Yinglong Miao

Yinglong Miao is an Associate Professor in the Department of Pharmacology and Computational Medicine Program at the University of North Carolina at Chapel Hill School of Medicine. His research bridges computational biology, chemistry, molecular biophysics, bioinformatics, and pharmacology to advance biomolecular modeling and drug discovery.

Dr. Miao's primary research focuses on overcoming computational limitations in biological simulations through innovative methodologies. Key areas include:

• AI-driven drug discovery for G-protein-coupled receptors (GPCRs), membrane-embedded proteases, RNA-binding proteins, and RNA targets
• Development of enhanced sampling techniques (GaMD, LiGaMD, Pep-GaMD, PPI-GaMD) enabling microsecond-scale binding/unbinding simulations
• Multiscale modeling of cellular signaling pathways relevant to neurological disorders, heart failure, and cancer

The Miao Lab collaborates extensively with experimental groups to validate computational findings, with current emphasis on Adenosine A1 receptor drug design for cardiovascular and neurological diseases. The lab integrates AI with molecular dynamics to address critical challenges in GPCR flexibility and allosteric drug development.