جستجوی استاد راهنمای دانشگاهی

Thibault Mayorمشاهده پروفایل

استاد

• Protein Homeostasis
• Ubiquitin Proteasome System
• Neurodegenerative Diseases
• +۷ مورد دیگر

Thibault Mayor is a Professor in the Department of Biochemistry and Molecular Biology and the Michael Smith Laboratories at the University of British Columbia (Vancouver). His research focuses on understanding how cells manage misfolded proteins, with implications for neurodegenerative diseases like Parkinson's and Alzheimer's. He holds academic affiliations with the Centre for High-Throughput Biology (CHiBi) and has been recognized with awards including the UBC Killam Teaching Award (2020). Education: BSc, University of Geneva, Switzerland (1997) PhD, University of Geneva & Max Planck Institute of Biochemistry, Germany (2001) Postdoctoral Fellow, California Institute of Technology (2002) Research Interests: Mayor's lab investigates protein homeostasis, ubiquitin-proteasome system dynamics, and the molecular mechanisms underlying protein aggregation in aging and disease. Projects include proteomic approaches to identify aggregation-prone proteins and develop microbial cell factories for protein production. Grants & Awards: CIHR Project Grant ($730K, 2018) Michael Smith Foundation Career Award (2012) UBC Killam Teaching Award (2020) Labs & Collaborations: The Mayor Lab is part of the Michael Smith Laboratories and collaborates with computational biologists like Jörg Gsponer. They maintain active partnerships in proteomics and systems biology, contributing to initiatives like the BC Proteomics Network.

Waldemar Kolanusمشاهده پروفایل

استاد

• Molecular Immunology
• Cell Signaling
• Signal Transduction Pathways
• +۴ مورد دیگر

Prof. Waldemar Kolanus leads the Molecular Immunology and Cell Biology department at the University of Bonn's Life & Medical Sciences Institute (LIMES) . His research bridges immunoregulation , stem cell dynamics , and metabolic stress responses in immune cells. Unit 2 member at LIMES Principal investigator in SFB 704 and ImmunoSensation Cluster Leads a multidisciplinary lab with postdocs, PhD students, and technical staff His work focuses on intracellular signaling pathways connecting immune activation to tissue homeostasis, particularly through: Cytohesin proteins in integrin-mediated adhesion and migration TRIM71 in stem cell regulation and congenital hydrocephalus High-salt environments affecting macrophage function Publication trends show expertise in immune cell migration , genetic models , and chemical inhibition , with frequent use of mice and zebrafish for in vivo studies. Key articles explore: TRIM71's dual role in auditory development and germ cell maintenance Cytohesin family's Golgi regulation and insulin signaling Ruxolitinib's off-target migration inhibition of dendritic cells Contact details: Address: LIMES Institute, Carl-Troll-Straße 31, Bonn Email: kolanus.sekretariat@uni-bonn.de Phone: +49 228 73-62788

Jens S. Andersenمشاهده پروفایل

استاد

• Proteomics
• Quantitative Mass Spectrometry
• Cell Biology
• +۱۱ مورد دیگر

Jens S. Andersen is a Professor in the Department of Biochemistry and Molecular Biology at the University of Southern Denmark, where he leads research in Biomedical Mass Spectrometry and Systems Biology. His work is centered on the development and application of quantitative mass spectrometry and microscopy-based proteomics to study human cell biology, particularly the structure and function of organelles such as centrosomes, cilia, autophagosomes, and mitochondria. His research focuses on determining the protein composition and dynamic properties of cellular organelles, the roles of specific protein groups, and their contributions to biological processes and diseases. He investigates cell signaling mediated by post-translational modifications, especially within the DNA damage response, autophagy, and immune systems. His lab, the Jens S. Andersen Lab, is part of the Research Section of Biomedical Mass Spectrometry. The analysis of his recent publications reveals a strong interdisciplinary trend combining proteomics, structural biology, and cell signaling. His work spans cilia biology, RNA metabolism, DNA repair, and cancer mechanisms, with frequent use of advanced techniques like mass spectrometry, CRISPR, and live-cell imaging. The integration of systems biology approaches is evident across his research outputs. Professor, Department of Biochemistry and Molecular Biology, University of Southern Denmark Head of Research, Biomedical Mass Spectrometry and Systems Biology Principal Investigator, Jens S. Andersen Lab ORCID: 0000-0002-6091-140X While no specific scientific awards are mentioned in the provided texts, his extensive publication record in high-impact journals such as Science , Nature Communications , Molecular Cell , and EMBO Journal reflects significant scholarly contributions. He has supervised research projects and collaborated widely across Europe, though specific names of students are not listed. His research is supported by multiple ongoing projects, reflecting sustained funding and academic leadership. The Jens S. Andersen Lab operates at the intersection of proteomics and cell biology, contributing to fundamental understanding of organelle dynamics and disease mechanisms. The lab's work is highly collaborative, involving partnerships with groups in structural biology, RNA research, and cancer biology.

