معرفی
Yu Chen serves as a Postdoctoral Associate in the Department of Psychiatry at Yale School of Medicine. Their research focuses on integrating traditional herbal medicines with modern therapeutic strategies, particularly in oncology and infectious diseases. Key areas include developing novel antitumor agents like YIV-818-A, enhancing chemotherapy efficacy through PHY906 formulations, and investigating mechanisms of antibiotic synergy against MRSA biofilms.
Research interests emphasize drug discovery from natural products, mechanism-based quality control (MBQC) of herbal preparations, and translational research in immune-oncology. Their work bridges traditional Chinese medicine (TCM) principles with contemporary pharmacological approaches, addressing challenges in antibiotic resistance, cancer treatment resistance, and inflammation-driven pathologies.
Recent studies highlight advancements in combining YIV-906 with immunotherapy (e.g., anti-PD1), demonstrating enhanced tumor microenvironment modulation. Preclinical and clinical trials evaluate therapeutic synergies in rectal cancer and hepatocellular carcinoma. Publications span herbal pharmacology, drug delivery systems, and regulatory science frameworks for TCM standardization.