جستجوی استاد راهنمای دانشگاهی

Han Liمشاهده پروفایل

پژوهشگر

• Stem cell biology
• Cellular reprogramming
• Aging
• +۷ مورد دیگر

Han Li is a permanent researcher and structural leader at the Institut Pasteur in Paris, affiliated with the team Membrane, Cytosquelette et Division Cellulaire under the Department of Cell Biology and Infection. Han Li leads research projects focused on cellular plasticity in aging and cancer, exploring mechanisms of cellular reprogramming, senescence, and regeneration. Research Interests: Cellular reprogramming and stem cell biology Mechanisms of aging and cellular senescence Aberrant plasticity in cancer development In vivo models of tissue regeneration Gene regulation in pluripotency (e.g., Sox2) The recent publications highlight work in in vivo reprogramming, particularly in skeletal muscle, using mouse models to study how injury-induced senescence can be leveraged for regenerative purposes. The research bridges fundamental cell biology with implications for regenerative medicine and oncology. Scientific Contributions: Pioneering studies on injury-induced senescence enabling reprogramming Development of assays for detecting senescence during reprogramming Exploration of p27 and Sox2 in dysplastic cell states Han Li supervises PhD students and postdoctoral researchers, contributing to training the next generation of scientists in cell and developmental biology. The work is supported by institutional funding and collaborative initiatives at Institut Pasteur, including LabEx Revive in regenerative biology. Laboratory and Team: The research is conducted within a dynamic team studying cell division, cytoskeleton, and cellular identity, with access to advanced core facilities including organ-on-chip and animal models.

Adil Khanمشاهده پروفایل

دانشگاهی

• Neuroscience
• Systems Neuroscience
• Cognitive Neuroscience
• +۳ مورد دیگر

Dr. Adil Khan is a Reader in Developmental Neurobiology at the Centre for Developmental Neurobiology, King's College London. His research focuses on the neural circuit basis of cognition, including working memory, decision-making, and attentional switching, using mice and rats as model organisms. He combines in-vivo two-photon calcium imaging, optogenetics, and behavioral assays to study prefrontal and visual cortex circuits. Neuroscience Systems Neuroscience Cognitive Neuroscience Neural Circuits Visual Cortex Neurobiology His recent work explores prediction-error signals in task-switching, VIP interneuron disinhibition, and attentional modulation mechanisms. He has secured major grants, including a £3.44M Wellcome Career Development Award (2023-2031) for studying flexible behavior. His publications span journals like Nature Neuroscience and Neuron , emphasizing visual cortex plasticity and cognitive control. Key collaborators include Professor Claudia Clopath (Imperial College London), Dr. Aditya Gilra (Amsterdam), Dr. Katharina Wilmes (University of Bern), and Dr. Angus Chadwick (University of Edinburgh). Scientific awards include the Wellcome Career Development Award (2023).

• Peptide Chemistry
• Bioorganic Chemistry
• Enzyme Inhibition
• +۳ مورد دیگر

Dr. Agata Gitlin-Domagalska serves as an Adjunct Professor at the Faculty of Chemistry, University of Gdańsk, where she leads research in the Department of Molecular Biochemistry and Laboratory of Bioorganic Chemistry. Her work bridges peptide chemistry and bioorganic drug design, focusing on innovative synthetic strategies and therapeutic applications. Academic Affiliation: Faculty of Chemistry, University of Gdańsk Department: Department of Molecular Biochemistry Laboratory: Laboratory of Bioorganic Chemistry Specializing in peptide synthesis and prodrug development , Dr. Gitlin-Domagalska investigates strategies to enhance oral bioavailability of charged peptides through lipophilic charge masking and non-covalent inhibition of serine proteases like matriptase and furin . Her research extends to antimicrobial peptide conjugates with dual therapeutic functions and Zika virus suppression via protease inhibition. Recent publications highlight her expertise in peptide splicing mechanisms , solid-phase synthesis optimization , and nanoparticle-based delivery . She has developed cyclic RGD prodrugs for targeted intestinal permeability and bicyclic furin inhibitors using combinatorial chemistry approaches. Her work contributes to antibiotic conjugates with leukemia-selective antifungal activity , neuroprotective humanin analogs , and vasopressin derivatives with expanded therapeutic potential. Current trends emphasize matriptase-selective inhibitors and earthworm-derived antimicrobial nanoparticles . Dr. Gitlin-Domagalska employs model membrane biosensing for drug-membrane interaction studies and has pioneered high-shear mixing techniques to improve amide bond formation efficiency in peptide synthesis processes.

