معرفی
You-Shin Chen is an Assistant Professor of Biology in the College of Innovation and Technology at the University of Michigan-Flint. Her work bridges molecular and cellular biology with environmental health, cancer research, and regenerative medicine through innovative 3D cell culture models.
Education:
- B.S. in Biotechnology, Washington State University
- M.S. in Biotechnology, Georgetown University
- Ph.D. in Biochemistry and Molecular Biology, Georgetown University
Dr. Chen's research focuses on molecular mechanisms of cancer, toxic effects of environmental contaminants like microplastics, and enhancing bone repair via mesenchymal stem cells. She integrates advanced 3D co-culture systems to model tumor microenvironments and fetal tissue responses. Her teaching emphasizes experiential learning in cell biology and biotechnology, using AI-assisted tools and career-oriented training.
The recent publications highlight her expertise in cancer signaling pathways, particularly in melanoma and squamous cell carcinoma, with recurring themes in Id protein regulation, apoptosis, and cell motility. Her work spans from basic cell survival mechanisms to translational applications in diagnostics and therapy.
Scientific Awards:
- Golden Apple Award, University of Michigan-Flint (2024)
- Golden Apple Award, University of Michigan-Flint (2022)
Dr. Chen has actively mentored graduate students and secured competitive research funding. As Principal Investigator, she leads projects on microplastic toxicity in human intestinal organoids funded by the National Science and Technology Council (Taiwan) and UM-Flint. She also contributes as CoPI on studies examining breast cancer metastasis under microenvironmental stress. Her prior industry experience at FAST Diagnostics enriched her translational perspective in developing portable diagnostic platforms.
She is affiliated with research labs utilizing 3D cell culture and organoid technologies, focusing on fetal health and cancer progression. These teams integrate molecular biology, toxicology, and regenerative medicine approaches to address pressing human health challenges.
