جست‌وجوی استاد و پژوهشگر

Rick Dobrowskyمشاهده پروفایل

استاد

• Diabetic Neuropathy
• Molecular Chaperones
• Neurotrophin Signaling
• +۳ مورد دیگر

Rick Dobrowsky is a Professor and Director of the Graduate Program in Neuroscience at the University of Kansas School of Pharmacy , Department of Pharmacology & Toxicology. His research focuses on diabetic peripheral neuropathy, molecular chaperones, and sphingolipid signaling in neuronal degeneration. Location: Malott Hall, Room 5064, Lawrence, KS Contact: dobrowsky@ku.edu | 785-864-3531 Research Overview : The Dobrowsky Lab investigates how hyperglycemia alters neurotrophin signaling and mitochondrial proteomes in diabetic neuropathy. Key projects include: Hyperglycemia and IGF-1 signaling effects on superoxide generation Neuregulinism's role in segmental demyelination Development of HSP90 inhibitors for neuroprotection Publications (15 Most Recent): 2025: PERK signaling and Cemdomespib therapy in Charcot-Marie-Tooth disease 2024: Demyelination progression in R75W-Connexin 32 models 2023: Biphenyl amides as HSP90/HSP70 modulators 2022: Cyclohexyl noviomimetics and mitochondrial function 2021: HSP70/thioredoxin interactions in diabetic neurons 2020: HSP90 inhibition and c-Jun proteasomal clearance 2019: Mitochondrial superoxide reduction with KU-596 2018: HSP70 targeting for demyelination 2016: Cemdomespib and neurotrophin receptor dynamics 2015: Molecular chaperones and mitochondrial bioenergetics 2014: KU-32 and heat shock protein mechanisms 2013: Neuregulin-1 isoforms in diabetic neuropathy 2012: C-terminal HSP90 inhibitors in sensory neuron protection 2011: Mitochondrial proteome changes in diabetes 2010: P35/CDK5 in beta-amyloid toxicity

Bill Luمشاهده پروفایل

استادیار

• Nanomedicine
• Targeted Drug Delivery
• Gene Therapy
• +۵ مورد دیگر

Bill Lu is an Assistant Professor at Santa Clara University's School of Engineering, Department of Bioengineering. With dual expertise in medicine (MD from Shanghai Medical University) and Biochemistry and Human Genetics (PhD from University of Manitoba), he focuses on developing genetic tools for treating complex diseases. MD: Shanghai Medical University, Clinical Medicine PhD: University of Manitoba, Biochemistry and Medical Genetics BS: University of Manitoba, Computer Sciences His research spans Nanomedicine (genetic disease, Alzheimer's, cancer), Targeted Drug Delivery (exosome-based systems), Gene Therapy (viral/non-viral delivery), and Molecular Imaging (fluorescence/bioluminescence probes). Recent publications highlight trends in exosome engineering, genome editing, and therapeutic vesicle design. 2023 Teaching Excellence Award 2021 Research Excellence Award 2013 Technology Innovation Award 2004 Distinguished PhD Dissertation Award He has filed 4 patents, served on editorial boards, and advised students through courses like Molecular and Cell Biology and Genome Engineering. His work bridges academic research and industry applications in biotechnology.

