جستجوی استاد راهنمای دانشگاهی

Dr. Camila Aquino serves as Assistant Professor in both the Department of Clinical Neurosciences and Department of Community Health Sciences at the University of Calgary's Cumming School of Medicine, and is a Full Member of the Hotchkiss Brain Institute. As Medical Director of the Deep Brain Stimulation Program, she specializes in Parkinson's disease, essential tremor, dystonia, and chorea management, including EMG-guided botulinum toxin injections. Her educational background includes: M.D. in Medicine from Escola Superior de Ciencias da Santa Casa (2005) M.S. in Neurosciences from Federal University of Sao Paulo (2012) Ph.D. in Neurosciences from Federal University of Sao Paulo (2019) M.S. in Health Research Methods, Clinical Epidemiology from McMaster University (2020) Dr. Aquino's research addresses unmet needs in movement disorders through innovative clinical trial designs for Parkinson's disease, focusing on precision-medicine approaches, early intervention, and outcome optimization. She actively evaluates neuromodulation therapies including Deep Brain Stimulation, Spinal Cord Stimulation, and MRgFUS, with emphasis on expanding indications and improving patient outcomes. As an International Parkinson and Movement Disorder Society member, she chairs the web-based learning committee and serves on evidence-based medicine and outcome measure committees. Analysis of her 15 most recent publications (2021-2025) reveals a cohesive research trajectory centered on Parkinson's disease management, with dominant themes in motor fluctuation treatments, deep brain stimulation methodology, and clinical trial innovation. Her work bridges fundamental clinical practice guidelines with advanced neuromodulation technologies, demonstrating consistent commitment to evidence-based solutions for movement disorders. Her scientific recognition includes: Parkinson Canada research grant Mohammed Al Zaibak Foundation scholarship CAPES scholarship from Brazilian Ministry of Education Dr. Aquino has secured significant research funding supporting clinical trials in Parkinson's disease neuroprotection and neuromodulation therapies. While specific student advisees aren't listed, her leadership of the DBS Program and active clinical trial portfolio indicate substantial mentorship responsibilities. Her grant portfolio emphasizes translational research with direct clinical impact. She directs the University of Calgary's Deep Brain Stimulation Program and contributes to the MRI-guided focused ultrasound initiative. Through her International Parkinson and Movement Disorder Society committee roles, she shapes global educational standards and evidence-based practices in movement disorders.

• Movement Disorders
• Parkinson's Disease
• Deep Brain Stimulation
• +۵ مورد دیگر

Dr. Steven G. Clarke is a Distinguished Professor at UCLA Department of Chemistry & Biochemistry and director of research at the Molecular Biology Institute . His work bridges protein chemistry , methylation biology , and aging research through studies of spontaneous protein damage and its repair mechanisms. Education: BA in Chemistry and Zoology, Pomona College (magna cum laude, Phi Beta Kappa) PhD in Biochemistry and Molecular Biology, Harvard University (NSF Fellow) Postdoctoral Fellowship at UC Berkeley (Miller Fellow) Dr. Clarke's research focuses on protein isoaspartyl repair via PCMT1/PIMT enzymes , ribosomal protein methylation in Saccharomyces cerevisiae , and PRMT family characterization including PRMT7 and PRMT9. His lab combines biochemical assays , genetic models , and structural analysis to investigate aging mechanisms and disease implications. Recent publications highlight: COQ5 structure-function analysis in coenzyme Q biosynthesis PCMTD1 ubiquitin ligase interactions PRMT7 substrate specificity in histone H2B Protein isoaspartyl impacts on T cell function in lupus Novel PRMT inhibitors for cancer therapy Methionine addiction in osteosarcoma malignancy Major scientific awards: American Chemical Society Ralph F. Hirschmann Award in Peptide Chemistry NIH MERIT Award Ellison Medical Foundation Senior Scholar Award William C. Rose Award, ASBMB UCLA Distinguished Teaching Award (Eby Award winner) Current lab members include PhD candidates Eric Pang (UCSB) and Sining "Cindy" Wang (UCLA), while undergraduates Celeste Medina-Seymoure , Elizabeth Oroudjeva , Olivia Pacheco , and Jasmine Winter contribute to ongoing proteostasis studies. Collaborations with Profs. Jose Rodriguez and Catherine Clarke demonstrate interdisciplinary research approaches.

