جستجوی استاد راهنمای دانشگاهی

Kimberly M. Alongeمشاهده پروفایل

استادیار

• Glycobiology
• Neuroscience
• Diabetes
• +۶ مورد دیگر

Kimberly M. Alonge is an Assistant Professor in the Department of Medicinal Chemistry at the University of Washington School of Pharmacy, with dual affiliation in the Division of Metabolism, Endocrinology, and Nutrition (DOM). She serves as Program Director for Matrix Biology at the UW Medicine Diabetes Institute and is faculty at the Plein Center for Aging. Her educational background: B.S. in Biology, Salisbury University Ph.D. in Biochemistry and Molecular Biology, West Virginia University School of Medicine Postdoctoral training at UW Medicine Diabetes Institute, University of Washington Dr. Alonge's research centers on glycobiology and extracellular matrix dynamics , with emphasis on perineuronal net reorganization, glycosaminoglycan sulfation patterning, and glycan sequencing technology. Her work bridges neuroscience (Alzheimer's, neurodegeneration), metabolic disorders (diabetes, obesity), and translational applications using advanced techniques like laser capture microdissection and mass spectrometry. Analysis of her 13 recent publications (2021-2025) reveals three dominant themes: (1) Perineuronal net alterations in Alzheimer's pathology across species, (2) Chondroitin sulfate sulfation signatures in metabolic and inflammatory diseases, and (3) Extracellular matrix roles in immune regulation and cancer. Her work demonstrates how glycan modifications serve as critical biomarkers and therapeutic targets. Dr. Alonge currently does not take students but mentors through the Alonge Lab , which collaborates with the Plein Center for Aging, UW Medicine Diabetes Institute, and CHOICE Institute. Her research is supported by institutional frameworks including the Matrix Biology Program and Washington Entrepreneurial Research Evaluation and Commercialization Hub (WE-REACH).

Fanxin Longمشاهده پروفایل

استاد

• Skeletal Development
• Bone Disorders
• Metabolic Regulation
• +۷ مورد دیگر

Fanxin Long, Ph.D., is a Professor of Orthopaedic Surgery at the University of Pennsylvania's Perelman School of Medicine, holding the William Wikoff Smith Endowed Chair in Pediatric Genomic Research at The Children's Hospital of Philadelphia. His research focuses on skeletal development, metabolic and epigenetic regulation of bone cells, and pathologies like diabetic osteopenia and osteoarthritis. Education: B.S. in Cell Biology, Peking University (1988) M.A. in Biochemistry and Molecular Biology, University of California, Santa Barbara (1992) Ph.D. in Developmental Biology, Tufts University School of Medicine (1997) Research Interests: The Long Lab investigates molecular mechanisms of skeletal development and diseases, emphasizing developmental signals (Hh, Wnt, Notch, Bmp) and their metabolic reprogramming roles. Key areas include osteoblast differentiation , diabetic osteopenia , osteoporosis , and skeletal aging , using mouse genetics and single-cell sequencing . Recent Publication Trends: Recent studies highlight metabolic pathways (glycolysis, glutamine catabolism, mitochondrial oxidation) in skeletal health, with applications in diabetes-induced bone loss , osteoarthritis , and anti-sclerostin therapy . Collaborative work explores Wnt7b and HIF1 as therapeutic targets, alongside biomaterials for RNA delivery. Honors: William Wikoff Smith Endowed Chair in Pediatric Genomic Research Labs & Collaborations: The Long Lab combines genetic lineage tracing with biochemical studies to uncover skeletal stem cell contributions to bone pathology. Collaborative projects include work on metabolic signaling and therapeutic interventions for bone disorders.