• Bioengineering
• Systems Glycobiology
• Thrombosis & Hemostasis
• +۳ مورد دیگر

Sriram Neelamegham is the UB Distinguished Professor of Chemical & Biological Engineering, Biomedical Engineering, and Medicine at the University at Buffalo, SUNY. His research focuses on applying engineering principles to study molecular mechanisms of blood cell interactions in diseases such as inflammation, thrombosis, and cancer. He leads the Bioengineering Laboratory within the School of Engineering and Applied Sciences. Education: PhD in Chemical/Biomedical Engineering, Rice University, 1996 B.Tech in Chemical Engineering, Indian Institute of Technology Delhi, 1991 Research Interests: Systems Glycobiology: Investigating glycan biosynthesis and its role in disease Leukocyte and Platelet Adhesion Dynamics under Fluid Flow Von Willebrand Factor (VWF) Structure-Function Relationships Engineering Glycoengineered Therapeutics and Diagnostic Tools Key Contributions: Developed computational models and experimental tools for glycosylation pathway analysis Discovered mechanisms of VWF conformational changes under shear stress Pioneered glycoengineering strategies for stem cell targeting Awards & Recognition: NIH Independent Scientist Award (2015) SUNY Chancellor's Award for Excellence (2015) AIMBE Fellow (2012) and BMES Fellow (2019) 2018 Schoellkopf Medal (ACS) Lab Activities: Recruitment of postdocs, full-time, and part-time research technicians Development of glycan-engineered technologies for drug delivery and diagnostics Collaborations with biomedical industries and academic institutions

Christopher D. Limaمشاهده پروفایل

استاد

• Structural Biology
• Ubiquitin and Ubiquitin-like Protein Pathways
• RNA Processing and Decay
• +۶ مورد دیگر

Christopher D. Lima is a Professor and Chair of the Structural Biology Program at the Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, and an Investigator at the Howard Hughes Medical Institute. He holds academic appointments at Weill Cornell Graduate School of Medical Sciences and is affiliated with the Tri-Institutional PhD Program in Chemical Biology. His research focuses on structural and biochemical mechanisms of ubiquitin and ubiquitin-like protein pathways and RNA quality control. PhD, Northwestern University Postdoctoral Training, Columbia University (Helen Hay Whitney Fellow) Dr. Lima’s research investigates the structural basis of post-translational modifications, particularly ubiquitination and SUMOylation, and RNA processing pathways. His lab combines cryo-EM, X-ray crystallography, and biochemistry to study enzyme mechanisms in ubiquitin activation and RNA exosome function. His work has elucidated key intermediates in E1 enzyme catalysis and the architecture of RNA surveillance complexes. These insights are fundamental to understanding cellular quality control and have implications for cancer and neurodegenerative diseases. His recent publications, including high-impact studies in Nature and Cell , reflect a consistent focus on macromolecular structure-function relationships in ubiquitin signaling and RNA metabolism. Trends in his publications show a deepening exploration of enzyme dynamics, conformational changes, and the development of chemical tools to probe these pathways. National Academy of Sciences (2020) American Academy of Arts and Sciences (2017) Howard Hughes Medical Institute Investigator (2013) Rita Allen Scholar (2003–2006) Beckman Young Investigator (1999–2002) Dr. Lima has advised numerous PhD students and postdoctoral fellows and has received continuous funding from the NIH and HHMI. His lab is actively involved in training and mentoring within the Tri-Institutional programs. He leads a multidisciplinary research team focused on structural mechanisms in cellular regulation and is engaged in collaborative and translational research, with disclosed interests in biotechnology companies such as Biogen and Vertex Pharmaceuticals. He is a member of the Structural Biology Program at SKI and leads a vibrant research laboratory that bridges basic science and disease mechanisms. His lab fosters innovation in structural biology and continues to make foundational contributions to the understanding of protein and RNA quality control pathways.

• Molecular Biology
• Microbiology
• Biochemistry
• +۴ مورد دیگر

Stefan Irniger serves as a faculty member at a German-speaking academic institution, where he has supervised numerous doctoral candidates between 2004 and 2014. His academic position as a Privatdozent (PD) indicates he has completed the habilitation process, the highest academic qualification in the German system. Dr. Irniger's research spans multiple areas of molecular and cellular biology, with particular emphasis on: Microbial pathogenesis and host-pathogen interactions Fungal and yeast molecular genetics Protein regulation and post-translational modifications Enzyme structure and function Cellular metabolism and signaling pathways His doctoral students have published work examining diverse biological systems including Toxoplasma gondii, Saccharomyces cerevisiae, Aspergillus nidulans, and various plant-pathogen interactions. The publications demonstrate a consistent focus on molecular mechanisms underlying cellular processes, with particular attention to protein regulation, metabolic pathways, and host-microbe interactions. His students' work appears across multiple subdisciplines including parasitology, fungal genetics, enzymology, and membrane biology. Dr. Irniger has guided 18 doctoral students to completion, with dissertation topics spanning from 2004-2014. His students have investigated fundamental biological questions with implications for infectious disease, agricultural pathology, and basic cellular mechanisms. While specific awards are not documented in the available records, the breadth and quality of supervised research indicates significant scholarly contribution to his fields of expertise.

