جست‌وجوی استاد و پژوهشگر

John C Goreمشاهده پروفایل

استاد

• Biomedical Imaging
• Medical Physics
• Neuroscience
• +۳ مورد دیگر

John C Gore is a University Professor and holds the Hertha Ramsey Cress Chair in Medicine at Vanderbilt University. He is affiliated with the School of Engineering, serving as Director of the Vanderbilt University Institute of Imaging Science (VUIIS). His academic roles include Professorships in Radiology and Radiological Sciences, Biomedical Engineering, Molecular Physiology and Biophysics, and Physics and Astronomy. Gore's research focuses on advancing biomedical imaging techniques, particularly MRI applications in neuroscience and clinical diagnostics. He holds a Ph.D. in Physics from the University of London and has authored over 700 publications. His work bridges multiple disciplines, including neuroimaging, diffusion MRI, and AI integration in medical imaging. Education: Ph.D., Physics, University of London B.A., Law, Ealing College B.Sc., Physics, University of Manchester Research Interests: Development of MRI technologies for studying brain function, cellular imaging, and translational applications in medicine. His lab, VUIIS, specializes in cutting-edge imaging modalities for disease diagnosis and treatment monitoring. Articles Overview: Recent work includes AI-driven imaging algorithms, spinal cord injury diagnostics, and amyloid-beta nanobody targeting. His studies span from basic physics to clinical translation, emphasizing cross-disciplinary collaboration.

Christoph Rauمشاهده پروفایل

استادیار

• Cardiovascular Disease
• Genetics
• Epigenetics
• +۳ مورد دیگر

Dr. Christoph Rau is an Assistant Professor in the Department of Genetics at the UNC School of Medicine, with affiliations in the Computational Medicine Program and McAllister Heart Institute. He earned a PhD in Microbiology, Immunology & Molecular Genetics from UCLA and completed a postdoc in Cardiology there. His research focuses on systems genetics approaches to study genetic and epigenetic factors influencing cardiovascular disease, particularly using mouse models like the Collaborative Cross. His work integrates genomic, epigenetic, and transcriptomic data to identify regulators of heart failure progression. Key grants include an NIH R01 and a K99/R00 award. He mentors students in the Biological & Biomedical Sciences Program (BBSP) and teaches courses on animal models in disease research. Education: BSc from Harvey Mudd College (Mathematical Biology), PhD from UCLA (201?), Postdoc at UCLA Cardiology (201?). Research Interests: Epigenetic regulation of cardiac disease Cardiac cell-type composition dynamics Systems genetics approaches to heart failure RNA splicing regulators like RBFox1 Publications: Over 40 peer-reviewed articles since 2011, emphasizing translational genetics and computational methods in cardiovascular research. Recent work highlights DNA methylation pathways, cardiomyocyte ploidy dynamics, and cell-type composition analysis in heart failure. Mentorship & Grants: BBSP admissions committee member; emphasized trainee development across academia/industry. Active in lab environment fostering work-life balance and scientific curiosity. Labs/Teams: Leads the Rau Lab at UNC, collaborating on multi-omics studies with institutions like the McAllister Heart Institute.

• Diabetes
• Obesity
• Beta-cell Biology
• +۳ مورد دیگر

Dr. Jean Buteau is a Professor at the University of Alberta, holding dual roles as Professor in the Department of Agricultural, Food & Nutritional Sciences within the Faculty of Agricultural, Life and Environmental Sciences, and as Division Director of Human Nutrition. He earned his PhD in Biochemistry from the University of Montreal. His research focuses on molecular mechanisms governing pancreatic beta-cell function, with particular emphasis on diabetes and obesity-related metabolic disorders. Research interests include the hormonal and nutritional regulation of beta-cell mass and function, exploring novel therapeutic targets to enhance beta-cell proliferation and survival. He has been recognized with prestigious awards such as the Canadian Institutes of Health Research New Investigator Award (2013–2018) and the Canadian Diabetes Association Scholar Award (2008–2013). Dr. Buteau teaches advanced courses on diabetes, cardiovascular disease, and lifestyle interventions (AFNS 543/NUTR 443) and supervises undergraduate research projects (NUTR 450). His work bridges biochemical mechanisms with clinical applications in metabolic disease treatment. Education: PhD in Biochemistry, University of Montreal Affiliations: Department of Agricultural, Food & Nutritional Sciences, Faculty of Agricultural, Life and Environmental Sciences His publications explore GLP-1 signaling, beta-cell stress responses, and molecular pathways in metabolic dysfunction, contributing to advancements in diabetes therapy strategies.

