جست‌وجوی استاد و پژوهشگر

• RNA modifications
• Diabetes
• Aging
• +۵ مورد دیگر

Dario De Jesus is an Assistant Professor in the Section of Genetic Medicine at the University of Chicago . His research focuses on RNA modifications, particularly m6A methylation, in the context of diabetes and aging. Supported by NIH R00DK135927 and K99DK135927 awards, he investigates how RNA modifications govern pancreatic beta-cell function and systemic metabolism. His work bridges molecular biology, cell biology, and metabolism, with significant contributions to understanding epigenetic mechanisms in metabolic diseases. NIH R00DK135927 : 2025-2028 NIH K99DK135927 : 2023-2025 His research has been recognized by the American Diabetes Association and European Association for the Study of Diabetes , and he has published extensively in journals like Nature Cell Biology and Cell Metabolism . His publications frequently address m6A methylation, insulin resistance, and beta-cell biology, with high citation metrics reflecting their impact. Dr. De Jesus is also an active mentor, combining his research pursuits with teaching and academic training. Prior to his current position, he held roles at Harvard Medical School and Joslin Diabetes Center, developing expertise in molecular metabolism and epigenetics.

• Immunology
• Gastroenterology
• Diabetes Research
• +۶ مورد دیگر

Daria Esterhazy is an Assistant Professor at the University of Chicago in the Department of Pathology . Her research focuses on immunological niche specialization in the digestive system, spanning gut, liver, and pancreas interactions. She investigates how lymph node heterogeneity and organ crosstalk shape disease susceptibility in food allergies , autoimmune disorders , and cancers . PhD in Metabolism and Pancreatic Islet Biology from ETH Zurich (2010) MSci in Biochemistry from University of Cambridge (2006) BA in Natural Sciences from University of Cambridge (2005) Her work employs mice models with techniques like lymph node dissection , single-cell gene analysis , and gnotobiotic studies . She emphasizes cross-organ immune regulation via shared lymphatics and ductal systems , particularly in pancreatic diseases including diabetes and cancer. Publications highlight her expertise in: 2025 : Helminth-altered intestinal lymphatics 2023 : Helminth infection and immune tolerance 2019 : Gut lymph node compartmentalization 2017 : Microbiota-GPCR ligand mimicry 2012 : Pancreatic beta-cell proteomics Awards include the Swiss National Science Foundation Fellowships , Rockefeller University Helmsley Trust , and Swiss Diabetes Foundation Prize . Her lab (Esterházy Lab) bridges immunology with metabolic disease research , utilizing translational models and multimodal imaging to connect mouse findings to human pathologies.

Pablo Peñaمشاهده پروفایل

پژوهشگر

• Leukemia Research
• Acute Myeloid Leukemia
• Targeted Cancer Therapies
• +۷ مورد دیگر

Pablo Peña serves as a Research Engineer and Associate Researcher within the Department of Clinical Genetics at Lund University, specifically contributing to targeted therapies in leukemia research at the Lund University Cancer Centre (LUCC). His work spans multiple research groups focused on clinical genetics and cancer biology. His research interests center on leukemia pathogenesis with particular emphasis on acute myeloid leukemia (AML) and B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Dr. Peña investigates metabolic plasticity in leukemia cells, single-cell genomic approaches to identify therapeutic vulnerabilities, and novel targets such as IL1RAP and C3AR in cancer therapy. His work bridges basic science with translational applications, focusing on how metabolic and genomic mechanisms can be exploited for therapeutic benefit. Analysis of his publication record reveals a strong focus on molecular mechanisms in leukemia , with recent work exploring metabolic inhibitors, genomic vulnerabilities in specific leukemia subtypes, and the tumor microenvironment's role in disease progression. His research demonstrates interdisciplinary integration of genomics, metabolism, and immunology to develop novel therapeutic approaches. Dr. Peña actively collaborates with multiple research groups across Lund University, contributing to projects that have garnered significant attention with multiple publications being picked up by news outlets and receiving substantial readership on academic platforms like Mendeley.

