Catherine Louise Douthwright

Dr. Catherine Louise Douthwright is an Assistant Professor in the Department of Neurology at UMass Chan Medical School, with an additional appointment in Neurology at T.H. Chan School of Medicine. Her research specializes in neurodegenerative disorders, particularly amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), with emphasis on molecular mechanisms, biomarker discovery, and gene therapy approaches.

Her work explores:

• Glial cell dysfunction in C9orf72-related disorders
• SOD1 protein misfolding and nanobody therapeutics
• Antisense oligonucleotide suppression of mutant genes
• Cerebrospinal fluid biomarkers for ALS/FTD
• FUS/TLS protein dynamics in cellular stress response

Publication analysis reveals consistent focus on ALS/FTD pathogenesis across 12+ studies, with recent work advancing gene therapy (AAV vectors) and biomarker applications (poly(GA)/poly(GR) in CSF). Earlier research established fundamental mechanisms of FUS/TLS proteins in stress granule assembly and DNA repair.

Collaborative networks include prominent researchers in neurodegeneration, with co-authorship across institutions on high-impact studies. No awards, grants, or student mentorship details were documented in available materials.