جست‌وجوی استاد و پژوهشگر

Peter C. Hollenhorstمشاهده پروفایل

استاد

• Transcription factor function
• Cancer research
• Genomic targets of ETS family transcription factors
• +۷ مورد دیگر

Peter C. Hollenhorst is a Professor of Biochemistry, Molecular Biology & Pharmacology at Indiana University School of Medicine - Bloomington. He leads the Hollenhorst Lab, which focuses on transcription factor function and its role in cancer development and progression. His research spans molecular biology, cancer genetics, and signal transduction pathways with a particular emphasis on ETS family transcription factors. Dr. Hollenhorst received his B.S. from St. Norbert College and his Ph.D. in Biomolecular Chemistry from the University of Wisconsin-Madison under the mentorship of Dr. Catherine Fox. He completed his postdoctoral training as an American Cancer Society fellow at the Huntsman Cancer Institute, University of Utah, working in Dr. Barbara Graves' laboratory on genomic targets of ETS family transcription factors. His research primarily investigates transcription factor specificity, particularly focusing on ETS family proteins like ERG and their roles in prostate cancer, renal cell carcinoma, and ovarian cancer. The lab examines how oncogenic transcription factors interact with signaling pathways including Ras/ERK and PI3K/AKT, how chromosomal rearrangements create cancer-driving transcription factors, and mechanisms of therapy resistance. Recent work has identified potential therapeutic targets in translocation renal cell carcinoma and mechanisms of docetaxel resistance in prostate cancer. Dr. Hollenhorst was promoted to Professor in 2022 after joining Indiana University School of Medicine - Bloomington in 2010. His publication record shows consistent productivity with significant contributions in high-impact journals including Journal of Biological Chemistry, PLoS Genetics, Cancer Research, and Clinical Cancer Research. His work demonstrates an evolving research trajectory from basic transcription factor biochemistry to translational cancer research with therapeutic implications. American Cancer Society postdoctoral fellowship Dr. Hollenhorst's lab maintains active research programs investigating transcription factor function in cancer, with recent publications demonstrating ongoing productivity and scientific impact. His work bridges fundamental molecular mechanisms with potential clinical applications, particularly in identifying therapeutic vulnerabilities in cancers driven by aberrant transcription factors. The Hollenhorst Lab operates within the Department of Biochemistry, Molecular Biology & Pharmacology at Indiana University School of Medicine - Bloomington, with research supported by competitive grants. The lab maintains a website at http://hollenhorstlab-iu.strikingly.com/ where additional information about current projects and publications can be found.

Mudit Tyagiمشاهده پروفایل

دانشیار

• HIV transcription and latency
• Epigenetics
• Drugs of abuse and HIV
• +۴ مورد دیگر

Mudit Tyagi is an Associate Professor in the Department of Medicine at Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia. His research focuses on HIV molecular biology with emphasis on transcriptional regulation, epigenetic mechanisms, and substance abuse interactions. Dr. Tyagi earned his PhD in Molecular Biology of HIV from the International Centre for Genetic Engineering and Biotechnology (ICGEB) in Trieste, Italy. His laboratory employs advanced methodologies including RNA-Seq, ChIP-Seq, ATAC-Seq, confocal microscopy, and transcriptomic analyses to investigate HIV pathogenesis. His primary research directions include: Defining molecular mechanisms regulating HIV transcription/latency for therapeutic applications Characterizing how drugs of abuse enhance HIV replication and neurocognitive complications Dr. Tyagi maintains active affiliations with the Center for Translational Medicine and directs a specialized research laboratory focused on HIV eradication strategies and neuroHIV complications.

Zi-Xuan (Zoe) Wangمشاهده پروفایل

دانشیار

• Genomic Medicine
• Personalized Medicine
• Molecular Pathology
• +۵ مورد دیگر

Zi-Xuan (Zoe) Wang serves as Associate Professor in the Department of Pathology & Genomic Medicine at Thomas Jefferson University's College of Life Sciences, concurrently holding leadership positions as Technical Director of Molecular Pathology and Scientific Director of the Pathology Translational Genomics Laboratory she recently established. Her research program pioneers genomic and personalized medicine through advanced molecular technologies. The laboratory specializes in whole genome profiling for microDNA expression, DNA methylation, and copy number variation analysis using microarray platforms, alongside next-generation sequencing (Roche 454 FLEX) for RNA seq, ChIP seq, mutation detection, and bisulfite conversion-based methylation verification. She maintains active collaborations with basic scientists and clinicians to investigate genomic mechanisms underlying human diseases. Dr. Wang's publication record demonstrates translational impact across diverse disease domains including thyroid cancer diagnostics, sarcoma genetics, myeloid neoplasms, pancreatic adenocarcinoma, and immunotherapies for infectious diseases, reflecting her laboratory's broad genomic application capabilities. She directs the Pathology Translational Genomics Laboratory as a central hub for genomic research integration into clinical pathology practice, driving innovation in molecular diagnostics and personalized treatment approaches.