• Organoid Engineering
• Systems Biology
• Developmental Biology
• +۳ مورد دیگر

Keisuke Ishihara is an Assistant Professor in the Department of Computational and Systems Biology at the University of Pittsburgh School of Medicine. His research focuses on engineering human brain and cardiac organoids using genetic, chemical, and computational approaches to uncover novel regulatory mechanisms and physical principles underlying tissue development. His lab is located at Biomedical Science Tower 3, with an office in room 10020A. Dr. Ishihara holds a PhD in Systems Biology from Harvard University. His work bridges synthetic biology, developmental biology, and biophysics to address fundamental questions in organogenesis and cellular morphogenesis. Recent research highlights include studies on BMP-mediated neural tube patterning in organoids and the biophysical dynamics of microtubule assemblies in large cells. Publications from his lab emphasize interdisciplinary approaches to understand cell size scaling, mitotic spindle dynamics, and self-organization in synthetic tissues. His team has contributed to advancements in organoid technology, uncovering dormant genetic programs and physical principles governing tissue architecture. Laboratory activities are centered at the University of Pittsburgh, collaborating with the School of Medicine's computational and systems biology initiatives. For more details, visit his lab website linked below.

Jian Zhangمشاهده پروفایل

استادیار

• Biomedical Engineering
• Mechanobiology
• Cancer Metabolism
• +۵ مورد دیگر

Jian Zhang is an Assistant Professor in the Department of Biomedical Engineering at the University of Arkansas. He obtained his B.S. in Theoretical and Applied Mechanics from Peking University (2011) and a Ph.D. in Biomedical Engineering from Carnegie Mellon University (2016), followed by postdoctoral research at Vanderbilt University (2017-2022). His work integrates engineering , mechanics , and computational biology to study cancer mechanobiology and regenerative medicine. Education: B.S., Theoretical & Applied Mechanics, Peking University (2011) Ph.D., Biomedical Engineering, Carnegie Mellon University (2016) Dr. Zhang's research focuses on cancer mechano-metabolism —how mechanical forces interact with cellular bioenergetics to influence tumor progression. His lab develops bioengineering tools and computational models to study cell migration in 3D environments, nuclear mechanics, and extracellular matrix interactions. Recent work explores leader-follower dynamics in collective invasion and mitochondrial transfer in aggressive cancers. The 15 most recent publications highlight themes in cancer metabolism , nuclear deformation , and matrix stiffness , with applications in metastasis and regenerative medicine. His articles span computational modeling of energy-driven invasion hierarchies, biophysical studies of nuclear mechanics, and translational research connecting tissue density to cancer progression. At the University of Arkansas, Dr. Zhang teaches BMEG 26104 Introduction to Biomedical Engineering (Fall) and BMEG 4700V/5700V Special Topics: Physics of the Cell (Spring). The Zhang Lab (Cell Biophysics Laboratory) emphasizes collaborative research, mentorship, and the development of precision mechanomedicine tools to address challenges in cancer and regenerative medicine.

M. (Mike) Boxemمشاهده پروفایل

استاد

• Developmental Biology
• Cell Polarity
• Protein-Protein Interactions
• +۳ مورد دیگر

Prof. Mike Boxem is a Professor in the Department of Biology at Utrecht University's Faculty of Science, specializing in Developmental Biology. His research focuses on epithelial polarity, cell polarity complexes, and C. elegans genetics. He holds a PhD from Utrecht University (2002) and completed postdoctoral work at the Dana-Farber Cancer Institute. Notable honors include the NWO Vici (2016), NWO Vidi (2010), and ECHO grants. He leads the PolarNet Marie Curie ITN network and has supervised 8 research projects. His work contributes to understanding cell polarity mechanisms and developmental processes in C. elegans. Educations: BSc Medical Biology, VU University Amsterdam PhD in Biology, Utrecht University (2002) Research Interests: Boxem’s lab investigates how cell polarity complexes regulate epithelial tissue organization in C. elegans. Key topics include Crumbs polarity proteins, intermediate filaments, and signaling pathways controlling lumen formation and germline development. His work integrates genetic, biochemical, and imaging approaches to dissect molecular mechanisms underlying polarity establishment and maintenance. Grants & Awards: NWO Vici Grant (2016) - Supports long-term research NWO Vidi Grant (2010) - Established his independent lab ECHO Grant (2014) - European funding for collaborative projects Labs/Teams: His group is part of the Biodynamics and Biocomplexity research division. Collaborations span global networks, including the PolarNet consortium focusing on epithelial polarity.