Phillip D. Zamoreمشاهده پروفایل

استاد

• RNA Interference
• Small RNA Biology
• piRNA Pathways
• +۳ مورد دیگر

Phillip D. Zamore serves as Chair and Professor of the RNA Therapeutics Institute at the University of Massachusetts Chan Medical School School of Medicine and is an Investigator of the Howard Hughes Medical Institute. He holds the Gretchen Stone Cook Professorship in Biomedical Sciences and leads pioneering research in RNA biology. Dr. Zamore earned his A.B. (1986) and Ph.D. (1992) in Biochemistry and Molecular Biology from Harvard University, followed by postdoctoral training at The Whitehead Institute for Biomedical Research. His research focuses on small RNA silencing pathways including RNA interference (RNAi), microRNA, and PIWI-interacting RNA (piRNA) mechanisms across eukaryotic and prokaryotic systems. Key investigations explore how Argonaute proteins achieve sequence-specific regulation of transcription and translation, with emphasis on piRNA biogenesis in germ cells and bacterial Argonaute functions. Analysis of his recent publications reveals dominant themes in transposon silencing, piRNA pathway evolution, RNA therapeutic development, and molecular mechanisms of gene regulation. His work bridges fundamental biochemistry with clinical applications, particularly in RNA-based therapies for genetic disorders. Notable scientific honors include: Chancellor’s Medal for Excellence in Scholarship (2015) Dean's Award for Research Mentoring (2011) Fellow of the National Academy of Inventors (2014) Election to the American Academy of Arts & Sciences, National Academy of Sciences, and National Academy of Medicine (2023) Dr. Zamore has co-founded multiple biotechnology companies including Alnylam Pharmaceuticals (2002), which developed the FDA-approved RNAi therapeutic ONPATTRO for hereditary transthyretin-mediated amyloidosis, and Voyager Therapeutics (2014). His laboratory has trained dozens of researchers now leading institutions worldwide, with over 150 publications and 119 patents reflecting his translational impact. Current research leverages biochemical and genetic approaches to develop RNA-guided therapies for diseases like Huntington's. The Zamore Laboratory operates within the RNA Therapeutics Institute at UMass Chan Medical School, utilizing advanced genomic, biochemical, and imaging technologies to study small RNA pathways in model organisms including Drosophila, mice, and bacterial systems.

Benjamin Schwessingerمشاهده پروفایل

استاد

• Plant Pathology
• Genomics
• Fungal Biology
• +۳ مورد دیگر

Prof Benjamin Schwessinger is a Professor at the Australian National University (ANU), affiliated with the Division of Plant Sciences. His research focuses on plant pathogens, fungal genomics, and the evolutionary dynamics of pathogen adaptation. Key areas include understanding rust fungi biology, host-pathogen interactions, and structural genomic variations in plants like Eucalyptus. He has pioneered methodologies for high-throughput protein secretion optimization in yeast and developed diagnostic tools for invasive pathogens such as Austropuccinia psidii (myrtle rust). Research Interests: Plant-microbe interactions and immunity Fungal genomics and sexual recombination mechanisms Evolving pathogen populations in agricultural systems Genomic tools for disease surveillance and biosecurity His recent work explores the genomic basis of pathogen adaptation, including studies on wheat stripe rust and myrtle rust. Collaborations span fungal pathogenomics, eucalyptus structural genomics, and yeast biotechnology. He leads multiple projects funded by ANU and ARC, including the Plant Biosecurity Training Centre. His lab emphasizes reproducible research practices and early career researcher development. Key projects include: Digital yeast bioprospecting for non-alcoholic beer production Surveillance of airborne pathogens in Australian Botanic Gardens Genome evolution of cereal rust fungi Labs/Teams: Core member of ANU's Plant Biosecurity Group and collaborator in the ARC Training Centre in Plant Biosecurity.