Liping Huangمشاهده پروفایل

استاد مدعو

• Zinc Homeostasis
• Adiposity Regulation
• Insulin Metabolism
• +۳ مورد دیگر

Liping Huang, Ph.D., is a Research Geneticist at the USDA ARS Western Human Nutrition Research Center (WHNRC) and an Adjunct Professor in the Department of Nutrition at the University of California, Davis. Her research focuses on zinc transporter proteins and their roles in body zinc homeostasis, adiposity regulation, insulin metabolism, and prostate cancer prevention. She employs mouse models and cell lines to investigate zinc’s impact on metabolic disorders and cancer risk reduction. Dr. Huang holds an M.D. from Shanghai Medical University (PR China) and a Ph.D. in Microbiology from the University of Iowa. Her work bridges nutritional science, molecular genetics, and clinical implications, with a particular emphasis on zinc’s role in health and disease. She collaborates with USDA and academic institutions to advance understanding of nutrient-gene interactions. Her research interests include zinc transporters (SLC30 and SLC39 families), the molecular mechanisms of zinc in prostate cancer suppression, and the interplay between zinc metabolism and metabolic syndromes such as insulin resistance and obesity. She investigates dietary interventions, such as soy-derived lunasin peptides, for their chemopreventive effects in prostate health. Dr. Huang’s contributions span over two decades, with publications in journals like *Advances in Nutrition*, *Journal of Biological Chemistry*, and *Cancer Letters*. Her lab is affiliated with the USDA ARS WHNRC and UC Davis, emphasizing translational research in nutritional and molecular biology.

Amminikutty Jeevanمشاهده پروفایل

استادیار مدعو

• Microbial Pathogenesis
• Immunology
• Infectious Diseases
• +۳ مورد دیگر

Amminikutty Jeevan, PhD, is an Adjunct Assistant Professor in the Department of Microbial Pathogenesis & Immunology at Texas A&M University's School of Medicine. His research focuses on understanding how ultraviolet radiation (UVR) impacts immune responses to Mycobacterium tuberculosis infections, particularly after BCG vaccination. He investigates mechanisms of immune suppression mediated by cytokines like IL-10 and TGF-β, as well as reactivation of latent infections through Th2 phenotype shifts. Education and Training: University of Bombay: MSc (1975), PhD (1979) MRC Clinical Research Centre, England: Postdoctoral Research (1985–1987) U.T. MD Anderson Cancer Center, Houston: Postdoctoral Research (1988–1989) Research Interests: Jeevan's work integrates UV exposure studies with guinea pig models of tuberculosis. He explores vaccine efficacy, cytokine dynamics (e.g., gamma interferon, TNF-α), and macrophage functions. Key studies include UVR-induced immunosuppression, chemokine receptor CXCR1/CXCR2 identification in guinea pigs, and vaccine-induced cytokine responses in infectious challenges. Publications Trends: His articles consistently address UV radiation’s role in immune modulation, BCG vaccination outcomes, and guinea pig models for tuberculosis research. Themes include macrophage dysfunction, cytokine regulation (IL-10, TGF-β, Rantes), and translational studies between murine and guinea pig systems. Lab Affiliation: Based in the Reynolds Medical Building, Room 407, College Station, TX, Jeevan collaborates with institutions like U.T. MD Anderson Cancer Center and international labs, contributing to interdisciplinary immunology and infectious disease research.

Margarita Martinez-Moczygembaمشاهده پروفایل

استادیار

• Immunology
• Microbial Pathogenesis
• Cytokine Signaling
• +۳ مورد دیگر

Margarita Martinez-Moczygemba, PhD, is an Assistant Professor in the Department of Microbial Pathogenesis & Immunology at Texas A&M University School of Medicine. Her research focuses on understanding molecular mechanisms regulating interleukin-5 (IL-5) receptor signaling and endocytic trafficking, specifically exploring how ubiquitin/proteasome pathways control receptor degradation and signal termination in allergic respiratory diseases. Education : Bachelor of Science (BS), Texas A&M University, 1989 Master of Science (MS), Texas A&M University, 1992 Doctor of Philosophy (PhD), State University of New York at Stony Brook, 1997 Postdoctoral Fellowship, Baylor College of Medicine, Houston, 1997–2002 Research Interests : Her lab investigates cytokine receptor biology, emphasizing IL-5's role in eosinophil activation. Key areas include: (1) Ubiquitin-mediated regulation of IL-5 receptor internalization, (2) Endocytic pathway compartmentalization effects on signaling, and (3) Mechanisms preventing cytokine-induced tissue damage. This work has implications for asthma and inflammatory disease therapies. Publications : Recent work includes studies on IL-5 receptor ubiquitination mechanisms (J Biol Chem 2011), Shiga toxin-induced autophagy (Cell Microbiol 2011), and GM-CSF receptor deficiencies in pulmonary disorders (J Exp Med 2008). Her research bridges molecular immunology with translational medicine. Affiliations : Located at Texas A&M University Health Science Center in Houston, her lab collaborates with immunology and respiratory disease programs. No grant information or student advisees are explicitly listed in available materials.