• Structural Biology
• Molecular Biophysics
• Cryo-Electron Microscopy
• +۹ مورد دیگر

David Agard is a Professor in the Department of Biochemistry and Biophysics at the University of California San Francisco (UCSF), where he leads a research group focused on uncovering the structural basis of biological function at the molecular and cellular levels. His lab specializes in advanced cryo-electron microscopy (cryo-EM) and fluorescence light microscopy, developing novel imaging technologies to study dynamic cellular processes. His research interests span structural biology , molecular chaperone function (particularly Hsp90 and its role in disease), microtubule nucleation , centrosome and cilium structure , and the structure of phage-encoded tubulins . He is deeply involved in methodological innovations in cryo-EM data processing , including deconvolution, heterogeneous reconstruction, and tomography, enabling atomic-level insights into complex biological systems. Recent publications highlight his lab’s work on the structural mechanisms of Hsp90-client regulation, microtubule organization, phage nucleus formation, and high-resolution imaging techniques using functionalized graphene-oxide grids. His work increasingly integrates AI-driven structural modeling and in situ approaches to understand macromolecular complexes in their native cellular context. Dr. Agard has made seminal contributions to understanding the ATPase cycle of Hsp90, the architecture of the gamma-tubulin complex, and the structural dynamics of viral and cellular tubulins. His research bridges biochemistry, biophysics, and cell biology, with implications for cancer, neurodegeneration, and antimicrobial strategies.

Michael Shelleyمشاهده پروفایل

استاد

• Fluid Dynamics
• Active Matter
• Biophysics
• +۳ مورد دیگر

Michael Shelley is the Lilian and George Lyttle Professor of Applied Mathematics at New York University's Courant Institute of Mathematical Sciences. He holds additional roles as Professor of Mathematics, Neural Science, and Mechanical Engineering. His research focuses on fluid dynamics, active matter, and biophysical systems, with notable contributions to microswimmer dynamics, cytoplasmic flows, and fluid-structure interactions. Shelley leads the Applied Mathematics Laboratory at Courant and directs the Center for Computational Biology at the Flatiron Institute. His work bridges theoretical, computational, and experimental approaches to understand complex biological and physical phenomena. Research interests include nonlinear dynamics of fluids, collective behavior in active matter systems, and biomechanical processes such as mitosis and cellular transport. Recent studies involve modeling microtubule networks, cytoplasmic stirring, and spindle positioning in cells. His publications span topics like fluid-structure interactions, viscoelastic flows, and the mechanics of swimming organisms. Key projects include the dynamics of erodible bodies in fluid flows, optimization of microswimmer designs, and the rheology of active suspensions. Shelley collaborates across disciplines, integrating applied mathematics with biology, physics, and engineering. His work has advanced understanding of self-organization in living systems and fluid-driven morphological changes.

Zoi Diamantopoulouمشاهده پروفایل

پژوهشگر ارشد

• Metastasis
• Circadian Rhythm
• Cancer Biology
• +۳ مورد دیگر

Dr. Zoi Diamantopoulou is a Beatson Research Fellow at the Cancer Research UK Scotland Institute (School of Cancer Sciences), Glasgow. Previously, she held Senior Postdoctoral Marie Curie Fellowships at ETH Zürich and University of Basel. Her research focuses on the interplay between circadian rhythms and cancer metastasis, particularly through circadian regulation of Circulating Tumour Cells (CTCs). Education: PhD in Cellular Biology (2010), University of Patras, Greece BSc in Biology (2005), University of Patras, Greece Her work employs in vivo mouse models, microfluidics, genetic engineering, and next-generation sequencing to explore how circadian disruptions influence metastatic progression. She also investigates chronotherapy for optimized drug administration and analyzes patient blood samples to identify circadian-related molecular vulnerabilities. Scientific Awards: 2021 Marie Skłodowska-Curie Postdoctoral Fellowship 2018 The BACR Chris Marshall Prize for Cell Signalling Lab Members: Senior Scientific Officer Gurman Pall, PhD Student Sara Ortega.

