جست‌وجوی استاد و پژوهشگر

• Developmental Biology
• Neurosciences
• Dopamine Neurons
• +۴ مورد دیگر

Thomas Perlmann is a Professor in Molecular Developmental Biology at the Karolinska Institutet , leading research at the Department of Cell and Molecular Biology and serving as Director of the Stockholm Branch of the Ludwig Institute for Cancer Research. He also holds the position of Secretary General of the Nobel Assembly and Nobel Committee for Physiology or Medicine since 2016. Ph.D. , Karolinska Institutet, 1991 M.Sc. , Stockholm University, 1987 Research Interests : The Perlmann lab investigates the specification and maintenance of dopamine neurons in the central nervous system, with a focus on transcriptional regulation , signaling pathways , and regenerative medicine applications for Parkinson’s disease and other neurodegenerative disorders. His work bridges developmental biology and neuroscience , emphasizing the role of transcription factors in neuronal identity and function. Recent Research Trends : Perlmann’s recent publications highlight the use of single-cell RNA sequencing to dissect dopamine neuron heterogeneity , epigenetic regulation during development, and transcriptomic changes in Parkinson’s disease models. His studies increasingly leverage multiomics and bioinformatics to map neuronal lineage trajectories and gene expression dynamics. Scientific Awards : Royal Medal by HM the King (2025) Nicholson Lecturer, Rockefeller University (2011) Göran Gustafsson Prize in Molecular Biology (1999) Eric K. Fernström Young Investigator Prize (1997) Advising & Collaborations : While no student names are explicitly listed, Perlmann collaborates extensively with researchers such as Malin Parmar , Agnete Kirkeby , and Per Svenningsson on projects related to neuronal development and cell therapy . His lab receives funding from institutions like the Ludwig Institute for Cancer Research . Labs & Teams : The Perlmann Lab at Karolinska Institutet includes researchers like Linda Gillberg , Laura Lahti , and Behzad Yaghmaeian Salmani , who work on mouse models , single-cell transcriptomics , and bioinformatics to study dopamine neuron biology.

Marc V Fuccilloمشاهده پروفایل

دانشیار

• Synaptic transmission
• striatal circuits
• inhibition
• +۹ مورد دیگر

Marc V Fuccillo is an Associate Professor of Neuroscience at the Perelman School of Medicine, University of Pennsylvania, where he leads a research laboratory focused on understanding the neural circuit mechanisms underlying behavioral control. His work bridges molecular, synaptic, and behavioral approaches to investigate how striatal circuits regulate mouse behavior from simple motor patterns to complex goal-directed actions. Fuccillo holds dual appointments in the Neuroscience and Cell and Molecular Biology Graduate Groups at Penn and maintains an active laboratory investigating the synaptic and circuit basis of neuropsychiatric disorders. Education: B.A. in Molecular and Cellular Biology and Music Performance (Violin) from Brown University (1998) Ph.D. in Developmental Genetics from New York University School of Medicine (2007) M.D. from New York University School of Medicine (2008) Fuccillo's research centers on the synaptic and circuit mechanisms of behavioral control, with particular emphasis on striatal circuits. His laboratory employs a range of technologies including mouse genetics, in vitro electrophysiology, in vivo imaging, and quantitative behavioral analysis to explore how neural circuits of the striatum regulate behavior and how disruptions in these circuits contribute to neuropsychiatric disorders. His work has particularly focused on autism-associated abnormalities in behavioral control, examining how synaptic adhesion molecules like neuroligins and neurexins shape circuit function and behavior, with significant findings regarding D1 dopamine receptor positive medium spiny neurons in the nucleus accumbens. Analysis of Fuccillo's recent publications reveals a strong focus on striatal circuit function across multiple dimensions. His work spans molecular neuroscience (examining synaptic adhesion molecules), cellular physiology (studying specific neuron types in striatal circuits), systems neuroscience (mapping circuit connectivity), and behavioral neuroscience (quantifying motor learning and decision-making). A unifying theme is how disruptions in specific molecular pathways lead to circuit-level abnormalities that manifest as behavioral phenotypes relevant to neuropsychiatric disorders, with particular attention to autism, OCD, and schizophrenia models. Scientific Recognition: Publications in high-impact journals including Nature Neuroscience, Current Biology, Cell Reports, and Neuron Research supported by multiple NIH grants including NIMH F32, NIMH K01, and HHMI Gilliam Fellowship awards for lab members Fuccillo actively mentors a diverse group of trainees including postdoctoral fellows, graduate students, and undergraduates. His laboratory has produced numerous successful alumni who have gone on to faculty positions, medical residencies, and graduate programs at prestigious institutions. His mentoring approach emphasizes technical skill development across multiple neuroscience disciplines while fostering independent scientific thinking. Current research in his lab is supported by NIH funding focused on understanding the molecular architecture of striatal circuits and their role in behavioral control, with three major research directions exploring molecular logic of striatal circuits, circuit mechanisms of behavioral control, and striatal dysfunction in neuropsychiatric disease models. The Fuccillo Laboratory operates within the Department of Neuroscience at the University of Pennsylvania, with access to state-of-the-art facilities for molecular, electrophysiological, imaging, and behavioral neuroscience research. The lab maintains active collaborations with other neuroscience research groups at Penn and beyond, creating a rich intellectual environment for studying the neural basis of behavior. Current research directions include investigating whether there is a molecular logic to striatal circuit composition, how striatal circuits shape behavioral control, and what mouse models of autism, schizophrenia, and OCD can reveal about striatal circuit dysfunction in disease pathophysiology.