Thomas Weimbsمشاهده پروفایل

استاد

• Kidney Disease
• Metabolic Health
• Chronic Kidney Disease
• +۴ مورد دیگر

Thomas Weimbs is a Professor in the Department of Molecular, Cellular, and Developmental Biology at the University of California, Santa Barbara. His research focuses on understanding the molecular mechanisms underlying kidney diseases, particularly polycystic kidney disease (PKD) and chronic kidney disease (CKD), and developing therapies based on metabolic interventions such as ketogenic diets. His lab investigates how ketosis—induced by low-carbohydrate diets—modulates cellular pathways to slow disease progression. Weimbs has launched a startup, Santa Barbara Nutrients, to translate research into medical foods like KetoCitra and the Ren-Nu program, which provide nutritional strategies for PKD patients. He emphasizes the role of diet and lifestyle in managing kidney health, challenging traditional protein-restriction paradigms. His work bridges basic science and clinical applications, with a strong focus on patient-centered therapies. Research Interests: Polycystic kidney disease, metabolic therapy, renal cystogenesis, ketosis, and kidney healthspan. Key Projects: Development of Ketogenic Metabolic Therapy (KMT) programs, analysis of crystal-induced cyst formation, and GPR109A signaling pathways. Startup Involvement: Co-founded Santa Barbara Nutrients to commercialize research findings into medical foods and dietary programs. Weimbs collaborates with clinicians and industry to implement therapies, such as the Ren-Nu program, which combines nutrition and lifestyle changes to improve kidney function. His research also explores the role of dietary supplements like citrate and beta-hydroxybutyrate in mitigating disease progression. He actively communicates findings through academic publications, public talks, and social media, advocating for evidence-based nutritional approaches in kidney care.

Mathieu Ferronمشاهده پروفایل

استاد

• Vitamin K Metabolism
• Energy Metabolism
• Diabetes Research
• +۴ مورد دیگر

Mathieu Ferron is a tenured Professor in the Department of Biochemistry and Molecular Medicine at the Université de Montréal. He leads the Integrative and Molecular Physiology Research Unit at the Montreal Clinical Research Institute (IRCM). His research focuses on the physiological and pathological roles of vitamin K and γ-carboxylation in energy metabolism, diabetes, and bone diseases. Ferron holds the Canada Research Chair in Bone and Energy Metabolism. His work bridges biochemistry, proteomics, and molecular biology to uncover novel mechanisms linking bone-derived hormones to systemic metabolism. Affiliations: IRCM, Réseau CMDO, Réseau RSBO Education: Ph.D. in Molecular Biology (2006, Université de Montréal), Postdoc at Columbia University (2013) Research Interests: Vitamin K-dependent proteins, osteocalcin, β-cell function, gamma-carboxylation, metabolic diseases . His lab uses genetically modified mice, proteomics, and CRISPR-Cas9 to study how vitamin K influences diabetes and osteoporosis. Recent breakthroughs include identifying novel γ-carboxylated proteins and their roles in endocrine signaling. Awards: 2020 Jean-Davignon Young Investigator Award, 2019 Étoiles Effervescence Prize, Pierre-Bois Excellence Award (2017). Grants: Over $32M in funding from CIHR, Diabetes Canada, and FRQS. Current projects include vitamin K’s role in beta-cell function and γ-carboxylome characterization. Labs/Teams: Head of the Integrative and Molecular Physiology Unit at IRCM, collaborates with the Montreal Diabetes Research Center.

Adam Snyderمشاهده پروفایل

استادیار

• Visual Attention Mechanisms
• Neural Dynamics
• Cognitive Neuroscience
• +۳ مورد دیگر

Adam Snyder is an Assistant Professor in the Department of Brain and Cognitive Sciences at the University of Rochester, School of Arts & Sciences. His research focuses on understanding the computational mechanisms that allow the brain to process goal-relevant visual information while filtering distractions, examining both small neuronal populations and large-scale cortical coordination. His work spans micro- and macro-scale mechanisms of visual attention, aiming to develop interventions for visual navigation challenges. Research Interests include: Neural dynamics underlying visual attention Cortical coordination and population activity False alarm mechanisms in visual processing Generative models of visual scenes EEG and neural oscillations in attention His publications highlight advancements in understanding attentional coding in prefrontal and visual cortices, dynamic neuronal signaling in V4, and global arousal signatures via EEG. While no awards or grants are explicitly listed, his work contributes significantly to computational and experimental neuroscience. He can be contacted at adam.snyder@rochester.edu or through his office at 318 Meliora Hall.

