جست‌وجوی استاد و پژوهشگر

Alexis Battleمشاهده پروفایل

دانشیار

• Genomics
• Machine Learning
• Computational Biology
• +۳ مورد دیگر

Alexis Battle is an Associate Professor at Johns Hopkins University with appointments in Biomedical Engineering , Computer Science , and Genetic Medicine (secondary). She directs the Malone Center for Engineering in Healthcare and serves as Deputy Director of the Data Science and AI Institute . Educated at Stanford University (PhD in Computer Science, 2013), Battle transitioned to academia after leadership roles at Google. Research Focus: Battle’s work bridges genomics and machine learning , emphasizing the impact of genetic variation on human health. Her lab develops tools like Watershed to predict functional effects of rare variants, aiming to enhance rare disease diagnosis. Key themes include non-coding DNA analysis , personalized genomics , and systems biology , with applications in cardiovascular disease and neurodegenerative disorders . Publications & Awards: Over 60 peer-reviewed articles in journals like Nature , Science , and Genome Biology , with recent emphasis on single-cell transcriptomics , multiomics integration , and telomere biology . Recipient of the President’s Frontier Award (2022), Microsoft Investigator Fellowship (2019), and Searle Scholar (2016). Scientific Awards: 2022 President’s Frontier Award 2019 Microsoft Investigator Fellowship 2019 Johns Hopkins Discovery Award 2017 Johns Hopkins Catalyst Award 2016 Searle Scholar Advising & Funding: Mentors 11 PhD students, 3 undergraduates, and postdoctoral fellows. Her research is funded by NIH, Searle Scholars, and institutional grants. The Battle Lab collaborates on projects like the GTEx Consortium , focusing on gene regulation and clinical genomics .

Waldemar Kolanusمشاهده پروفایل

استاد

• Molecular Immunology
• Cell Signaling
• Signal Transduction Pathways
• +۴ مورد دیگر

Prof. Waldemar Kolanus leads the Molecular Immunology and Cell Biology department at the University of Bonn's Life & Medical Sciences Institute (LIMES) . His research bridges immunoregulation , stem cell dynamics , and metabolic stress responses in immune cells. Unit 2 member at LIMES Principal investigator in SFB 704 and ImmunoSensation Cluster Leads a multidisciplinary lab with postdocs, PhD students, and technical staff His work focuses on intracellular signaling pathways connecting immune activation to tissue homeostasis, particularly through: Cytohesin proteins in integrin-mediated adhesion and migration TRIM71 in stem cell regulation and congenital hydrocephalus High-salt environments affecting macrophage function Publication trends show expertise in immune cell migration , genetic models , and chemical inhibition , with frequent use of mice and zebrafish for in vivo studies. Key articles explore: TRIM71's dual role in auditory development and germ cell maintenance Cytohesin family's Golgi regulation and insulin signaling Ruxolitinib's off-target migration inhibition of dendritic cells Contact details: Address: LIMES Institute, Carl-Troll-Straße 31, Bonn Email: kolanus.sekretariat@uni-bonn.de Phone: +49 228 73-62788

• Stem Cell Biology
• Genetic Engineering
• Epigenetics
• +۵ مورد دیگر

Konstantinos Anastassiadis is a Professor at the Center for Molecular and Cellular Bioengineering (CMCB) of Dresden University of Technology , leading the Stem Cell Engineering group at the Biotechnology Center (BIOTEC) . His research focuses on unraveling molecular pathways regulating stem cell self-renewal and lineage commitment, with a strong emphasis on genetic engineering tool development and epigenetic mechanisms during cellular reprogramming. The lab utilizes mouse and human embryonic stem cells, neural stem cells, mesenchymal stromal cells, and induced pluripotent stem cells (iPSCs) in their investigations. Core Research Areas: Molecular regulation of stem cell fate Epigenetic mechanisms (e.g., UTX/UTY histone demethylases) Genetic engineering tool development (Flp, Dre, Vika recombinases, CRISPR protocols) Conditional immortalization systems for rare cell expansion Publications highlight his contributions to understanding: Role of histone methyltransferases (MLL1, MLL2, Setd1b) in hematopoiesis and cancer Epigenetic regulation during mouse development and spermatogenesis Genetic tools for protein tagging, transposon-mediated BAC transgenesis Interactions between stem cells and niche microenvironments Transcriptional and mechanical markers during reprogramming Collaborations span immunology , developmental biology , and bioinformatics . The lab actively participates in teaching activities at CMCB and maintains a focus on translational applications of stem cell research.