Omer Bayraktarمشاهده پروفایل

پژوهشگر

• Neural Diversity
• Spatial Transcriptomics
• Glia Biology
• +۳ مورد دیگر

Omer Bayraktar is a Group Leader at the Wellcome Sanger Institute , leading research in the Cellular Genomics Programme. His work focuses on decoding human brain cellular diversity using spatial transcriptomics , imaging , and functional screening to study neural complexity in health and disease. Bayraktar's educational background includes a PhD from HHMI under Chris Doe, investigating neural diversity development in Drosophila , followed by postdoctoral work at University of California, San Francisco and University of Cambridge as a Life Sciences Research Foundation Fellow. He developed a spatial transcriptomic pipeline during his postdoc to analyze astrocyte heterogeneity in the cerebral cortex. His research explores neural cell type mapping , glial-neuronal interactions , and cellular pathways in neurodevelopmental disorders . Recent publications emphasize 3D tissue mapping , multi-omic integration , and computational tools like Cell2fate and WebAtlas. His work bridges neurogenetics and computational biology to advance understanding of human tissue ecosystems. Bayraktar's lab collaborates with the Human Cell Atlas initiative and develops technologies such as automated histology pipelines and highly-multiplexed smFISH for molecular cell typing. His team also investigates glia-based therapies and astrocyte functional heterogeneity in neurodevelopmental contexts. Key scientific contributions include: Discovering astrocyte layer patterns independent of neuronal laminae Developing cell2location for spatial cell mapping Characterizing Drosophila neural stem cell models with human relevance Notable awards include the Life Sciences Research Foundation Fellowship during his postdoctoral training. His current group includes a PhD student , Senior Data Scientists , and Bioinformaticians .

Xiaoyu Caiمشاهده پروفایل

استادیار

• Lung Regeneration
• Inflammation Resolution
• Aging Biology
• +۵ مورد دیگر

Xiaoyu Cai is an Assistant Professor at the Department of Medicine, Loyola University Chicago, specializing in lung regeneration, aging biology, and stem cell plasticity. Her research focuses on the molecular mechanisms governing alveolar type 2 (AT2) stem cell dynamics during aging and chronic lung diseases. Education: Bachelor of Medicine (Peking University, 2012), Master of Science (Peking University, 2015), PhD in Biology of Aging (USC & Buck Institute, 2021) Key Research Areas: Lung regeneration, inflammation resolution, stem cell aging, 3D organoid cultures Methodologies: Single-cell multiome, mouse genetics, multicellular organoid systems Collaborations: Translational partnerships with clinical teams for bench-to-bedside applications Dr. Cai's recent work explores lineage plasticity in aged lung stem cells, ferroptosis suppression via CRISPR screens, and cellular aging atlases across species. She previously held a postdoctoral position at Genentech Inc. and maintains a professional lab website. Contact: xcai2@luc.edu | Office: CTRE 123

