Yulong Wei

Yulong Wei is a Researcher in the Department of Microbial Pathogenesis at Yale School of Medicine. His work focuses on understanding viral persistence mechanisms, particularly in HIV-1 and SARS-CoV-2, using cutting-edge genomic and immunological approaches. He explores how host cellular environments influence viral integration, reservoir formation, and immune evasion.

Research interests include:

• HIV reservoir dynamics and latency mechanisms
• Host-pathogen interactions in viral persistence
• Single-cell multiomics analysis of viral infections
• Antiviral drug discovery and repurposing
• Ribosomal adaptation and translation mechanisms in bacteria

Recent work highlights his contributions to understanding how interferon signaling and chromatin structure affect HIV integration sites, as well as computational studies of griseofulvin's potential in combating SARS-CoV-2. He has also investigated evolutionary genomic signatures in microbes related to translation efficiency and environmental adaptation.

His lab is part of the Yale School of Medicine's broader efforts in microbial pathogenesis and infectious disease research, with a focus on translational applications for persistent viral infections.