Laura Soltمشاهده پروفایل

دانشیار

• Autoimmune Disease
• Cancer Immunotherapy
• Immunometabolism
• +۵ مورد دیگر

Laura Solt, Ph.D. is an Associate Professor in the Department of Immunology and Microbiology at the Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology in Jupiter, Florida. She also serves as Associate Dean of the Skaggs Graduate School of Chemical and Biological Sciences. Dr. Solt began her independent research career at Scripps Florida in 2013 and has established herself as a leading researcher in nuclear receptor biology within the immune system. Her research focuses on understanding the biologically relevant roles of nuclear receptors, particularly RORα and REV-ERBs, in the immune system with emphasis on TH17 cell development and autoimmune disease. Her lab employs a multidisciplinary approach combining molecular biology, genetic techniques, and chemical biology coupled with mouse models of autoimmunity and chronic inflammation. Dr. Solt's laboratory has made significant contributions to understanding how nuclear receptors regulate immune cell function, particularly in TH17-mediated inflammation. Her work has demonstrated roles for RORα and REV-ERBs in TH17 cell development and has developed synthetic ligands to these receptors for potential therapeutic applications in autoimmune diseases. Her extensive publication record shows a clear trajectory of research focused on nuclear receptor signaling in immunity, with recent work expanding into applications for cancer immunotherapy, neuroimmunology, and metabolic aspects of immune cell function. Her articles demonstrate expertise in both basic nuclear receptor mechanisms and translational applications. Ruth L. Kirschstein National Research Service Awards (2010-2013) Dr. Solt actively mentors graduate students including Adrianna Wilson (recipient of NIDDK F31 and Scheller Graduate Student Fellowship) and Sarah Mosure (recipient of NIH NRSA F31 award and Wendy Havran award). Her laboratory receives substantial funding from multiple NIH institutes (NIDDK, NCI, NIAID, NIGMS) as well as the Crohn's & Colitis Foundation. Current research directions include investigating the roles of NR2F6 in TH17 cells, exploring RORα function in CD8 T cells, and developing novel nuclear receptor modulators for therapeutic applications.

• Cancer Research
• Immunology
• Oncology
• +۳ مورد دیگر

Dr. Karen Anderson is a Professor at Arizona State University (ASU), affiliated with the School of Life Sciences, the Biodesign Center for Personalized Diagnostics, and the College of Health Solutions. Her research focuses on tumor biology and immune system interactions in cancer, particularly developing biomarkers for early detection of cancers like breast, ovarian, pancreatic, and HPV-related cancers. She employs molecular techniques such as protein arrays, next-gen sequencing, and functional genomics to identify therapeutic targets and vaccine candidates. Education: Ph.D. in Microbiology and Immunology (Duke University), M.D. from Duke University School of Medicine, and B.A. in Chemistry (University of Virginia). Research interests include cancer immunotherapy, autoantibody profiling, and translational applications of proteomics. Key achievements include pioneering autoantibody-based biomarker assays and investigating HPV serology in head and neck cancers. Awards include the Health Care Heroes Award and recognition as one of Arizona's Most Influential Women. Teaching responsibilities include courses on research techniques and honors thesis supervision. Grants span biomarker validation, cancer genomics, and point-of-care diagnostics. Active in professional service, including roles in grant review panels and public health initiatives.