• Biochemistry
• Systems Biology
• Biological Regulation
• +۸ مورد دیگر

Professor Victor Fung is a leading academic in neurology and motor control at the Sydney Medical School , University of Sydney. He serves as Director of the Movement Disorders Unit at Westmead Hospital and holds prominent roles in the International Parkinson and Movement Disorder Society (President) and the Asia Pacific Affairs Committee of the Australian and New Zealand Association of Neurologists. His research focuses on Parkinson's disease , dystonia , tremor , and movement disorder genetics , with over 250 peer-reviewed publications and an h-index of 61. His work spans Clinical trials for Parkinson's treatments (e.g., foslevodopa/foscarbidopa infusion, incobotulinumtoxinA) Genetic studies on dystonia and Parkinsonism Neurophysiological assessments of tremor and balance Development of screening tools for dystonia and Parkinson's complications Key article trends highlight genetic diversity in dystonia, neuroinflammatory mechanisms in tremor, and behavioral neurology in Parkinson's disease. He contributes to editorial boards of npj Parkinson's Disease , Journal of Clinical Movement Disorders , and Faculty Opinions . While no explicit student lists are provided, his collaborations span global institutions. His clinical work at Westmead Hospital addresses device-assisted therapies and complex movement disorders.

• Neurology
• Movement Disorders
• Parkinson's Disease
• +۶ مورد دیگر

Jessica Williams, PhD is an Assistant Professor in the Department of Neurosciences at the Cleveland Clinic Lerner Research Institute (LRI) with additional faculty appointments at Case Western Reserve University, Kent State University, and Cleveland State University. She serves as the Cleveland Clinic liaison for Kent State University and represents the Clinic on the Executive Council for the Brain Health Institute and the Biomedical Sciences Graduate Program Executive Committee. Education: Postdoctoral Fellowship in Neuroimmunology, Washington University School of Medicine (2017) Ph.D. in Immunology, The Ohio State University (2011) M.S. in Physiology, Purdue University (2006) B.S. in Biology/Chemistry, Lindenwood University (2004) Dr. Williams' research focuses on neuroimmune interactions during multiple sclerosis, particularly examining regional responses of CNS glia to immune stimuli and astrocyte-immune crosstalk. Her lab employs murine MS models, primary human and murine cell analyses, and MS patient lesion assessment to investigate cytokine-mediated neuroprotection and CNS repair mechanisms. Recent work highlights protective astrocyte functions mediated by traditionally deleterious cytokines. Analysis of her 15 most recent publications reveals consistent focus on neuroimmune crosstalk in MS, with increasing emphasis on astrocyte heterogeneity, cytokine signaling (particularly IFNγ), and novel therapeutic targets like immunoproteasomes. Key themes include regional CNS differences in immune responses, glial cell repair mechanisms, and translating basic findings into potential MS therapies. Scientific Awards: Lerner Research Institute Excellence in Education Award (2022) Mentor of the Year Award (2023) Dr. Williams actively mentors the next generation of scientists as evidenced by her CIMER Trained Mentor certification and the graduation of PhD student Brandon Smith. Her research is supported by significant funding from the NIH, National MS Society, W.M. Keck Foundation, Brain Health Research Institute, and Neurological and Vision Impact Area. She regularly serves on study sections for the NIH, National MS Society, and Department of Defense. The Williams Laboratory investigates the interplay between immune and central nervous systems during MS, with current projects examining cytokine-mediated neuroimmune crosstalk for CNS repair and regionally distinct glial responses to inflammation. The lab employs advanced techniques including murine MS models and primary human cell analyses to identify novel therapeutic pathways for MS patients.