• Pharmacology
• Toxicology
• Respiratory Tract Allergy
• +۵ مورد دیگر

Annet Zuidhof (ing. A.B. Zuidhof) is a Lecturer at the Faculty of Science and Engineering, University of Groningen, Netherlands. She contributes to research in pharmacology, toxicology, and pharmaceutical science, focusing on respiratory diseases and regenerative medicine. Allergen Guinea Pig Models Respiratory Tract Allergy Chronic Obstructive Lung Disease Osteoglycin Epithelial Cell Repair Her work addresses UN Sustainable Development Goals (SDGs) such as Good Health and Well-Being. She actively collaborates on international projects, with recent studies on fibroblast-derived osteoglycin's role in tissue repair and arginase inhibitors for asthma/COPD therapies. Research trends include in vitro/ex vivo drug testing, small airway hyperresponsiveness, and leveraging guinea pig models to understand respiratory inflammation. She uses precision-cut lung slices and advanced pharmacological assays. As part of the Lab Team Pharmacy and Lecturers Team 2, she works within the Department of Pharmacology, focusing on translational models for respiratory diseases. Contact: a.b.zuidhof@rug.nl

• Neuroscience
• Endocrinology
• Metabolic Disorders
• +۳ مورد دیگر

Helena Tomás Marcelino Lopes serves as a Visiting Assistant Professor in the Department of Chemistry at the University of Beira Interior. She teaches Clinical Biochemistry and Chemical-Biological Analysis for Clinical Application courses scheduled through 2025, demonstrating her ongoing active role within the institution. Her research spans multiple critical areas of biomedical science with particular focus on neurodegenerative diseases and metabolic disorders. Dr. Marcelino Lopes investigates the role of sex hormones in Alzheimer's disease neuroprotection, mechanisms of glucose homeostasis during catch-up growth, and the effects of environmental endocrine disruptors like bisphenol A on vascular function. Her work consistently examines gender-specific responses and hormone-dependent mechanisms across various biological systems. Analysis of her publication record from 2010-2023 reveals a strong trajectory in neuroscience and metabolic research, with increasing focus on cancer biology in recent years. Her work appears in reputable journals including International Journal of Molecular Sciences, Environmental Science and Pollution Research, and Neuroscience, demonstrating both disciplinary breadth and scientific impact. Dr. Marcelino Lopes participates in significant research initiatives including the Health Sciences Research Center (UID/Multi/00709/2019) and has contributed to projects examining metabolic syndrome risk factors and the serological survey of academic communities. Her collaborative approach is evident through co-authorship with researchers across multiple institutions on studies ranging from molecular mechanisms to population-level investigations.

Ernesto BernalMizrachiمشاهده پروفایل

استاد

• Pancreatic Beta Cell Biology
• Diabetes Research
• Signal Transduction
• +۳ مورد دیگر

Ernesto BernalMizrachi, MD , is a Professor and Chief of the Division of Endocrinology, Diabetes and Metabolism at the University of Miami School of Medicine. His research focuses on pancreatic beta cell mass regulation, Akt/mTOR signaling pathways, and islet transplantation for diabetes therapy. Secondary appointment in Biochemistry and Molecular Biology Deputy Director of Beta Cell Biology and Signal Transduction Research Highlights: His work explores the molecular mechanisms of beta cell proliferation and survival, nutrient signaling via mTOR, and the role of alpha cells in glucose homeostasis. He aims to develop pharmacological agents for diabetes treatment and improve islet transplantation outcomes. Scientific Awards: American Diabetes Association Career Development Award American Diabetes Association Junior Faculty Award Soderquist Endowed Professorship Clinical Scientist Award (VA) Elected member, American Society for Clinical Investigation Publications highlight his contributions to understanding Akt/mTOR signaling, beta cell biology, and novel therapeutic strategies for diabetes. He also mentors students and serves on NIH and JDRF review panels.

