Arpan Mehta

Dr. Arpan Mehta is an Independent Investigator at the MRC Protein Phosphorylation and Ubiquitylation Unit, specializing in neurodegenerative diseases with a focus on Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia. He was awarded the 51st Sir John Halliday Croom Medal and Lectureship by the Royal College of Physicians of Edinburgh for his groundbreaking research on ALS mechanisms. His work explores the role of kinases and genetic mutations (e.g., C9ORF72) in neurodegeneration, alongside mitochondrial dysfunction and clinical trial methodologies.

Research interests include molecular mechanisms underlying ALS, neuroimmunology, and improving clinical trial designs for neurodegenerative diseases. Dr. Mehta advocates for rigorous research standards, addressing reproducibility challenges, and optimizing therapeutic approaches. His recent studies investigate mitochondrial bioenergetic deficits in ALS motor neurons and the impact of cerebrospinal fluid (CSF) toxicity.

Awards:

• Sir John Halliday Croom Medal and Lectureship (2025)

His publications span clinical neurology, neurodegenerative disease mechanisms, and ethical aspects of medical practice. Dr. Mehta emphasizes interdisciplinary collaboration to advance understanding of ALS pathogenesis and translational therapies.