Carla R Scanzelloمشاهده پروفایل

دانشیار

• Osteoarthritis
• Synovial Inflammation
• Immunology
• +۵ مورد دیگر

Carla R. Scanzello, MD, PhD, is an Associate Professor of Medicine (Rheumatology) at the University of Pennsylvania's Perelman School of Medicine. She holds affiliations with the Penn Institute for Immunology, Penn Center for Musculoskeletal Disorders, and Penn Institute for Translational Medicine and Therapeutics. Additionally, she serves as a Staff Physician at the Corporal Michael J. Cresenz VA Medical Center, where she co-directs the Translational Musculoskeletal Research Center and is Associate Director of the VA RR&D CReATE Motion Center. Education: B.S. in Biochemistry, University of Delaware (1991) Ph.D. in Immunology & Microbiology, Temple University School of Medicine (2001) M.D., Temple University School of Medicine (2001) Her research expertise centers on synovial inflammation in osteoarthritis (OA) and post-traumatic joint injury. She investigates molecular pathways like Toll-like receptors and chemokine signaling, aiming to develop anti-inflammatory therapies. Her work bridges clinical observations with preclinical models to understand how immune activation drives pain and structural degeneration. Recent publications (2023-2025) focus on CD14's role in OA pain and bone remodeling, novel therapeutic targets (e.g., RHO/ROCK pathway), advanced imaging techniques for synovial analysis, and translational challenges in OA drug development. Key themes include neuroimmune interactions, mechanobiology, and standardization of disease models. Laboratory & Teams: Dr. Scanzello leads the Scanzello Laboratory for Osteoarthritis Research, emphasizing bedside-to-bench approaches. She collaborates with multidisciplinary teams at Penn and the VA to explore immune mechanisms in joint degeneration. Current projects include defining synovial macrophage diversity, CD14 inhibition strategies, and vascular interactions in joint injury. The lab actively recruits postdoctoral fellows and research assistants to advance these initiatives.

Kathrin Plathمشاهده پروفایل

استاد

• Stem Cell Biology
• Epigenetics
• Gene Regulation
• +۵ مورد دیگر

Kathrin Plath, Ph.D., is a Professor and Vice Chair in the Department of Biological Chemistry at the David Geffen School of Medicine, University of California, Los Angeles (UCLA) . Her research focuses on epigenetic regulation of cell fate transitions, particularly in stem cell biology, reprogramming, and X-chromosome dynamics. Education: Ph.D., Biochemistry, Humboldt University, Germany (1999) Post-doctoral Fellowships: Stem Cell Biology (Whitehead Institute, 2006), Chromatin Biology (UC San Francisco, 2003), Cell Biology (Harvard Medical School, 2000) Research Interests: Plath investigates mechanisms governing pluripotency, X-chromosome inactivation, and nutrient regulation of stem cell differentiation. Her lab develops single-cell omics technologies like SEC-seq to study transcriptomes and secretomes simultaneously, and explores 3D genome organization's role in gene regulation. Scientific Awards: HHMI Faculty Scholar (2016) ISSCR Board of Directors (2011-2017) NIH Director’s New Innovator Award (2007) Kimmel Foundation Scholar (2007) V Foundation Scholar (2007) Advising & Collaborations: Mentors students like Clara Cano and Sasha Barinsky. Collaborates with Jason Ernst (UCLA), Dino Di Carlo (UCLA), and international researchers on projects involving iPSC reprogramming, X-chromosome dosage compensation, and lung disease modeling.

Maria Tenjeمشاهده پروفایل

استاد

• Biomedical Engineering
• Microsystems Engineering
• Microfluidics
• +۵ مورد دیگر

Maria Tenje is a Professor of Microsystems Engineering at the Department of Materials Science , Uppsala University. Since July 2021, she has served as Director of the Department of Medical Technology. She leads the EMBLA research group , focusing on miniaturized systems for life science applications through advanced micro- and nanofabrication methods integrated into microfluidic platforms. Research Interests : Her work centers on biomedical engineering , microfluidics , organ-on-chip technology , and acoustophoresis . Key areas include droplet-based microfluidics, biomaterial evaluation, and developing cell culture systems with enhanced physiological relevance. Recent publications highlight innovations in 3D acoustic mixing , antibiotic resistance detection , and microfluidic platforms for single-cell respiration . Publications Trends : Her 15 most recent articles (2021-2025) span droplet microfluidics, organ-on-chip systems, and acoustic particle manipulation. These studies explore biomaterial biocompatibility , cellular response modeling , and microscale diagnostic tools , often in collaboration with interdisciplinary teams.