• Neuroimmunology
• Multiple Sclerosis
• Astrocyte Biology
• +۵ مورد دیگر

KEMAL OZAN LÜLE is an Assistant Professor at Gaziantep University, Faculty of Medicine, Department of Internal Medicine , with an email contact at ozan@gantep.edu.tr . He holds an ORCID identifier and is registered in the YÖK Academic Information System. Education: Medical License from Dokuz Eylül University (2009–2016), Medical Specialization from Gaziantep University (2017–2021). Professional Experience: Specialist at Gaziantep Abdulkadir Yuksel State Hospital (2021–2024), General Practitioner at Arapgir Ali Özge State Hospital (2016–2017). Administrative Roles: Member of Measurement and Evaluation Board (2024), Internal Medicine Internship Education Coordinator (2024), English Medicine Assistant Coordinator (2024). His research focuses on Internal Medicine , with emphasis on Diabetes , Fatty Liver Disease , Neurocognitive Effects of diabetes treatments, Cancer Development linked to food preparation, Irritable Bowel Syndrome , and Adrenal Incidentaloma . Book Chapters: Development and Natural Course of Diabetic Fatty Liver Disease (2025), Effects of Pharmacological Agents on Neurological Functions (2023), Food Preparation Methods and Cancer (2023). He has co-authored multiple proceedings papers on topics including Temporal Arthritis , Lymphoma , Behçet’s Disease , and Fahr Syndrome , presented at national and international conferences.

• Internal Medicine
• Endocrinology
• Gastroenterology
• +۶ مورد دیگر

Aditi Das is a Full Professor in the School of Chemistry and Biochemistry at the Georgia Institute of Technology, College of Sciences. She leads the Das Laboratory, which focuses on the biochemistry and chemical biology of lipids, particularly studying cytochrome P450 enzymes and their role in lipid metabolism, endocannabinoid systems, and inflammatory pathways. Her educational background includes: B.Sc. in Chemistry from St. Stephen's College M.Sc. in Chemistry from Indian Institute of Technology, Kanpur (I.I.T) Ph.D. in Chemistry from Princeton University Postdoctoral research at Northwestern University (NSF-NSEC fellow) and Beckman Institute for Advanced Science and Technology, University of Illinois UC Professor Das's research interests center around understanding the physiological role of lipids in sustaining homeostasis and their implications in disease states such as neurodegenerative disorders, cancer, and cardiovascular diseases. Her laboratory specializes in: Enzymology of cytochrome P450s, particularly CYP2J2 epoxygenase Metabolism of ω-3 and ω-6 fatty acids and their derivatives Minor cannabinoid metabolism by cytochrome P450 enzymes Discovery of novel anti-inflammatory lipid metabolites and endocannabinoids Mechanistic studies of membrane proteins using nanodisc technology Her work bridges biochemistry, chemical biology, and pharmacology to uncover novel therapeutic targets related to lipid signaling pathways. Analysis of Professor Das's recent publications (2023-2025) reveals a strong focus on cannabinoid metabolism by cytochrome P450 enzymes, with particular emphasis on how these metabolic processes generate bioactive compounds that interact with the endocannabinoid system. Her research increasingly explores the therapeutic potential of omega-3 derived endocannabinoid epoxides in inflammatory and neurodegenerative conditions. The use of nanodisc technology for studying membrane proteins in near-native environments remains a consistent methodological thread throughout her work, enabling detailed mechanistic insights into enzyme function. Professor Das has received numerous prestigious awards recognizing her research excellence and teaching: 2024 NIH Outstanding Researcher Award (MIRA R35) for established investigators 2024 Vasser Woolley Faculty Fellowship 2023 Plenary Lecture at the International Society of the Study of Xenobiotics (ISSX) 2021 E.L.R. Stokstad Award 2019-2021 List of Teachers Ranked as Excellent 2019 Eicosanoid Research Foundation Young Investigator Award 2019 Zoetis Research Excellence Award 2019 Mary Swartz Rose Young Investigator Award 2015 National Scientist Development Award from the American Heart Association 2022 El Sohly Award from the American Chemical Society Professor Das actively mentors a diverse group of students and postdoctoral researchers, with several former lab members now holding faculty positions or working at prestigious institutions. Her laboratory has secured significant funding from NIH, NSF, and other sources to support research on lipid metabolism, cannabinoid pharmacology, and membrane protein biochemistry. Notable grants include an NIH R35 Outstanding Investigator Award (MIRA), an NIH R21 grant from NIDA, and multiple collaborative grants with other research groups. The Das Laboratory operates within the Petit Institute of Bioengineering and Biosciences (IBB) at Georgia Tech, utilizing state-of-the-art facilities for biochemical and biophysical studies. The lab specializes in nanodisc technology to study membrane proteins in near-native environments, with particular expertise in cytochrome P450 enzymes and their interactions with lipid substrates. Recent work has expanded into collaborative projects involving lipidomics, structural biology, and translational applications of lipid signaling research.