Celeste Saguiمشاهده پروفایل

استاد

• Computational Biophysics
• Biomolecular Simulations
• Free Energy Methods
• +۵ مورد دیگر

Celeste Sagui is a Professor in the Department of Physics at North Carolina State University (NC State), affiliated with the College of Sciences. She holds additional roles as a faculty affiliate in Genomics Sciences at NC State and is a member of the Center for High Performance Simulation. Her research focuses on computational biophysics, biomolecular simulations, and free energy methods applied to nucleic acid structures, protein dynamics, and nanotechnology systems. She has contributed to the AMBER simulation package development, co-authoring versions from 10 to 14. Education: Doctorate in Physics, University of Toronto (1995) Licentiate degree, National University of San Luis, Argentina Research Interests: Sagui’s work explores DNA/RNA structure and phase transitions, electrostatic interactions, and methodologies for large-scale molecular simulations. Recent studies include nucleic acid hairpin instabilities linked to neurodegenerative diseases, polyglutamine aggregation mechanisms, and novel DNA motifs like the eGZ structure in Z-DNA. She employs quantum chemistry, density functional theory, and phase-field models to investigate systems ranging from biomolecules to nanomaterials. Publications: Her recent work emphasizes nucleic acid dynamics, free energy landscapes, and computational methods for studying diseases such as Friedreich’s ataxia and polyglutamine disorders. Key contributions include advancements in laser-driven simulations and infrared spectroscopy analysis of protein structures. Labs/Teams: Active in the Center for High Performance Simulation, focusing on high-throughput computational modeling and collaborative software development for biomolecular research.

Chen Ranمشاهده پروفایل

استادیار

• Interoceptive Processing
• Neurophysiology
• Brainstem Function
• +۵ مورد دیگر

Chen Ran, PhD, is an Assistant Professor in the Department of Neuroscience at Scripps Research in San Diego. His laboratory focuses on understanding how the brain processes internal sensory signals from visceral organs, such as hunger, satiety, nausea, and visceral pain. Using advanced techniques like in vivo two-photon calcium imaging, optogenetics, and circuit tracing, his team maps the functional architecture of brainstem circuits responsible for interoceptive processing. Key contributions include the discovery of a 'visceral homunculus' in the brainstem and the development of novel calcium indicators for high-resolution neuronal activity tracking. Education : PhD in Biology, Stanford University (2017) Bachelor of Science in Biology, Peking University (2011) Research Interests : Dr. Ran’s work integrates experimental and analytical approaches to decode how visceral stimuli are transduced into conscious sensations. Current projects investigate the coding logic of mechanical, chemical, and thermal signals from internal organs, with implications for developing therapies for obesity, diabetes, visceral pain, and eating disorders. The lab employs cutting-edge tools to visualize and manipulate neural circuits in awake behaving mice, linking circuit-level activity to physiological states. Awards & Honors : NARSAD Young Investigator Award (2022) NIH K01 Career Development Award (2023) Simons Collaboration on the Global Brain Award (2022) Harvard Brain Science Initiative Award (2021) Grants & Funding : Supported by NIH, Simons Foundation, and private philanthropy, his research bridges basic science and translational medicine. Current grants focus on brainstem circuit mapping and developing therapeutic targets for interoceptive disorders. Labs & Affiliations : Dr. Ran leads an interdisciplinary team at Scripps Research’s Neuroscience Department, collaborating with engineers, geneticists, and clinicians to advance interoceptive neuroscience.