Sean Palecekمشاهده پروفایل

استاد

• Biomedical Engineering
• Stem Cell Research
• Tissue Engineering
• +۴ مورد دیگر

Sean Palecek is the Milton J. and A. Maude Shoemaker Professor in the Department of Chemical and Biological Engineering at the University of Wisconsin–Madison. His research focuses on engineering platforms to regulate human pluripotent stem cell (hPSC) differentiation for cardiovascular and neurovascular applications. He is based in 3637 Engineering Hall and leads the Palecek Lab, which develops innovative methods for stem cell fate specification and tissue engineering. BChE, Chemical Engineering, University of Delaware MS, Chemical Engineering, University of Illinois at Urbana-Champaign PhD, Chemical Engineering, Massachusetts Institute of Technology Postdoc., Molecular Genetics and Cell Biology, University of Chicago His research integrates stem cell biology with biomaterials and engineering principles to generate functional cardiomyocytes, brain endothelial cells, and mural cells. His lab leverages Notch3 signaling, proteomics, and organoid systems to model diseases and develop regenerative therapies. Current projects emphasize hypoimmunogenic cardiac organoids, vascular grafts, and blood-brain barrier models for neurotherapeutic screening. The 15 most recent articles highlight his work in human pluripotent stem cell (hPSC) differentiation to cardiomyocytes, endothelial cells, and brain mural cells. Key trends include organoid manufacturing , neurovascular unit modeling , metabolic profiling , and biomaterials for cell transport . His team explores Notch3 activation, SNRK signaling, and transcriptional analysis to optimize cell therapy and disease models. Scientific contributions include the Milton J. and A. Maude Shoemaker Professorship, a named chair recognizing his leadership in chemical and biological engineering. For more details, visit his lab’s website: Palecek Lab .

• Avian Virology
• Poultry Health Management
• Infectious Disease Pathogenesis
• +۳ مورد دیگر

Dr. José A. Quinteros is a Lecturer in Poultry Health at the Sydney School of Veterinary Science, University of Sydney. He holds a DVM from the University of Chile (2004), followed by an MVSc and PhD. His career began in 2005 as a field veterinarian at Sopraval S.A., where he specialized in diagnosing and treating prevalent poultry diseases like Fowl Cholera, avian influenza H1N1, and Ornithobacterium rhinotracheale (ORT). He later joined the Quality Assurance team, overseeing national/international regulatory programs. Research focuses on avian virology, including coronaviruses (e.g., infectious bronchitis virus) and bacterial pathogens. His work explores genomics, pathogenesis, and diagnostic tools for poultry diseases. Notable projects include optimizing protein nutrition for poultry resilience in tropical climates (2024 SSEAC Grant) and reconnecting with the Australian poultry industry for critical research (2023 SSVS Grant). He has been featured in media, including an ABC interview (January 2025) discussing avian flu H5N1 in humans. He is a member of the Sydney Southeast Asia Centre and contributes to interdisciplinary collaborations.

