جست‌وجوی استاد و پژوهشگر

• Computational Biology
• Molecular Biology
• Cell Biology
• +۵ مورد دیگر

Roy Wollman is a Professor at the University of California, Los Angeles (UCLA) in both the Department of Integrative Biology and Physiology and the Department of Chemistry and Biochemistry within the College of Letters and Science. His work bridges experimental and computational approaches to study dynamic signaling networks and their impact on cellular decisions. Research Focus: Computational and systems biology of signaling pathways Key Techniques: Single-cell analysis, spatial transcriptomics, quantitative modeling Major Themes: Information transmission in biochemical networks, cellular decision-making, epigenetic regulation Recent work has emphasized spatial transcriptomics mapping of brain regions, wound response signaling, and multi-scale analysis from cell biology to physiology. His lab has developed computational tools like scPNMF for gene selection and JSTA for cell segmentation and annotation. Key findings include mechanisms of TNF-induced cell death tradeoffs and laminin scarring effects in stem cell function. Roy Wollman has received continuous NIH funding since 2009, including grants for studying NFκB dynamics (R01GM117134), corneal wound signaling (R01EY024960), and single-cell technologies for traumatic brain injury (R01NS117148). His research combines high-throughput microscopy with computational modeling to understand how cells process dynamic signals.

• Animal Physiology
• Reproductive Biology
• Livestock Metabolism
• +۴ مورد دیگر

Prof. Dr. Susanne E. Ulbrich is a Full Professor of Animal Physiology at the Department of Environmental Systems Science, ETH Zurich, where she leads the Chair of Animal Physiology since September 2013. Her research focuses on livestock metabolism with emphasis on relationships affecting fertility and reproduction, contributing significantly to the World Food strategy of the Department of Environmental Systems Science and the Agrovet-Strickhof project in collaboration with the University of Zurich and the Canton of Zurich. Prof. Ulbrich's educational background includes studies in Agricultural Sciences with a focus on Animal Sciences at the Technical University Munich (TUM), followed by postgraduate studies in Biotechnology. She received her doctorate in physiology at the Science Center Weihenstephan of the TUM in 2005 with the distinction "summa cum laude" and subsequently managed a research group at TUM. Her international research experience includes research stays at the University of Adelaide in Australia and the Universidad de Concepcion in Chillán, Chile. Prof. Ulbrich's research interests span animal physiology with particular focus on reproductive biology, embryonic development, and metabolism. Her work on livestock metabolism has brought her international recognition, especially her research on embryonic diapause in roe deer, uterine fluid composition, and the effects of embryos on maternal physiology. She applies advanced techniques such as metabolomics, proteomics, and extracellular vesicle analysis to investigate reproductive processes across species. Her recent publications demonstrate a strong focus on comparative reproductive biology, particularly examining the European roe deer as a model for embryonic diapause and conceptus elongation. She also investigates mastitis mechanisms, bovine reproduction, and applications of extracellular vesicles in reproductive medicine. Her work bridges wildlife biology, livestock science, and human reproductive medicine, revealing fundamental principles of embryo-maternal communication. Graduation Award Bund der Freunde der TU München (2005) Research Award Dr.-Heinrich-Baur-Preis (2011) Prof. Ulbrich serves as a reviewer for numerous scientific journals and is an active member of professional societies including the German Society of Endocrinology, the Society for the Study of Reproduction, and the International Embryo Transfer Society. Her research is supported by grants such as "Embryonic Diapause: pluripotency on hold?" (SNF 185026), reflecting her leadership in understanding reproductive mechanisms across species. Her laboratory at ETH Zurich focuses on comparative reproductive biology, utilizing advanced techniques to study embryo-maternal communication, with particular emphasis on the European roe deer as a natural model of embryonic diapause. Her team comprises researchers with expertise in metabolomics, molecular biology, and reproductive physiology, working collaboratively to unravel the complex mechanisms governing early embryonic development and maternal recognition of pregnancy.

Brad Schwartzمشاهده پروفایل

استاد

• Hemostasis
• Protease Cascades
• Blood Clotting
• +۳ مورد دیگر

Brad Schwartz is a Professor at the University of Wisconsin–Madison, affiliated with the Department of Medicine and Biomolecular Chemistry. He serves as the Chief Executive Officer of the Morgridge Institute for Research, a private, nonprofit institute dedicated to interdisciplinary biomedical research in partnership with UW–Madison. As a physician-scientist, his research focuses on protease cascades governing physiological processes like blood clotting and cell death. Education: BS in Chemistry, University of Illinois at Urbana-Champaign (1972); MD, Rush University (1977); Postdoctoral Fellowship, Scripps Clinic (1979–1981); Residency, Loyola University Medical Center and UW–Madison. His research expertise spans hemostasis, protease cascades, and biomedical science, with clinical training in hematology. He has held leadership roles including Vice Chair of the Department of Medicine, director of the MD/PhD program, and Dean of the University of Illinois College of Medicine at Urbana-Champaign (1999–2011). He later led the Institute for Clinical and Translational Research at UW–Madison before becoming Morgridge’s CEO.