Peter A. Jonesمشاهده پروفایل

استاد

• Epigenetics
• DNA methylation
• Cancer epigenetics
• +۷ مورد دیگر

Peter A. Jones is President and Chief Scientific Officer at the Van Andel Institute (VAI) in Grand Rapids, Michigan, where he leads the Department of Epigenetics. He previously served as Director of the USC Norris Comprehensive Cancer Center from 1993 to 2011 and has been a central figure in advancing epigenetics research, particularly in cancer. His laboratory investigates DNA methylation, chromatin dynamics, and epigenetic therapies. Research Interests: Dr. Jones's work centers on epigenetic mechanisms in cancer, including DNA methylation, histone modifications, nucleosome positioning, and the therapeutic potential of epigenetic drugs. His research has pioneered the use of DNA methylation inhibitors like 5-azacytidine and explored viral mimicry as a mechanism for immune activation in cancer. He also studies transposable elements and their role in gene regulation and immune response. Publication Trends: His recent publications (2021–2024) reveal a strong focus on the interplay between epigenetics and immunotherapy, particularly how DNA methyltransferase inhibitors (DNMTi) induce viral mimicry, enhance immune recognition, and improve responses to checkpoint blockade. Studies span hematological malignancies, solid tumors, and T cell biology, with frequent collaboration with Stephen Baylin and others. Scientific Awards: Member, National Academy of Sciences Member, National Academy of Medicine Fellow, AACR Academy Fellow, AAAS Fellow, American Academy of Arts and Sciences Kirk A. Landon Award for Basic Cancer Research (2009) Medal of Honor, American Cancer Society (2011) Outstanding Investigator Grant, NCI Harvey Prize (2024) Advising and Grants: Dr. Jones mentors multiple postdoctoral fellows, graduate students, and research scientists. His lab is supported by major grants, including the VAI-SU2C Epigenetics Dream Team, which has launched 15 clinical trials. He has received sustained funding from the National Cancer Institute and collaborates with institutions worldwide to advance epigenetic therapies. Labs and Teams: He leads the Peter Jones Laboratory at VAI, a multidisciplinary team investigating epigenetic regulation in cancer. The lab includes computational biologists, clinical researchers, and molecular biologists, working on both basic mechanisms and translational applications. The team is part of larger collaborative initiatives such as the VAI-SU2C Epigenetics Dream Team and the International Linked Clinical Trials Program.

Li Tangمشاهده پروفایل

دانشیار

• Immunoengineering
• Cancer Immunotherapy
• Immune Metabolism
• +۷ مورد دیگر

Li Tang is an Associate Professor with tenure at École polytechnique fédérale de Lausanne (EPFL), affiliated with the Institute of Bioengineering (IBI) and the Institute of Materials Science and Engineering (IMX) within the School of Engineering (STI). She leads the Laboratory of Biomaterials for Immunoengineering, focusing on developing innovative strategies at the intersection of immunology, materials science, and cancer therapy. Her work bridges fundamental research and clinical translation, with multiple ongoing clinical trials based on CAR-T cell therapies developed in her lab. B.S. in Chemistry, Peking University (2003–2007) Ph.D. in Materials Science and Engineering, University of Illinois at Urbana-Champaign (2007–2012) Postdoctoral Fellow, MIT (2013–2016) Her research lies at the forefront of immunoengineering, integrating chemical, metabolic, and mechanical approaches to modulate immune responses. Key areas include cancer immunotherapy, immune metabolism, mechano-immunology, and biomaterials. She investigates how physical and biochemical cues can reprogram T cells, overcome exhaustion, and enhance tumor targeting. Her work emphasizes multidimensional immunity-disease interactions, aiming to develop safer and more effective therapies for cancer and autoimmune diseases. The recent publications highlight a strong trend in engineering immune cells (especially CAR-T) for enhanced durability and function, using advanced biomaterials and metabolic reprogramming. There is a clear focus on overcoming challenges in solid tumors, modulating the tumor microenvironment, and translating findings into clinical applications. The use of nanoparticle delivery, single-cell analysis, and biomechanical cues are recurring themes across her work. Notable scientific awards include: Friedrich Miescher Award (2025) ERC Starting Grant (2018) MIT TR35 Innovators Under 35 (China Region, 2020) Nano Research Young Innovator Award (2018) Biomaterials Science Emerging Investigator (2019) Materials Horizons Emerging Investigator (2020) Li Tang actively mentors PhD students across multiple doctoral programs (EDBB, EDMS, EDMX) and has advised numerous graduates who have gone on to prestigious postdoctoral and faculty positions. She is involved in significant research grants, including an Innosuisse project with Novochizol SA, and her lab is supported by competitive funding. She teaches core courses such as Immunoengineering and Next-Generation Biomaterials, shaping the next generation of scientists. Her lab fosters interdisciplinary collaboration and innovation, with active projects in chemical, metabolic, and mechanical immunoengineering, as well as CAR-T cell development. She is the Principal Investigator of the Tang Lab, which includes postdoctoral fellows, PhD students, and technical staff. The lab is actively recruiting and has a strong publication and clinical translation record. Tang Lab is also involved in multiple MA/BA training projects and promotes student engagement in cutting-edge research. The lab’s discoveries are being translated into clinical trials, reflecting a strong commitment to translational science.