Alfredo Franco-Obregónمشاهده پروفایل

دانشیار

• Regenerative Medicine
• Mechanobiology
• Electromagnetics
• +۱۱ مورد دیگر

Professor Alfredo Franco-Obregón is a Research Associate Professor at the National University of Singapore (NUS), with multiple appointments across the Yong Loo Lin School of Medicine. He holds positions in the Department of Surgery and the Department of Physiology, and is affiliated with the Institute for Health Innovation & Technology, the Healthy Longevity Translational Research Programme, the NUS Centre for Cancer Research, and the Nanomedicine Translational Research Programme. He leads the Biolonic Currents Electromagnetic Pulsing Systems (BICEPS) Laboratory, which focuses on developing non-invasive electromagnetic technologies to enhance muscle function and systemic health, particularly for aging populations and those with mobility limitations. Dr. Franco-Obregón's research centers on understanding how biophysical forces, particularly mechanical and electromagnetic stimuli, translate into tissue regeneration and survival. His work specifically investigates the role of Transient Receptor Potential (TRP) channels, particularly TRPC1, in skeletal muscle development and how magnetic fields can activate mitochondrial respiration through a process he terms "Magnetic Mitohormesis." This research has significant implications for metabolic health, cancer therapy, and aging interventions. His laboratory has demonstrated that brief (10-minute) weekly exposure to low-energy pulsed electromagnetic fields (PEMFs) can enhance muscle development, improve metabolic efficiency, and even produce anticancer effects through the activation of muscle secretome responses. His recent publication record demonstrates a strong focus on translating these findings into clinical applications, with numerous randomized controlled trials examining the effects of PEMF therapy on conditions including knee osteoarthritis, Achilles tendinopathy, metabolic disorders, and breast cancer. His research bridges fundamental cellular mechanisms with practical clinical applications, showing how magnetic field exposure can serve as a non-invasive exercise mimetic for populations unable to engage in physical activity. 2020: Innovation of the Year Product Winner by the Ageing Asia World Ageing Festival (for QuantumTx) 2015: Wong Hock Boon Society Best Mentor Award (NUS) 2008: Goldenen Eule (The Golden Owl Excellence in Teaching Award) (ETH) 1990: Martin Luther King Mentorship Award (UCSF) Dr. Franco-Obregón is actively engaged in mentoring students and collaborating on international research projects. He has established the BICEPS Laboratory as a hub for interdisciplinary research, bringing together engineers, clinicians, and basic scientists. His work has led to the founding of QuantumTx Pte. Ltd., a NUS spin-off company developing magnetic therapeutic devices, and he is currently conducting human clinical trials in Singapore, China, Southeast Asia, and the US to evaluate the efficacy of his magnetic therapeutic platforms. The BICEPS Laboratory operates at the intersection of engineering and clinical medicine, with a mission to develop non-invasive technologies that enhance muscle function and bioenergetics. The lab's research has significant potential to transform clinical practice, particularly in preventative medicine and rehabilitation. Dr. Franco-Obregón is also working to establish international collaborations, including potential student exchange programs between ETH/UZH and NUS, to further advance this field of research.