• Biochemistry and Chemical biology of Lipids
• Mechanism of Membrane proteins in Nanodiscs
• Enzymology of metalloproteins
• +۵ مورد دیگر

Debra Moore-Hill is an Associate Professor in the Department of Neurology at the Medical College of Georgia, Augusta University. She serves as Section Chief of Epilepsy and Vice Chair for Neurology Education, playing a pivotal role in clinical leadership and medical education. Her work spans epilepsy care, neurophysiology, and resident training. MPH in Public Health, Augusta University, 2017 MD, Medical College of Georgia, 2007 Her research and clinical interests focus on ICU EEG monitoring, epilepsy in women of childbearing age, and epilepsy in neuro-oncology patients. She is deeply committed to curriculum development and resident education, with a strong emphasis on clinical neurophysiology and the management of intractable epilepsy. Her work also addresses health disparities in epilepsy clinical trials and innovative treatments for autoimmune encephalitis. Recent publications highlight her expertise in spreading depolarization in stroke models, NORSE treatment with VNS, and disparities in epilepsy research. Her work bridges translational neuroscience, clinical innovation, and educational excellence. Clinical Science Teaching Distinguished Faculty Award, 2024 Alpha Omega Alpha Honor Society, 2022 Exemplary Teaching Award (2022, 2018) Top percentile scorer on national residency examination, 2011 Dr. Moore-Hill is actively involved in graduate medical education, serving as Chair of the GME Cardiology Special Review Committee and member of multiple GME and institutional quality committees. She mentors students through SEEP and has led public health initiatives, including CPR training and Women in STEM outreach. Her service extends to national organizations like the American Academy of Neurology and the American Clinical Neurophysiological Society. She contributes to resident education through courses such as Neurology Clerkships, Consult Clinics, and the Osler Apprenticeship. Her leadership in the Department of Neurology Quality/OPPE and GME Housestaff in Difficulty Consult Team underscores her commitment to educational and clinical excellence.

• Epilepsy
• Clinical Neurophysiology
• ICU EEG Monitoring
• +۶ مورد دیگر

Prof. Casper Hoogenraad is a full professor in Molecular Neuroscience at the Department of Cell Biology, Faculty of Science, Utrecht University. His research focuses on understanding how intracellular protein trafficking underlies neuronal development and function, with particular emphasis on the microtubule cytoskeleton, synaptic cargo trafficking, and synaptic plasticity. He leads an active research group within Utrecht University's Cell Biology department and collaborates extensively with other neuroscience research groups. Education: PhD, Erasmus University Rotterdam (1996-2001) Postdoc, Massachusetts Institute of Technology (2002-2005) Hoogenraad's research spans three main themes: cytoskeleton dynamics during neurodevelopment and synaptic plasticity, motor proteins and adaptors as regulators of synaptic transport, and psychiatric and neurologic disease disorders linked to intracellular transport. His work combines genetics, biochemistry, molecular, and cellular biology methods in in vitro (neuron cultures), ex vivo (brain slices), and in vivo (mice) systems, along with advanced microscopy techniques including immunofluorescent confocal microscopy, high-resolution live cell imaging, and photo-activated localization microscopy (PALM). Analysis of Hoogenraad's recent publications reveals a strong focus on microtubule organization, neuronal polarity, and the molecular mechanisms underlying synaptic function and dysfunction. His work frequently explores how disruptions in intracellular transport contribute to neurological disorders including Alzheimer's disease, schizophrenia, and autism spectrum disorders, with particular attention to the relationship between cytoskeletal organization and cargo transport in neuronal compartments. Scientific Awards and Memberships: ZonMW-VIDI (2004) European Young Investigators (EURYI) award (2005) NWO-ALW VICI (2011) ERC Consolidator grants (2013) FENS-Kavli Network of Excellence (2014) European Molecular Biology Organization (EMBO) (2015) Young Academy of Europe (YAE) (2015) IBRO Kemali Prize (2016) Hoogenraad leads a research group studying neuronal development and function, with a particular focus on how intracellular transport mechanisms contribute to both normal brain function and neurological disorders. His laboratory employs a multidisciplinary approach combining molecular, cellular, and systems neuroscience techniques to investigate the molecular basis of neuronal polarity, synaptic plasticity, and the pathogenesis of neurological disorders. He has secured significant research funding through prestigious grants including ERC Consolidator grants. The Hoogenraad lab operates within the Cell Biology department at Utrecht University, collaborating with other research groups focusing on cellular dynamics, biophysics, and neurobiology. The lab utilizes advanced microscopy techniques including immunofluorescent confocal microscopy, high-resolution live cell imaging (spinning disc microscopy and total internal reflection fluorescence microscopy), and quantitative analysis using advanced high-resolution microscopy (photo-activated localization microscopy). Current lab technicians include Phebe Wulf and Bart de Haan.