Gregory C. Rogersمشاهده پروفایل

استاد

• Centriole Duplication
• Centrosome Instability
• Chromosomal Instability (CIN)
• +۶ مورد دیگر

Gregory C. Rogers is a Professor in the Department of Cellular and Molecular Medicine at the University of Arizona, with additional appointments in the BIO5 Institute, Cancer Biology GIDP, and Genetics GIDP. He specializes in molecular mechanisms governing centriole duplication and centrosome instability in cancer progression. Education: BA in Biology from the University of Rochester PhD in Cell and Developmental Biology from University of California, Davis Postdoctoral training at Albert Einstein College of Medicine and University of North Carolina, Chapel Hill His research focuses on centriole duplication control, centrosome amplification/loss in prostate cancer, and the role of Polo-like kinase 4 (Plk4) in mitotic errors. Articles from 2010-2025 highlight his work on centrosome dynamics, cancer-related chromosomal instability, and Drosophila model applications. Recent studies (2023-2025) explore PIM kinase inhibition in immunotherapy, Plk4 regulation, and centrosome loss as a driver of prostate malignancy. Earlier work (2010-2019) established foundational knowledge of centriole assembly and condensin II function.

Marta de Ruijter-Villaniمشاهده پروفایل

استادیار

• Reproductive Biology
• Developmental Biology
• Chromosome Segregation
• +۴ مورد دیگر

Marta de Ruijter-Villani serves as an Assistant Professor in the Faculty of Medicine at Utrecht University, focusing on medical research within the Child Health strategic program at UMC Utrecht. Her academic role centers on investigating the fundamental biological processes governing embryonic development and reproduction from the earliest stages through adulthood. Her research spans reproductive biology and developmental genetics, with specialized expertise in chromosome segregation mechanisms during oocyte maturation and early embryonic divisions. She utilizes equine models to study reproductive aging effects on fertility, examining spindle assembly dynamics, centrosome behavior, and metabolic influences on embryonic viability. This work provides critical translational insights into human reproductive disorders and age-related infertility. Analysis of her publication trajectory reveals a consistent focus on large animal models to dissect conserved cellular mechanisms in reproduction. Her studies bridge basic cell biology with clinical reproductive medicine, addressing chromosome dynamics, embryo development under metabolic stress, and the molecular basis of aneuploidy. This integrative approach has established significant connections between equine reproductive aging and human fertility challenges. Dr. de Ruijter-Villani leads research within the FUTURA Utrecht group (Future Health and Reproduction Academy Utrecht), which investigates developmental origins of health and disease with direct relevance to pediatric health outcomes and reproductive medicine advancements.

Takashi Ishikawaمشاهده پروفایل

استاد

• Structural Biology
• Cryo-electron Tomography
• Flagella/Cilia Research
• +۴ مورد دیگر

Professor Takashi Ishikawa is a distinguished researcher and Group Leader at the Paul Scherrer Institute (PSI) in Switzerland, where he heads the Laboratory for Multiscale Bioimaging within the PSI Center for Life Sciences. His work focuses on the structural biology of eukaryotic flagella and cilia using advanced electron cryo tomography and microscopy techniques. Dr. Ishikawa's research program centers on understanding the 3D molecular architecture and functional mechanisms of flagellar/ciliary components, particularly dynein motor proteins. His laboratory employs cutting-edge cryo-EM methodologies to visualize biological macromolecules and organelles in their native hydrated states, enabling three-dimensional reconstructions at increasingly higher resolutions. The team's work has revealed critical insights into the molecular arrangement of dyneins and other proteins on microtubule doublets, the structural basis of dynein power stroke, and the mechanisms underlying flagellar/ciliary bending motion. His research has significant implications for understanding ciliopathies—diseases caused by defects in flagella/cilia—which affect multiple organ systems including respiratory tracts, reproductive systems, and the brain. The fundamental insights gained from studying these natural nanomachines also inform the development of artificial nanoscale devices and systems. Dr. Ishikawa has established numerous collaborative research projects with groups across various disciplines, including biochemistry, biophysics, and medical research. His laboratory serves as a hub for structural biology research at the intersection of cell biology and nanotechnology, training the next generation of scientists in advanced imaging techniques.

