معرفی
Yasir Alsiraj, PhD, serves as an Assistant Professor in the Departments of Pharmacology and Nutritional Sciences and Pediatrics at the University of Kentucky College of Medicine. He maintains additional affiliation with the Saha Aortic Center, focusing on translational vascular research.
Education:
- University of Kentucky
Research Interests: Dr. Alsiraj investigates cardiovascular pathophysiology with emphasis on sex-specific mechanisms in abdominal aortic aneurysms and atherosclerosis. His work integrates renin-angiotensin system dynamics, metabolic programming, and adipose tissue biology using murine models. Key areas include pediatric fatty liver disease, nicotine/fructose impacts on vascular health, and developmental origins of cardiometabolic disorders.
Publication Trends: His 2021-2025 publications reveal consistent exploration of sex chromosome effects (XX vs. XY) on vascular disease susceptibility, particularly regarding angiotensin II responses. Major contributions include identifying periaortic fat's serotonin role in aneurysm formation, maternal diet programming of sex-specific cardiovascular outcomes, and metabolic dysfunction mechanisms in pediatric obesity models.
