Yao Jiguang

Dr. Yao Jiguang is an Associate Research Fellow at the Institute of Biochemistry, Academia Sinica, where he has worked since 2011. His research focuses on neurodevelopmental and neurodegenerative diseases, particularly the pathogenic roles of endolysosomal dysfunction and lysosomal damage, as well as mechanisms of neuronal-glial communication and synaptic vesicle regulation.

• Ph.D. in Genetics (2001-2005), National Yang-Ming University
• Postdoctoral training at Baylor College of Medicine (2006-2011)

His work integrates Drosophila models with advanced techniques like CRISPR, RNAi, electrophysiology, and super-resolution microscopy. He has published extensively on Alzheimer's disease mechanisms, synaptic regulation, and interorganelle communication, with key contributions to calcium channel function and endocytic pathways.

Scientific expertise includes:

• Neurodegenerative disease pathogenesis
• Synaptic vesicle dynamics
• Calcium signaling
• Drosophila genetics

His laboratory (ckyao.ibc.sinica.edu.tw) leverages cross-species approaches using both Drosophila and human neuronal models for disease mechanism discovery.