• Molecular Neuroscience
• Neuronal Development
• Intracellular Protein Trafficking
• +۷ مورد دیگر

Dr Jonathan Cook is a Research Fellow at Jesus College, University of Oxford, affiliated with the Medical Sciences division. He holds a primary medical qualification from Queen’s University (Canada, 2021) and a PhD investigating viral immune evasion mechanisms under Prof Jeffrey Lee. His work was supported by the Vanier Canada Graduate Scholarship and recognized with the Stuart Alan Hoffman Memorial Prize. As an incoming Banting Fellow at the Jenner Institute, he focuses on vaccine design for infectious diseases. His research interests include malaria eradication, emerging pathogens, and structure-based vaccine strategies. **Education**: - PhD (Investigation of viral entry glycoproteins), University of Toronto, supervised by Prof Jeffrey Lee - Primary Medical Qualification, Queen’s University, Canada **Research Interests**: - Malaria Eradication : Developing vaccines targeting Plasmodium species. - Emerging Infectious Diseases : Designing rapid-response strategies for pathogens like SARS-CoV-2. - Structure-Based Vaccine Design : Leveraging protein structural data to enhance immunogenicity. **Awards**: - Vanier Canada Graduate Scholarships Programme (2017–2020) - Stuart Alan Hoffman Memorial Prize (2021) - Banting Fellowship (incoming) **Grants/Advising**: Works on Jenner Institute-funded projects. No listed advisees yet. **Labs/Teams**: Collaborates with Prof Lee's lab at the Jenner Institute and the University of Toronto's Medical Microbiology program.

• Malaria Eradication
• Emerging Infectious Diseases
• Structure-Based Vaccine Design
• +۳ مورد دیگر

