معرفی
Yisong Wan is a Professor in the Department of Microbiology & Immunology at the University of North Carolina at Chapel Hill School of Medicine. His research focuses on the molecular mechanisms underlying T cell function, particularly regulatory T cells (Tregs) and their role in immune homeostasis, autoimmunity, and cancer immunology.
Dr. Wan's research interests center on three main areas: Function and regulation of Treg cells, where his lab discovered that transcription factor GATA-3 is highly expressed in Treg cells and controls their function and immune homeostasis; TGF-beta signaling in T cells, where his group revealed novel pathways involving Smad4 and TGF-beta in controlling T cell-mediated autoimmunity and tumor rejection; and Molecular networks underlying T cell function, where they use cutting-edge proteomic analysis to elucidate protein networks during T cell growth, quiescence, proliferation and differentiation.
His extensive publication record demonstrates a consistent focus on understanding the molecular basis of immune regulation. Recent work has increasingly bridged basic immunology with translational applications in cancer immunotherapy and autoimmune disease treatment, with particular attention to how Treg cells and TGF-beta signaling influence tumor immunity and response to checkpoint inhibitors.
Dr. Wan has received several prestigious awards including the Laboratory Travel Grant from the American Association of Immunologists, the Yang Family Biomedical Scholars award from UNC, the AAI Early Career Faculty Travel Grant, and the Jefferson-Pilot Fellowships in Academic Medicine award.
His laboratory has made significant contributions to understanding T cell biology, particularly in the areas of Treg cell function, TGF-beta signaling, and molecular networks in immune regulation. His work has been published in top journals including Nature, Immunity, Nature Immunology, and Nature Communications.