Christina Leslieمشاهده پروفایل

استاد پژوهشی

• Computational Biology
• Systems Biology
• Machine Learning
• +۷ مورد دیگر

Dr. Christina Leslie is a Research Professor and Member of the Computational & Systems Biology Program at Memorial Sloan Kettering Cancer Center (MSK). She leads an active research laboratory focused on developing computational approaches to understand complex biological systems. Dr. Leslie earned her PhD from the University of California, Berkeley and has established herself as a leading computational biologist in cancer research and immunology. Computational & Systems Biology Program, Memorial Sloan Kettering Cancer Center Gerstner Sloan Kettering Graduate School of Biomedical Sciences Dr. Leslie's research focuses on developing novel computational methods to study cellular biological systems from a global and data-driven perspective. Her lab exploits diverse high-throughput functional and genomic data to understand molecular networks underlying fundamental cellular processes, including transcription regulation, pre-mRNA processing, signaling, and post-transcriptional gene silencing. Her algorithmic methods draw heavily on machine learning to build accurate predictive models from noisy and high-dimensional biological data. Key areas of interest include modeling cell-type specific transcriptional programs and dissecting co- and post-transcriptional regulation, particularly microRNA-mediated gene regulation. Analysis of Dr. Leslie's publication record over the last five years reveals a strong focus on computational approaches to cancer genomics, immunology, and epigenetics. Her work bridges multiple disciplines, with a particular emphasis on developing machine learning methods to interpret complex biological data. The publications demonstrate increasing sophistication in integrating multiple data types (genomic, transcriptomic, epigenomic) to understand cancer biology and immune responses. Recent work shows a growing emphasis on single-cell technologies and spatial analysis of tumor microenvironments. Introduction of string kernel methodology for SVM classification of biological sequences Development of algorithms for predictive modeling of gene regulation First systems-level analyses of competition between microRNAs and between target transcripts Dr. Leslie actively mentors numerous graduate students and research associates, with current lab members including Vianne Gao, Alireza Karbalaghareh, Erik Ladewig, and several others. Her lab has received significant research funding to support their work on computational approaches to cancer biology and immunology. The Leslie Lab maintains close collaborations with multiple experimental groups at MSK, facilitating the translation of computational insights into biological understanding. The Leslie Lab operates within the Computational & Systems Biology Program at MSK, with strong ties to both the research and clinical missions of the institution. The lab maintains state-of-the-art computational infrastructure for analyzing large-scale genomic and proteomic datasets and collaborates extensively with wet-lab researchers to validate computational predictions experimentally.

• Immunology
• Fungal Infections
• T Cell Biology
• +۳ مورد دیگر

Som G Nanjappa is an Associate Professor in the Department of Pathobiology at the University of Illinois. His academic background includes a Ph.D. in Immunology from the University of Wisconsin-Madison (2009). He specializes in T cell biology, fungal infections, and vaccine development, with a focus on CD8+ T cells, Tc17 cells, and their roles in combating fungal pathogens like Blastomyces dermatitidis and Cryptococcus neoformans. His research explores mechanisms of vaccine-induced immunity, particularly in immunocompromised hosts, and investigates how T cell responses contribute to protection against fungal pneumonia. Recent work highlights the role of GM-CSF+ Tc17 cells in vaccine efficacy and the importance of molecules like sialophorin in CD8+ T cell activation. Collaborations span immunology, oncology, and microbiology, with studies on 27-hydroxycholesterol’s impact on breast cancer progression and T cell dysfunction. Publications emphasize fungal vaccine strategies, immune memory persistence, and the interplay between innate and adaptive immunity. His findings have been featured in journals like Cell Reports, PLoS Pathogens, and Frontiers in Immunology, with impactful contributions to understanding antifungal immunity and T cell plasticity.