Helena Jernberg Wiklundمشاهده پروفایل

استاد

• Translational research
• Epigenetics
• Drug discovery
• +۷ مورد دیگر

Helena Jernberg Wiklund is a Professor at Uppsala University's Department of Immunology, Genetics and Pathology within the Faculty of Medicine. She leads the Cancer Precision Medicine Research Program and serves as Director of Postgraduate Studies at Rudbeck Laboratory. Professor Jernberg Wiklund also sits on the Faculty Board at the Medical Faculty and participates in international (MMRF, IMF, AICR) and national (Barncancerfonden and Cancerfonden) grant review committees. Her research focuses on translational cancer biology with particular emphasis on multiple myeloma (MM), one of Sweden's most common blood cancers. She investigates mechanisms of survival and cell death in MM, using various model systems including cultured cells, patient tumor cells, and mouse models that accurately represent human disease. Her work aims to identify molecules essential for tumor cell survival that could be targeted to restore apoptosis and improve therapeutic outcomes. Analysis of her recent publications reveals a strong focus on epigenetic mechanisms in multiple myeloma, particularly involving EZH2, DNMTs, and lncRNA-mediated chromatin dynamics. Her research spans across molecular biology, cancer metabolism, and immunotherapy approaches, demonstrating an integrated approach to understanding and treating hematological malignancies. Professor Jernberg Wiklund actively mentors PhD students and researchers in her laboratory, contributing to the next generation of cancer researchers. She also engages in course administration, examination, and teaching at both undergraduate and postgraduate levels, while serving as a moderator and abstract coordinator for international scientific meetings.

Florian Grebienمشاهده پروفایل

استاد

• Molecular Biology
• Cancer Research
• Pediatric Oncology
• +۴ مورد دیگر

Florian Grebien is a Professor at the Department for Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, and Principal Investigator at the St. Anna Children’s Cancer Research Institute (CCRI) and Adjunct PI at CeMM. His research focuses on molecular mechanisms of pediatric leukemia driven by oncoproteins. Research Interests: Pediatric leukemia Fusion oncoproteins Transcriptional/epigenetic networks CRISPR/Cas9 screening Targeted degradation of oncoproteins Proteomic/transcriptomic analysis Scientific Awards: ERC Starting Grant His lab combines cellular models, animal models, and primary human samples to validate molecular mechanisms, collaborating with institutions like Ludwig Boltzmann Institute and CeMM. Funding sources include the European Research Council.

• Bioinformatics
• Computational Biology
• Epigenetics
• +۵ مورد دیگر

Dr. Ning Liu is a Postdoctoral Research Fellow at the South Australian Immunogenomics Cancer Institute (SAiGENCI) within the Faculty of Health and Medical Sciences at the University of Adelaide. As a bioinformatician and computational biologist, Dr. Liu specializes in developing computational tools for epigenetics and transcriptomics research, with particular expertise in next-generation sequencing data analysis including ChIP-seq, ATAC-seq, Hi-C, RNA-seq, single cell RNA-seq, and spatial transcriptomics. Dr. Liu's research focuses on developing novel computational methods to study the human genome in the context of transcriptomics and epigenomics. Currently, Dr. Liu maintains three Bioconductor software packages: standR for spatial transcriptomics analysis of GeoMx DSP data, hoodscanR for cellular neighborhood detection in spatial transcriptomics, and scider for modeling global cell density in spatial transcriptomics data. With strong emphasis on translating biological insights to medical applications, Dr. Liu's work bridges computational methodology with clinical relevance in cancer research and immunology. Dr. Liu is eligible to supervise Masters and PhD students as a Co-Supervisor, reflecting their established expertise in bioinformatics and computational biology. Their research has resulted in numerous publications focusing on spatial transcriptomics, cancer immunology, and computational tool development, with applications in understanding tumor microenvironments and immunotherapy response. Dr. Liu's scholarly contributions demonstrate a consistent focus on spatial biology methodologies applied to cancer research, particularly head and neck cancer. Their publications reveal expertise in developing computational frameworks that address technical challenges in spatial transcriptomics while providing biological insights with potential clinical applications in immunotherapy. As a research supervisor, Dr. Liu contributes to the academic community by mentoring graduate students in computational biology techniques and applications. Their work environment at the Adelaide Health and Medical Sciences building on the West End Health Precinct provides access to state-of-the-art facilities supporting their computational research in cancer immunogenomics.