• Antimicrobial Agents
• Antibiotic Drug Discovery
• Infectious Diseases
• +۳ مورد دیگر

Soumya Ramu is a researcher affiliated with the University of Queensland's Frazer Institute, focusing on antimicrobial drug discovery and antibiotic development. Her work spans antibacterial, antifungal, and antiparasitic compounds with an emphasis on overcoming antibiotic resistance mechanisms. Research Interests: Ms. Ramu's research includes developing novel antibiotics against drug-resistant bacteria, evaluating existing drugs for repurposing (e.g., cannabidiol), and studying chemical agents targeting biofilm-associated infections. She explores metal-ion complexation effects on antibiotic activity and investigates mechanisms of bacterial resistance. Collaborations: Her work involves interdisciplinary teams across medicinal chemistry, microbiology, and pharmacology, collaborating with institutions like the Translational Research Institute and global researchers in antibiotic development. Publications: Ramu's 24+ journal articles and conference papers (2012-2022) highlight contributions to antibiotic design, resistance mechanisms, and drug-activity optimization. Key topics include lipoglycopeptides for biofilm infections, platinum-based antibacterial complexes, and minor groove binder therapeutics.

Rutilio A. Frattiمشاهده پروفایل

استاد

• Membrane Biology
• Ion Channels
• Protein Dynamics
• +۵ مورد دیگر

Rutilio A. Fratti is a Professor of Biochemistry and Biophysics & Quantitative Biology at the University of Illinois, affiliated with the College of Liberal Arts & Sciences and the School of Molecular & Cellular Biology. His research focuses on protein-lipid interactions, membrane fusion, and lipid metabolism, particularly in the context of diseases like cancer, diabetes, and Alzheimer's. He earned his B.S. from California State University, Long Beach (1992), Ph.D. from the University of Michigan (2002), and completed postdoctoral work at Dartmouth Medical School (2002-2006). Key research interests include regulatory lipids (e.g., phosphatidic acid, phosphoinositides) and their roles in membrane microdomains, SNARE protein function, and drug discovery targeting fungal pathogens. His lab uses yeast vacuoles and synthetic vesicles to study lipid-protein interactions during membrane fusion. Publications highlight advancements in methods like Bio-Layer Interferometry, microscale thermophoresis, and spectroscopic techniques for studying lipid-protein interactions. Collaborations span drug discovery (e.g., SQ109 antifungal mechanisms) and mechanistic insights into Sec18 protein dynamics and Ypt7 regulation. Affiliated with the Center for Biophysics & Quantitative Biology, his work bridges fundamental lipid biology with translational applications in metabolic and infectious diseases.

Paul R Selvinمشاهده پروفایل

استاد

• Biophysics
• Molecular Motors
• Neuroscience
• +۳ مورد دیگر

Paul R Selvin is a Professor of Biological Physics at the University of Illinois at Urbana-Champaign, affiliated with the Departments of Physics, Electrical and Computer Engineering, Cell and Developmental Biology, and Chemistry. He earned his Ph.D. in Physics from UC Berkeley (1990) and joined UIUC in 1997. His research focuses on molecular motors, super-resolution microscopy, and biophysical techniques like FIONA (Fluorescence Imaging with One-Nanometer Accuracy). Selvin pioneered studies on motor protein mechanics, including kinesin and dynein, and developed quantum dot-based imaging technologies. He has received prestigious awards such as the Sackler Prize in Biophysics (2006) and the Gregorio Weber Award (2020). Education: B.S. in Physics (University of Michigan, 1983), Ph.D. in Physics (UC Berkeley, 1990). Key research areas include neuroscience, single-molecule dynamics, and fluorescence resonance energy transfer (FRET). Recent work explores in situ measurements in Planaria and C. elegans. His lab develops advanced imaging tools like STED and DNA-PAINT for cellular and subcellular visualization. Notable contributions include discovering hand-over-hand motion in molecular motors and advancing quantum dot applications in live-cell imaging. His team collaborates across disciplines, integrating biophysics, nanotechnology, and cell biology. Awards also include the NSF CAREER Award (2000) and Fellowships from the American Physical Society and Research Corporation.