David Junckerمشاهده پروفایل

استاد

• Microfluidics
• Nanotechnology
• Lab-on-a-Chip
• +۶ مورد دیگر

David Juncker is a Professor and Department Chair of the Department of Biomedical Engineering at McGill University. He serves as a Principal Investigator at the McGill University & Genome Quebec Innovation Centre and holds associate memberships in the Department of Neurology and Neurosurgery, Department of Electrical and Computer Engineering, Division of Experimental Medicine, Department of Surgery, and Goodman Cancer Research Centre. His research focuses on micro- and nano-bioengineering technologies for bioanalysis, precision medicine, and organs-on-chips. Key areas include microfluidics, lab-on-a-chip devices, biomedical sensors, medical diagnostics, biomaterials, tissue engineering, and cancer biomarker discovery. His lab develops scalable antibody microarrays, self-powered diagnostic platforms, microfluidic probes for brain tissue perfusion, and nanogradients for neuronal navigation, with applications in cancer diagnostics, global health, and neuroscience. Recent publications (2023-2025) reveal strong emphasis on extracellular vesicle analysis, single-cell proteomics, 3D-printed microfluidic/organ-on-a-chip systems, and capillary-driven circuits. Key trends include low-cost point-of-care diagnostics, advanced circulating tumor cell isolation methods, and biomimetic synthetic vesicles for drug delivery, demonstrating translational potential in early disease detection. Dr. Juncker leads a highly interdisciplinary team comprising undergraduate and graduate students, post-doctoral fellows, and staff from diverse scientific, engineering, and cultural backgrounds. His lab actively recruits Canadian/permanent resident graduate students for projects on single extracellular vesicle and protein detection in cancer and infectious diseases, leveraging microfluidics and wearables for biomarker discovery. The Juncker Lab operates from the McGill University & Genome Quebec Innovation Centre (740 Dr. Penfield Avenue, Room 6206). It maintains a collaborative, multicultural environment focused on developing transformative micro- and nano-bioengineering technologies with significant potential impact on human health diagnostics and treatment.

Ruben Portuguesمشاهده پروفایل

استاد

• Neuroscience
• Systems Neuroscience
• Behavioral Neuroscience
• +۷ مورد دیگر

Ruben Portugues is a Professor of Brain Circuit Function and Dysfunction at the Institute of Neuroscience, Technical University of Munich (TUM). He is a full member of the Graduate School of Systemic Neurosciences (GSN), an associate and advisory board member of the Munich Center for Neurosciences (MCN), and leads a research group focused on understanding the neural basis of behavior. His lab uses larval zebrafish as a model organism to investigate sensorimotor control, decision-making, and motor learning through whole-brain imaging and circuit analysis. His research interests lie at the intersection of systems neuroscience and behavior. He investigates how brain circuits process sensory information, integrate it with motor output, and enable adaptive and flexible behavior. Key areas include the function of the cerebellum, heading direction networks, sensorimotor transformations, and the neural mechanisms of decision-making. His lab employs cutting-edge techniques including custom-built microscopes, behavioral assays, and computational analysis. The recent publications and preprints from his lab demonstrate a strong trend in decoding distributed neural circuits underlying navigation and decision-making in zebrafish. There is a clear focus on identifying specific brain regions (e.g., interpeduncular nucleus, cerebellum) and cell types involved in processing visual, motor, and spatial information. The work increasingly emphasizes whole-brain functional imaging and the emergence of cognitive-like representations such as allocentric heading direction. FENS-Kavli Network of Excellence (FKNE) PhD Thesis Prize (awarded to student Luigi Petrucco) Ruben Portugues actively mentors PhD students, including current advisees Luigi Petrucco, Ot Prat, and Shuhong Huang, and has successfully graduated Dr. Elena Dragomir and Dr. Vilim Štih. His lab engages in extensive collaborations, hosts visiting researchers, participates in teaching (e.g., CSHL Imaging Course, Cajal Course), and secures resources for advanced research. The lab is known for building its own microscopes and software, fostering technical innovation. The Portugues Lab operates as a dynamic, interdisciplinary team that combines experimental neuroscience with computational and engineering approaches. They regularly hold retreats, participate in scientific events, and contribute to community initiatives like the Munich Brain Day. The lab is preparing to relocate to the Department of Neurobiology and Behavior at Cornell University, marking a new phase in its research trajectory.