Leonard Shultzمشاهده پروفایل

استاد

• Immunodeficiency Diseases
• Autoimmunity
• Hematological Diseases
• +۴ مورد دیگر

Leonard Shultz is a Professor at the University of Maine Graduate School of Biomedical Science and Engineering. His research focuses on the development and application of humanized SCID mice for translational biomedical research, particularly in immunodeficiency diseases, autoimmunity, and hematological disorders. He has pioneered mouse models like the NOD/SCID/IL2rγ null strain to study human immune system development and disease mechanisms. Education: PhD in Immunology from the University of Massachusetts (1972). Shultz’s work leverages genetically engineered mouse models to investigate diabetes, bone development, anemia, thrombocytopenia, infectious diseases , and transplantation tolerance . His research has significant implications for regenerative medicine and preclinical testing of therapies. In 2010, he identified the Abcg5 gene mutation in the trac mouse model, linking elevated plant sterols to thrombocytopenia and cardiomyopathy , mirroring human Mediterranean Macrothrombocytopenia . This discovery established a critical single-gene model for studying sterol-related hematological and cardiovascular pathologies. His publications from 2008–2011 highlight interdisciplinary applications of humanized mice in leukemia stem cell research, HIV-1 gene editing, dengue virus studies , and solid tumor xenografts . Collaborations span institutions like the University of Massachusetts Medical School and Riken Research Center for Allergy and Immunology.

• Molecular Imaging
• Heterocyclic Chemistry
• PET Chemistry
• +۳ مورد دیگر

Luke Odell is a Full Professor at the Department of Medicinal Chemistry; Preparative Medicinal Chemistry at Uppsala University. He holds a BSc (Honours) in Forensic Science from the University of Newcastle (Australia, 2002) and a PhD in Chemistry from the same institution (2006), focusing on enzyme inhibitor synthesis. After a postdoctoral position under Professor Mats Larhed at Uppsala University, he became a Senior Lecturer in 2016 and was promoted to Full Professor in 2022. His research focuses on molecular imaging, heterocyclic chemistry, PET chemistry, and medicinal chemistry, with a strong emphasis on drug discovery and radiopharmaceutical development. Key areas include designing PET tracers for neurodegenerative diseases, developing novel synthetic methods for bioactive compounds, and exploring enzyme inhibitors with therapeutic potential. Recent work includes studies on psilocin derivatives, IRAP inhibition for neuroprotection, and optimized radiolabeling techniques for Affibody molecules. Dr. Odell’s publications span over 15 years, with a focus on organic synthesis, medicinal applications, and analytical techniques like MALDI-MS imaging. His team collaborates on projects addressing challenges in drug delivery, enzyme mechanisms, and molecular imaging technologies, contributing to advancements in both academic and clinical settings.

Martin Ulmschneiderمشاهده پروفایل

استاد

• Computational Chemistry
• Membrane Biology
• Antimicrobial Peptides
• +۳ مورد دیگر

Professor Martin Ulmschneider is a Professor of Computational Chemistry in the Department of Chemistry at King's College London, part of the Faculty of Natural, Mathematical & Engineering Sciences. He leads the Ulmschneider Group, focusing on peptide-membrane interactions for biomedical applications. His research employs computational and experimental techniques to design membrane-active peptides for diagnostics and therapies, particularly in oncology and neurodegenerative diseases. Ulmschneider holds a DPhil from the University of Oxford’s Laboratory of Molecular Biophysics and has held international fellowships at institutions including the Indian Institute of Science, University of Rome La Sapienza, and Johns Hopkins University. He joined King’s in 2017 and became Department Head in 2022. His research interests span molecular dynamics simulations, antimicrobial peptide design, blood-brain barrier permeability modeling, and cancer nanotherapeutics. Recent work includes developing peptides targeting triple-negative breast cancer and elucidating mechanisms of drug transport across biological barriers. Ulmschneider supervises a team of postgraduate researchers and research associates, and has led projects funded by the BBSRC. His lab collaborates globally on topics like Alzheimer’s disease protein interactions and nanoparticle peptide delivery systems. Key achievements include simulating amyloid-beta precursor protein mechanisms and designing novel antimicrobial peptides with selective bacterial targeting.