Nathaniel R. Landauمشاهده پروفایل

استاد

• Virology
• Immunology
• Innate Immunity
• +۴ مورد دیگر

Nathaniel R. Landau is a Professor in the Department of Microbiology at NYU Grossman School of Medicine. His research spans HIV molecular biology, dendritic cell immunology, lentiviral vector vaccine development, and SARS-CoV-2 therapeutics. He has pioneered tools for neutralizing antibody assays and developed a soluble ACE2-based therapeutic for coronavirus infections. PhD in Biology from Massachusetts Institute of Technology Postdoctoral Fellowships: University of California, San Francisco (Microbiology & Immunology); MIT Biology Department Dr. Landau's work focuses on innate immunity mechanisms, including restriction factors like APOBEC3 and SAMHD1 that inhibit retroviruses, and how viruses counteract these defenses. His lab has engineered lentiviral vectors that overcome SAMHD1 barriers for dendritic cell transduction and developed second-generation dendritic cell vaccines for HIV and cancer. Recent research includes creating SARS-CoV-2 spike-pseudotyped lentiviruses for neutralization assays and a recombinant ACE2 microbody with enhanced antiviral activity. The lab has validated these tools in convalescent sera studies and developed rapid assays for antibody titers. Key trends in his publications include innate immune evasion, lentiviral vector innovations, and cross-disciplinary approaches to viral pathogenesis. His team has automated neutralization assays using robotic platforms to process large sample volumes efficiently. Dr. Landau's laboratory has contributed to understanding how toll-like receptor agonists like imiquimod induce antiviral states via ISGs, and explored Vpr/Vpx accessory protein functions in lentivirus immune escape. Current projects extend these findings toward immunotherapeutic cancer strategies.

• Protein Structure and Function
• Mass Spectrometry
• Biochemical Methods Development
• +۳ مورد دیگر

Professor Peter Højrup is affiliated with the Department of Biochemistry and Molecular Biology at the University of Southern Denmark, focusing on protein structure and function through advanced biochemical techniques such as mass spectrometry and chemical cross-linking. His research spans biomedical mass spectrometry, systems biology, and proteomics, with a particular emphasis on endoplasmic reticulum proteins like calreticulin and calnexin. Education: PhD in Molecular Biology (1986, Odense University), MSc in Molecular Biology (major) and Chemistry (minor) (1982, University of Aarhus) His research interests include: Developing methods for determining protein 3D structures and interactions via chemical cross-linking and mass spectrometry. Fast glycosylation analysis of immunoglobulins and cancer markers. De novo proteomics of fish mucus proteins. The articles highlight trends in mass spectrometry applications, structural biology, and glycosylation studies, with recent work on SARS-CoV-2 epitope mapping, therapeutic antibody characterization, and host cell protein quantitation. Supervision includes training postdocs, PhD, MSc, and BSc students, though specific student names are not provided.