• DNA Repair Mechanisms
• Cancer Biology
• Genome Stability
• +۳ مورد دیگر

J. Ross Chapman is a Professor of Genome Maintenance Biology at the University of Oxford, holding positions at the MRC Molecular Haematology Unit (part of the Radcliffe Department of Medicine) and the Wellcome Centre for Human Genetics. He is a Cancer Research UK (CRUK) Career Development Fellow, Lister Institute Research Fellow, and EMBO Young Investigator Programme member. His research focuses on DNA repair mechanisms, particularly the balance between accurate and mutagenic repair pathways in cancer and immune systems. Key affiliations include the Francis Crick Institute and previous roles at the University of Sussex and Gurdon Institute. Education and Career Path: Started as a Research Assistant at the MRC Genome Damage and Stability Centre (2002), earned his PhD in Steve Jackson’s lab (2006), and held postdoctoral roles at Simon Boulton’s lab (2010). Established his independent group at Oxford in 2013, becoming an Associate Professor in 2017 and moving to the MRC Unit in 2020. Research Interests: Investigates genetic recombination mechanisms, DNA double-strand break (DSB) repair pathways, and their roles in immune system development and cancer. Recent work explores how faulty repair mechanisms drive cancer and immune disorders, targeting vulnerabilities for therapies like PARP inhibitors. Publications: Recent studies include discoveries on Shieldin/CST complex roles in DNA repair, BLM-BRCA1 interactions, and chronic inflammation in leukemia. His work bridges basic biology with clinical applications, such as drug resistance mechanisms in BRCA-deficient cancers. Awards: CRUK CDF, Lister Fellowship, EMBO Young Investigator Programme membership, and recognition for contributions to DNA repair research. Lab Team: Includes postdoctoral researchers (e.g., Ashleigh King, My Khanh Pham), DPhil students, and technical staff. Collaborates on projects like PARP inhibitor efficacy and immune system DNA repair dynamics.

Amity L. Manningمشاهده پروفایل

استاد

• Cancer Cell Biology
• Genomic Instability
• Cell Cycle Progression
• +۳ مورد دیگر

Dr. Amity L. Manning is the Helen G. Vassallo Distinguished Presidential Professor in the Department of Biology and Biotechnology at Worcester Polytechnic Institute (WPI). Her research focuses on understanding cellular mechanisms maintaining genome stability in normal cells and their corruption in cancer cells, particularly studying chromosome instability (CIN) and its role in tumor evolution. She holds a BS from Brandeis University (2002) and a PhD from the Geisel School of Medicine at Dartmouth (2008). Her work combines molecular biology, bioinformatics, and imaging to identify therapeutic targets for cancers exhibiting genomic instability. Key areas include RB tumor suppressor regulation, centrosome dynamics, and mitotic error correction. Recent grants include a $1.1M NSF CAREER Award and an American Cancer Society Research Scholar Grant. She advises multiple PhD students and postdoctoral researchers through the Manning Lab at WPI's Life Sciences & Bioengineering Center. Her lab's discoveries highlight how manipulating CIN can exploit cancer vulnerabilities, including enhanced drug sensitivity through PARP inhibition and suppression of acquired resistance via cohesion modulation. Publications span high-impact journals like Nature and Molecular Cancer Therapeutics . Dr. Manning actively collaborates on projects involving mathematical modeling of spindle dynamics and epigenetic regulation of mitosis. Her lab hosts annual symposia, summer internships, and international collaborations, emphasizing training the next generation of cancer researchers. Current projects target STK25-LATS signaling pathways and PUMILIO-mediated miRNA processing in cancer progression.

Lukas Kapiteinمشاهده پروفایل

استاد

• Biophysics
• Cell Biology
• Neurobiology
• +۸ مورد دیگر

Prof. Dr. Lukas C. Kapitein is a leading researcher in Cell Biology, Neurobiology and Biophysics at the Faculty of Science, Utrecht University . His work bridges physics and neuroscience to understand how cells maintain their shape and intracellular organization, particularly in neurons. Academic Affiliation: Full Professor of Molecular and Cellular Biophysics since 2018 Key Collaborations: Co-manages the Gravitation project IMAGINE! with Anna Akhmanova Research Focus: The lab investigates the neuronal cytoskeleton , emphasizing microtubule organization and motor protein dynamics. They develop advanced optical methods to map cytoskeletal architecture and design intracellular assays to probe motor-cargo interactions, linking these to neurodegenerative disease mechanisms. Awards: ERC Consolidator Grant (2018), ERC Starting Grant (2013), NWO VIDI (2013), NWO ALW-VENI (2011), Erasmus MC Fellowship (2011). Students: PhD students include Albert Serweta, Thijs Makaske, Jasper Schelt, and Varsha Mahapatra. The lab also features postdocs and technical staff in microscopy and protein engineering. Methods: Combines protein engineering , super-resolution microscopy (STED, Localization, Expansion), and mathematical modeling to resolve microtubule polarity, transport rules, and dendritic spine dynamics.