team investigates how chromatin structure influences gene expression and epigenetic inheritance, with applications from plant development to human health. Key areas include: CRISPR-based epigenetic modifications RNA-directed DNA methylation (RdDM) mechanisms Chromatin compaction via MORC proteins Histone variant functions in methylation Transposon control in plant genomes Comparative epigenomics across species Advising Legacy: Over two decades, Dr. Jacobsen has mentored 21 former lab members who now hold academic and industry positions globally, including professors at Chinese Academy of Sciences, University of Georgia, and Southern University of Science & Technology. His lab's publications reveal a consistent focus on DNA methylation dynamics, chromatin remodeling, and small RNA pathways, with recent work emphasizing CRISPR innovations and structural insights into epigenetic regulators.

Jochen Wolfمشاهده پروفایل

استاد

• Evolutionary Biology
• Speciation Genomics
• Genome Evolution
• +۷ مورد دیگر

Jochen Wolf is Chair of the Evolutionary Biology Division at Ludwig-Maximilians-Universität München (LMU) and a Max Planck Fellow of the Max Planck Institute for Biological Intelligence since 2022. His research integrates evolutionary biology, genomics, and ecology to address fundamental questions about speciation, adaptation, and biodiversity across multiple biological systems. Dr. Wolf's research program applies an integrative approach to understand microevolutionary processes and genetic mechanisms underlying species divergence. His work combines large-scale genomic analyses with laboratory and field experiments to characterize genomic divergence across populations and species. Key empirical systems include natural populations of birds (particularly corvids, swallows, and cuckoos), marine mammals (pinnipeds and killer whales), plant communities, and experimental evolution in fission yeast. His research spans multiple scales from immediate microevolutionary processes to broader evolutionary patterns across time. His recent publications reveal a sophisticated integration of genomic, epigenetic, and ecological perspectives. A notable trend shows increasing focus on structural genomic variation, chromosomal rearrangements, and epigenetic mechanisms as drivers of evolutionary processes. His work demonstrates how these molecular mechanisms interact with ecological factors to shape patterns of biodiversity and adaptation. Dr. Wolf's research has gained significant recognition through publications in top-tier journals including Nature, Science, and Nature Ecology & Evolution. His groundbreaking studies on crow hybrid zones, killer whale ecotypes, and experimental evolution of speciation have been featured in prominent media outlets such as The New Yorker, The Guardian, Scientific American, and Der Spiegel, demonstrating the broad impact of his work. As Principal Investigator, Dr. Wolf actively mentors doctoral students and postdoctoral researchers, fostering the next generation of evolutionary biologists. His lab maintains strong international collaborations, particularly through affiliations with SciLifeLab in Uppsala. Research in his group is supported by multiple funding sources including German Research Foundation grants and European Union programs, enabling both fundamental research and applications to conservation biology. The Wolf lab operates within LMU's Division of Evolutionary Biology, which provides access to state-of-the-art facilities including the Leibniz Supercomputing Centre. The lab maintains strong connections with the Max Planck Institute for Biological Intelligence and SciLifeLab in Uppsala, creating a rich collaborative environment for interdisciplinary research in evolutionary genomics. This network enables comprehensive studies spanning from molecular mechanisms to ecological and evolutionary consequences across diverse biological systems.

Guillaume Bourqueمشاهده پروفایل

استاد

• Bioinformatics
• Computational Genomics
• Comparative Genomics
• +۵ مورد دیگر

Guillaume Bourque is a Professor in the Department of Human Genetics at McGill University's Faculty of Medicine. He serves as an Investigator at the Victor Phillip Dahdaleh Institute of Genomic Medicine and as the Scientific Director of the Canadian Centre for Computational Genomics (C3G). His laboratory is based at 740 Dr Penfield Ave, Room 6103, Montréal, Québec, Canada, H3A 1A4, where he leads research in computational genomics and bioinformatics. Professor Bourque's research focuses on understanding mammalian genomes using comparative genomic and epigenomic analyses. His lab investigates the evolution of regulatory sequences , the role of transposable elements in gene regulation , and the impact of genome rearrangements in evolution and cancer . His team develops computational methods and resources for the functional annotation of genomes with special emphasis on sequencing-based assays including ChIP-seq, RNA-Seq, exome- and whole-genome sequencing, and single-cell analysis. The lab's work involves examining billions of DNA base pairs to interpret how variation impacts basic biology and disease. Recent publications (2024-2025) demonstrate Bourque's leadership in pangenome graph construction , transposable element analysis , epigenomic profiling , and cancer genomics . His work spans multiple disciplines from basic genome evolution to clinical applications in cancer and infectious disease. Notable projects include the development of tools like DeepPolisher for genome assembly polishing and contributions to understanding the genomic basis of long COVID. Bourque's laboratory is actively recruiting postdocs and graduate students with backgrounds in programming or statistics. The lab emphasizes quantitative approaches to biology, requiring applicants to have experience in quantitative biology as a plus. His collaborative work extends across multiple institutions and international consortia, reflecting the interdisciplinary nature of modern genomic research.

Barbara Melloneمشاهده پروفایل

استاد

• Centromere Biology
• Chromosome Segregation
• Genetics
• +۴ مورد دیگر

Barbara Mellone is a Professor in the Department of Molecular and Cell Biology / Genetics and Genomics at the University of Connecticut. She leads the Mellone Lab, which focuses on understanding how genetic information is accurately passed from one cell generation to the next through the study of centromeres. Her research interests include: Centromere biology and function Chromosome segregation mechanisms Genetic and epigenetic regulation of centromeres Evolution of centromeres across species Using Drosophila melanogaster as a model system for chromosome studies Connections between chromosome segregation errors and human diseases like cancer Professor Mellone's recent publications demonstrate a strong focus on centromere structure and function, particularly examining CENP-A chromatin, centromere assembly factors like CAL1, and the evolutionary aspects of centromere biology. Her work combines genetic, molecular, and evolutionary approaches to unravel the fundamental mechanisms of chromosome inheritance. Her laboratory has made significant contributions to understanding how centromeres are built, maintained, and evolve, with implications for human diseases associated with chromosome segregation errors.