Aurora Martinezمشاهده پروفایل

استاد

• Structural Biology
• Drug Discovery
• Neurometabolic Disorders
• +۷ مورد دیگر

Aurora Martinez is a Professor in the Department of Biomedicine at the University of Bergen, Faculty of Medicine. She leads the Biorecognition research group, focusing on the structural and functional aspects of biomolecules in neurometabolic disorders such as phenylketonuria (PKU) and dopamine synthesis defects. She is also a partner in the KG Jebsen Centre for Neuropsychiatric Disorders and a Toppforsk-funded project on the Arc protein, a master regulator of synaptic plasticity. Position: Professor Institution: University of Bergen Department: Department of Biomedicine Research Group: Biorecognition Email: aurora.martinez@uib.no Her research integrates structural biology, molecular recognition, and drug discovery to develop therapeutic strategies for genetic and neurodegenerative diseases. Key areas include tyrosine hydroxylase regulation, mitochondrial dysfunction in dopaminergic cells, and neurotransmitter transport mechanisms. She employs biochemical, cellular, and computational approaches to understand disease mechanisms and identify novel therapeutics. The recent publications (2023–2025) reflect a strong trend toward understanding dopamine-related pathways, protein stabilization, and therapeutic interventions in Parkinsonism and related disorders. Themes include chaperone-mediated protein stabilization, high-throughput screening for VMAT2 modulators, and computational tools for drug discovery. The work combines experimental validation with translational applications in neurodegenerative models. She has supervised multiple Master’s students, including Md. Ekhtear Mahmud, Sofie Breisnes Wormdahl, and Kristine Kippersund Brokstad, indicating active mentorship and training roles. Her involvement in large-scale collaborative projects highlights leadership and interdisciplinary engagement. While no specific awards are listed, her participation in prestigious programs like Toppforsk and the KG Jebsen Centre underscores recognition and funding success. She has no listed grants explicitly, but project affiliations suggest competitive funding support. Her research group maintains strong technical capabilities in protein analysis, cellular screening, and structural modeling. The Martinez Lab is actively involved in both fundamental and applied research, with future directions likely to expand into gene therapy, precision medicine for metabolic disorders, and neuroprotective strategies.

John H. Reifمشاهده پروفایل

استاد

• DNA Computing
• Molecular Assembly
• Robot Motion Planning
• +۴ مورد دیگر

John H. Reif is a Professor of Computer Science at Duke University, with secondary appointments in the Thomas Lord Department of Mechanical Engineering and Materials Science (since 2024) and the Department of Electrical and Computer Engineering (since 2016). His research spans DNA computing , molecular assembly , robot motion planning , and quantum computation , focusing on programmable biomolecular systems and parallel algorithms. Education: Ph.D. in Applied Mathematics, Harvard University (1977) M.S. in Applied Mathematics, Harvard University (1975) B.S. in Applied Mathematics and Computer Science, Tufts University (1973) His recent publications emphasize DNA strand displacement , molecular-scale learning systems , and 3D DNA nanostructures , with applications in diagnostics, data storage, and nanofabrication. Articles highlight innovations in error-resilient DNA circuits, programmable self-assembly, and algorithmic modeling of molecular processes. Scientific Awards: Fellow of the American Association for the Advancement of Science (AAAS) Fellow of the Association for Computing Machinery (ACM) Fellow of the Institute of Electrical and Electronics Engineers (IEEE) He has supervised numerous Ph.D. students and postdoctoral researchers , including Rajiv Nagipogu (adaptive molecular systems) and Xin Song ( Daniel Fu , DNA computation on cell membranes). His work is funded by grants from the Defense Advanced Research Projects Agency (DARPA) and the National Science Foundation (NSF) , with recent focus on molecular-scale AI and DNA polymerase reaction networks. Reif co-founded Domus Diagnostics , developing affordable infectious disease testing solutions. He served as General CoChairman of FNANO24 and contributes to teaching courses like Computational Complexity and Molecular Assembly and Computation .

