معرفی
Zahoor Shah, Ph.D., is a Professor and Vice Chair in the Department of Medicinal and Biological Chemistry at the College of Pharmacy and Pharmaceutical Sciences, The University of Toledo. He serves as Associate Dean for Graduate Education and Research and Program Director. Dr. Shah obtained his doctorate in Toxicology from Hamdard University (New Delhi, India) and completed postdoctoral training at the University of Louisville (2005) and Johns Hopkins University (2007).
- 2005: Postdoctoral Fellow, University of Louisville
- 2007: Postdoctoral Fellow, Johns Hopkins University
- 2009: Instructor, Johns Hopkins University
Dr. Shah’s research focuses on identifying molecular targets and developing drugs for ischemic and hemorrhagic brain injuries. Key areas include:
- Neuroprotective agents targeting oxidative stress and inflammation
- Role of Nrf2/HO1 pathway in stroke recovery
- Mechanistic studies of cofilin signaling in neuroinflammation
- Preclinical models of stroke (t-MCAO, pMCAO, BCCAO) and zebrafish Alzheimer’s models
- Development of ROS-sensitive nitric oxide synthase inhibitors
- Patents in oxidative stress-related therapies
His 15 most recent articles (2022–2024) emphasize:
- Therapeutic targeting of cofilin and neuroinflammation in stroke and neurodegenerative diseases
- Interplay between gut microbiota and cognitive decline
- Preclinical validation of anti-inflammatory agents (e.g., triazole-pyrimidine hybrids)
- Impact of metabolic factors (diabetes, hyperglycemia) on brain injury outcomes
Dr. Shah has received major grants including NINDS R01 (2020–2025) and NIA R01 (2018–2023), and holds patents for neuroprotective compositions (US Patent 10,590,119; provisional applications D2018-11 and D2019-35). He has published over 83 peer-reviewed articles and mentored numerous graduate and undergraduate students.