Lukas Millesمشاهده پروفایل

استاد

• Protein Design
• Biophysics
• Deep Learning
• +۳ مورد دیگر

Prof. Dr. Lukas Milles is a Professor (W2) at the Gene Center, Ludwig-Maximilians-Universität (LMU) Munich and an Emmy Noether Group Leader at the Max Planck Institute (MPI) of Biochemistry in Martinsried. His research focuses on de novo protein design, leveraging deep learning and biophysical characterization to engineer proteins with novel functions. He holds appointments at both LMU and the MPI, bridging computational and experimental approaches in biomolecular design. Academically, Milles earned a PhD in Physics/Biophysics from LMU (2014–2018) under Prof. Hermann Gaub, followed by postdoctoral training at the University of Washington’s Institute for Protein Design (2019–2023) with Prof. David Baker. His interdisciplinary work spans protein stability, host-pathogen interactions, and synthetic biology, with a focus on autocatalytic enzymes and catch-bond mechanisms inspired by bacterial pathogens. Key research interests include single-molecule biophysics, high-throughput protein screening, and machine learning-driven design. His lab develops tools like RFdiffusion and ProteinMPNN to predict and engineer protein structures and functions. Notable achievements include designing mechanically robust proteins and elucidating the molecular basis of pathogen adhesin stability. Scientific awards include the HFSP Cross-Disciplinary Fellowship (2020–2023) and EMBO Long-Term Fellowship (2019–2020). His group actively collaborates with institutions worldwide, advancing applications in biomedicine and biomaterials. Current projects prioritize synthetic protein systems for targeted therapies and mechanoresponsive biomolecules.

• Beta Cell Therapy
• Signal Transduction Mechanisms
• Biomaterials Engineering
• +۳ مورد دیگر

Karine Hellemans is a Professor of Clinical Sciences at Brussels Free University-VUB since 2006, coordinating the Diabetes Research Center and the Center for Beta Cell Therapy in Diabetes. Her research focuses on beta cell biology, biomaterials, and preclinical methods to enhance beta cell function. She holds a PhD in Medical Sciences (2003) and an MSc in Biology (1991). Affiliations: Brussels Free University-VUB, Diabetes Research Center, Center for Beta Cell Therapy Research interests include signal transduction pathways in beta cells, biomaterial development for cell therapy, and improving functional beta cell mass. Recent work emphasizes microfluidic techniques for drug delivery and beta cell implant optimization. Key Projects: Core Facility Animalarium (2018–2025), μFlow Cell (2024–2028), and HERC67 (2024–2028). Awards: 2007 Poster Prize from the Belgian Society for Cell Biology. Labs/Teams: Head of the Beta Cell Therapy Coordination Unit, involved in multidisciplinary collaborations on beta cell therapy and biomaterials.

Willem Staelsمشاهده پروفایل

پژوهشگر

• Pancreatic Biology
• Type 1 Diabetes
• Beta Cell Regeneration
• +۳ مورد دیگر

Willem Staels is an Unpaid employee at the Vrije Universiteit Brussel (VUB), affiliated with the Faculty of Medicine and Pharmacy and the Department of Genetics, Reproduction and Development. He holds a MD and PhD and maintains a clinical role as a UZB Physician in Pediatrics. His research focuses on pancreatic beta cell biology, diabetes mechanisms, iron metabolism, and pediatric obesity. Staels leads multiple interdisciplinary projects, including investigations into beta cell regeneration and vascular signaling in diabetes therapy. Education: MD and PhD (specific institutions not detailed in text, inferred from titles). Research Interests: Staels' work spans diabetes pathophysiology, particularly beta cell dysfunction and regeneration. He explores iron's role in beta cell maturation and investigates pediatric obesity's metabolic and inflammatory consequences. Recent projects include studies on beta cell iron metabolism and vascular signals for maturation of stem cell-derived beta cells. Awards: Recognized with the Young Investigator Award (ESPE 2021), Horlait Dapsens Prize (2018), and SANDOZ BELSPEED ESPE Award (2024). His research has been featured in high-impact journals like Trends in Endocrinology and Metabolism and Diabetes Care . Grants & Projects: Leads 11 active projects, including the FWOAL1158 (neurogenin3 in beta cell regeneration) and HERC66 (3D cellular imaging). Collaborates widely with institutions like the University of Leuven and VIB. Labs/Teams: Works within the Genetics Reproduction and Development group at VUB, contributing to multi-institutional initiatives like the 3D-CELLMAP imaging project.