• Virology
• Immunology
• Cell Biology
• +۳ مورد دیگر

Xinyan Zhang is a Researcher in the Department of Cell Biology at Yale School of Medicine, Yale University. Her research focuses on understanding the molecular mechanisms of viral infections, particularly cytomegalovirus (CMV), and their interactions with host cellular processes such as autophagy and apoptosis. She investigates how viral infections trigger inflammatory responses and contribute to pathologies in organs like the retina and liver. Her work includes studies on the role of caspase-12 in retinal cell death during CMV retinitis, the impact of autophagy inhibition on viral replication, and the long-term ocular pathologies caused by neonatal CMV infection in mice models. She also explored adipokine involvement in Kawasaki disease and meta-inflammation in obese children during her graduate studies. Zhang collaborates with mentors Dr. Feng Fang (pediatric infectious disease expert) and Dr. Ming Zhang, contributing to interdisciplinary projects at the Su Lab. Her research integrates molecular biology, immunology, and clinical insights to address translational challenges in virology and infectious diseases.

Arnold J M Driessenمشاهده پروفایل

استاد

• Molecular Microbiology
• Biochemistry & Molecular Biology
• Biophysics
• +۷ مورد دیگر

Arnold J M Driessen is a Professor of Molecular Microbiology at the University of Groningen, within the Faculty of Science and Engineering and the Groningen Biomolecular Sciences and Biotechnology Institute (GBB). He leads the Molecular Microbiology research group, focusing on microbial cell biology, membrane proteins, lipid biosynthesis, and extremophiles. His work bridges fundamental research with biotechnological applications, including biofuel production and antibiotic development. He holds prestigious awards, including the Knight of the Order of the Lion of the Netherlands (2025) and membership in the Royal Netherlands Academy of Arts and Sciences. Driessen has authored nearly 500 publications and 10 patents, supervising 90+ PhD students and 40+ postdocs. His research explores protein translocation, archaeal lipid synthesis, and synthetic cellular systems. Driessen collaborates widely, contributing to public-private partnerships on antibiotic resistance and photopharmacology with Ben Feringa. He has driven the GBB’s international development and serves on committees like the TKI Chemistry Council. His mentorship emphasizes innovation and sustainability, fostering independent research while ensuring project success.

Steven McMahonمشاهده پروفایل

استاد

• Cancer Biology
• Transcriptional Regulation
• Molecular Biology
• +۸ مورد دیگر

Steven McMahon is a Professor and Chair of the Department of Biochemistry & Molecular Biology at Thomas Jefferson University. He also serves as Senior Associate Dean for Basic Science Research at Sidney Kimmel Medical College and Senior Associate Provost for Programmatic Science. His research focuses on transcriptional deregulation in cancer, particularly MYC and p53 pathways. PhD in Immunology, University of Pennsylvania MS in Physiology, Temple University BS in Biology, Albright College Research Interests: Dr. McMahon's work investigates how mutations in transcription factors like MYC and p53 alter cellular processes in cancer. Specific projects include mitochondrial transcriptional regulation, post-translational modifications of tumor suppressors, and genetic lesions in coactivator complexes. His findings highlight novel therapeutic targets in transcriptional networks. Scientific Awards: Sidney Kimmel Comprehensive Cancer Center Mentorship Award Ralph and Marian Falk Medical Research Trust Catalyst Award Gertrude Elion Award (AACR) Special Fellow Award (Leukemia and Lymphoma Society) Research Scholar Award (American Cancer Society) Scholar Award (V Foundation) Labs & Collaborations: Leads the McMahon Research Lab at Thomas Jefferson University, focusing on biochemical pathways in cancer. Collaborates with teams in the Basic Science Research division and Programmatic Science initiatives.

