Yuki Shindo

Yuki Shindo is an Assistant Professor in the Department of Biological Sciences at the University of Texas at Dallas, affiliated with the School of Natural Sciences and Mathematics. Their research focuses on quantitative cell biology, particularly nuclear-cytoplasmic transport mechanisms and their roles in cell cycle regulation, development, and disease.

• Postdoctoral Research: Cell and Developmental Biology (Princeton University/Dartmouth College, 2024)
• Postdoctoral Research: Cell Biology/Biophysics (RIKEN, Japan, 2017)
• Ph.D.: Cell Biology/Biophysics (Osaka University/RIKEN, 2016)
• B.A.: Bioinformatics (Keio University, 2012)

Research integrates quantitative fluorescence microscopy, genetics, biochemistry, and kinetic modeling using Drosophila, mammalian tissue culture, and in vitro systems. Key interests include histone regulation of cell cycle checkpoints, nuclear import/export dynamics, and nonlinear biochemical networks in signaling pathways.

Recent publications (2016-2024) address topics such as histone H3 inhibition of Chk1 in embryonic development, cortical polarity mechanisms in cell division, and modeling of single-cell signaling noise. The work combines experimental and computational approaches to dissect fundamental cellular organization principles.

Laboratory members investigate nuclear transport regulation in both normal and disease contexts, emphasizing quantitative analysis of subcellular architecture and dynamics.