معرفی
Alan Daugherty, PhD, DSc, FAHA, is a distinguished Professor and Associate Vice President for Research at the University of Kentucky. He serves as Chair of the Department of Physiology and Director of the Saha Cardiovascular Research Center. Additionally, he holds the Gill Foundation Chair in Preventive Cardiology and is Editor-in-Chief of ATVB.
Education:
- Sunderland Polytechnic, UK - B.Sc. (Hons) in Pharmacology (1978)
- University of Bath, UK - Ph.D. in Pharmacology (1982)
- University of Bath, UK - Fellow in Cardiology Physiology (1981-1982)
- Washington University, St. Louis, MO - Fellow in Atherosclerosis (1982-1985)
- University of Bath, UK - D.Sc. in Pharmacology (2002)
Research Focus: Dr. Daugherty's laboratory investigates the molecular mechanisms of human vascular diseases, with particular emphasis on atherosclerosis and aortic aneurysms. His research has evolved from studying lipoprotein modifications and immune responses to focusing on the renin-angiotensin system in vascular pathology. The lab's pioneering work demonstrated that angiotensin II infusion significantly promotes atherosclerosis and aortic aneurysms in hypercholesterolemic mice.
Current research examines several components of the renin-angiotensin system including angiotensinogen, renin, angiotensin-converting enzyme, and angiotensin II receptors. The lab employs innovative approaches including conditional cell-specific deficient mice, adeno-associated virus vectors, and antisense oligonucleotides to explore molecular mechanisms and potential therapeutic targets.
Research Impact: Dr. Daugherty's translational research has led to significant clinical applications. A 2008 Journal of Clinical Investigation study initiated a clinical trial (AQUARIUS) investigating renin inhibition effects on coronary atherosclerosis progression. Ongoing studies on angiotensinogen inhibition have shown promise in preventing hypertension, atherosclerosis, and obesity, with a human antisense oligonucleotide targeting angiotensinogen awaiting clinical trial approval.
Scientific Contributions: With over 380 publications and 25,000+ citations, Dr. Daugherty is a leading figure in cardiovascular research. His extensive publication record spans high-impact journals, focusing on vascular disease mechanisms, therapeutic targets, and translational applications.
Leadership and Affiliations: In addition to his primary roles, Dr. Daugherty serves as a mentor in the MD/PhD Program, is core faculty in the CVRC, and is part of the Nutritional Sciences Graduate Faculty. His leadership positions reflect his significant contributions to cardiovascular research and education at the University of Kentucky.