Xia Gaoمشاهده پروفایل

استادیار

• Nutrition
• Metabolism
• Cancer Metabolism
• +۷ مورد دیگر

Xia Gao is an Assistant Professor in the Department of Pediatrics-Nutrition and the Department of Molecular and Cellular Biology at Baylor College of Medicine. She leads the Gao Lab, based at the USDA/ARS Children's Nutrition Research Center in Houston, Texas, where she investigates the role of nutrition and metabolism in diseases such as cancer and obesity. Her research focuses on amino acid metabolism, particularly the impact of dietary methionine and serine restriction on cancer progression and therapy efficacy. She employs in vivo mouse models and in vitro systems combined with metabolomics, molecular biology, and immunology techniques. The most recent publications from her lab reveal a strong trend in cancer metabolism, especially in prostate and liver cancers, with a focus on dietary interventions, metabolic reprogramming, and immune cell metabolism. Her work bridges nutritional science and precision oncology, aiming to develop effective dietary therapies. Dietary methionine influences therapy in mouse cancer models and alters human metabolism (Nature, 2019) HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer (Nature Communications, 2020) Targeting glutamine metabolism in therapy-resistant prostate cancer (Oncogene, 2022) Dr. Gao is supported by competitive grants, including a CPRIT award (RP210056) on dietary methionine restriction to enhance chemotherapy, and an NIH/NCI R00 grant on methionine metabolism in cancer. These grants underscore her role as an independent investigator with significant research funding. The Gao Lab is part of the USDA/ARS Children's Nutrition Research Center, a premier research facility equipped with advanced laboratories, a metabolic kitchen, and interdisciplinary teams focused on child and adult nutrition and disease prevention.

• Magnetic resonance spectroscopic imaging
• Tumor micro-environment imaging
• Multinuclear MRI (¹H/²³Na)
• +۴ مورد دیگر

Sandeep Kumar Mishra, PhD, is an Associate Research Scientist in the Department of Radiology & Biomedical Imaging at Yale School of Medicine, where he holds a primary appointment in the Magnetic Resonance Research Center within the Division of Bioimaging Sciences. He completed his doctoral training at Pondicherry University (2017) and finished post-doctoral research at Yale in 2024 before transitioning to his current research-intensive faculty role. Education: PhD, Pondicherry University – 2017 Post-doctoral Associate, Yale University – 2024 Research Focus: Mishra’s work integrates multinuclear magnetic resonance spectroscopy, responsive paramagnetic probes, and nano-constructs to quantify the tumor microenvironment. Major themes include in-vivo mapping of interstitial pH and sodium gradients in gliomas, development of Fe(II)/Co(II)/Ni(II)-DOTA tetraglycinate complexes for simultaneous pH–temperature sensing, and engineering dual-modal nano-agents that couple MR angiography with therapeutic delivery (chemo-photothermal, cryo-ablation, MMP inhibition). Publication Trends: Across 28 peer-reviewed articles (2016-2025) he demonstrates a sustained trajectory in cancer imaging, moving from theranostic nanoparticles toward sophisticated spectroscopic imaging of tumor acid–base and ionic homeostasis, with increasing translational orientation involving rodent glioma and hepatocellular carcinoma models. Collaborations & Affiliations: He is embedded in Yale’s inter-disciplinary MR research ecosystem, collaborating recurrently with faculty in Radiology, Biomedical Engineering, and the Magnetic Resonance Research Center (D. Coman, F. Hyder, P. Herman, J. Verhagen, J. Santana, A. Shewarega). Contact: sandeepkmishra11@gmail.com | Magnetic Resonance Research Center, 300 Cedar Street, New Haven, CT 06519, USA

