Zhaozhu Qiu

Zhaozhu Qiu is an Associate Professor in the Department of Physiology at Johns Hopkins University School of Medicine. His research is centered on the molecular physiology of ion channels, particularly chloride channels, and their roles in the nervous system and neurological diseases.

Research Interests: Dr. Qiu's work focuses on cellular and molecular neuroscience, especially the neurobiology of disease. His laboratory investigates the molecular identity and regulation of novel ion channels such as SWELL1 and PAC, with an emphasis on their function in neurons and glial cells. These studies have implications for understanding ischemic stroke, epilepsy, pain, and glioma.

Research Trends: His recent publications highlight a strong focus on volume-regulated and proton-activated chloride channels. The work integrates functional genomics, electrophysiology, and mouse models to uncover how ion channel dysfunction contributes to brain pathologies. A recurring theme is the role of astrocytic ion channels in modulating synaptic transmission and promoting brain injury during stroke.

Scientific Contributions:

• Pioneered identification of SWELL1 as a key component of volume-regulated anion channels.
• Discovered PAC as a proton-activated chloride channel with evolutionary conservation.
• Demonstrated astrocytic SWELL1’s role in glutamate release and stroke damage.

Advising and Grants: Dr. Qiu is affiliated with the Biochemistry, Cellular and Molecular Biology Graduate Program, the Neuroscience Training Program, and the Graduate Program in Cellular and Molecular Physiology. He actively recruits motivated graduate students to his lab, indicating ongoing research funding and mentorship activities. While specific grants are not listed, his publication record in high-impact journals suggests sustained NIH or equivalent support.

Lab and Team: The Qiu Lab develops and applies high-throughput functional genomics screening methods. It utilizes a multidisciplinary approach combining mouse genetics, brain slice electrophysiology, biochemistry, and imaging to study ion channel biology in health and disease.