Balveen Kaurمشاهده پروفایل

استاد

• Virology
• Cancer Biology
• Immunotherapy
• +۳ مورد دیگر

Balveen Kaur is Associate Director of Basic Science and Professor at the Medical College of Georgia , Augusta University. Her academic appointments span the Department of Pathology and Georgia Cancer Center , with a focus on oncolytic virotherapy and glioblastoma research. Ph.D. , Biomedical Sciences, Emory University (1999) B.S. , Biotechnology, University of Delhi (1990) Her research centers on oncolytic herpesvirus therapy , tumor-immune interactions, and signal transduction in glioblastoma multiforme and breast cancer brain metastasis . She investigates metabolic reprogramming, immunosuppressive pathway inhibition (e.g., IDO, IGF2-IGF1R), and the role of stromal cells in tumor progression. Her work often combines viral engineering with pharmacological and immunotherapeutic approaches to overcome treatment resistance. The 2025-2024 articles highlight her leadership in HSV-1 strain development , Notch and CD73 signaling , and multi-drug synergy for glioblastoma. Publications emphasize metabolic-immune crosstalk (reductive carboxylation, ferroptosis), bi-specific antibodies penetrating the blood-brain barrier, and targeted stromal modulation in pancreatic and ovarian cancers. These span disciplines like Virology , Cancer Biology , and Immunology , with subfields including tumor microenvironment engineering, epigenetic drug interactions, and neuro-immuno-oncology. Ande Leon and Dorothy Bloom Distinguished Chair in Cancer Research (2023) She chairs the GCC Research Retreat and MOI Career Development committee, and serves on the American Society for Cell and Gene Therapy meetings. Her work includes collaborations with UGA Cancer Center and translational applications in remote heart failure monitoring systems (TCC-HF).

Ankit Malikمشاهده پروفایل

استادیار

• Mucosal Immunology
• Gastrointestinal Biology
• Inflammatory Bowel Diseases
• +۳ مورد دیگر

Ankit Malik is an Assistant Professor at the University of North Carolina (UNC) School of Medicine, affiliated with the Department of Microbiology and Immunology. His research focuses on mucosal immunity, specifically how immune responses at gastrointestinal surfaces distinguish between pathogens, commensals, and environmental antigens, and how dysregulation leads to inflammatory bowel diseases (IBD) and gastrointestinal cancers. His interdisciplinary work combines immunology, genetic engineering, microbiology, and bioinformatics. Research Focus Dr. Malik’s lab investigates intestinal immune homeostasis , immune tolerance breakdown in inflammatory diseases , and chronic inflammation-driven carcinogenesis . Key projects include: Mapping cellular pathways that maintain gut immune balance Elucidating mechanisms linking gut inflammation to cancer Developing translational models for IBD and sepsis Publications His work spans immune signaling (e.g., IFNγ, TNF/TNFR, SYK-CARD9), inflammasome biology , and microbiome research . Recent contributions include studies on: 2023 : Epithelial IFNγ signaling in gut immunity 2022 : Autoimmune neuropathy after Campylobacter infection 2020 : Microbiota restoration in sepsis

Michael Hölzelمشاهده پروفایل

استاد

• Tumor Cell Plasticity
• Inflammation
• Therapy Resistance
• +۳ مورد دیگر

Michael Hölzel serves as Professor and Director of the Institute of Experimental Oncology at University Hospital Bonn (University of Bonn), leading the Hölzel Lab within the Bonn cluster of excellence ImmunoSensation. His dual role bridges clinical oncology and fundamental cancer research. Education: 2003: Medical School, Ludwig-Maximilians University (LMU) Munich, Germany 2004: MD Doctorate Thesis, Helmholtz Zentrum München under Prof. Dirk Eick (c-Myc oncogene research) Residency in Hematology/Oncology, Klinikum Grosshadern (LMU Munich) Post-Doctoral Fellowship, Netherlands Cancer Institute under Prof. René Bernards (2007-2012) Research Focus: His work centers on three interconnected domains: tumor cell plasticity mechanisms driving therapy resistance; engineering novel adoptive cell transfer therapies; and spatial phenotyping of human tumor microenvironments to predict immunotherapy efficacy. These efforts aim to overcome treatment barriers in solid tumors through interdisciplinary approaches combining immunology, genomics, and clinical translation. Laboratory Leadership: As Principal Investigator of the Hölzel Lab, he directs a research program investigating inflammation-driven tumor evolution and microenvironmental determinants of immunotherapy response. His team operates at the intersection of the University Hospital Bonn's clinical infrastructure and the ImmunoSensation excellence cluster, facilitating direct patient-relevant discovery.