Prashant Rajbhandariمشاهده پروفایل

دانشیار

• Adipose Biology
• Diabetes
• Metabolism
• +۵ مورد دیگر

Prashant Rajbhandari, PhD is an Associate Professor in the Department of Medicine, Division of Endocrinology, Diabetes and Bone Disease at the Icahn School of Medicine at Mount Sinai. His research program bridges immunology and metabolism, focusing on the complex interplay between immune cells and adipose tissue function. Dr. Rajbhandari's research interests encompass three primary areas: immune cell regulation of lipid metabolism, developmental processes of brown/beige and white fat, and adipose-liver crosstalk in obesity. His work employs cutting-edge techniques including cell and molecular biology, biochemistry, next-generation sequencing (ChIP-seq, RNA-seq, ATAC-seq), animal models, single cell/nuclei RNA sequencing, and advanced imaging. The Rajbhandari Lab's publications reveal a strong focus on the intersection of immunology and metabolism, with particular attention to sex-specific differences, neurotensin signaling, and immune regulatory crosstalk in adipose tissue thermogenesis. This research has significant implications for understanding obesity-related diseases and developing novel therapeutic approaches. Dr. Rajbhandari maintains an active collaboration with St. Luke's Hospital, facilitating translational research that bridges basic science discoveries with clinical applications in human adiposity. His lab's work is particularly relevant to diabetes research given his appointment in the Division of Endocrinology, Diabetes and Bone Disease. Office Location: Atran Berg Laboratory Building, 5th Floor, Room AB5-12, 1428 Madison Ave, New York, NY 10029

• Hematopoiesis
• Acute Myeloid Leukemia
• Stem Cell Biology
• +۳ مورد دیگر

Anne-Katrine Frank serves as a Special Consultant in the Porse Group at the Biotech Research & Innovation Centre (BRIC), part of the University of Copenhagen's Faculty of Health and Medical Sciences. Her research is centered on hematopoiesis and blood cancers, with a particular focus on genetic and molecular mechanisms underlying acute myeloid leukemia. Her research interests span hematopoietic stem cell biology, transcription factor function in blood cell development, and the role of specific genetic mutations in leukemia pathogenesis. Dr. Frank's work primarily investigates CEBPA mutations, TET2 lesions, and other molecular alterations that drive leukemogenesis and affect disease progression. Her research employs advanced genomic techniques including ChIP-seq and has contributed to understanding how transcription factors like ERG and PTBP1 regulate stem cell maintenance and differentiation. Dr. Frank has published extensively in high-impact journals including Nature Communications, Science Translational Medicine, Cell Reports, and Blood. Her research has been widely recognized with numerous citations and has influenced clinical understanding of familial AML and potential therapeutic approaches. Her work on engineering human mini-bones represents innovative approaches to modeling hematopoiesis and cancer metastasis. As a member of the Porse Group led by Professor Bo Torben Porse, Dr. Frank collaborates extensively with researchers across Denmark and internationally, contributing to significant advances in understanding the molecular basis of blood cancers and stem cell regulation.

Isaac J. Kremskyمشاهده پروفایل

استادیار

• Bioinformatics
• Epigenetics
• RNA Biology
• +۲ مورد دیگر

Dr. Isaac J. Kremsky serves as Assistant Professor in the Department of Basic Sciences at Loma Linda University School of Medicine, where he specializes in bioinformatics analysis of high-throughput sequencing data for epigenetic and RNA biology research. His work bridges computational methodologies with experimental biology to explore epigenomic plasticity in disease contexts. His research centers on epigenetic phenomena and RNA Biology, with particular emphasis on how epigenomic manipulations could revolutionize disease treatment. Dr. Kremsky actively collaborates with wet lab biologists to design and interpret genomic experiments, viewing epigenetics as a transformative field with near-future therapeutic applications. His expertise spans RNA-seq, ChIP-seq, and BS-seq data analysis for studying biological plasticity. Current research engagements include: Reversing Chemoresistance in Ovarian Cancer models (Other Significant Contributor, 2024-2025) LLISN International Surveillance Network (Co-Investigator, 2021-2025) Cerebrospinal Fluid Liquid Biopsy for CNS Tumors (Statistician, 2024) Reversing Chemoresistance in Recurrent Ovarian Cancer (Other Significant Contributor, 2022-2025) He teaches core bioinformatics curriculum including Introduction to Bioinformatics, Advanced Bioinformatics, and Dissertation Research across multiple academic terms.

Mohsen Hajheidariمشاهده پروفایل

پژوهشگر

• Plant Biology
• Genomics
• Bioinformatics
• +۳ مورد دیگر

Mohsen Hajheidari is a Researcher at the Institute for Plant Sciences, University of Cologne, focusing on the molecular interface between plant development and metabolic regulation through advanced genomic methodologies. His primary research domains include: Optimizing Plant Performance by Mapping Development-Metabolism Interfaces Plant Microbiota Metabolic Networks and Edaphic Adaptation Synthetic and Reconstruction Biology Theoretical Plant Biology and Data Science Applications Current work centers on annotating functional cis-regulatory elements by resolving discrepancies between ChIP-seq and RNA-seq data, specifically investigating non-functional transcription factor binding sites through integrated analysis of gene expression, chromatin states, and population variation using the FLC transcription factor model for flowering time and seed dormancy regulation. He utilizes institutional resources including the Plant Metabolism and Metabolomics Facility, Imaging Platform, and CEPLAS data infrastructure for ongoing research under current funding cycles following the 2013-2018 project period.