Danielle Dubeمشاهده پروفایل

استاد

• Chemical Biology
• Glycobiology
• Antibiotic Resistance
• +۳ مورد دیگر

Danielle Dube is the Norma L. and Roland G. Ware, Jr. Professor of Chemistry and Biochemistry and Chair of the Chemistry Department at Bowdoin College. A chemical biologist by training, she received her PhD from UC Berkeley and completed postdoctoral work at Stanford University. Her research focuses on bacterial surface glycans linked to pathogenesis, particularly in Helicobacter pylori , where she develops chemical tools to study and disrupt glycan-mediated interactions. Education : Cornell University (AB in Biology), UC Berkeley (PhD in Chemistry), Stanford University (Postdoctoral) Teaching : Biochemistry, Chemical Biology, General Chemistry, Drug Discovery courses Research Highlights : Structural characterization of H. pylori glycans Development of metabolic inhibitors for glycan biosynthesis Creation of imaging probes for bacterial glycocalyx Immune recognition enhancement through glycan modification Antibiotic hypersensitization via glycan disruption Scientific Recognition : 2022: Recognized in Nobel Prize awarded research by Prof. Carolyn Bertozzi 2018: Recipient of external grant for women scientists 2014: Collaborator on $18.4M INBRE grant Lab & Collaborations : Leads the Dube Research Laboratory at Bowdoin, specializing in chemical approaches to bacterial glycobiology. Collaborates with biochemistry and microbiology teams on antibiotic resistance solutions.

Shana O. Kelleyمشاهده پروفایل

استاد

• Clinical Diagnostics
• Drug Delivery
• Nanotechnology
• +۶ مورد دیگر

Dr. Shana O. Kelley is a Professor at the University of Toronto , holding cross-appointments in the Departments of Biochemistry, Pharmaceutical Sciences, Chemistry, and Biomedical Engineering . Her work focuses on developing novel technologies for clinical diagnostics and drug delivery , integrating nanotechnology , chemical biology , and materials science . Education : Ph.D. in Chemistry from the California Institute of Technology (Caltech), NIH postdoctoral fellow at the Scripps Research Institute Her research spans mitochondrial chemical biology , peptide-based intracellular targeting , and ultrasensitive biomolecular detection . She pioneered peptide vectors for organelle-specific drug delivery and nanoscale biosensors for disease diagnostics. Recent trends highlight her work in electrochemical cancer detection , nanotechnology-enabled diagnostics , and pathogen sensing . Notable awards : 2013 University of Toronto Distinguished Professor Award 2012 Queen Elizabeth II Diamond Jubilee Medal NSERC E.W.R. Steacie Fellowship (2010) NSF CAREER Award (2004) Dr. Kelley has founded two molecular diagnostics companies, GeneOhm Sciences (acquired by Becton Dickinson) and Xagenic Inc. , demonstrating her translation of research into clinical tools. She teaches graduate courses in precision medicine and nanobiotechnology , and her lab collaborates extensively with engineers and clinical researchers.

• Analytical chemistry
• Nutritional metabolomics
• Clinical and biomedical metabolomics
• +۶ مورد دیگر

Dr. Armaghan Shafaei Darestani is a Lecturer at the School of Science, Edith Cowan University (ECU) , and a Research Fellow with the Centre of Integrative Metabolomics & Computational Biology . She previously held postdoctoral roles at the Norwegian University of Science and Technology (NTNU) and the University of Western Australia, focusing on metabolomics and proteomics method development. Research Areas : Analytical chemistry, Nutritional metabolomics, Clinical metabolomics, and Proteomics. Key Techniques : Liquid chromatography-mass spectrometry (LC-MS), HILIC-MS, HPTLC, GC-MS. Scientific Contributions include targeted metabolite assays for dietary intervention studies and deep phenotyping of biological models. She has contributed to understanding sulfur-containing compounds (e.g., S-methyl cysteine sulfoxide) in chronic disease prevention. Major Awards : 2018 - Endeavour Postdoctoral Fellowship (Australian Government) 2014 - Gold Medal at ITEX 2014 for anti-hypertension plant-based medicine PhD Research Fellowship (University of Science Malaysia) Grants and Projects : AU$210,909 (2025-2027): Forensic protein identification via human hair shaft proteomics. AU$243,343 (2023-2025): Metabolomics for Asthma Prediction 2 (MAP-2). AU$701,666 (2017-2023): Research Fellowship in Analytical Chemistry/Proteomics.