Terhi Hannele Kärpänenمشاهده پروفایل

مدرس

• Molecular Biology
• Functional Genetics
• Developmental Biology
• +۵ مورد دیگر

Terhi Hannele Kärpänen serves as a Lecturer at Nord University, where she teaches Molecular Cell Biology (BI210F) and actively supervises graduate research. Her academic foundation includes a PhD in Biomedical Sciences from the University of Helsinki (2006), establishing her expertise in molecular and developmental biology. Education: PhD in Biomedical Sciences, University of Helsinki, Finland (2006) Research Focus: Dr. Kärpänen's work centers on molecular regulation of early embryonic development through small regulatory RNAs, with significant contributions to lymphangiogenesis and cancer biology. Her competence spans lymphatic tumor metastasis, lymphedema mechanisms, and cancer immunotherapy development. She employs zebrafish models and molecular genetics to investigate vascular development pathways, particularly VEGF-C/VEGFR-3 signaling and lymphatic vessel formation. Publication Landscape: Her 15 most recent publications (2023-2008) reveal consistent focus on lymphatic system biology, with increasing emphasis on immunotherapy applications. Key trends include molecular dissection of VEGF-C activation mechanisms, genetic regulation of embryonic lymphangiogenesis, and translational T-cell receptor therapies for leukemia. Her work bridges basic developmental biology with oncological applications, frequently utilizing zebrafish models for in vivo validation. Academic Mentorship: Dr. Kärpänen has supervised 1 BSc and 4 MSc theses, demonstrating commitment to undergraduate and master's education. She currently co-supervises 3 PhD students, indicating active engagement in doctoral training and research leadership within her specialized fields.

Abdel Rahman Abdel Fattahمشاهده پروفایل

پژوهشگر

• Mechanobiology
• Tissue Engineering
• Extracellular Matrix (ECM) Dynamics
• +۷ مورد دیگر

Abdel Rahman Abdel Fattah is a Principal Investigator at CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences in Vienna, Austria. He previously held a postdoctoral position at CeMM (2022–2024) and KU Leuven (Belgium) (2018–2022). Education: BSc and PhD in Mechanical Engineering from McMaster University (Canada) Current Role: Lab Head at CeMM since 2024 Research Interests focus on multiscale mechanobiology, specifically how cells use mechanical forces and extracellular matrix (ECM) dynamics to coordinate tissue organization. His group combines bioengineered mechanical stimulation tools with advanced imaging and computational models to study: Dynamic Cellular and ECM Interactions in health and disease Mechano-Transcriptomic Mapping using spatial transcriptomics and atomic force microscopy (AFM) Computational Modeling of tissue organization via reaction-diffusion systems and positional information theory Disease Applications: Traumatic brain/spinal cord injuries and liver fibrosis Publications highlight interdisciplinary work across mechanobiology, bioengineering, and vascular pathology, with a focus on magnetic actuation, organoid modeling, and ECM dynamics. Articles appear in Nature Communications , Cell Reports , and Lab on a Chip . Recent studies (2024–2025) explore force-mediated vascular lesion growth and transcriptional hallmarks of aging using single-cell analysis. Technological Innovations include: Magnetic Microactuators for local organoid stimulation 3D Soft Microfluidic Systems for perfused tissues Diamagnetophoresis-Based Bioprinting Single-Cell Transcriptomic Atlases for mechanical stress responders

Jenny Perssonمشاهده پروفایل

استاد

• Cancer Metastasis
• Molecular Oncology
• Targeted Cancer Therapy
• +۵ مورد دیگر