Rustom Antiaمشاهده پروفایل

استاد

• Population Biology
• Evolutionary Biology
• Immunology
• +۴ مورد دیگر

Rustom Antia is the Samuel C. Dobbs Professor in the Department of Biology at Emory University, affiliated with the Emory College of Arts and Sciences. His research focuses on the quantitative analysis of pathogen dynamics, immune responses, and evolutionary biology using mathematical models and experimental collaborations. He leads the Antia Lab (located in Rollins 1164), working closely with experimental immunologists like Dr. Rafi Ahmed at Emory. Education: Ph.D., University of Massachusetts (1990); MSc, Indian Institute of Technology (1983). His research interests include population biology, computational biology, and the evolutionary interactions between pathogens and hosts. He explores how immune memory shapes viral evolution and transmission, with recent emphasis on SARS-CoV-2, influenza, and dengue viruses. Key research themes include modeling immune responses to vaccines, understanding antibody waning and viral escape, and developing transmissible vaccines for disease control. His work integrates experimental data with theoretical frameworks to predict outbreak dynamics and inform public health strategies. Notable collaborations include studies on CD8+ T cell-mediated immunity in respiratory infections, the role of menstrual cycles in immune surveillance, and immune dysfunction in autoimmune diseases like SLE. His lab’s contributions span from basic immunology to translational applications in vaccine design and cancer therapy.

Doron Betelمشاهده پروفایل

استادیار

• Computational Genomics
• Bioinformatics
• Single-cell RNA-seq Analysis
• +۳ مورد دیگر

Doron Betel serves as an Assistant Professor at Weill Cornell Medicine's Graduate School of Medical Sciences, with affiliations in both the Physiology, Biophysics & Systems Biology and Computational Biology programs. He directs the Applied Bioinformatics Core (ABC), a central service group providing specialized computational and analytical support for biomedical research across multiple institutions. Dr. Betel's research focuses on developing computational genomic tools for studying human diseases and cellular development, with emphasis on integrative analyses of genomic and epigenomic data from high-throughput assays. His work addresses specific questions related to disease progression, treatment response, stem cell differentiation, and neurological processes through two closely interacting research groups: the Applied Bioinformatics Core and his independent research lab. The analysis of his recent publications reveals a strong emphasis on single-cell and spatial genomics, cross-species data integration, and machine learning applications in cancer immunology and neurodegenerative disease modeling. His research spans multiple high-impact areas including cancer immunotherapy, stem cell biology, diabetes research, and cardiovascular regeneration, with numerous publications in top journals like Nature, Cell, and Nature Immunology. Through the Applied Bioinformatics Core, Dr. Betel provides extensive analytical support across various genomic platforms including single-cell RNA-seq, spatial transcriptomics, ChIP-seq, ATAC-seq, and variant calling. The Core serves as a vital resource for researchers at Weill Cornell Medicine and the broader Tri-Institutional network, offering specialized analysis, computational pipelines, and training services. Dr. Betel maintains extensive collaborations with leading researchers including Lorenz Studer at MSKCC for stem cell and neurodegenerative disease research, Tuomas Tammela for cancer genomics, and multiple immunology researchers studying T cell function in autoimmunity and cancer. His work bridges computational methodology development with direct biomedical applications across multiple disease areas.

Xin Luمشاهده پروفایل

دانشیار

• Cancer Biology
• Tumor Microenvironment
• Tumor Immunology and Immunotherapy
• +۱۲ مورد دیگر