• DNA Repair Mechanisms
• Genetics
• Pharmacology
• +۷ مورد دیگر

Colin R Campbell is an Associate Professor in the Department of Pharmacology at the University of Minnesota Medical School . His research focuses on DNA repair mechanisms , particularly DNA-protein crosslink repair , homologous recombination , and mitochondrial DNA stability , with significant contributions to understanding cancer mechanisms and genetic toxicology . Research Themes DNA-Protein Crosslink Repair Homologous Recombination Pathways Mitochondrial DNA Maintenance Chemotherapy-Induced DNA Damage Enzymatic Processing Mechanisms Article Trends 2024-2025 work emphasizes transcription-coupled DNA repair and ubiquitin-mediated repair pathways 2020-2023 studies explore mitochondrial crosslink repair and interdisciplinary sustainability leadership 2000-2018 publications cover rad51 interactions , nitrogen mustard effects , and calpain-mediated repair enzyme degradation Grants & Projects NIH/NHLBI: Summer Research (2024-2029) NIH/NIEHS: DNA-Protein Crosslink Repair (2019-2025) NIH/NHLBI: Cellular Repair Mechanisms (2018-2024) Collaborations Natalia Tretyakova (Chemistry) Hoang D Nguyen (Microbiology) Paul B Bitterman (Medicine) Beverly S Moriarity (Genetics)

• Innate Immunity
• Inflammation
• IBD (Inflammatory Bowel Disease)
• +۶ مورد دیگر

Averil Ma, MD is a Professor of Medicine at the University of California, San Francisco (UCSF) School of Medicine. He serves as Director of the UCSF IBD Center and Chief of the Division of Gastroenterology. His research focuses on molecular and cellular mechanisms underlying inflammation and cancer, particularly studying ubiquitin-regulating proteins like A20. He holds notable roles such as Chair of the NIH CMI-A Study Section (2010-2012) and Founding Chair of the KRF Scientific Advisory Board (2009). Education: A.B. in Biochemistry from Harvard College (1980), M.D. from Columbia University (1984), Internal Medicine residency at Massachusetts General Hospital (1987), and Gastroenterology fellowship at Columbia (1989). Research interests include host-commensal interactions in the gut, innate immunity, and ubiquitin-dependent immune regulation. His lab investigates A20’s role in preventing inflammation and cancer via NF-κB signaling, inflammasome control, and tissue integrity. Techniques used include CRISPR, mass spectrometry, and mouse models. Key awards include election to the American Society for Clinical Investigation (2001) and AGA/GRG Young Investigator Award (2001). Publications focus on A20’s functions in inflammation, cancer, and autoimmune diseases, with contributions to understanding ubiquitin pathways and therapeutic targets for IBD, psoriasis, and SLE.

Zheng Zhouمشاهده پروفایل

استاد

• Cell Biology
• Molecular Genetics
• Developmental Biology
• +۳ مورد دیگر

Zheng Zhou is a Professor at the Verna and Marrs McLean Department of Biochemistry and Molecular Biology at Baylor College of Medicine. He is also a member of the Dan L Duncan Comprehensive Cancer Center. His research focuses on the molecular mechanisms of apoptotic and necrotic cell clearance in Caenorhabditis elegans , particularly the recognition, engulfment, and degradation of dying cells. Zhou holds a BS from Fudan University (Shanghai, China) and a PhD in Biochemistry from Baylor College of Medicine. He completed postdoctoral training at MIT and Baylor College of Medicine. His honors include the Norton Rose Fulbright Faculty Excellence Award (2018) and multiple fellowships, including from the Robert A. Welch Foundation and the Rita Allen Foundation. His research interests include understanding how dying cells expose 'eat-me' signals like phosphatidylserine and how phagocytic receptors (e.g., CED-1) mediate clearance. His lab uses genetic screens, live imaging, and molecular tools to study these processes in C. elegans . Recent work highlights roles of calcium signaling in necrotic cell recognition and autophagy-phagocytosis crosstalk in apoptotic cell degradation. Zhou has mentored numerous students and postdocs, including Omar Peña-Ramos (now a postdoc) and Jonathan Pickett. His lab is funded by grants such as an R35 MRA award and an RO1 supplement supporting research on lipid transfer proteins' roles in cell-cell interactions. Labs/Teams: The Zhou Lab at Baylor College of Medicine focuses on programmed cell death and clearance mechanisms. Collaborations include work on dynamin function and signaling pathways in phagocytosis.