Professor Jenny Persson leads cutting-edge cancer metastasis research at Umeå University's Department of Molecular Biology within the Faculty of Medicine. Her work focuses on deciphering molecular mechanisms driving cancer spread and developing targeted therapies, particularly for prostate and breast cancers. She maintains active laboratory facilities at the Hospital Area (Plats 6K and 6L) in Umeå and serves on the Faculty of Medicine Council for AI and Autonomous Systems. Her research centers on lipid kinase pathways (PIP5K1α/PI3K/AKT), androgen receptor signaling, and tumor microenvironment interactions. Key interests include: Mechanisms of bone metastasis in prostate/breast cancers Development of PIP5K1α inhibitors (e.g., ISA-2011B) Nanoparticle-based cancer detection systems Integration of AI for diagnostic algorithms and treatment prediction Recent publications demonstrate a strong shift toward AI-enhanced diagnostics, liquid biopsies, and nanoparticle therapeutics. Persson directs significant research funding including EU framework projects (GlycoImaging 721297, REVERT 848098-H2020-SC1-2) and grants from the Swedish Cancer Foundation, Swedish Research Council, and Swedish Children Cancer Foundation. She serves on the Research Grant Review Committee of the Swedish Cancer Foundation and previously held positions as Professor and Head of Experimental Cancer Research at Lund University and Honorary Professor at the University of Nottingham. Her laboratory maintains extensive national and international collaborations with clinical and preclinical researchers, focusing on translating molecular discoveries into clinical applications for metastatic cancers.

• Microfluidics
• Lab-on-a-chip technology
• Analytical chemistry
• +۷ مورد دیگر

Jörg P. Kutter is a Professor in the Department of Pharmacy at the University of Copenhagen, where he leads the Microscale Analytical Systems research group. His work focuses on the design and development of lab-on-a-chip devices and microfluidic systems for analytical applications across biomedical, pharmaceutical, environmental and industrial fields. Professor Kutter's research expertise spans multiple areas of microfluidics and analytical chemistry. He specializes in chemical separation techniques including chromatography and electrophoresis, as well as FIA-based systems and integration of optical detection elements. His current work emphasizes microfabricated lab-on-a-chip systems with focus on separation and sample preparation techniques, and advanced micro and nano liquid handling. His research group has developed numerous applications using thiol-ene based microfluidic platforms, which have become a signature technology in his laboratory. Analysis of Professor Kutter's recent publications (2022-2024) reveals a strong progression from fundamental microfluidic techniques toward increasingly complex biological applications. His work now prominently features DNA analysis (particularly extrachromosomal circular DNA), olfactory mucus analysis using humanized yeast biosensors, pulmonary delivery of siRNA-loaded nanoparticles, glycopeptide enrichment for inflammation-related protein analysis, and microfluidic steroidogenesis assays. This evolution demonstrates the maturation of microfluidics technology and its growing impact on biomedical research and clinical diagnostics. Professor Kutter has secured several millions of Euros in funding support for national and international (EU) projects. He served as coordinator for a European STREP project (2007-2010) with seven partners and a European IP (2010-2015) with 16 partners. He has supervised 14 post-doctoral fellows, 20 PhD students, and 12 master's theses, demonstrating a strong commitment to academic mentoring and research training. He serves as Deputy editor for Electrophoresis and is a member of the Board of Directors of the Chemical and Biological Microsystems Society. He participates in technical program committees for major conferences including µ-TAS, MEMS, MSB and Transducers. Additionally, he acts as a scientific advisor for the Institute for Microtechnology in Mainz, Germany, and evaluates proposals for national and international funding agencies as well as educational accrediting agencies.

