Panagiotis Mastorakos

Dr. Panagiotis Mastorakos is an Assistant Professor in the Department of Neurosurgery at UT Southwestern Medical Center, affiliated with the Peter O'Donnell Jr. Brain Institute. His clinical expertise focuses on cerebrovascular neurosurgery, managing vascular lesions, ischemic/hemorrhagic stroke, and aneurysms. His research investigates innate immune pathways in cerebrovascular diseases, particularly subarachnoid hemorrhage (SAH) and stroke, aiming to bridge bench-to-bedside therapies.

• Education: Medical and doctoral training at the University of Athens School of Health Sciences, Neurosurgery residency at NIH/University of Virginia, and cerebrovascular fellowship at Thomas Jefferson University.
• Research Interests: Immune responses in CNS injury, nanotherapeutics delivery, myeloid cell dynamics, meningeal repair mechanisms, and intracranial pressure effects.

Key publications highlight innovations in Woven EndoBridge aneurysm treatment, immunological mechanisms in CNS injury, and nanoparticle-based therapies. His lab collaborates on NIH-funded grants (R01/R24) and employs advanced models (e.g., MCAO, SAH) and techniques (multiphoton microscopy, single-cell RNAseq). The team includes researchers like Vaidehi Shah (Research Technician), Lu Han (Postdoc), and Jordan Mattke (Postdoc).

Grants include NIH-funded studies on neurovascular injury repair and nanomedicine. No specific awards listed, but patents exist for brain-penetrating nanoparticles.