Yevgeny Brudno

Yevgeny Brudno is an Associate Professor at North Carolina State University, with affiliations in the Department of Chemistry (College of Sciences), the Joint Department of Biomedical Engineering (College of Engineering), and the Pharmacoengineering and Molecular Pharmaceutics program at the University of North Carolina, Chapel Hill. His research focuses on biomaterials engineering, drug delivery systems, and CAR-T cell therapy, with a particular emphasis on developing implantable scaffolds, prodrugs, and targeted delivery mechanisms.

Brudno's work integrates materials science with biological systems, addressing challenges in cancer therapy, immunology, and regenerative medicine. Key areas include optimizing T cell activation and transduction using biomaterial platforms, designing refillable drug depots, and enhancing tissue-specific drug targeting through click chemistry and nanoparticle systems.

His recent publications highlight advancements in biomaterial scaffolds for in vivo CAR-T cell manufacturing, toxicology studies of tissue-anchored prodrugs, and novel approaches to non-invasive drug refill systems. These contributions bridge engineering and medicine, emphasizing translational research.

Brudno's interdisciplinary roles reflect his expertise in biomaterials, pharmacology, and biomedical engineering. His lab (brudnolab@med.unc.edu) focuses on developing next-generation therapeutic delivery systems and cell-based therapies.