Ralph Bockمشاهده پروفایل

استاد

• Plant Molecular Biology
• Chloroplast Biology
• Organelle Biotechnology
• +۷ مورد دیگر

Prof. Dr. Ralph Bock serves as Director of Department 3: Organelle Biology, Biotechnology and Molecular Ecophysiology at the Max Planck Institute of Molecular Plant Physiology in Potsdam, Germany, where he also leads the Organelle Biology and Biotechnology research group. Previously, he held positions as C4 Professor for Plant Biochemistry and Biotechnology at the University of Münster (2001-2004) and Group Leader at the Institute of Biology III, University of Freiburg (1996-2001). His academic credentials include: Habilitation: University of Freiburg, 1999 Doctorate: University of Freiburg, 1996 Diploma: University of Halle, 1993 Prof. Bock's research focuses on plant molecular biology with particular emphasis on chloroplast biology, organelle biotechnology, and molecular ecophysiology. His work spans genetic engineering of plastids, photosynthesis research, plant biotechnology applications, and understanding organelle-nucleus communication. He has made significant contributions to developing chloroplast transformation systems and applying them to molecular farming, metabolic engineering, and understanding fundamental processes in plant cell biology. His research has important implications for sustainable agriculture, bioenergy, and pharmaceutical production, particularly through the development of plant-based systems for producing vaccines and therapeutic proteins. Analysis of Prof. Bock's recent publications (2023-2025) reveals a strong focus on chloroplast biology, genetic engineering, and molecular farming applications. His work spans fundamental research on organelle genetics, photosynthesis, and stress responses, as well as applied research on using plant and algal systems for biopharmaceutical production. A notable trend is the increasing use of advanced genetic engineering techniques, including CRISPR-based approaches, to manipulate organelle genomes. His research also shows growing interest in algal systems as alternative expression platforms for molecular farming, particularly red algae like Porphyridium for producing viral antigens and glycoproteins.

Anna Mathia Klawonnمشاهده پروفایل

دانشیار

• Neuroscience
• Neuroimmunology
• Affective Disorders
• +۶ مورد دیگر

Anna Mathia Klawonn is an Associate Professor affiliated with three units at Aarhus University: the Danish Research Institute of Translational Neuroscience (DANDRITE), the Department of Biomedicine, and the Department of Molecular Biology and Genetics - Neurobiology. As a group leader at DANDRITE, she explores neural circuits and immune-to-brain signaling mechanisms regulating affective states through transgenic strategies and neurocircuitry techniques. Neuroscience Neuroimmunology Immune-to-Brain Signaling Affective Disorders Her research focuses on understanding how brain circuits and glial cells (microglia and astrocytes) contribute to affective states in both health and disease. Current projects investigate mechanisms in major depressive disorder and Parkinson's disease, emphasizing prostaglandin signaling, nicotinic receptor function, and striatal neuron modulation. Recent publications highlight her work in molecular neuroscience, neuropharmacology, and behavioral neuroscience. Key themes include cholinergic transmission in motivation, neuroimmune interactions in aversion, and reward/aversion circuitry. Her studies employ advanced neurocircuitry methods and transgenic models. In teaching, Klawonn is course responsible for the 3rd-semester Neuroscience course (10 ECTS) in the medical bachelor program. She actively engages in didactic development, frequently speaking about student motivation, flipped learning, and challenge-based learning. Klawonn leads the Klawonn Group at DANDRITE, with lab and office spaces in the Skou Building (Høegh-Guldbergs Gade 10, Aarhus C). Her work involves collaborations across neuroscience, neuroimmunology, and affective disease research.

Sudin Bhattacharyaمشاهده پروفایل

دانشیار

• Systems Toxicology
• Computational Biology
• Gene Expression Analysis
• +۳ مورد دیگر

Sudin Bhattacharya is an Associate Professor at the BioMolecular Science Gateway, Michigan State University, with affiliations in the Genetics & Genome Sciences Program and Cell & Molecular Biology Program. His research bridges computational biology and toxicology to understand complex biological systems. Email: sbhattac@msu.edu Research Interests Dr. Bhattacharya specializes in systems toxicology, focusing on computational modeling of gene regulatory networks, single-cell transcriptomics, and molecular dynamics in response to environmental toxicants. His work examines how chemical exposures disrupt cellular pathways and contribute to disease mechanisms. Article Trends His recent publications emphasize: Single-cell and single-nucleus RNA sequencing for toxicological profiling Computational models of circadian rhythms and intercellular communication Dose-dependent responses to environmental chemicals like TCDD and heavy metals Mechanistic studies of adipose tissue remodeling and hypertension Applications of machine learning in chemical risk assessment Integrative approaches to liver metabolism and disease modeling Scientific Contributions Dr. Bhattacharya has pioneered multiscale modeling of biological systems, particularly in hepatic and vascular contexts. His work on the aryl hydrocarbon receptor and PPARα signaling networks has advanced predictive toxicology frameworks.