Martin Reaneyمشاهده پروفایل

استاد

• Food Science
• Bioengineering
• Lipid Chemistry
• +۳ مورد دیگر

Martin Reaney is a Professor and Ministry of Agriculture Strategic Research Program (SRP) Chair in Lipid Quality and Utilization at the University of Saskatchewan's Department of Food and Bioproduct Sciences, within the College of Agriculture and Bioresources. His research focuses on lipid chemistry, sustainable agriculture, and food technology, particularly in biodiesel production, flaxseed bioactives, and novel food products. Key research interests include optimizing lipid quality through refining techniques (e.g., electrostatic field processing, enzymatic degumming), developing functional food ingredients (e.g., aquafaba-based emulsifiers, flaxseed-derived peptides), and enhancing biofuel production. His work bridges agricultural innovation with industrial applications, emphasizing sustainability and nutritional value. Key Projects: Biodiesel optimization, flaxseed lignan extraction, cyanogenic glycoside removal in flaxseed through fermentation, and electrostatic refining of crude oils. Lab/Affiliations: SRP Chair in Lipid Quality & Utilization, affiliated with the University of Saskatchewan's Ministry of Agriculture initiatives. Contact: martin.reaney@usask.ca | 6E02 Agriculture Building. Publications span lipid processing, food safety, and nutraceutical development, with a focus on interdisciplinary approaches to address global food and energy challenges.

• Neurodegenerative Diseases
• Axonal Transport
• Motor Neurone Disease
• +۳ مورد دیگر

Dr Andrew Grierson is a Senior Lecturer in Neuroscience at the School of Medicine and Population Health, University of Sheffield, based at the Sheffield Institute for Translational Neuroscience (SITraN). His research focuses on molecular mechanisms of neurodegenerative diseases with translational applications. His educational background includes: PhD in Molecular Genetics from the University of Sheffield (1991-1994) BSc in Genetics from the University of Sheffield (1988-1991) Dr Grierson's work centers on axonal transport regulation in motor neurone disease (MND) and hereditary spastic paraplegia (HSP) , utilizing zebrafish and mouse models to investigate disease mechanisms and therapeutic interventions. Current projects include HDAC6 inhibition studies for CMT2A and HSP, C9ORF72 protein function analysis in ALS, and spastin gene replacement therapy development. His laboratory emphasizes preclinical translation with strong industry and charity partnerships. Analysis of his 15 most recent publications (2013-2022) reveals consistent focus on ALS/MND pathophysiology, with increasing emphasis on C9ORF72-related mechanisms , mitochondrial dysfunction , and therapeutic target validation . The work bridges basic molecular neuroscience and clinical applications, predominantly using in vivo models and translational biomarkers . Dr Grierson supervises multiple PhD students and collaborates with Pamela Shaw and Bob Johnston at Sheffield. His research group includes technicians Katie Adamson and Gary Shaw, operating within SITraN's specialized facilities for neurodegenerative disease research.

Andrea N. Kravatsمشاهده پروفایل

دانشیار

• Protein Remodeling
• Protein Quality Control
• Molecular Chaperones
• +۴ مورد دیگر

Andrea N. Kravats is an Associate Professor at Miami University , affiliated with the Department of Chemistry and Biochemistry . Her research focuses on protein folding, quality control, and molecular chaperone mechanisms in cellular environments. Education Ph.D. in Chemistry, University of Cincinnati (2013) Postdoctoral Fellow, National Cancer Institute/National Institutes of Health (2014–2018) B.A. in Chemistry, West Virginia University (2008) Research Interests Chaperone-assisted protein remodeling Endoplasmic reticulum (ER) protein quality control Grp94 chaperone mechanisms Protein-protein interactions Computational modeling and molecular dynamics simulations Contact: kravatan@MiamiOH.edu