• Breast Cancer Biology
• Tumor Microenvironment
• Cell Signaling (Notch/Wnt)
• +۴ مورد دیگر

Rumela Chakrabarti, Ph.D., is an Associate Professor of Surgery at the University of Miami Miller School of Medicine and Co-Director of the Surgical Breast Cancer Research Group. She is a full member of the Sylvester Cancer Center's Tumor Biology Program. Ph.D. in Cellular and Molecular Biology from Kent State University Postdoctoral training at Princeton University and State University of New York Her research focuses on cell signaling mechanisms in breast cancer, particularly: Notch/Wnt signaling in tumor development Role of MDSCs and tumor-associated macrophages in metastasis Paradoxical functions of interferon gamma in cancer progression Lipid metabolism connections to TNBC aggressiveness Recent publications highlight her work on: Molecular mechanisms of chemoresistance Immune cell interactions in TNBC Development of novel mouse tumor models Scientific honors include: Breast Cancer Alliance Exceptional Award DoD Breast Cancer Research Fellowship McCabe Grant Fellowship, University of Pennsylvania Gallo Award for Outstanding Cancer Research Her laboratory employs advanced techniques including organoid co-culture, PDX models, single-cell RNA-sequencing, and confocal microscopy to develop combination therapies targeting both stromal and cancer cells in aggressive breast cancer treatment.

• Immunology
• Oncology
• Infectious Diseases
• +۹ مورد دیگر

Dr. Ronald Anderson is a distinguished researcher affiliated with the Faculty of Health Sciences at the University of Pretoria , the School of Clinical Medicine at the University of the Witwatersrand , and institutions such as the National Health Laboratory Service , South African Medical Research Council , and Institute for Cellular and Molecular Medicine . His work spans immunology, oncology, and infectious diseases. Dr. Anderson’s research focuses on immune dysregulation in cancer , including studies on soluble immune checkpoints and systemic inflammatory stress in patients with conditions like xeroderma pigmentosum. He also investigates inflammatory responses in viral co-infections (e.g., HIV and COVID-19), neutrophil function , and pharmacological impacts on immune cells . His publications highlight trends in immunopharmacology and inflammatory stress , with a strong emphasis on infectious disease interactions and cellular immunity . Grants from the Medical Research Council , National Institute of Allergy and Infectious Diseases , and National Science Foundation have supported his work. Collaborations and co-authorships span institutions including the National Research Foundation of Korea , Alexander von Humboldt-Stiftung , and Abbott Laboratories . Research teams include experts from the National Health Laboratory Service and Central Drug Research Institute India .

Jan Beckendorfمشاهده پروفایل

مدرس ارشد

• Molecular Cardiology
• Heart Failure
• Cardiac Imaging
• +۲ مورد دیگر

Jan Beckendorf is a Senior Physician and Clinician-Scientist at the Department of Cardiology, Angiology, and Pulmonology within Heidelberg University Hospital . He also serves as a Research Associate at the Institute of Experimental Cardiology , leads the Pregnancy Heart Team: Cardiology of Pregnancy , and is the Medical Director of the Mathes Wunderlich Ward . Education: Medical Degree: Medical University of Graz Doctorate: University of Heidelberg (2018) - "Characterization of calcium/calmodulin-dependent kinase II isoforms delta and gamma deficient mice under normal conditions and in a model of ischemic cardiomyopathy" Research Focus: His work bridges molecular cardiology and clinical cardiology, with a particular emphasis on heart failure, cardiac imaging, and pregnancy-related cardiac conditions. He has extensively studied calcium/calmodulin-dependent kinase II (CaMKII) in cardiac remodeling, ventricular assist devices, and novel therapeutic approaches for advanced heart failure. His translational research includes both in vivo murine models and clinical cohort studies. Clinical Expertise: Beckendorf is a board-certified specialist in internal medicine and cardiology, with additional qualifications in heart failure management. His clinical roles span advanced heart failure care, heart transplantation, and specialized pregnancy cardiology services. Publications & Impact: With publications spanning from 2010 to 2024, his research has significantly contributed to understanding cardiac remodeling post-infarction, biomarker trajectories in chronic heart failure, and novel imaging techniques for myocardial infarction quantification in small animal models.