Pierre Stallforthمشاهده پروفایل

استاد

• Paleobiotechnology
• Natural products from prehistoric microbiomes
• Microbial predator-prey associations
• +۷ مورد دیگر

Pierre Stallforth is Professor of Bioorganic Chemistry and Paleobiotechnology at Friedrich Schiller University Jena and Deputy Director of the Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (Leibniz-HKI) since 2022. He also heads the Department of Paleobiotechnology at Leibniz-HKI, a position he has held since 2020. His research bridges ancient and modern microbiology to discover novel natural products with potential therapeutic applications. Dr. Stallforth's research focuses on paleobiotechnology—exploring natural products from prehistoric microbiomes—and understanding microbial predator-prey interactions. His work combines ancient DNA analysis with modern molecular biology to resurrect ancient biosynthetic pathways and discover novel compounds. He investigates polymicrobial communities, particularly amoebae-bacteria interactions, and studies polyketides in Dictyostelium discoideum . His innovative approach adds a temporal dimension to natural product discovery, searching for molecules that have disappeared from modern ecosystems but could hold keys to new antibiotics. His recent publications reveal a strong trend toward interdisciplinary research combining paleogenomics, chemical ecology, and molecular biology. The work spans from fundamental studies of microbial interactions to applied research on antibiotic discovery, with a particular emphasis on how bacteria defend themselves against predators through specialized metabolites. His group has made significant contributions to understanding the chemical language of microbial communities and how this informs new approaches to combating antibiotic resistance. 2024 Medac Research Award 2023 Medac Research Award 2020 Academy of Sciences Göttingen, Academy Prize for Chemistry 2019 DECHEMA Research Award Natural Product Research 2018 Medac Research Award and Best Talk Prize at Bioorganic Symposium 2016 Medac Research Award PNAS Cozzarelli Prize 2021 for paper on bacterial cooperation Professor Stallforth actively mentors doctoral researchers in his department, with current students including Harikumar R Suma, Raed Nachawati, and Kevin Schlabach. His group collaborates extensively with Prof. Christina Warinner from the Max Planck Institute for Evolutionary Anthropology and Harvard University on paleobiotechnology projects. The Stallforth lab has secured significant funding through fellowships including the Feodor Lynen-postdoc fellowship, Swiss National Fund Postdoc fellowship, and Daimler and Benz Foundation fellowship, supporting innovative research at the intersection of ancient and modern microbiology. The Stallforth lab maintains a vibrant research environment with numerous postdocs, PhD students, and technical staff working on cutting-edge projects in paleobiotechnology and microbial interactions. The team utilizes advanced equipment including PCR machines, fluorescence microscopes, HPLC/LC-MS systems, and protein purification systems to investigate natural product biosynthesis and microbial ecology. Their collaborative approach extends to multiple departments within Leibniz-HKI and international partners, fostering a dynamic research ecosystem focused on discovering novel bioactive compounds from both ancient and contemporary microbial sources.

Aude G. Chapuisمشاهده پروفایل

دانشیار

• Immunotherapy
• T-cell Therapy
• Cancer Immunology
• +۳ مورد دیگر

Dr. Aude G. Chapuis is an Associate Professor in the Division of Hematology and Oncology at the University of Washington and holds the John C. and Karyl Kay Hughes Endowed Chair at Fred Hutchinson Cancer Center. She specializes in hematopoietic stem cell transplantation and immunotherapy, leading clinical trials for T-cell therapies targeting cancers like leukemia, Merkel cell carcinoma, and solid tumors. Her translational research focuses on optimizing T-cell receptor engineering to enhance anti-tumor efficacy and persistence. Her research interests include: Developing TCR-engineered immunotherapies for WT1 and viral antigens Overcoming immunotherapy resistance mechanisms Enhancing T-cell survival and function in adoptive transfer Targeting cancer-testis antigens like MAGE-A1 in solid tumors Her publications emphasize innovations in TCR gene therapy, mechanisms of immune evasion, and clinical strategies for hematologic and dermatologic malignancies. Awarded the John C. and Karyl Kay Hughes Endowed Chair, she leads a laboratory advancing cellular therapies and collaborates on multicenter trials. Dr. Chapuis mentors researchers in her lab and coordinates clinical studies, including Investigational New Drug (IND) applications for novel immunotherapies. She directs the Chapuis Lab, focusing on translational pipelines from target identification to clinical implementation.