• Auditory Neuroscience
• Neuromodulation
• Neuronal Excitability
• +۴ مورد دیگر

Dr. Conny Kopp-Scheinpflug is an Associate Professor (PD) at the Faculty of Biology, Ludwig Maximilian University of Munich, where she leads a research group focused on auditory neuroscience. Her laboratory investigates the function and mechanisms of activity-dependent neuromodulation in the mammalian auditory system, with particular interest in how ambient sensory stimulation activates neuromodulators and how these influence neural processing of relevant information. Dr. Kopp-Scheinpflug's research spans auditory neuroscience, neuromodulation, neuronal excitability, and synaptic transmission. She employs electrophysiological (single cell in vivo and patch clamp in brain slices), anatomical, and optogenetic techniques to study how hyper- or hypo stimulation lead to acquisition or loss of function in the auditory system. Her work has significant implications for understanding and potentially treating functional disorders of neuronal excitability. Current research examines potassium channels, nitric oxide signaling, and neuromodulators like urocortin 3 in auditory processing. Analysis of Dr. Kopp-Scheinpflug's recent publications (2016-2022) reveals consistent focus on auditory processing mechanisms, particularly potassium channels (Kv3.1, Kv3.3, Kv1.1), nitric oxide signaling, and activity-dependent changes in myelination. Her research spans molecular mechanisms to systems-level auditory processing, with emphasis on sound localization, temporal processing, and recovery from hearing impairment. Key findings include how sound-evoked activity influences myelination, how nitric oxide regulates postsynaptic excitability, and how urocortin 3 aids hearing recovery. Dr. Kopp-Scheinpflug has secured funding from multiple research agencies. She maintains active collaborations with researchers at Lehigh University (Michael Burger Lab), University of Edinburgh (Matthias Hennig Lab), Ben-Gurion University of the Negev (Michal Hershfinkel Lab), and UCL (Dr. Jennifer Linden). Her laboratory currently includes Ezhilarasan Rajaram, Dr. Mihai Stancu, Oskar Kalle Juhani Markkula, Sara Pagella, and Katharine Krueger. Past lab members who have completed their training include Dr. James Sinclair, Dr. Matthew Fischl, Max Bayer, Alkmini Damkou, Alyahyay Mansour, Leander Mrowka, Joseph Kroeger, and Myriam Schmidt-Pauly.

Ashutosh Agrawalمشاهده پروفایل

استاد

• Biophysics
• Materials Science
• Mechanics
• +۴ مورد دیگر

Ashutosh Agrawal is a Professor at Texas A&M University whose research bridges biophysics and materials science. He leads the "Life at the Interface" research group, investigating engineering principles governing two-dimensional structures through the interplay of mechanics, geometry, and electrostatics. His work spans lipid-protein interactions in neurons to biomimetic topological materials design. His academic credentials include: Ph.D. in Civil and Environmental Engineering from University of California, Berkeley (2009) Master of Science in Civil and Environmental Engineering from Rice University (2003) Bachelor of Technology in Civil Engineering from Indian Institute of Technology Bombay (2001) Dr. Agrawal's research focuses on the mechanical behavior of biological interfaces with particular emphasis on: Electromechanics of Neuronal Signaling Interfacial Mechanics of Cellular Organelles Mechanics of Cellular Transport Electromechanics of Topologically Complex Plates and Shells His methodology integrates mathematical modeling, atomistic simulations, Monte Carlo techniques, and finite element analysis to explore cellular membrane functionality and develop novel biomaterials. Analysis of his 2015-2023 publications reveals consistent exploration of electromechanical phenomena in cellular structures, with recurring themes in lipid bilayer transitions, organelle dynamics, and topological material design. These works demonstrate interdisciplinary convergence between fundamental biophysics and engineering applications. His recognition includes: Teaching Excellence Award from University of Houston (2015) As an educator, he develops innovative teaching methodologies promoting hands-on learning of engineering principles across disciplines. While specific advisees aren't listed, his research group actively pursues collaborative projects in cellular biophysics and materials engineering. The "Life at the Interface" laboratory serves as an interdisciplinary hub investigating mechanical principles of cellular structures through computational and theoretical approaches.