Xin Lu is the John M. and Mary Jo Boler Collegiate Associate Professor in the Department of Biological Sciences at the University of Notre Dame. She is a full member of the Harper Cancer Research Institute (HCRI), the Boler-Parseghian Center for Rare and Neglected Diseases (CRND), and the Tumor Microenvironment and Metastasis Program at the Indiana University Simon Comprehensive Cancer Center. Her research spans tumor immunology, immunotherapy, metastasis, and multi-omics, with a focus on prostate, breast, and rare cancers. Ph.D. in Molecular Biology, Princeton University (2004–2010) B.S. in Biological Sciences, Tsinghua University, China (2000–2004) Postdoctoral Fellow, Dana-Farber Cancer Institute and M.D. Anderson Cancer Center (2010–2016) Assistant to Associate Professor, University of Notre Dame (2017–Present) Dr. Lu's research investigates the molecular and cellular mechanisms of tumor-immune crosstalk, particularly the role of myeloid-derived suppressor cells (MDSCs) and neutrophils in promoting immunotherapy resistance. Her lab uses genetically engineered mouse models, functional genomics, single-cell and spatial transcriptomics, and high-throughput screening to uncover novel therapeutic targets. A major focus is on how cancer-cell-intrinsic oncogenic signaling shapes the immunosuppressive tumor microenvironment. Her recent publications reveal mechanisms such as Acod1-mediated ferroptosis resistance in neutrophils, Pygo2-driven immunosuppression in prostate cancer, and the efficacy of ketogenic diets in overcoming checkpoint blockade resistance. These studies span multiple disciplines including cancer biology, immunology, metabolism, epigenetics, and bioengineering, reflecting a highly integrative approach to immuno-oncology. Jane Coffin Childs Postdoctoral Fellow John M. and Mary Jo Boler Faculty Appointment Cluster Chair, Cellular & Molecular Biology, IBMS PhD Program Junior Chair, Boler-Parseghian Center for Rare and Neglected Diseases Dr. Lu mentors a diverse team of graduate students, postdoctoral fellows, and undergraduates. Her lab is actively recruiting and has secured funding from federal agencies and private foundations. She collaborates with chemists, bioengineers, and bioinformaticians to develop novel therapeutics, including antibody-drug conjugates, CAR-NK cells, and small-molecule inhibitors. Her lab also develops innovative platforms like mini-tumor chips for immunotherapy evaluation. Her lab maintains affiliations with multiple interdisciplinary centers including the Warren Family Center for Drug Discovery, Eck Institute for Global Health, and Berthiaume Institute for Precision Health, underscoring her collaborative and translational research vision.

• Transplantation Immunology
• Immunological Tolerance
• Humoral Immunity
• +۷ مورد دیگر

Professor Anita Chong is a distinguished immunologist at the University of Chicago's Pritzker School of Medicine, Department of Surgery-Transplant, where she leads groundbreaking research in transplantation immunology and tolerance mechanisms. Her laboratory has established herself as a leading authority in understanding the complex interplay between the immune system and organ transplantation. Dr. Chong's educational background includes a BS (Hons) from the University of Malaya, Malaysia, a PhD from Australian National University, Australia, and postdoctoral training at Tufts University, Boston, MA, followed by research associate work at the University of Arizona, Tucson, AZ. Her research program focuses on immunological tolerance and humoral immunity following allogeneic transplantation, with particular emphasis on understanding how infections prevent the induction of transplantation tolerance or destabilize established tolerance. Dr. Chong has developed innovative approaches to track defined populations of endogenous allospecific T cells (including CD4+ effectors, CD4+ Tregs, and CD8 effectors) and B cells, examining their behavior under conditions of rejection, memory/sensitization, and tolerance. She actively investigates memory alloreactive B cells in transplantation settings and has expanded her research into vaccination strategies to prevent infections as a means of stabilizing tolerance. Analysis of Dr. Chong's recent publications reveals a strong focus on cellular mechanisms of transplant tolerance and rejection, with particular emphasis on B cell biology, T regulatory cells, and the impact of infections on transplant outcomes. Her work increasingly incorporates multi-omics approaches and examines sex and gender differences in transplant outcomes, reflecting evolving trends in precision medicine within transplantation. Dr. Chong serves as Principal Investigator on multiple significant NIH-funded research projects, including R01AI182097 (Mechanistic studies on pregnancy-induced humoral sensitization in organ transplantation), R01AI148705 (Intrarenal B cells in acute kidney allograft rejection), and R01AI142747 (Deconstructing B cell transplantation tolerance). She has also served as Co-Principal Investigator on numerous collaborative grants. Her laboratory maintains extensive collaborations with Dr. Marisa Alegre studying infections and transplantation tolerance, Dr. Roger Sciammas at UC Davis, clinical transplant faculty at the University of Chicago and Ohio State University, Dr. Chris Montgomery on vaccination research, and Dr. Joel Collier at Duke University developing nanoparticulate adjuvant-free vaccines. These collaborative efforts have positioned her laboratory at the forefront of translational transplantation research with significant implications for clinical practice.