Hilary Ann Collerمشاهده پروفایل

استاد

• Cellular Quiescence
• Cancer Biology
• Metabolism
• +۴ مورد دیگر

Hilary Ann Coller is a Professor at the University of California, Los Angeles (UCLA), jointly appointed in the Department of Molecular, Cell and Developmental Biology and the Department of Biological Chemistry within the College of Letters and Science. She leads a research laboratory focusing on cellular quiescence, metabolism, and their implications in cancer and disease progression. Her research integrates molecular biology, epigenetics, and systems approaches to study: Transcriptional and epigenetic control of quiescence Metabolic adaptations in tumor microenvironments RNA biology and gene regulation networks Development of biomedical technologies (e.g., biosensors) Recent publications (2022–2025) highlight trends in: Cellular quiescence mechanisms and transcription factor dynamics Cancer epigenetics and metabolic reprogramming Innovative tools for metabolomics and drug monitoring Educational research on remote STEM training programs She directs multiple NIH-funded projects, including R01CA221296 (stromal autophagy in melanoma) and R01GM086465 (microRNA mechanisms). Her lab mentors graduate students and postdocs, and she co-leads UCLA’s Bruins-in-Genomics summer initiative for undergraduate computational biology training.

Douglas B. Cowanمشاهده پروفایل

پژوهشگر

• Cardiovascular Biology
• Mitochondrial Transplantation
• Ischemia-Reperfusion Injury
• +۳ مورد دیگر

Douglas B. Cowan serves as a Staff Scientist in the Cardiology and Vascular Biology Program at Boston Children's Hospital and holds an Associate in Surgery position at Harvard Medical School. His career spans over three decades with foundational training in genetics and molecular biology. B.Sc. in Honors Genetics, University of Western Ontario (1987) M.Sc. and Ph.D., University of Toronto (1989, 1994) Postdoctoral Fellowship, MRC-sponsored at Mount Sinai Hospital and Toronto General Hospital Dr. Cowan's research focuses on mitochondrial transplantation as a novel therapy for ischemia-reperfusion injury, with pioneering work demonstrating that autologous mitochondria injected during reperfusion significantly enhance cardiac recovery. His expertise bridges cardiovascular molecular biology , bioengineering , and translational surgical innovation , particularly in developing rapid mitochondrial isolation techniques and coronary delivery systems. Current investigations explore mitochondrial integration mechanisms in human cardiomyocytes using super-resolution microscopy. His publication portfolio includes 124 works with 4,810 citations and an h-index of 39, dominated by high-impact studies in PLoS ONE , American Journal of Physiology , and Journal of Thoracic and Cardiovascular Surgery . Key trends show evolution from foundational work on endothelial junctions (1999) to mitochondrial therapy dominance since 2009, with recent expansion into stroke applications (2023) and donor heart preservation (2022). Dr. Cowan collaborates extensively with James D. McCully (135+ co-publications), Pedro J. del Nido, and Ingeborg Friehs within the Cardiac Surgery Research Laboratory at Boston Children's Hospital. Current projects include optimizing mitochondrial delivery for pediatric cardiac applications and investigating metabolic mechanisms in fatty acid metabolism post-transplantation.

• Mathematical Biology
• Applied Mathematics
• Cancer Research
• +۵ مورد دیگر

Dr. Marianna Cerasuolo is a Reader in Numerical Analysis and Scientific Computation at the University of Sussex's School of Mathematical and Physical Sciences. Her research focuses on mathematical and computational modeling for medical, biological, and environmental applications, including cancer dynamics, soil microbiome analysis, and sustainable agriculture. She has held positions at the University of Portsmouth and Rothamsted Research, and leads projects like the Horizon Europe-funded BIOservicES and the H2020 Diverfarming initiative. Her work integrates statistical, mathematical, and computational methods to address problems in oncology, ecology, and public health. Education: Advanced degrees in applied mathematics and mathematical biology (not explicitly listed). Research Interests: Cancer modeling, epidemiology, plant-environment interactions, bio-statistics, and computational biology. Her grants include the £6M BIOservicES (2023-2028) and a London Mathematical Society grant on microbial dynamics. She teaches courses like Machine Learning and Statistics for Health and Monte Carlo Simulations. Key contributions include developing the SusDiver app for agricultural sustainability and models predicting prostate cancer therapy efficacy.