Maria Hondeleمشاهده پروفایل

استادیار

• Membraneless Organelles
• Biomolecular Condensates
• Liquid-Liquid Phase Separation
• +۷ مورد دیگر

Maria Hondele is a Tenure-track Assistant Professor at the Biozentrum, University of Basel, Switzerland, where she leads a research group dedicated to understanding the formation, regulation, and function of membraneless organelles, particularly those associated with RNA processing. Her interdisciplinary work bridges biochemistry, biophysics, and cell biology to dissect how RNA-protein condensates influence gene expression. Her research focuses on liquid-liquid phase separation and the role of DEAD-box ATPases as master regulators of biomolecular condensates. She investigates how these dynamic structures control RNA flux, processing, and localization within cells. Her lab employs a multidisciplinary approach including biochemical reconstitution, biophysical measurements, high-throughput screening, and advanced imaging techniques to uncover the molecular mechanisms underlying condensate formation and function. The recent publications of her group reveal a strong thematic focus on RNA-protein interactions, phase separation, stress granules, and the enzymatic regulation of condensates by ATPases. These studies span model systems from synthetic coacervates to human cells, reflecting a comprehensive strategy to understand both fundamental principles and biological implications of membraneless organelles. ERC Starting Grant (2020) SNSF Eccellenza Professorship (2019) HFSP Long-Term Postdoctoral Fellowship (2015–2018) ETH and EMBO Postdoctoral Fellowship (2015) PhD Prize, University of Munich (2014) Boehringer Ingelheim PhD Fellowship (2008–2011) Dr. Hondele advises a vibrant team of postdoctoral fellows, PhD students, and master’s students, indicating an active and expanding research program. She has secured competitive grants and leads a productive research group contributing significantly to the field of RNA biology and cellular organization. She is also an Associate Member of the National Center of Competence in Research (NCCR) RNA & Disease, reflecting her integration into major national research initiatives. Her research group is embedded within the Biozentrum, a leading interdisciplinary research center at the University of Basel, providing access to state-of-the-art facilities and collaborative networks in molecular and cellular biology.

Maxim Artyomovمشاهده پروفایل

استاد

• Systems Immunology
• Immunometabolism
• Cancer Immunology
• +۲ مورد دیگر

Maxim Artyomov is an Alumni Endowed Professor and Professor of Pathology and Immunology at Washington University School of Medicine , with affiliations to the Institute of Clinical and Translational Sciences (ICTS), Bursky Center for Human Immunology & Immunotherapy Programs (CHiiPs), and Siteman Cancer Center. His research spans Systems Immunology , Immunometabolism , and Cancer Immunology , focusing on integrating epigenetic, transcriptional, and metabolic regulation in immune cells. 2018 promoted to Associate Professor with Tenure 2017 awarded LEAP Inventor Challenge 2018 Unanue Prize for Innovative Research in Immunology Key research contributions include: Discovery of itaconate's anti-inflammatory role (2016) Metabolic reprogramming in macrophage polarization (2015) TREM2's function in microglial metabolic fitness (2017) Development of CORESH gene signature search engine (2025) His high-throughput omics pipelines enable cross-disciplinary analysis of immune responses in tuberculosis, Alzheimer's, and cancer. Notable collaborations include work with Schreiber's lab on immune checkpoint therapy (2018) and ITMO University on systems biology workshops (2017-2018). Awards and grants include the Unanue Prize (2018), LEAP Inventor Challenge (2017), and R01 grant from NIAID (2017). He mentors PhD/MSTP students and co-organizes international systems biology workshops.