معرفی
Amminikutty Jeevan, PhD, is an Adjunct Assistant Professor in the Department of Microbial Pathogenesis & Immunology at Texas A&M University's School of Medicine. His research focuses on understanding how ultraviolet radiation (UVR) impacts immune responses to Mycobacterium tuberculosis infections, particularly after BCG vaccination. He investigates mechanisms of immune suppression mediated by cytokines like IL-10 and TGF-β, as well as reactivation of latent infections through Th2 phenotype shifts.
Education and Training:
- University of Bombay: MSc (1975), PhD (1979)
- MRC Clinical Research Centre, England: Postdoctoral Research (1985–1987)
- U.T. MD Anderson Cancer Center, Houston: Postdoctoral Research (1988–1989)
Research Interests:
Jeevan's work integrates UV exposure studies with guinea pig models of tuberculosis. He explores vaccine efficacy, cytokine dynamics (e.g., gamma interferon, TNF-α), and macrophage functions. Key studies include UVR-induced immunosuppression, chemokine receptor CXCR1/CXCR2 identification in guinea pigs, and vaccine-induced cytokine responses in infectious challenges.
Publications Trends:
His articles consistently address UV radiation’s role in immune modulation, BCG vaccination outcomes, and guinea pig models for tuberculosis research. Themes include macrophage dysfunction, cytokine regulation (IL-10, TGF-β, Rantes), and translational studies between murine and guinea pig systems.
Lab Affiliation:
Based in the Reynolds Medical Building, Room 407, College Station, TX, Jeevan collaborates with institutions like U.T. MD Anderson Cancer Center and international labs, contributing to interdisciplinary immunology and infectious disease research.
