Wan-Lin Lo

Wan-Lin Lo is an Assistant Professor in the Department of Microbiology and Immunology at the University of Utah School of Medicine. Her research focuses on T cell biology, specifically mechanisms of T cell sensitivity and ligand discrimination in adaptive immunity. She investigates how signaling kinetics regulate T cell responses to pathogens and tumors while maintaining self-tolerance.

Dr. Lo received her B.S. from National Taiwan University School of Medicine and Ph.D. from Washington University School of Medicine in St. Louis. Her work explores molecular regulation of TCR signaling, with implications for autoimmune disease prevention and cancer immunotherapy.

• Education:
• B.S., National Taiwan University School of Medicine
• Ph.D., Washington University School of Medicine in St. Louis

Research interests include:

• T cell ligand discrimination
• Kinetic proofreading mechanisms
• Cysteine sulfenylation in signaling
• Tumor immunology
• Autoimmune disease regulation

Recent publications highlight work on:

• LAT phosphorylation kinetics
• SHP2 mutation effects
• CTLA-4 ligand interactions
• ZAP70 signaling thresholds