John S. Kaddisمشاهده پروفایل

دانشیار

• Type 1 Diabetes
• Systems Biology
• Bioinformatics
• +۵ مورد دیگر

John S. Kaddis, Ph.D. is an Associate Professor in the Department of Diabetes & Cancer Discovery Science within the Arthur Riggs Diabetes & Metabolism Research Institute at City of Hope. With over 15 years of experience at City of Hope, Dr. Kaddis has developed scientific resources for team-based research initiatives focused on type 1 diabetes, creating data systems, analysis tools, and websites used by researchers worldwide. Dr. Kaddis earned his B.S. (Honors) in Biochemistry from California State University Los Angeles, where he completed undergraduate research supported by two National Science Foundation fellowships. He later earned his Ph.D. in Systems Biology and Disease from the University of Southern California. His academic journey includes positions as Assistant Professor since 2015 and Associate Professor since 2022 at City of Hope. Dr. Kaddis's research primarily focuses on the complex mechanisms of type 1 diabetes through systems biology and bioinformatics approaches. His work centers on understanding islet cell biology, beta cell dysfunction, and the immunological aspects of type 1 diabetes. His research has evolved from developing collaborative data resources to conducting cutting-edge investigations into genetic factors in diabetes pathogenesis. He has pioneered the creation of bioinformatics platforms that enable global collaboration in diabetes research. The trends in Dr. Kaddis's publications reveal a progression from foundational work on biobanking and data management toward increasingly sophisticated investigations of genetic and immunological mechanisms in type 1 diabetes. His recent work emphasizes translational applications, including potential therapeutic strategies and predictive models that span diverse ancestral backgrounds. His research bridges basic science with clinical applications through the Human Islet Research Network. Member, American Association for the Advancement of Science (2011-Present) Professional Member, American Diabetes Association (2010-Present) Member, Society of Clinical Research Associates (2003-2012) Lifetime Member, Tri-Beta Honor Society (2000-Present) Dr. Kaddis serves as principal investigator and co-investigator on multiple NIH and JDRF-funded projects, including the Human Islet Research Network Bioinformatics Center and the JDRF nPOD DataShare initiative. His work has established critical infrastructure for collaborative diabetes research, enabling researchers worldwide to access and analyze complex datasets. His laboratory has developed specialized data management systems that facilitate the sharing of islet cell research data across international boundaries while maintaining appropriate security and privacy protections. Dr. Kaddis's athletic pursuits in marathons and triathlons mirror his research approach—requiring stamina and perseverance to achieve long-term goals in diabetes research.

Susan C. Bakerمشاهده پروفایل

استاد

• Virology
• Coronavirus replication mechanisms
• Innate immune response evasion
• +۳ مورد دیگر

Susan C. Baker, PhD is a Professor in the Department of Microbiology and Immunology at Loyola University Chicago's Stritch School of Medicine. With over three decades of research experience, her work focuses on coronavirus replication mechanisms and host immune response modulation. PhD from Vanderbilt University Leading expert in coronavirus pathogenesis Key contributor to Kawasaki Disease etiology research Her coronavirus research examines: RNA polymerase polyprotein processing Interferon antagonism by viral proteins Live attenuated vaccine development Endoribonuclease function in immune evasion Protease stability and pathogenesis Double membrane vesicle formation Recent publication trends show: 2025 studies on necroptosis inhibition 2024 work on coronavirus evolution 2023 analysis of SARS-CoV-2 mutations 2020-2018 investigations of interferon antagonism 2019 structural-functional studies of replication proteins 2017 research on viral protein interactions The laboratory investigates both fundamental coronavirus biology and translational applications for vaccine development, maintaining active collaborations with infectious disease experts like Dr. Anne Rowley in Kawasaki Disease research.

Volker Lipkaمشاهده پروفایل

استاد

• Plant Innate Immunity
• Molecular Biology
• Plant-Fungal Interactions
• +۳ مورد دیگر

Prof. Volker Lipka is a Professor of Plant Cell Biology at the University of Göttingen, leading research on plant innate immunity mechanisms. His work focuses on molecular dissection of basal defense activation in Arabidopsis thaliana , plant defense against fungal pathogens, and fungal effector molecules. He combines genetics, cell biology, and biochemistry to study complex plant-pathogen interactions. Education and Career: Dr. rer.nat., Technical University Aachen (1999) Postdoctoral Fellow, Sainsbury Laboratory (1999-2000) Postdoctoral Fellow, Max Planck Institute for Plant Breeding Research (2000-2004) Independent Research Group Leader, University of Tübingen (2004-2007) Independent Research Group Leader, John Innes Centre (2007-2009) Professor at University of Göttingen since 2009 Research Interests: Molecular mechanisms of plant immunity, pathogen entry control, effector molecule interference, and subcellular defense dynamics. His lab investigates chitin receptor signaling, mitochondrial roles in pathogen defense, and fungal-induced stress adaptations. Labs/Teams: Heads the Plant Cell Biology department within the Schwann-Schleiden Research Center, affiliated with the GGNB's Molecular Biology of Cells group and the International Research Training Group 2172 (PRoTECT).