Ramon Klein Geltinkمشاهده پروفایل

استادیار

• Immunometabolism
• T cell function
• Cancer Immunotherapy
• +۷ مورد دیگر

Ramon Klein Geltink is an Assistant Professor in the Department of Pathology and Laboratory Medicine at the University of British Columbia's Faculty of Medicine, and an Investigator at BC Children's Hospital Research Institute (BCCHR). His research program focuses on understanding how immune cell metabolism influences function in both cancer and autoimmune conditions, with particular emphasis on childhood diseases. Dr. Klein Geltink's research interests center on immunometabolism, specifically how metabolic pathways regulate T cell function in cancer immunotherapy and autoimmune diseases. His lab investigates the role of metabolite availability, transport, enzyme expression, and cofactor availability in immune cell activation and function. Key research areas include adoptive cellular therapy, metabolic reprogramming of immune cells, and the application of metabolomic techniques to develop better treatments for children with immune-related diseases. Analysis of Dr. Klein Geltink's recent publications reveals a strong focus on CD8+ T cell metabolism in cancer immunotherapy, with particular attention to how nutrients like glutamine, fatty acids, and redox balance influence T cell function in the tumor microenvironment. His work bridges fundamental metabolic research with clinical applications, particularly in pediatric oncology and autoimmune disorders. The research spans from basic metabolic mechanisms to translational applications, with several publications examining how metabolic interventions could improve cellular therapies. Dr. Klein Geltink collaborates extensively with clinicians and clinician-scientists at BCCHR to translate metabolic findings into potential therapeutic approaches. His lab utilizes biochemical and metabolomic techniques to understand immune cell metabolism and its implications for disease treatment. His research group includes multiple postdoctoral fellows, graduate students, and research assistants working on various aspects of immunometabolism. Dr. Klein Geltink's work has been supported by competitive funding mechanisms including CIHR Project Grants, indicating recognition of the significance and quality of his research program.

Megan Levingsمشاهده پروفایل

استاد

• Immunology
• Cell Therapy
• Immune Tolerance
• +۴ مورد دیگر

Megan Levings is a Professor at the University of British Columbia in the Department of Surgery and School of Biomedical Engineering. She serves as Head of the Immunity in Health and Disease program at BC Children's Hospital Research Institute while maintaining associate membership in the Department of Microbiology and Immunology. Her research focuses on harnessing regulatory T cells (Tregs) for immune tolerance therapies in transplantation and autoimmune diseases. Research Themes: Treg molecular/cellular biology Clinical Treg therapy trials Standardized immune monitoring implementation Engineering antigen-specific Tregs Transplant rejection prevention Autoimmune disease treatment Key Collaborations: Canadian National Transplantation Research Program Canucks for Kids Fund Childhood Diabetes Laboratories BC Diabetes Research Network Facilities: Located at BC Children's Hospital Research Institute Laboratory Room A4-186

Francis Lynnمشاهده پروفایل

استاد

• Diabetes Research
• Pancreatic Beta-Cell Biology
• Human Pluripotent Stem Cells
• +۴ مورد دیگر

Francis C. Lynn is a Professor at the University of British Columbia (UBC) , affiliated with the Department of Surgery and School of Biomedical Engineering . His research focuses on pancreatic β-cell biology, diabetes pathogenesis, and regenerative therapies using human pluripotent stem cells. Key affiliations: UBC , BC Children's Hospital Research Institute , BC Diabetes Research Network Research emphasis: Gene regulatory networks in β-cell differentiation, CRISPR/Cas applications, and cell-based diabetes treatments. Recent research trends include stem cell-derived β-cell engineering, single-cell transcriptomics for lineage tracking, and strategies to enhance islet transplantation via immunomodulation (e.g., CCL22-expressing grafts). Publications in 2024–2025 highlight environmental toxin impacts (Dechlorane Plus), MED15’s role in β-cell maturation, and AHR-HIF1α pathway interactions in diabetes. Students include PhD candidate Alexander Garner , who explored pancreatic islet architecture. The Lynn Lab ( lynnlab.ubc.ca ) employs murine and human stem cell models to dissect β-cell failure mechanisms and regeneration pathways.

• Pharmacology
• Cellular Signalling
• Free Fatty Acid Receptors
• +۴ مورد دیگر

Dr. Kenneth Watterson is a Lecturer in Molecular Biosciences at the University of Glasgow. He is affiliated with the Molecular Pharmacology & Cellular Signalling research group, focusing on lipid signaling and metabolic regulation. Research Interests Pharmacology of free fatty acid receptors (FFA1, FFA4, GPR120) Role of sphingosine-1-phosphate (S1P) in smooth muscle contraction and wound healing AMPK signaling in glucose and lipid metabolism Neuroendocrine regulation of energy balance Development of pharmacological tools for metabolic disease research Article Trends Dr. Watterson's publications (2000-2017) demonstrate expertise in S1P signaling , FFA receptor pharmacology , and metabolic disease mechanisms . His work spans diabetes research , smooth muscle physiology , and lipid mediator biology , with recent emphasis on drug discovery for metabolic disorders. Labs & Teams Active member of the Molecular Pharmacology & Cellular Signalling group at University of Glasgow, collaborating on lipid signaling projects. His research involves interdisciplinary teams in pharmacology, endocrinology, and cell biology.

