Yue Leng

Dr. Yue Leng is an Associate Professor in Psychiatry at the University of California, San Francisco (UCSF) School of Medicine, and leads the Moon (Sleep) Lab for Artificial Intelligence Technology. Her work bridges epidemiology and neurodegenerative disease research through innovative digital biomarker development and machine learning applications.

• PhD in Epidemiology from University of Cambridge
• Postdoctoral training in sleep and neurodegeneration at UCSF

Research Interests:

• Investigating sleep-cognition relationships in aging populations
• Developing behavioral sleep interventions for mild cognitive impairment
• Exploring circadian rhythm disruption as early dementia markers
• Creating wearable-based sleep biomarkers through AI/ML
• Studying ethnic and sex disparities in sleep disorders
• Examining genetic-sleep interactions in Alzheimer's pathogenesis

Key Contributions:

• Developed LifeSPAN cohort for life-course sleep-neurodegeneration analysis
• Led STAI SHARP project on statistics/AI in sleep health
• Pioneered WeSleep wearable technology research

Scientific Awards:

• NIH Pathway to Independence Award (K99/R00)
• Global Brain Health Institute Atlantic Fellow
• Cambridge International Scholarship
• China Medical Board Next Generation Fellowship

Research Funding:

• NIH R01AG083836 (2024-2029): Multidimensional sleep patterns and Alzheimer's
• NIH R21AG085495 (2023-2025): Digital biomarker development
• NIH R00AG056598 (2017-2024): Sleep and cognitive decline