معرفی
Dr. Amity L. Manning is the Helen G. Vassallo Distinguished Presidential Professor in the Department of Biology and Biotechnology at Worcester Polytechnic Institute (WPI). Her research focuses on understanding cellular mechanisms maintaining genome stability in normal cells and their corruption in cancer cells, particularly studying chromosome instability (CIN) and its role in tumor evolution. She holds a BS from Brandeis University (2002) and a PhD from the Geisel School of Medicine at Dartmouth (2008).
Her work combines molecular biology, bioinformatics, and imaging to identify therapeutic targets for cancers exhibiting genomic instability. Key areas include RB tumor suppressor regulation, centrosome dynamics, and mitotic error correction. Recent grants include a $1.1M NSF CAREER Award and an American Cancer Society Research Scholar Grant. She advises multiple PhD students and postdoctoral researchers through the Manning Lab at WPI's Life Sciences & Bioengineering Center.
Her lab's discoveries highlight how manipulating CIN can exploit cancer vulnerabilities, including enhanced drug sensitivity through PARP inhibition and suppression of acquired resistance via cohesion modulation. Publications span high-impact journals like Nature and Molecular Cancer Therapeutics.
Dr. Manning actively collaborates on projects involving mathematical modeling of spindle dynamics and epigenetic regulation of mitosis. Her lab hosts annual symposia, summer internships, and international collaborations, emphasizing training the next generation of cancer researchers. Current projects target STK25-LATS signaling pathways and PUMILIO-mediated miRNA processing in cancer progression.
