معرفی
Xinxin Nie is an Associate Research Scientist in the Department of Immunobiology at Yale School of Medicine, affiliated with the Chen Lab. Their research focuses on immunological mechanisms in cancer, infectious diseases, and autoimmune conditions. Key areas include CD137 biomarker dynamics in immunotherapy, T-cell exhaustion in tumors, and PD-L2/RGMb signaling pathways. Nie collaborates on projects involving lipid metabolism's role in cancer and the suppression of autoimmunity in lupus. They have contributed to studies on bacterial infections like Pseudomonas aeruginosa keratitis, exploring molecular pathways such as β-catenin and microRNA-155.
Nie’s work spans peer-reviewed publications in journals like Journal for ImmunoTherapy of Cancer and Cellular & Molecular Immunology. Their research highlights the intersection of immunology, oncology, and microbiology, with a focus on translational applications in immunotherapy and infection control. Current efforts include investigating burned-out CD8+ T-cell subsets that hinder cancer treatment efficacy and identifying novel immune checkpoint targets like Siglec-15.
Labs/Teams: Active member of the Chen Lab at Yale School of Medicine, collaborating with Prof. Lieping Chen and colleagues such as Weiwei Yu.