Alicia Che is an Assistant Professor of Psychiatry at Yale University School of Medicine and serves as Director of Graduate Admissions for the Interdepartmental Neuroscience Program. She joined the Yale Department of Psychiatry in 2021 after completing her postdoctoral fellowship with Dr. Natalia De Marco García at Weill Cornell Medical College and Dr. Gord Fishell at NYU. Her research is conducted through the Che Lab at Yale, where she investigates how early life experiences impact brain circuit assembly and mature function in models of psychiatric illness. Yale School of Medicine, Department of Psychiatry Interdepartmental Neuroscience Program Center for Brain & Mind Health Division of Molecular Psychiatry Wu Tsai Institute Yale Center for the Science of Cannabis and Cannabinoids Dr. Che earned her Ph.D. in Physiology and Neurobiology from the University of Connecticut in 2014, where she worked in the laboratory of Dr. Joseph LoTurco. She received her B.S. with triple majors in Biology, Physics, and Physical Chemistry from Pacific Lutheran University in Washington state in 2009. Her research focuses on understanding developmental trajectories following early life experiences to develop diagnostics and early interventions for psychiatric illnesses. Dr. Che's research examines how sensory inputs, social bonding, stress, and substance exposure impact brain development. She employs a multi-dimensional approach to assess transcriptional, circuit, neuronal activity, and behavioral changes across the entire developmental timeline. Her lab currently focuses on four specific areas: the role of oxytocin in social behavior development, circuit dysfunction in PTSD, early-life cannabinoid exposure effects, and the impact of early life stress on development and adulthood. She utilizes advanced techniques including mouse genetics, slice electrophysiology, and longitudinal in vivo 2-photon imaging on behaving animals. Her most recent publications demonstrate significant contributions to understanding neural circuit development, PTSD mechanisms, and the effects of early life experiences on brain function. Her work spans from molecular neuroscience to behavioral outcomes, with publications in top journals including Nature, Neuron, and Nature Communications. Her research has revealed important insights into how translaminar neuronal activity strengthens cortical columns, how oxytocin facilitates social touch development, and how PTSD affects brain transcriptomics. NARSAD Young Investigator Award (2020) K99/R00 Pathway to Independence Award from NINDS (2019) Dr. Che's work has significant implications for understanding and treating neurodevelopmental disorders, PTSD, and the consequences of early life experiences on mental health. She collaborates extensively with researchers across Yale and beyond, with frequent co-authorship with colleagues including Lin Lin, Alex Kwan, and Christopher Pittenger. Her research program bridges basic neuroscience with clinical applications, aiming to translate findings into potential interventions for psychiatric conditions.

• Neuroscience
• Developmental Neuroscience
• Behavioral Neuroscience
• +۵ مورد دیگر

Eduardo E. Benarroch, M.D., is a Professor of Neurology and Consultant in the Department of Neurology at Mayo Clinic in Rochester, Minnesota. His research focuses on neurochemical mechanisms underlying neurodegenerative disorders such as multiple system atrophy (MSA) and Lewy body diseases, with emphasis on brainstem and hypothalamic neuronal groups controlling homeostasis. His work is supported by the MSA Coalition and has contributed to understanding autonomic, respiratory, and sleep symptom mechanisms in Parkinson's disease. Dr. Benarroch holds a D.Sci. in Physiology from Buenos Aires University and completed multiple fellowships including NIH Fogarty International Fellowship at Cornell University. He has held leadership roles including President of the American Autonomic Society and Co-Director of Mayo's Neuroscience Laboratory. His 286+ publications span neurochemical pathology, autonomic disorders, and clinical neurology. Awarded the AB Baker Lifetime Achievement Award in Neurologic Education, he has received repeated teaching honors including Mayo's Distinguished Educator Award. His professional memberships include American Academy of Neurology, Society for Neuroscience, and Sigma Xi. He has advised numerous trainees and contributed to consensus guidelines on dysphagia in neurodegenerative diseases.

• Neurodegenerative disorders
• Autonomic disorders
• Parkinson's disease
• +۳ مورد دیگر

Eino Solje is an Associate Professor and Research Director at the University of Eastern Finland (UEF), affiliated with the Institute of Clinical Medicine within the School of Medicine at the Faculty of Health Sciences. He specializes in Neurology and serves as the Director of the UEF Brain Research Unit and the leader of the Frontotemporal Lobar Degeneration and Early Onset Dementia research group. His academic roles also include partnership in the national FinFTD research consortium and clinical practice as a Neurologist at Kuopio University Hospital. Dr. Solje holds a PhD and MD from UEF, along with Adjunct Professor (Docent) status. His research focuses on neurodegenerative diseases, particularly frontotemporal dementia (FTD), Alzheimer’s disease, and early-onset dementia. Key interests include biomarkers, genetics, ethical/legal issues in dementia care, and clinical management. He leads projects such as 'Synapsing Mental Disorders and Neurodegenerative Diseases' and 'Shadows in Paradise? Rights of People with Dementia in a Welfare State.' His research explores diagnostic challenges, biomarker development, and the intersection of medicine and law in dementia care. Publications emphasize neuroimaging, ethical guardianship, and clinical outcomes. He advises numerous PhD and medical students and collaborates internationally on FTD/ALS genetics and biomarkers. His work spans clinical trials, epidemiological studies, and interdisciplinary teams addressing dementia’s societal impact. Dr. Solje’s contributions include advancing FTD diagnostic criteria, investigating neurodegenerative biomarkers, and advocating for patient rights. His labs focus on clinical trials, neuroimaging analysis, and ethical/legal frameworks in healthcare.