Sebastian Klingeمشاهده پروفایل

استاد

• Ribosome Biogenesis
• Structural Biology
• Molecular Machines
• +۴ مورد دیگر

Sebastian Klinge is the Lenore C. Ford Professor at The Rockefeller University , leading the Laboratory of Protein and Nucleic Acid Chemistry . His research focuses on the molecular mechanisms governing eukaryotic ribosome assembly, using structural biology techniques like cryo-electron microscopy and X-ray crystallography. He holds academic roles in the David Rockefeller Graduate Program and Tri-Institutional M.D.-Ph.D./Ph.D. Programs. Education: B.A. in Biochemistry, University of Cambridge (2005) Ph.D. in Biochemistry, University of Cambridge (2009) Postdoc, Swiss Federal Institute of Technology in Zurich (2009–2013) Research Interests: The Klinge lab investigates how ribosomes—the cell’s protein synthesis machines—are assembled from RNA and proteins. Key topics include: Early stages of ribosome biogenesis in Saccharomyces cerevisiae Structural dynamics of nucleolar precursors and multi-protein complexes Mechanisms governing ribosomal subunit maturation and quality control His work combines yeast genetics, biochemical tools, and advanced microscopy to map assembly pathways at near-atomic resolution. Publications: Recent work highlights structural insights into ribosomal subunit precursors and processome assembly, advancing understanding of eukaryotic translational machinery. Awards: Human Frontier Science Program Career Development Award (2014) NIH Director’s New Innovator Award (2016) Alfred P. Sloan Research Fellowship (2014) Advising & Grants: Klinge has mentored researchers in ribosome biogenesis and secured funding through major grants like the NIH New Innovator Award. His lab actively collaborates on projects involving mitoribosome structure and mitochondrial protein synthesis. Labs/Teams: Principal investigator of the Laboratory of Protein and Nucleic Acid Chemistry , integrating structural biology with cellular mechanisms to dissect fundamental aspects of ribosome assembly.

Daniel Gibbsمشاهده پروفایل

استاد

• Molecular Plant Science
• Protein Degradation
• Epigenetics
• +۸ مورد دیگر

Professor Daniel Gibbs is a faculty member at the University of Birmingham, leading the School of Biosciences as a Professor of Molecular Plant Science. He holds roles including Plant Science and Food Security Theme Lead and Deputy Head of Research in the school. His research focuses on plant response mechanisms to environmental stresses, particularly through targeted protein degradation pathways. Gibbs earned his PhD, MSc, and BSc in Biological Sciences (Genetics) from the University of Birmingham, followed by postdoctoral research at the University of Nottingham. He has held prestigious fellowships and established his independent research group in 2013, advancing to full professorship in 2020. Research Interests: Gibbs' lab investigates how plants use protein degradation (e.g., N-degron pathways) to regulate growth, development, epigenomes, and stress tolerance (e.g., flooding). Key areas include oxygen/nitric oxide signaling, chromatin modifications, and meiotic recombination. His work integrates genetic, biochemical, and cell biology approaches, aiming to identify targets for improving crop resilience. Grants & Awards: Gibbs has secured grants from BBSRC, ERC, and others. Notable awards include the 2019 SEB President’s Medal and the 2013 ISPA Outstanding Scientist Award. He chairs BBSRC Strategy Groups and serves as a journal editor and committee member. Education & Teaching: Teaches plant science modules, supervises undergraduate and graduate students, and mentors through programs like findaphd.com. His lab actively engages in training future scientists through hands-on research and academic mentorship.

Bruce A. Hayمشاهده پروفایل

استاد

• Genetic Engineering
• Cellular and Developmental Biology
• Evolutionary Biology
• +۴ مورد دیگر

Bruce A. Hay is a Professor of Biology at the California Institute of Technology (Caltech), affiliated with the Division of Biology and Biological Engineering. He earned his B.A. from Claremont McKenna College (1982) and Ph.D. from the University of California, San Francisco (1989). His research focuses on genetic engineering, mitochondrial quality control, and applied evolutionary biology. Key projects include developing gene drives for population modification (e.g., mosquitoes, citrus psyllids), engineering mitochondrial DNA repair mechanisms, and creating lifetime contraceptives for mammals. Research Themes: Genetic engineering, neurodegenerative diseases, population control, and biotechnology applications. Collaborations: Works with Ming Guo (UCLA Neurology) on mitochondrial dysfunction in Alzheimer’s/Parkinson’s disease. Lab Activities: The Hay Lab develops technologies like vectored contraception (VC) and Cleave and Rescue gene drives for ecological and biomedical applications. Recent work includes a 2024 Nature Plants study on plant gene drives and a 2022 PNAS publication on population elimination strategies for conservation. He also pioneered the SKIES learning system to enhance student engagement and co-founded the Community Science Academy (CSA@Caltech) to advance accessible science education. Grants: Principal Investigator on a Camille and Henry Dreyfus Foundation grant (2014-2015) supporting high school science initiatives and portable molecular sensors.

