معرفی
Zhongwu Liu is a Research Scientist in the Department of Comparative Medicine at Yale University. His research focuses on neuroendocrine mechanisms regulating metabolism, particularly the role of agouti-related peptide (AGRP) neurons in feeding behavior, stress responses, and obesity. He collaborates extensively with experts in neuroscience and metabolism, including Tamas Horvath and Xiao-Bing Gao. His work integrates epigenetic, cellular, and behavioral approaches to understand metabolic disorders.
Education: MD from Tongji Medical University (Yunyang Medical College, 1982). Research emphasizes hypothalamic circuitry, mitochondrial dynamics, and lipid metabolism. His studies have revealed how TET3 epigenetic regulation in AGRP neurons controls feeding and stress responses, and how astrocyte lipid metabolism influences obesity susceptibility. Recent work explores lysophospholipid signaling at cortical synapses and mitochondrial dysfunction's role in neuronal activity.
Publications highlight interdisciplinary approaches to metabolism, including discoveries about OGT's role in curbing obesity and LINE-1 retrotransposons driving cerebellar ataxia. His research bridges basic science and translational medicine, with implications for treating metabolic and neurological disorders.