• Frontotemporal dementia
• Alzheimer’s disease
• Early onset dementia
• +۴ مورد دیگر

Dr. Qin Li is an Assistant Professor of Genetics at the University of Pennsylvania Perelman School of Medicine, affiliated with the Penn Institute for Immunology & Immune Health (I3H), the Penn Institute for RNA Innovation, and the Penn Center for Genomic Integrity. He earned his BS and PhD in Biological Science and Biochemistry & Molecular Biology from Peking University, followed by postdoctoral training at Stanford University. Education : BS (Peking University, 2009), PhD (Peking University, 2014) Dr. Li’s research focuses on the ADAR1-dsRNA-MDA5 axis, exploring how RNA editing mediates self/non-self discrimination in the immune system. His work connects RNA editing quantitative trait loci (edQTLs) to inflammatory disease heritability and develops computational/experimental tools for RNA editing and sensing. Recent publications highlight his contributions to understanding RNA editing’s role in autoimmune diseases, CRISPR-based regulatory principles, and novel RNA ligand engineering. He mentors PhD and Master’s students in Bioengineering, Cell and Molecular Biology, and related programs.

• RNA Editing
• Immunology
• Genetics
• +۳ مورد دیگر

Dr. Arpan Mehta is an Independent Investigator at the MRC Protein Phosphorylation and Ubiquitylation Unit, specializing in neurodegenerative diseases with a focus on Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia. He was awarded the 51st Sir John Halliday Croom Medal and Lectureship by the Royal College of Physicians of Edinburgh for his groundbreaking research on ALS mechanisms. His work explores the role of kinases and genetic mutations (e.g., C9ORF72) in neurodegeneration, alongside mitochondrial dysfunction and clinical trial methodologies. Research interests include molecular mechanisms underlying ALS, neuroimmunology, and improving clinical trial designs for neurodegenerative diseases. Dr. Mehta advocates for rigorous research standards, addressing reproducibility challenges, and optimizing therapeutic approaches. His recent studies investigate mitochondrial bioenergetic deficits in ALS motor neurons and the impact of cerebrospinal fluid (CSF) toxicity. Awards: Sir John Halliday Croom Medal and Lectureship (2025) His publications span clinical neurology, neurodegenerative disease mechanisms, and ethical aspects of medical practice. Dr. Mehta emphasizes interdisciplinary collaboration to advance understanding of ALS pathogenesis and translational therapies.

• Neurodegenerative Diseases
• Amyotrophic Lateral Sclerosis (ALS)
• Molecular Neuroscience
• +۳ مورد دیگر

Sonia Mayoral is the Robert J. and Nancy D. Carney Assistant Professor of Neuroscience at Brown University. Her research focuses on studying cell-cell interactions in the brain, particularly the development and function of oligodendrocytes – glial cells critical for myelin formation. She explores how these cells contribute to myelination, remyelination processes, and their roles in neurological disorders like multiple sclerosis. Her work integrates cellular neuroscience, immunology, and drug screening methodologies. Research interests include glial cell biology, neuron-glial interactions, and the molecular mechanisms governing myelin repair. She investigates how environmental cues and signaling pathways regulate oligodendrocyte differentiation and function. Notable projects involve developing high-throughput screening platforms for MS therapeutics and studying sex-specific responses to neurodegenerative challenges. Her lab’s recent work includes clinical trials (Re-WRAP) evaluating Bazedoxifene for remyelination in women, and fundamental studies on regulatory T cell roles in myelin regeneration. She also examines how mechanical stimulation and epigenetic changes influence oligodendrocyte behavior. Her research bridges basic science and translational efforts, aiming to advance treatments for myelin-related disorders. Dr. Mayoral’s lab is active at Brown University, with a dedicated website detailing ongoing projects and collaborations. While no specific grants or students are listed here, her work reflects a strong focus on interdisciplinary approaches to neurodegenerative disease mechanisms.

• Glial Cell Biology
• Myelin
• Neuron-Glia Interactions
• +۳ مورد دیگر