Javier Caceresمشاهده پروفایل

استاد

• Gene expression
• RNA biology
• Nonsense-mediated decay
• +۲ مورد دیگر

Javier Caceres is a Professor of RNA and Gene Expression holding a Personal Chair at the MRC Human Genetics Unit within the Institute of Genetics and Molecular Medicine (IGMM) at the University of Edinburgh. He has served as Head of the Genome Regulation Section since 2015, leading research on RNA-mediated genetic mechanisms. His educational background includes a Ph.D. in Molecular Biology (1989) and an MSc. in Biology (1985), both obtained from the University of Buenos Aires. These degrees established his foundation in molecular genetics before his postdoctoral work at Cold Spring Harbor Laboratory and the University of Wisconsin-Madison. Dr. Caceres' research centers on RNA biology with emphasis on post-transcriptional gene regulation. His work investigates alternative splicing mechanisms, nonsense-mediated decay pathways, microRNA functions, and RNA-protein interactions. These studies provide critical insights into genetic disorders and potential therapeutic targets, particularly in splicing-related diseases. His experimental approaches combine biochemical, genomic, and cellular techniques to dissect RNA regulatory networks. Analysis of his publication record reveals consistent focus on RNA processing mechanisms across three decades. His work demonstrates evolving technical sophistication from foundational splicing studies to contemporary systems-level analyses of RNA regulation, with sustained contributions to understanding how RNA dysregulation causes human disease. Key themes include RNA-binding proteins, mRNP dynamics, and quality control pathways. His major scientific recognitions include: Election as Fellow of the Royal Society of Edinburgh (FRSE) in 2011 Award of the Wellcome Trust Senior Investigator Award in 2011 Membership in the European Molecular Biology Organization (EMBO) since 2008 Dr. Caceres actively shapes scientific discourse through editorial leadership as Associate Editor of RNA (since 2011) and service on editorial boards of EMBO Journal and Nucleic Acids Research. He has evaluated research proposals for major funding bodies including the European Research Council (ERC Starting Grants panel), German Research Foundation (DFG), and Swiss National Foundation, focusing on molecular biology and RNA research initiatives. He directs the Genome Regulation Section at the MRC Human Genetics Unit, where his team employs cutting-edge methodologies to investigate RNA-mediated gene regulation mechanisms and their roles in human disease pathogenesis.

Thomas V. O'Halloranمشاهده پروفایل

استاد

• Metallomics
• Metal Regulation
• Cancer Therapeutics
• +۴ مورد دیگر

Thomas V. O'Halloran is the Morrison Professor of Chemistry at Northwestern University, holding dual appointments in Molecular Biosciences and the Chemistry of Life Processes Institute (CLP). He directs the CLP Institute and serves as Associate Director of Basic Sciences at the Robert H. Lurie Comprehensive Cancer Center. His research integrates bioinorganic chemistry with molecular biology to study transition metal (zinc, copper, iron) regulation in biological systems. Dr. O’Halloran earned his B.S. from the University of Missouri (1979) and Ph.D. from Columbia University (1985). His work focuses on metalloregulatory proteins, metallochaperones, and metallome dysregulation in disease. Notable contributions include discovering zinc sparks during fertilization, developing arsenoplatin anticancer complexes, and pioneering nanobin drug delivery systems. Research interests span metallomics, metal trafficking in cancer, and zinc's role in developmental processes. His lab employs interdisciplinary methods: X-ray crystallography, fluorescence microscopy, ICP-MS metallomics, and nanoparticle engineering. Key projects include targeting ovarian cancer with uPA-receptor nanobins and understanding copper homeostasis in fungal pathogens. Education: B.S. University of Missouri (1979), Ph.D. Columbia University (1985) Affiliations: CLP Institute, Robert H. Lurie Cancer Center Key Techniques: Metal speciation analysis, nanoparticle synthesis, live-cell imaging His 150+ publications span Science , Nature Chemistry , and Angewandte Chemie . Awards include the Royal Society of Chemistry Dalton Award and NIH MERIT award.