• Nuclear Medicine
• Radiology
• Molecular Imaging
• +۱۲ مورد دیگر

Orhan K. Öz, M.D., Ph.D., is a Professor of Radiology at UT Southwestern Medical Center and Professor of Biomedical Engineering at the UT Southwestern Graduate School of Biomedical Sciences. He serves as Chief of Nuclear Medicine, Medical Director of Nuclear Medicine at Parkland Memorial Hospital, and Director of the Nuclear Medicine Residency Program. He holds the Wechun Pak Professorship of Bone Physics and the Robert W. Parkey, M.D. Distinguished Professorship in Radiology. B.S. in Biology, Chemistry, and Mathematics – Morehouse College M.S. in Applied Mathematics – Clark Atlanta University M.D. and Ph.D. in Biophysics – Stanford University Residency in Radiology – UT Southwestern Advanced Training in PET – University of California, Los Angeles Dr. Öz's research focuses on imaging pancreatic beta cells , diabetic foot infections , novel imaging probe development , and estrogen regulation of bone metabolism . His work bridges nuclear medicine, molecular imaging, endocrinology, and oncology. He has developed a SPECT/CT-based scoring system for diabetic foot infections, contributing significantly to clinical practice. His recent publications reflect a strong trend in molecular and hybrid imaging , particularly using SPECT/CT and PET for cancer, metabolic bone diseases, and endocrine disorders. The research emphasizes quantitative imaging , biomarker development , and translational applications in diabetes and neuroendocrine tumors. Scientific honors include: Wechun Pak Professorship of Bone Physics Robert W. Parkey, M.D. Distinguished Professorship in Radiology Recognition by peers in RSNA and SNMMI for contributions Dr. Öz is actively involved in academic service, mentoring, and grant-funded research. He has served as Co-Director of the Preclinical Nuclear Imaging Laboratory and the Molecular Imaging Probe Laboratory. He advises on radiation safety as Chief of Radiation Safety at Parkland Health & Hospital System and participates in key institutional and international committees, including the IRB Subcommittee on Human Use of Radiation and the International Society of Clinical Densitometry’s Scientific Advisory Council. He is a dedicated educator and frequently lectures nationally and internationally in countries including Australia, Turkey, and China. His editorial contributions include peer-reviewing for journals such as Bone , Journal of Nuclear Medicine , Endocrine , and PLOS One .

• Magnetic Resonance Imaging (MRI)
• Molecular Imaging Agents
• Metabolic Pathway Analysis
• +۵ مورد دیگر

A. Dean Sherry is a Professor of Chemistry at the University of Texas at Dallas and Professor of Radiology at UT Southwestern Medical Center, with over 50 years of combined academic service. He held the Cecil & Ida Green Distinguished Chair in Systems Biology (2005-2022) and directed UT Southwestern's Advanced Imaging Research Center (2005-2019). Key Research Areas: Development of paraCEST agents for pH/redox imaging, hyperpolarized 13C metabolic tracers, and zinc-responsive MRI contrast agents. Awards: Doherty Award (1990), Chancellor’s Teaching Award (1994), ISMRM Fellow (2011), World Molecular Imaging Society Fellow (2015), Gold Medals (ISMRM 2015, WMIS 2013), NAI Fellow (2023). Applications: Liver/heart metabolism studies, tumor imaging (glioblastoma, prostate cancer), pancreatic beta-cell function monitoring. Techniques: 13C isotopomer analysis, dynamic nuclear polarization, 31P MRS for ATP synthesis measurement. His group co-developed activatable MRI agents that respond to biological indices like pH and metal ions. Publications span molecular imaging probe design, metabolic pathway analysis, and high-field (7T) human metabolic studies using 31P magnetization transfer experiments.